Keywords
Adenomatous polyps
Colorectal adenoma
Traditional Chinese Medicine syndrome score
Submitted : 2025-07-08
Accepted : 2025-07-23
Published : 2025-08-07
Abstract
Objective: To investigate the efficacy of Buyang Huanwu Decoction in preventing the recurrence of advanced colonic adenomatous polyps after surgery. Methods: A total of 160 patients who underwent endoscopic treatment for advanced adenomatous polyps of the large intestine at the First People’s Hospital of Jintan, Changzhou, between March 2022 and March 2024 were enrolled in this study. The patients were randomly divided into an intervention group and a control group using a random number table. The control group received routine postoperative care, while the intervention group received Buyang Huanwu Decoction, starting one month after surgery. The decoction was administered warm, twice daily (200 ml per dose), one dose per day, for a total treatment duration of three months. Results: Before the intervention, there were no significant differences between the two groups in terms of TCM syndrome scores, and serum levels of G-17, IL-18, IL-6, COX2, and CRP (P > 0.05). After the intervention, both groups showed a decrease in TCM syndrome scores and serum levels of G-17, IL-18, IL-6, COX2, and CRP compared to pre-intervention values. The intervention group demonstrated a significantly greater reduction (P < 0.05). Three months after the intervention, there was no significant difference in polyp recurrence rates between the two groups (P > 0.05). However, six and twelve months after the intervention, the recurrence rates in the intervention group were significantly lower than those in the control group (P < 0.05). The incidence of adverse reactions was compared between two groups of patients. The intervention group had an incidence of 12.5%, while the control group had an incidence of 6.25%, with no statistically significant difference (P > 0.05). Conclusion: Buyang Huanwu Decoction has significant efficacy in preventing the recurrence of advanced colonic adenomatous polyps after surgery. It improves TCM syndrome scores, reduces oncogenic and inflammatory factors, significantly lowers postoperative polyp recurrence rates, and demonstrates good safety. It is a promising treatment for clinical promotion and application.
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