Keywords
Colorectal cancer
Expression
Targeted therapy
Submitted : 2025-07-09
Accepted : 2025-07-24
Published : 2025-08-08
Abstract
Human epidermal growth factor receptor 2 (HER-2) is a transmembrane receptor tyrosine kinase that is overexpressed in various solid tumors and is closely related to tumor invasion, metastasis, and poor prognosis. In recent years, the expression of HER-2 in colorectal cancer and its clinical significance have gradually attracted attention. This article reviews the expression of HER-2 in colorectal cancer, the clinicopathological characteristics of HER-2 positive colorectal cancer, the detection methods of HER-2, and the drug treatment targeting HER-2, to provide references for clinical diagnosis and treatment and research.
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