Objective: To explore the effect of targeted nursing based on basic living care on patients with chronic gastric ulcer. Method: Ninety patients with chronic gastric ulcer treated in our hospital from August 2018 to August 2019 were selected and divided into observation group (n = 45) and control group (n = 45) randomly. The control group was given routine care. On the basis of the control group, the observation group was given targeted care based on basic living care. Compare the compliance behavior in two groups. Results: After the intervention, the compliance score of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). Conclusion: The use of targeted care based on basic living care for patients with chronic gastric ulcer can improve their compliance behavior, which is worthy of clinical application.