Objective: To analyze the value of multi-slice spiral CT in the diagnosis and resectability of pancreatic cancer. Method: 56 patients with pancreatic cancer treated in our hospital from January 2018 to October 2019 were selected as the research subjects. All patients underwent multi-phase scanning by multi-slice spiral CT. According to the results of the images, observe whether the pancreatic cancer has affected the blood vessels surrounding the pancreas, evaluate the resectability based on the results of the examination, and analyze the final results of the operation which was taken as the standard. Results: all the 56 cases presented slightly low density or equal density, and 28 cases had complete outline. Multi-slice spiral assessment of patients’ vascular invasion types found that 192 branches can be resected with 70 branches cannot; Multi-slice spiral assessment of the main arterial and venous invasion grades around the pancreas of the patients found that 212 branches can be resected with 50 branches cannot; Multi-slice spiral CT was used to evaluate the resectability of pancreatic cancer compared with surgical results. The accuracy of resectable types of vascular invasion was 72.52%; the accuracy of resectable vascular invasion grades was 79.39%. Conclusion: the application of multi-slice spiral CT in the diagnosis of pancreatic cancer can provide a clear understanding of the condition of vascular invasion and distant metastasis, and the accuracy of assessing resection can reach more than 70.00%, which provides a reference for clinical application.