Keywords
Coix Seed
Cachexia
Malignant tumor
Submitted : 2025-07-09
Accepted : 2025-07-24
Published : 2025-08-08
Abstract
Objective: To investigate the therapeutic effects and safety of Dioscorea Decoction combined with Coix Seed in treating cancer cachexia (spleen-kidney Yang deficiency syndrome) in malignant tumor patients. Methods: A total of 90 patients with cancer cachexia admitted between June 2024 and June 2025 were randomly divided into a control group and a study group (45 cases each) using a random number generator. Both groups received antitumor therapy, oral megestrol acetate capsules, and conventional nutritional intervention. The study group additionally received oral Dioscorea Decoction combined with Coix Seed. Differences in TCM syndrome scores, nutritional indicators (serum albumin, hemoglobin), and adverse reactions were compared before and after treatment. Results: Baseline TCM syndrome scores and nutritional indicators were comparable between the two groups before treatment. After treatment, both groups showed significant reductions in TCM syndrome scores and increases in serum albumin and hemoglobin levels. The study group exhibited lower TCM syndrome scores and higher serum albumin and hemoglobin levels than the control group, with statistically significant differences. No significant difference in adverse reaction rates was observed between the two groups. Conclusion: Dioscorea Decoction combined with Coix Seed can further improve nutritional status, alleviate clinical symptoms, and demonstrate good safety in treating cancer cachexia patients.
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