Abstract
Abstract: objective: to investigate the diagnostic value of combined diffusion-weighted magnetic resonance imaging (DWI) and magnetic resonance spectroscopy (MRS) in prostate cancer (PCa).Materials and methods: A total of 25 patients in group A, ranging in age from 67 to 85 years, had diffuse lesions in 3 of them and bone metastases (ilium, pubis, etc.) in 5 of them were confirmed by final examination. All the patients in group A had higher TPSA levels than the reference standard of 4ng/ml within 7 days before mri examination, and the lowest concentration in one patient was 5.02ng/ml. Results greater than 100ng/ml were measured in 5 patients. The sensitivity, specificity and accuracy of DWI, MRS and DWI combined with MRS for PCa diagnosis were analyzed.Results: the mean ADC values of PCa area, peripheral band and central gland in patients with BPH were (0.83±0.12)× 10-3mm /s, (1.82±0.26)× 10-3mm /s and (1.46±0.16)× 10-3mm /s(F=31.1, P < 0.05), respectively.222The mean (Cho+Cr)/Cit values in PCa region, peripheral zone and central gland of BPH patients were 1.55±0.11, 0.53±0.16 and 0.64±0.13, respectively (F=18.2, P < 0.05).There was a statistically significant difference between PCa and BPH patients' peripheral zone and central gland (Cho+Cr)/Cit (P < 0.05), while there was no statistically significant difference between BPH patients' peripheral zone and central gland (Cho+Cr)/Cit (P >, 0.05).The sensitivity, specificity and accuracy of PCa diagnosed by DWI were 79.17%, 80% and 79.63% respectively.The sensitivity, specificity and accuracy of PCa were 87.5%, 86.67% and 87.03% respectively.The sensitivity, specificity and accuracy of DWI combined with MRS in diagnosing PCa were 91.67%, 93.33% and 92.59%, respectively.Conclusion: DWI combined with MRS is better than DWI and MRS alone in the diagnosis of PCa.