Keywords
PI3K/AKT/mTOR signaling pathway
Myocardial ischemia-reperfusion injury
Review
Submitted : 2025-05-06
Accepted : 2025-05-21
Published : 2025-06-05
Abstract
PI3K/AKT/mTOR signaling pathway is a key pathway of myocardial ischemia-reperfusion injury (MIRI). The mechanism of action is mainly oxidative stress, inflammatory response, calcium overload, ferroptosis, autophagy, and apoptosis. MIRI belongs to the category of chest obstruction in traditional Chinese medicine, and its etiology and pathogenesis are mainly “Yang Wei Yin Xian.” Traditional Chinese medicine has the effect of multi-target and multi-component effect, and has played a significant role in the treatment of MIRI in recent years. At present, the monomers of traditional Chinese medicine mainly include saponins, flavonoids, alkaloids, terpenoids, and phenols, and the compounds mainly include Zhigancao Decoction, Zhenyuan Capsule, Jiawei Shenqibai Powder, Qili Qiangxin Capsule, Tongmai Yangxin Pill, Zhilong Huoxue Tongyu Capsule, Guizhi Tongluo Tablets, etc. This paper reviews the research on the improvement of MIRI by regulating PI3K/ AKT/mTOR signaling pathway in recent years, and expounds the mechanism and advantages of traditional Chinese medicine in the treatment of MIRI.
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