Objective: To explore the clinical effect of acupuncture and moxibustion with acupoints on the treatment of chronic gastritis with sleep disorders. Methods: Sixty patients with chronic gastritis and sleep disorders in our hospital from January 2018 to January 2019 were selected and recruited. These patients were divided into two groups, namely the control group and experimental group by using random number table method. Each group consisted of 30 cases. The control group was treated with conventional drugs, whereas the observation group was treated with acupuncture and moxibustion with acupoints on top of the treatment prescribed for the patients in control group. The TCM syndrome score, gastrin level, and sleep quality level were compared between the two groups. Results: After four weeks of treatment, the Traditional Chinese Medicine (TCM) symptom score, gastrin level, and Pittsburgh Sleep Quality Index (PSQI) score in the observation group were lower than those in the control group, and the differences were statistically significant (P <0.05). Conclusion: Acupuncture and moxibustion with acupoints can improve TCM symptom scores, reduce gastrin levels, and improve sleep quality in patients with chronic gastritis and sleep disorders.