Objective: To explore the clinical effect of combination of traditional Chinese medicine and western medicine in treatment of vascular aging in patients with type 2 diabetes complicated by hypertension. Methods: Ninety patients with type 2 diabetes complicated by hypertension admitted to our hospital from May 2016 to August 2019 were selected as research objects. They were randomly divided into control group and observational group, with 45 cases each. Control group was given amlodipine besylate combined with metformin hydrochloride. On the basis of control group, observational group was given combination of TCM syndrome differentiation. Blood glucose, blood pressure and blood lipids before and after 14 days of treatment were compared between two groups. Results: Blood glucose, blood pressure and lipid indexes after treatment were lower than before treatment in both groups; observational group was lower than control group and the difference was statistically significant (P<0.05). Conclusion: Combination of traditional Chinese medicine and Western medicine could lower blood glucose and blood pressure indexes, control blood lipids and delay blood vessel aging in patients with type 2 diabetes complicated by hypertension, it is worthy of clinical popularization.