Abstract
Objective: To investigate the effect of restrictive infusion on ventilator-associated pneumonia (VAP) in elderly patients with colon cancer treated by operation. Methods: A total of 62 elderly patients underwent colon cancer from January 2015 to March 2016 were randomly divided into study group and control group. The patients in the study group were treated with restrictive rehydration strategy, central venous pressure (CVP) 5 ~ 7 cmH 2 O, the control group rubbed with conventional re-hydration program; the remaining treatment of the two groups of patients to maintain consistency. Results: There was no significant difference in MAP, HR and CO between the study group and the control group at the time of T0 ~ T4 (P> 0.05). The infusion volume of the study group was significantly lower than that of the control group (P (P < 0.05). There was no significant difference in the levels of LAC, IL-6 and TNF-α between the two groups (P > 0.05). There was no significant difference in the levels of LAC, IL-6 and TNF-α between the study group and the control group (P < 0.05). After treatment, the levels of IL-6 and TNF-α in the study group were significantly lower than those in the control group (P <0.05). There was no significant difference in the CPIS score between the two groups (P > 0.05). On the 3rd and 7th day after operation, the CPSI score of the study group was significantly lower than that of the control group (P < 0.05). Conclusion: The restrictive infusion has no obvious effect on the hemodynamics of elderly patients with colon cancer treated by surgery, but it can reduce the risk of VAP.