Oncology Treatment Discovery

Research Progress of the Occurrence Mechanism of Bone Cancer Pain

Dan Yi, Mengnan Du, Wentao Li, Shuo Dong, Ying Zhang — Mon, 20 Jan 2025 16:15:24 +0800

As one of the common complications of patients with malignant tumors, cancer pain seriously affects their quality of life, especially the bone cancer pain, and the conventional analgesic effect of some patients with bone cancer pain is not ideal. The pathogenesis of bone cancer pain is complicated, the pathogenesis can be deeply understood and provide diagnosis and treatment thoughts for clinical relief of bone cancer pain by consulting the literature and summarizing the pathogenesis of bone cancer pain.

Research on the Application of Lung Ground- Glass Nodule Screening Based on Gene Methylation Combined with Spiral CT and AI Recognition System in Teaching Practice

Yong Zhou, Cheng Zhou, Yingying Xu, Xiaojing Gan, Wenbo Jiang, Jie Ming — Wed, 02 Apr 2025 09:29:21 +0800

The application of gene methylation combined with spiral CT in the screening of lung ground-glass nodules (GGN) and the integration of AI recognition systems represent cutting-edge advancements in medical technology. This study explores the practical application of these techniques in teaching settings, aiming to enhance students’ understanding and proficiency in modern medical imaging and diagnosis. By incorporating these methods into educational curricula, we seek to assess their effectiveness in improving diagnostic accuracy, efficiency, and overall student engagement. The findings of this research have implications for enhancing medical education, particularly in the field of radiology and imaging sciences, ultimately leading to improved patient care and outcomes.

A Qualitative Study of Caregiving Experiences and Emotional Responses of Family Primary Caregivers of Patients Undergoing Brain Tumour Surgery

Xuefei Li, Can Zhang, Miaomiao Bai, Lian Xue, Xinrong Zhang — Wed, 02 Apr 2025 09:39:28 +0800

Objective: To understand the psychological dilemmas, emotional responses and caregiving experiences faced by family primary caregivers of patients undergoing brain tumour surgery in the process of caregiving, to explore problems in caregiving, and to provide a basis for the development of effective caregiving strategies and support measures. Methods: A phenomenological research method was used to interview the family primary caregivers of the enrolled 31 patients undergoing brain tumour surgery, and to analyze their emotional coping deficits, disease management experiences and social support needs during the patients’ perioperative period and in family caregiving. Discussion: The study found that caregivers’ caregiving experiences and emotional responses at different stages of patients’ illnesses were personal emotional coping deficits, lack of experience in disease management and urgent social support needs. Conclusion: Understanding the caregiving experience and emotional responses of family caregivers of patients undergoing brain tumour surgery helps caregivers better identify the psychological dilemmas and needs faced by caregivers during the caregiving process, which in turn helps them develop personalized emotional support, professional knowledge training and skills guidance, and has a positive clinical impact on facilitating the smooth adaptation of the primary caregiver’s role change, reducing the burden of caregiving, enhancing caregiving confidence and competence. It has positive clinical application value to promote family primary caregivers to adapt to the role change smoothly, reduce the burden of caregiving, enhance the confidence and ability of caregiving and improve the patients’ therapeutic effect and life quality.

Analysis of the Selective Killing Effect of Microplasma on Specific Cancer Cell Lines

Jie Bai — Wed, 02 Apr 2025 09:59:24 +0800

This article aims to deeply analyze the mechanism of the selective killing effect of microplasma on specific cancer cell lines. A comprehensive investigation of relevant literature expounds on the generation principle and characteristics of microplasma and its interaction process with cancer cells. The potential mechanisms of its selective killing of cancer cells are explored from multiple aspects including physics, chemistry, and biology, involving the generation of reactive oxygen and nitrogen species, damage to cell membranes, changes in intracellular signaling pathways, and immunomodulatory effects. Additionally, the existing problems in current research and future research directions are prospected, aiming to provide a theoretical foundation and reference for the further application of microplasma in the field of cancer treatment.

Clinical Efficacy of Tirilizumab in Combination with Conventional Chemotherapeutic Agents in Patients with Advanced Non-small Cell Lung Cancer

Wei Qin, Dongli Zhang — Wed, 02 Apr 2025 00:00:00 +0800

Objective: To explore the analysis of the application effect of tirilizumab combined with conventional chemotherapeutic drugs (paclitaxel + carboplatin) in the clinical treatment of advanced non-small cell lung cancer patients. Methods: Seventy-five patients with advanced non-small cell lung cancer who received chemotherapy treatment in a hospital from July 2023 to June 2024 were selected as objects, and grouped according to the choice of chemotherapy drugs, 37 patients who received regular chemotherapy drugs (paclitaxel + carboplatin) were included in the control group, and the other 38 patients who received tirilizumab + paclitaxel and carboplatin chemotherapy were included in the observation group, and the clinical efficacy of the two groups was compared. Results: Before treatment, the difference in serum tumour marker levels between the two groups was not significant (P > 0.05); after treatment, the levels of glycan antigen 125 (CA125), carcinoembryonic antigen (CEA), neuron-specific enolase NSE, and squamous carcinoembryonic antigen (SCC) in the patients of the two groups were significantly reduced, and the level in the observation group was lower than that in the control group (P < 0.05); before treatment, the level of immune function in the patients of the two groups, there was no statistically significant difference between the immune function levels of patients in the two groups (P > 0.05); after treatment, the levels of CD3⁺ , CD4⁺ and CD4⁺ /CD8⁺ were significantly higher and CD8⁺ were lower in the two groups, and the indicators of the observation group were better than those of the control group (P < 0.05); the incidence rate of toxic side effects such as nausea, vomiting, bone marrow suppression, liver and kidney function abnormalities, and so on, during the period of treatment of the observation group was significantly lower than that of the control group (5.26%) and the difference had a significant difference of 24.32%, the difference was statistically significant (P < 0.05); before treatment, there was no statistically significant difference in the quality of life SF-36 scores between the two groups (P > 0.05); after three courses of treatment, the quality of life SF-36 scores of the two groups were significantly higher, and the observation group was higher than the control group (P < 0.05). Conclusion: Tirilizumab combined with conventional chemotherapy drugs (paclitaxel + carboplatin) has remarkable efficacy in the treatment of advanced non-small cell lung cancer, which can effectively reduce the level of tumour markers and the risk of toxic and side effects, improve the immune function and enhance the quality of life of patients, and has positive clinical promotion value.

Investigating the Impact of Lifestyle Factors on Breast Cancer Prognosis in the Chinese Women Population

Thu, 03 Apr 2025 08:55:40 +0800

This study investigates the impact of lifestyle factors on breast cancer prognosis among Chinese women. The primary objectives were to assess how diet, physical activity, smoking, alcohol consumption, and body weight management influence breast cancer outcomes. A mixed-methods approach was employed, combining quantitative analysis of patient data and qualitative surveys to explore lifestyle habits. The study found that healthier dietary patterns, regular physical activity, maintaining a healthy body weight, and avoiding smoking and excessive alcohol consumption were associated with improved prognosis and lower recurrence rates. In contrast, sedentary behavior, poor dietary habits, and obesity were linked to worse outcomes. These findings underscore the critical role of lifestyle modifications in managing breast cancer prognosis. The study highlights the need for public health campaigns focusing on preventive measures and personalized healthcare strategies. Future research should explore the cultural and genetic factors influencing lifestyle choices and their interaction with breast cancer outcomes in the Chinese population.

Exploration of Ultrasonic-mediated Precise Ablation Strategies for Tumor Treatment

Chunlin Zhao — Wed, 02 Apr 2025 15:59:33 +0800

This article comprehensively explores the application of ultrasonic ablation technology in tumor treatment. It first elaborates on the basic principles of this technology, which utilizes thermal, mechanical, and cavitation effects. The advantages of precise focusing, minimally invasive procedures, and real-time monitoring, as well as limitations such as tissue heterogeneity interference, heat deposition, and acoustic shadow effects, are analyzed. Subsequently, ultrasonic-mediated precise ablation strategies for tumors are introduced, including imaging guidance techniques and ablation technologies such as microwave, cryoablation, and sonodynamic therapy. The therapeutic effects are demonstrated through clinical cases such as ultrasound-guided microwave ablation for the treatment of T1a stage renal cancer. Addressing the issues of inadequate technology popularization and lagging doctor training in promotion and application, solutions such as strengthening medical education and professional training, and further advancing research on equipment performance optimization are proposed, providing references for the development of ultrasonic ablation technology in the field of tumor treatment.

Evolution and Research Progress of Mesh Fixation Methods in Abdominal Wall Hernias

Yuanqing Zhu, Hongbing Zhou, Yapeng Yang — Thu, 03 Apr 2025 08:50:31 +0800

Abdominal wall hernia refers to a condition where there is a defect or weakness in the abdominal wall tissue, allowing abdominal organs or tissues to protrude through this defect or weakness and form a lump on the body surface. Surgical treatment is currently the most effective method for treating abdominal wall hernias, and mesh fixation hernia repair, as an important surgical approach, has rapidly developed and been widely used in the past 30 years. Early methods mainly relied on ligation. However, with continuous advancements in materials science and surgical techniques, and the invention of new materials and surgical instruments, various types of mesh-based methods have emerged, greatly enriching the clinical treatment options for hernia diseases and achieving good results. This article reviews the progress of mesh fixation methods over the past 20 years, provides a detailed introduction to various existing hernia repair techniques, compares their scope of application based on their respective advantages and disadvantages, and points out their respective strengths, weaknesses, and suitable patient populations. The aim is to promote further research on these surgical methods, provide more options for hernia surgeons, and bring more benefits to patients.

Study on the Effect of Sini Powder and Huatan Xiaoyu Decoction Combined in the Treatment of Whole Stomach Gastritis with Precancerous Lesions

Hai Wang — Wed, 02 Apr 2025 00:00:00 +0800

Objective: To analyze the combined effect of Sini Powder and Huatan Xiaoyu Decoction in treating whole stomach gastritis with precancerous stomach lesions. Methods: 138 patients with whole stomach gastritis with precancerous lesions of the stomach admitted to the hospital from January 2021 to June 2024 were selected. According to the difference in treatment methods, they were divided into the study group (Sini Powder, Huatan Xiaoyu Decoction combined treatment) and the control group (Huatan Xiaoyu Decoction treatment), with 69 cases in each. Results: The curative effect and negative rate of Helicobacter pylori in the study group were significantly higher than those in the control group (P < 0.05); the TCM syndrome score and carcinoembryonic antigen and carbohydrate antigen 125 in the study group were lower (P < 0.05). Conclusion: The treatment of patients with whole stomach gastritis with precancerous gastric lesions can be improved by using Sini Powder combined with Huatan and Xiaoyu Decoction.