Keywords
Cancer cell line
Selective killing
Mechanism of action
Submitted : 2025-03-04
Accepted : 2025-03-19
Published : 2025-04-03
Abstract
This article aims to deeply analyze the mechanism of the selective killing effect of microplasma on specific cancer cell lines. A comprehensive investigation of relevant literature expounds on the generation principle and characteristics of microplasma and its interaction process with cancer cells. The potential mechanisms of its selective killing of cancer cells are explored from multiple aspects including physics, chemistry, and biology, involving the generation of reactive oxygen and nitrogen species, damage to cell membranes, changes in intracellular signaling pathways, and immunomodulatory effects. Additionally, the existing problems in current research and future research directions are prospected, aiming to provide a theoretical foundation and reference for the further application of microplasma in the field of cancer treatment.
References
Tian W, 2010, Generation of Microplasma Using a Hairpin Resonator, thesis, Tsinghua University.
Wang H, 2023, Molecular Dynamics Simulation Study on the Apoptosis of Cancer Cells Induced by the Synergistic Effect of Plasma Active Particles and Electric Fields, thesis, Shandong University.
Wang Z, 2022, Molecular Dynamics Simulation Study on the Interaction Between Plasma and Cancer Cell Membranes, thesis, Shandong University.
Cui S, 2020, Study on Metformin Enhancing the Sensitivity of Colorectal Cancer Cells to Atmospheric Pressure Low-Temperature Plasma, thesis, University of Science and Technology of China.
Hu Y, 2020, Microscopic Mechanism of Selective Apoptosis of Cancer Cells by Active Particles in Plasma, thesis, Shandong University.
Yang X, 2020, Inhibitory Effects and Differential Gene Expression Analysis of Two Types of Low-Temperature Plasma-Activated Liquids on Skin Basal Cell Carcinoma Cells, thesis, Anhui Medical University.
Wang L, 2019, Inhibitory Effect of Low-Temperature Plasma-Activated Liquid on Skin Squamous Cell Carcinoma Cells, thesis, Anhui Medical University.
Chinese scholars, 2018, Discover the “Attack and Defense Mechanism” of Low-Temperature Plasma Killing Cancer Cells. Science Friends (First Half of the Month), 2018(12): 5.
Liu Y, Xia W, Zhu T, et al., 2017, Study on the Mechanism of Atmospheric Plasma Selectively Inducing Apoptosis of Cancer Cells. Abstracts of the 18th National Conference on Plasma Science and Technology, School of Life Sciences, University of Science and Technology of China, Institute of Plasma Physics, Chinese Academy of Sciences: 1.
Gao M, 2016, Study on the Discharge Characteristics of Atmospheric Pressure Ar/O2 Microplasma and Its Effect on Tumor Cells, thesis, Soochow University.