Keywords
Mechanism
Research progress
Submitted : 2024-12-21
Accepted : 2025-01-05
Published : 2025-01-20
Abstract
As one of the common complications of patients with malignant tumors, cancer pain seriously affects their quality of life, especially the bone cancer pain, and the conventional analgesic effect of some patients with bone cancer pain is not ideal. The pathogenesis of bone cancer pain is complicated, the pathogenesis can be deeply understood and provide diagnosis and treatment thoughts for clinical relief of bone cancer pain by consulting the literature and summarizing the pathogenesis of bone cancer pain.
References
Chen JY, Yin YK, Zhang QL, et al., 2023, Data Mining for Medication Rules of External Application of Chinese Medicines Based on Syndrome Differentiation in the Treatment of Cancer Pain. World Chinese Medicine, 18(7): 1039–1043.
Yi D, Du MN, Zhang X, et al., 2024, Jia Yingjie’s Clinical Experiences in Treating Cancer Pain by Dismissing Turbid and Enhancing Vital Qi Theory. Liaoning Journal of Traditional Chinese Medicine, 51(11): 20–21.
Mansoor MA, et al., 2021, The American Society of Pain and Neuroscience (ASPN) Best Practices and Guidelines for the Interventional Management of Cancer-Associated Pain. Journal of Pain Research, 14: 2139–2164.
National Health Commission of the People’s Republic of China, 2018, Diagnosis and Treatment Code of Cancer Pain 2018. Chinese Clinical Oncology, 23(10): 937–944.
Zheng XQ, Wu YH, Huang JF, et al., 2022, Neurophysiological Mechanisms of Cancer-Induced Bone Pain. Journal of Advanced Research, 35: 117–127.
Yang L, Liu B, Zheng S, et al., 2023, Understanding the Initiation, Delivery, and Processing of Bone Cancer Pain from the Peripheral to the Central Nervous System. Neuropharmacology, 237: 109641.
Bellacosa A, Testa JR, Staal SP, et al., 1991, A Retroviral Oncogene, Akt, Encoding a Serine-Threonine Kinase Containing an SH2-Like Region. Science, 254(5029): 274–277.
Zhang W, Suo M, Yu G, et al., 2019, Antinociceptive and Anti-Inflammatory Effects of Cryptotanshinone Through PI3K/Akt Signaling Pathway in a Rat Model of Neuropathic Pain. Chemical Biology Interactions, 305(22): 127–133.
Fan H, Wu Z, Zhu D, et al., 2022, Proanthocyanidins Inhibit the Transmission of Spinal Pain Information Through a Presynaptic Mechanism in a Mouse Inflammatory Pain Model. Frontiers in Neuroscience, 15(2): 804722–804738.
Yuan G, Lian Z, Liu Q, et al., 2019, Phosphatidyl Inositol 3-Kinase (PI3K)-mTOR Inhibitor PKI-402 Inhibits Breast Cancer-Induced Osteolysis. Cancer Letters, 443(12): 135–144.
Li T, Liu T, Chen X, et al., 2020, Microglia Induce the Transformation of A1/A2 Reactive Astrocytes via the CXCR7/PI3K/Akt Pathway in Chronic Post-Surgical Pain. Journal of Neuroinflammation, 17(1): 211–230.
Fu X, 2023, Mechanism of Bone Cancer Pain in BALB/c Mice Based on PI3K/Akt Pathway WNK1, thesis, Inner Mongolia Medical University.
Chen SP, Zhou YQ, Liu DQ, et al., 2017, PI3K/Akt Pathway: A Potential Therapeutic Target for Chronic Pain. Current Pharmaceutical Design, 23(12): 1860–1868.
Hou GJ, 2019, Clinical Observation of Chanlong Zhentong Paste in Treating Cancer Pain and Research of Its Analgesic Mechanism in a Rat Model of Bone Cancer Pain, thesis, Hunan University of Chinese Medicine.
Chen P, Pan M, Lin QS, et al., 2021, CSF-CN Contributes to Cancer-Induced Bone Pain via the MKP-1-Mediated MAPK Pathway. Biochemical and Biophysical Research Communications, 547: 36–43.
Zhou KX, He XT, Hu XF, et al., 2019, XPro1595 Ameliorates Bone Cancer Pain in Rats via Inhibiting p38-Mediated Glial Cell Activation and Neuroinflammation in the Spinal Dorsal Horn. Brain Research Bulletin, 149: 137–147.
Jiao M, Lei JJ, Zhang ZC, et al., 2021, Analgesic Effect of Paeonol Regulation of miR-21 on Bone Cancer Pain Rats and Its Effect on MAPK Signaling Pathway. Progress of Anatomical Sciences, 27(4): 453–457.
Wu SH, 2021, Effect of JIAJI Electroacupuncture Combined with Nerve Mobilization on Expression of NF-kB and MURF1 in Gastrocnemius Atrophy with Sciatic Nerve Injury in Rabbits, thesis, Heilongjiang University of Chinese Medicine.
Liu ZQ, 2021, Regulation Effect of Chaipu Decoction on HMGB1, TLR4, NF-kB in Airway Epithelial Cells of Asthmatic Mice, thesis, University of South China.
Zhang XQ, Zhang XQ, Qiu XZ, et al., 2020, Effect of Raw Bone Capsule on the Expression of OPG and RANKL in Tibia of Osteoporotic Rats. Progress of Anatomical Sciences, 28(8): 21–25.
Zhou TT, 2019, The Analgesic Effects of rBmK-AGAP in Rat Bone Cancer Pain Model via Inhibiting the Activation of NF-κB Pathway in Spinal Astrocytes, thesis, Dalian Medical University.
Tian J, Song T, Wang H, et al., 2019, Thalidomide Alleviates Bone Cancer Pain by Down-Regulating Expressions of NF-κB and GFAP in Spinal Astrocytes in a Mouse Model. International Journal of Neuroscience, 129(9): 896–903.
Yi D, Du MN, Zhang X, et al., 2024, Analgesic Effect and Mechanism of Ruanjianzhitong Ointment on Bone Cancer Pain Rats. Liaoning Journal of Traditional Chinese Medicine, 2024: 1–12.
Duan YX, Zhang ZQ, Yin J, et al., 2021, Effects of Internal Heat-Type Acupuncture Needle Intervention on Chronic Soft Tissue Pain Based on Central Sensitization in the Spinal Cord. Chinese Journal of Pain Medicine, 27(12): 888–897.
Huh Y, Ji RR, Chen G, 2017, Neuroinflammation, Bone Marrow Stem Cells, and Chronic Pain. Frontiers in Immunology, 8: 1014.
Ji RR, Donnelly CR, Nedergaard M, 2019, Astrocytes in Chronic Pain and Itch. Nature Reviews Neuroscience, 20(11): 667–685.
Zurn CA, Beauchene C, Duan W, et al., 2021, Predicting Wide-Dynamic Range Neuron Activity from Peripheral Nerve Stimulation Using Linear Parameter Varying Models. Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2021: 4428–4431.
Kim YS, Chu Y, Han L, et al., 2014, Central Terminal Sensitization of TRPV1 by Descending Serotonergic Facilitation Modulates Chronic Pain. Neuron, 81(4): 873–887.
Khan A, Khan S, Kim YS, 2019, Insight into Pain Modulation: Nociceptors Sensitization and Therapeutic Targets. Current Drug Targets, 20(7): 775–788.
Medeiros P, Negrini-Ferrari SE, Palazzo E, et al., 2019, N-Methyl-D-Aspartate Receptors in the Prelimbic Cortex Are Critical for the Maintenance of Neuropathic Pain. Neurochemical Research, 44(9): 2068–2080.
Zhang B, Wu L, Zhu Q, et al., 2021, Donepezil Attenuates the Development of Morphine Tolerance in Rats with Cancer-Induced Bone Pain: The Role of Cortical N-Methyl-D-Aspartate Receptors. Neuroscience Letters, 747: 135678.
Li D, Li Y, 2020, The Interaction Between Ferroptosis and Lipid Metabolism in Cancer. Signal Transduction and Targeted Therapy, 5(1): 108.
Yang HF, Liu HP, Zhang XS, et al., 2025, Research Progress in TCM Prevention and Treatment of Osteoarthritis Based on Iron Death Theory. Chinese Journal of Osteoporosis, 31(1): 118–123.
Cahng YB, Ma HB, Wei JH, et al., 2025, Research Progress on Traditional Chinese and Western Medicine Treatment of Renal Fibrosis Based on the Pathogenesis of Ferroptosis. Acta Chinese Medicine and Pharmacology, 2025(2): 108–114.
Zhao YH, Li Q, 2025, Targeting Ferroptosis Offers a Novel Therapeutic Approach in Epilepsy. Chinese Journal of Clinical Pharmacology and Therapeutics, 2025: 1–10.
Ding Z, Liang X, Wang J, et al., 2023, Inhibition of Spinal Ferroptosis-Like Cell Death Alleviates Hyperalgesia and Spontaneous Pain in a Mouse Model of Bone Cancer Pain. Redox Biology, 62: 102700.
Li K, Yu F, Yu GQ, et al., 2022, Regulatory Effect of Lnc-AK077216 on Osteoclast Differentiation and Maturation Through OPG/RANKL/RANK Pathway. China Journal of Modern Medicine, 32(11): 51–56.