Objective: To analyze the treatment effect of open fistulotomy on patients with anal fistula. Methods: A total of 42 patients with anal fistula who visited the hospital from March 2021 to March 2024 were selected as samples and grouped using a random number table. The observation group received open fistulotomy, while the control group received conventional treatment. The differences in efficacy, surgical indicators, inflammatory factors, pain scores, and complications were compared. Results: The cure rate of patients with anal fistula in the observation group was higher than that in the control group, and the infection rate and recurrence rate were lower than those in the control group (P < 0.05). The surgical operation time, wound healing time, and hospital stay in the observation group were shorter than those in the control group (P < 0.05). There was no significant difference in intraoperative blood loss between the observation group and the control group (P > 0.05). The interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-10 (IL-10), and visual analog scale (VAS) scores in the observation group were lower than those in the control group (P < 0.05). The complication rate of patients with anal fistula in the observation group was lower than that in the control group (P < 0.05). Conclusion: Open fistulotomy for the treatment of patients with anal fistula can reduce inflammatory reactions, optimize surgical indicators, reduce pain, and is safe and efficient.
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