Keywords
Electrospinning
Tayler’s Cone
Bending instabilities
Application of electrospinning
Submitted : 2024-12-04
Accepted : 2024-12-19
Published : 2025-01-03
Abstract
Scaffolds in tissue engineering provide essential support for new tissue growth. Such scaffolds could be fabricated from materials like natural and synthetic polymers with prime properties such as biocompatibility and mechanical strength. Among other developments made, electrospinning has been a significant factor in making intricate scaffolds that imitate the extracellular matrix of tissue. It gives various properties in the fibers for specific applications by the controlled parameter conditions like voltage and flow rate. It is innovations like multi-component fibers and 3D structures that assist in the problem of uniformity and mechanical strength. Electrospinning research still is on the front line in increasing its potential applications in tissue engineering, filtration, and drug delivery. Process parameters optimization is among the strategies deployed to lessen the electrospinning problem of bending instabilities. The modified setups offer fiber production versatility. The setups introduced include far-field electrospinning that provides long, directed nanofibers and near-field electrospinning that gives good fiber deposition. Electromechanical spinning unifies electrical and mechanical aspects to have controlled fiber properties. In the area of applications of electrospun nanofibers, so far, the areas like biomedical, environmental, energy, textile, sensor, agriculture, cosmetic, and food packaging industries come as a real versatile bunch. This potential of the technology in divergent fields is ever-growing, in ongoing research continues to enhance its effectiveness toward tissue engineering solutions.
References
Liu C, Xia Z, Czernuszka JT, 2007, Design and Development of Three-Dimensional Scaffolds for Tissue Engineering. Chemical Engineering Research and Design, 85(7): 1051–1064.
Dhandayuthapani B, Yoshida Y, Maekawa T, et al., 2011, Polymeric Scaffolds in Tissue Engineering Application: A Review. International Journal of Polymer Science, 2011(1): 290602.
Eltom A, Zhong G, Muhammad A, 2019, Scaffold Techniques and Designs in Tissue Engineering Functions and Purposes: A Review. Advances in Materials Science and Engineering, 2019(1): 3429527.
Hutmacher DW, Goh JCH, Teoh SH, 2001, An Introduction to Biodegradable Materials for Tissue Engineering Applications. Annals-Academy of Medicine Singapore, 30(2): 183–191.
Asti A, Gioglio L, 2014, Natural and Synthetic Biodegradable Polymers: Different Scaffolds for Cell Expansion and Tissue Formation. The International Journal of Artificial Organs, 37(3): 187–205.
Loh QL, Choong C, 2013, Three-Dimensional Scaffolds for Tissue Engineering Applications: Role of Porosity and Pore Size. Tissue Engineering, 19(6): 485–502.
Roseti L, Parisi V, Petretta M, et al., 2017, Scaffolds for Bone Tissue Engineering: State of the Art and New Perspectives. Materials Science and Engineering: C, 78: 1246–1262.
Hosseinpour S, Ghazizadeh AM, Rezai RM, et al., 2017, Application of Selected Scaffolds for Bone Tissue Engineering: A Systematic Review. Oral and Maxillofacial Surgery, 21: 109–129.
Wang L, Ryan AJ, 2011, Introduction to Electrospinning. Electrospinning for Tissue Regeneration, Woodhead Publishing, Sawston, 2011: 3–33.
Bölgen N, Demir D, Aşık M, et al., 2022, Introduction and Fundamentals of Electrospinning. Electrospun Nanofibers: Principles, Technology and Novel Applications, Springer International Publishing, Cham, 2022: 3–34.
Li Z, Wang C, 2013, Introduction of Electrospinning. One-Dimensional Nanostructures: Electrospinning Technique and Unique Nanofibers, 2013: 1–13.
Nie G, Lu X, Wang C, 2019, Introduction to Electrospinning Technology. Advanced Nanofibrous Materials Manufacture Technology Based on Electrospinning, CRC Press, Florida, 2019: 1–21.
Mitchell GR, 2015, Electrospinning: Principles, Practice and Possibilities. Royal Society of Chemistry, London, 2015.
Babar AA, Iqbal N, Wang X, et al., 2019, Introduction and Historical Overview. Electrospinning: Nanofabrication and Applications, William Andrew Publishing, New York, 2019: 3–20.
Bhagure SS, Rao AR, 2020, A Review: Electrospinning and Electrospinning Nanofiber Technology, Process & Application. International Journal of Innovative Science and Research Technology, 5(6): 528–538.
Xue J, Wu T, Dai Y, et al., 2019, Electrospinning and Electrospun Nanofibers: Methods, Materials, and Applications. Chemical Reviews, 119(8): 5298–5415.
Sahay R, Thavasi V, Ramakrishna S, 2011, Design Modifications in Electrospinning Setup for Advanced Applications. Journal of Nanomaterials, 2011(1): 317673.
Li Y, Zhu J, Cheng H, et al., 2021, Developments of Advanced Electrospinning Techniques: A Critical Review. Advanced Materials Technologies, 6(11): 2100410.
Long YZ, Yan X, Wang XX, et al., 2019, Electrospinning: The Setup and Procedure. Electrospinning: Nanofabrication and Applications, William Andrew Publishing, New York, 21–52.
Kijeńska E, Swieszkowski W, 2017, General Requirements of Electrospun Materials for Tissue Engineering: Setups and Strategy for Successful Electrospinning in Laboratory and Industry. Electrospun Materials for Tissue Engineering and Biomedical Applications, Woodhead Publishing, Sawston, 43–56.
Teo WE, Ramakrishna S, 2006, A Review on Electrospinning Design and Nanofibre Assemblies. Nanotechnology, 17(14): R89.
Nadaf A, Gupta A, Hasan N, et al., 2022, Recent Update on Electrospinning and Electrospun Nanofibers: Current Trends and Their Applications. RSC Advances, 12(37): 23808–23828.
Oprea AE, Ficai A, Andronescu E, 2019, Electrospun Nanofibers for Tissue Engineering Applications. In: Materials for Biomedical Engineering, Elsevier, Cham, 77–95.
Liu H, Ding X, Zhou G, et al., 2013, Electrospinning of Nanofibers for Tissue Engineering Applications. Journal of Nanomaterials, 2013(1): 495708.
Vasita R, Katti DS, 2006, Nanofibers and Their Applications in Tissue Engineering. International Journal of Nanomedicine, 1(1): 15–30.
Stanger J, Tucker N, Kirwan K, et al., 2009, Effect of Charge Density on the Taylor Cone in Electrospinning. International Journal of Modern Physics B, 23(6–7): 1956–1961.
Zhao K, Wang W, Yang Y, et al., 2019, From Taylor Cone to Solid Nanofiber in Tri-Axial Electrospinning: Size Relationships. Results in Physics, 15: 102770.
Singh SK, Sarma S, 2022, Taylor Cone Height as a Tool to Understand Properties of Electrospun PVDF Nanofibers. Journal of Electrostatics, 120: 103770.
Liu Y, Li J, Tian Y, et al., 2014, Multi-Physics Coupled FEM Method to Simulate the Formation of Crater-Like Taylor Cone in Electrospinning of Nanofibers. Journal of Nano Research, 27: 153–162.
Yarin AL, Koombhongse S, Reneker DH, 2001, Bending Instability in Electrospinning of Nanofibers. Journal of Applied Physics, 89(5): 3018–3026.
Reneker DH, Yarin AL, Fong H, et al., 2000, Bending Instability of Electrically Charged Liquid Jets of Polymer Solutions in Electrospinning. Journal of Applied Physics, 87(9): 4531–4547.
Robb B, Lennox B, 2011, The Electrospinning Process, Conditions and Control. In: Electrospinning for Tissue Regeneration, Woodhead Publishing, Sawston, 51–66.
Khajavi R, Abbasipour M, 2017, Controlling Nanofiber Morphology by the Electrospinning Process. Electrospun Nanofibers, Woodhead Publishing, Sawston, 109–123.
Thompson CJ, Chase GG, Yarin AL, et al., 2007, Effects of Parameters on Nanofiber Diameter Determined from Electrospinning Model. Polymer, 48(23): 6913–6922.
Sahay R, Thavasi V, Ramakrishna S, 2011, Design Modifications in Electrospinning Setup for Advanced Applications. Journal of Nanomaterials, 2011(1): 317673.
Wang H, Bao Y, Yang X, et al., 2022, Study on Filtration Performance of PVDF/PUL Composite Air Filtration Membrane Based on Far-Field Electrospinning. Polymers, 14(16): 3294.
Hosseinian H, Jimenez-Moreno M, Sher M, Rodriguez-Garcia A, Martinez-Chapa SO, Hosseini S, 2023, An Origami-Based Technique for Simple, Effective and Inexpensive Fabrication of Highly Aligned Far-Field Electrospun Fibers. Scientific Reports, 13(1): 7083.
Nazemi MM, Khodabandeh A, Hadjizadeh A, 2022, Near-Field Electrospinning: Crucial Parameters, Challenges, and Applications. ACS Applied Bio Materials, 5(2): 394–412.
Canton G, Kulinsky L, Madou MJ, 2013, Electro-Mechanical Spinning: A New Manufacturing Technique for Micro/Nano-Fabrication of Carbon Fibers. 2013 IEEE International Symposium on Advanced Packaging Materials, IEEE, New Jersey, 230–239.