Keywords
Cancer pathogenesis
Reactive oxygen/nitrogen species
Pro-inflammatory signaling pathways
Immune cell infiltration
Therapeutic implications
Submitted : 2024-06-18
Accepted : 2024-07-03
Published : 2024-07-18
Abstract
Chronic inflammatory diseases as a cause of global cancer trend? Chronic inflammation is a condition where inflammation has persisted for a long time and is not relieved on its own as it promotes tumor growth. This paper aims to outline some of the vital biological processes and signaling pathways involved in the association of cancer with chronic inflammation. One of the functions of this relationship is to create reactive oxygen species (ROS) and nitric oxides (NOs) involved in mediating signal pathways that activate inflammation, the migration of immune cells, and cytokines. Recent studies imply that chronic inflammation may be involved in the pathogenesis of cancer conditions like hepatitis-B virus-induced hepatocellular carcinoma and colon carcinoma arising in the context of inflammatory bowel disease. These processes are necessary for creating therapies for both prevention and diseases. Consequently, the discovery and production of new drugs that can prevent cancer prevalence and increase survival rate within a population depends on correctly identifying the molecular mechanisms that connect disease to inflammation. The study collects the current research and lays out the foundation for future research that may use these conclusions to improve further the diagnosis and treatment of cancer and cancer prevention strategies.
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