Keywords
Colorectal cancer
Immunotherapy
Submitted : 2024-02-28
Accepted : 2024-03-14
Published : 2024-03-29
Abstract
Microsatellite stabilized (MSS) rectal cancer is a highly prevalent cancer in the middle-aged and elderly population. There exists some expertise in detecting and evaluating the chemotherapy effect in advanced colorectal cancer patients. Multiple studies have combined targeted therapy, chemotherapy, and immunotherapy as a breakthrough. Programmed cell death protein 1 (PD-1) inhibitors have certain therapeutic effects in the treatment of MSS rectal cancer patients. The combination of PD-1 inhibitors and furoquinib can improve the disease control rate (DCR) and progression- free survival (PFS) in colorectal cancer (CRC) patients with advanced MSS, and the adverse reactions are controllable. The combination of erlotinib hydrochloride and Xindilizumab was more effective in treating MSS-type colorectal cancer patients than clinical standard treatment. This study analyzes the various treatment methods for MSS-type CRC in middle- aged and elderly people to provide a reference basis in clinical practice.
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