Keywords
Colorectal cancer
Clinical symptoms
T-lymphocyte subpopulation
Submitted : 2024-04-17
Accepted : 2024-05-02
Published : 2024-05-17
Abstract
Objective: To investigate the clinical efficacy of applying the addition and subtraction of Jianpi Jiedu decoction (JPJD) in patients suffering from colorectal cancer and changes in their clinical symptoms. Methods: Seventy-two colorectal cancer cases were selected and randomly divided into the control group and the observation group, where both groups received the same comprehensive treatment and chemotherapy intervention after surgery. The observation group received the addition and subtraction therapy of JPJD based on the control group. The Chinese medicine (TCM) symptom scores, the intestinal bacterial flora, and the changes in the T-lymphocyte subsets of the two groups were compared. Results: The observation group had lower TCM evidence points, more Escherichia coli, less Bifidobacterium and Lactobacillus, and higher T-lymphocyte subpopulation levels than that of the control group after treatment (P < 0.05). Conclusion: The application of addition and subtraction therapy of JPJD in conjunction with postoperative radiotherapy for colorectal cancer patients further improved the patient's clinical symptoms and intestinal flora environment, and effectively enhanced their immunity. which is worthy of promotion.
References
Wei M, 2023, Clinical Observation of Jianpi Jiedu Quyu Formula Combined with Western Medicine in Treating Advanced Spleen Deficiency and Toxic Stasis Type Colorectal Cancer Patients, dissertation, Chengde Medical College.
Chen Y, Jiang H, Xu Y, et al., 2022, Therapeutic Efficacy and Safety Observation of Jianpi Bushen Jiedu Formula Combined with Low-Dose Apatinib and Tiglio in The Treatment of Metastatic Colorectal Cancer. Journal of Beijing University of Chinese Medicine, 45(5): 438–445.
Song C, Ma T, Chu J, et al., 2023, Effects of Jiedu Jianpi Formula on Immune Function and Gastrointestinal Function of Colorectal Cancer Patients After Surgery. Guangming Traditional Chinese Medicine, 38(22): 4398–4401.
Medical Affairs Bureau of the Health and Family Planning Commission of the People’s Republic of China, Chinese Society of Medical Oncology, 2018, Chinese Colorectal Cancer Diagnosis and Treatment Standard (2017 Edition). Chinese Journal of Surgery, 56(4): 241–258.
Zheng X, 2002, Guiding Principles for Clinical Research of New Chinese Medicines (Trial). China Pharmaceutical Science and Technology Press, Beijing, 212–213.
Wang J, Cao L, Han J, et al., 2021, Clinical Efficacy of Jianpi Jiedu Formula Combined with FOLFOX4 Regimen in Patients Treated with Chemotherapy for Colorectal Cancer. Chinese Patent Medicine, 43(11): 3258–3261.
Chen B, Liang F, Yuan X, et al., 2020, Effects of Adding and Subtracting Jianpi Jiedu Formula on Intestinal Flora and Immune Function of Advanced Colorectal Cancer Chemotherapy Patients with Spleen-Qi Deficiency Syndrome. Journal of Traditional Chinese Medicine, 61(5): 423–427.
Chen X, Liu Z, Lu M, et al., 2023, Effects of Spleen-Strengthening and Detoxification Formula on The Efficacy, Immune Function and Intestinal Microecology of Spleen Deficiency after Colorectal Cancer Surgery. Jilin Chinese Medicine, 43(10): 1170–1173.
Song H, 2021, Effects of Adding and Subtracting Jianpi Jiedu Formula on Clinical Symptoms, Intestinal Flora and T-Lymphocyte Subpopulation Changes in Colorectal Cancer Patients. Liaoning Medical Journal, 35(6): 44–47.
Chou Y, Gao J, Liu M, et al., 2022, Study on The Mechanism of Action of Jianpi Jiedu Formula Against Colorectal Cancer Based on Network Pharmacology. Journal of Nanjing University of Traditional Chinese Medicine, 38(2): 136–146.