Observation on the Effect of Interventional Devascularization in the Treatment of Liver Cirrhosis with Portal Hypertension
Download PDF (English)

DOI

10.26689/otd.v1i2.5302

Submitted : 2023-08-28
Accepted : 2023-09-12
Published : 2023-09-27

摘要

Objective: To analyze the clinical effect of interventional devascularization in the treatment of liver cirrhosis with portal hypertension. Methods: 80 patients with liver cirrhosis and portal hypertension admitted between January 2020 and January 2023 were selected as research subjects. They were divided into a control group (surgical devascularization) and an experimental group (interventional devascularization) through the computer grouping method, and the effect of the treatment received by both groups were compared. Results: (i) The efficacy of the treatment received in the experimental group was 94.87%, which was significantly higher than that of the control group, which was 76.92% (P < 0.05). (ii) There was no difference in the levels of alanine transaminase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) between the control group and the experimental group before treatment (P > 0.05); after treatment, the levels of ALT, AST, and ALP in the experimental group were statistically significantly lower than those in the control group (P < 0.05). (iii) Compared with the total complication rate of 28.21% in the control group, the total complication rate of the experimental group was lower at 10.25%, and the statistical significance was established (P < 0.05). Conclusion: Interventional devascularization has demonstrated positive outcomes in treating liver cirrhosis and portal hypertension. This is evident in the enhancement of liver function and its high safety profile. Consequently, it merits wider adoption and utilization in clinical practice.

参考

Wang Z, Zhang Z, Xu Hao, et al., 2022, Efficacy Analysis of TIPS in the Treatment of Recurrent Portal Hypertension with Upper Gastrointestinal Bleeding After Splenectomy Combined with Devascularization. Chinese Journal of Hepatobiliary Surgery, 28(2): 117–121.

Zhang C, Liu Z, 2020, Current Status and Progress of Surgical Treatment of Cirrhosis and Portal Hypertension. Journal of Clinical Hepatobiliary Diseases, 36(2): 417–420.

Liu J, Wang S, Zhao Y, et al., 2020, Discussion on the Concept of Precise Treatment of Liver Cirrhosis and Portal Hypertension in the Minimally Invasive Era. Chinese Journal of Endoscopic Surgery (Electronic Edition), 13(6): 337–341.

Huang J, You N, Nie X, et al., 2022, Clinical Efficacy of Endoscopic Variceal Ligation Before Portal Azygos Devascularization in Patients with Cirrhosis and Portal Hypertension in Preventing Rebleeding. Chongqing Medicine, 51(6): 954–958.

Du G, Qiao S, Yang J, 2022, Application Effect of Portal Devascularization Combined with Splenectomy in Patients with Liver Cirrhosis And Portal Hypertension. Sichuan Journal of Physiological Sciences, 44(11): 2004–2006.

Zhu B, Wang D, Huang W, et al. 2022, Comparative Study on the Efficacy of Splenorenal Shunt and Devascularization in the Treatment of Portal Hypertension. Chinese Journal of General Surgery, 37(12): 903–906.

Duan J, Yu H, Ye H, et al. 2021, Analysis of the Clinical Value of Selective Spleen and Stomach Region Reduction in The Treatment of Liver Cirrhosis and Portal Hypertension. Chinese Journal of Hepatobiliary Surgery, 27(7): 525–528.

Chen Y, Ma J, Liu Q, et al., 2021, Effect of Laparoscopic Splenectomy Combined with Selective Pericardia Devascularization on Liver Volume and Liver Reserve Function in Patients with Portal Hypertension. China Journal of Minimally Invasive Surgery, 21(11): 982–986.

Jiang A, Zhang J, Chen Y, et al., 2021, Significance of Liver Reserve Function Classification Method in Risk Assessment of Splenectomy and Devascularization for Portal Hypertension. Western Medicine, 33(7): 1031–1034 + 1038.

Huang X, Wang S, Liu R, 2021, Observation on the Curative Effect of Laparoscopic Splenectomy Plus Devascularization in the Treatment of Liver Cirrhosis with Portal Hypertension. Journal of Aerospace Medicine, 32(3): 302–303.

Peng S, Xia G, Fang T, 2021, Clinical Application of Laparoscopic Splenectomy Combined with Devascularization in Portal Hypertension with Giant Spleen. International Journal of Surgery, 48(10): 675–679.

Zhang K, Wang J, Li L, 2021, Observation on the Curative Effect of Laparoscopic Splenectomy Plus Portal Azygos Devascularization in The Treatment of Recurrent Upper Gastrointestinal Bleeding In Portal Hypertension. Sichuan Anatomy Journal, 29(4): 153–156.

Yu T, Wang J, Yin X, et al., 2022, Application of Rapid Recovery Surgery in Laparotomy Radiofrequency Ablation Combined with Splenectomy and Devascularization in Patients with Liver Cancer and Portal Hypertension. Journal of Local Interpretation Surgery, 31(9): 833–836.

Wu Y, Cui T, Yue Z, et al., 2022, Analysis of the Safety and Clinical Efficacy of Invasive Treatment of Portal Vein Thrombosis After Splenectomy or Devascularization. Chinese Journal of General Surgery, 37(6): 420–424.

Zhao X, Zeng D, Li G, et al., 2023, Characteristics of Hemodynamic Changes in Proper Hepatic Artery and Portal Vein After Splenectomy and Portal Azygos Devascularization. Journal of Clinical Hepatobiliary Diseases, 39(1): 104–109.