Abstract: Esophageal cancer is one of the common malignant tumors in China with a high mortality rate. Neoadjuvant chemoradiotherapy (nRCT) is currently the primary treatment method for locally advanced esophageal cancer. However, nRCT has not been not widely applied in China due to several reasons. First, the radiotherapy equipment and technology vary in different regions, and the learning curve for these technologies is steep, making rapid implementation difficult. Furthermore, the combined toxicity of radiotherapy and chemotherapy can counteract the survival benefits of preoperative treatment. In recent years, a promising approach involves combining neoadjuvant chemotherapy with immunotherapy for patients with locally advanced esophageal cancer. This article offers an overview of the progress in neoadjuvant therapy for this condition.
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