Efficacy of GnRH-α Combined with Mirena in the Treatment of Adenomyosis and its Impact on Ovarian Function
Download PDF


Gonadotropin-releasing hormone agonist drugs
Ovarian function



Submitted : 2024-02-19
Accepted : 2024-03-05
Published : 2024-03-20


Objective: To discuss and analyze the clinical effects and changes of ovarian function after GnRH-α combined with Mirena treatment in patients with adenomyosis. Methods: The research subjects in this study were all adenomyosis patients (60 cases) who were admitted to our hospital from January 2020 to June 2022. They were randomly divided into a control group (30 cases, received Mirena treatment) and an observation group (30 cases, received GnRH-α combined with Mirena treatment). The relevant indicators of both groups were compared. Results: After treatment, both the observation group and the control group exhibited reduced uterine volume, thinner endometrial thickness, lower VAS score, PBAC score, serum FSH, LH, and E2 levels compared to pre-treatment values. The serum AMH level and various FSFI scores were higher than before treatment, with the observation group showing a more noticeable increase. Additionally, the observation group had a lower incidence of adverse reactions compared to the control group (all P < 0.05). Conclusion: The application of GnRH-α combined with Mirena in patients with adenomyosis can reduce the amount of menstrual bleeding, reduce the volume of the uterus, relieve pain, promote the recovery of ovarian function, improve the quality of sexual life, and it is safe. Therefore, this method of treatment should be promoted in clinical practice.


Zhang F, Xin D, 2022, The Effect of Laparoscopic Lesion Resection Combined with Gnrh-A in the Treatment of Adenomyosis and its Effect on Serum MMP-9, VEGF, CA125 Levels. Chinese Journal of Obstetrics and Gynecology, 23(5): 507–508.

Dong A, Liu H, 2022, Application Value Analysis of Levonorgestrel Intrauterine Sustained-Release System in the Treatment of Adenomyosis. Electronic Journal of Practical Gynecology Endocrinology, 9(22): 36–38.

Chen W, Wang L, Su X, et al., 2022, Therapeutic effect of comprehensive nursing intervention combined with ultrasound-guided radiofrequency ablation, GnRH-a, and LNG-IUS on adenomyosis. Hebei Medicine, 44(1): 157–160.

Zhang X, 2003, Practical Obstetrics and Gynecology (2nd Edition), People’s Medical Publishing House, Beijing, 245.

Wang F, Luo X, Zhang Jiaying, et al., 2019, Application of Visual Analogue Scale in the Consultation of Influenza Patients. Chinese Journal of General Practice, 22(20): 2472–2475.

Lin P, Zhou K, Yao J, 2021, Effect of Desogestrel Ethinylestradiol Tablets Combined with LNG-IUS on PBAC Score and Sex Hormone Levels in Patients with Aovulatory Abnormal Uterine Bleeding. Clinical Medical Engineering, 28(4): 467–468.

Zhang Y, Su S, Zheng X, 2020, Analysis of the Effect of Combined Application of Vaginal Hysterectomy and Vaginal Top Suspension on Female Sexual Function Index and Prognosis in Patients with Uterine Prolapse. Chinese Journal of Sexology, 29(9): 96–99.

Sun A, 2021, Effect of Guizhi Fuling Capsules Combined with Mirena on Endometrial Thickness and Sex Hormones in Patients with Adenomyosis. Liaoning Medical Journal, 35(6): 17–19.

Chen X, Zhou H, Wu W, et al., 2021, Clinical Effect of HIFU Combined with Ultra-Long-Cycle Half-Dose GnRH-a in the Treatment of Adenomyosis. Journal of Logistics College of Armed Police Force (Medical Science), 30(8): 71–72.

Zhu Y, Zhang L, Yang Y, 2022, Efficacy and Safety Evaluation of GnRH-a Combined with Yasmin on Hysteroscopic Endometrial Resection for Adenomyosis. Hebei Medicine, 28(8): 1303–1306.

Tang J, 2021, Effects of Uterine Artery Embolization with Different Embolization Agents on Dysmenorrhea Pain Degree and Serum FSH Level in Patients with Severe Adenomyosis. Electronic Journal of Practical Gynecology Endocrinology, 8(7): 16–19.

Xie T, Chu B, 2020, The Curative Effect of Xiaojie’an Capsule Combined with Gestrinone in the Treatment of Patients with Adenomyosis and its Effect on Serum CA125 and Prostaglandin F-2a. Chinese Maternal and Child Health Care, 35(3): 436–438.

Wang L, Tang C, 2021, Effects of GnRH-a Combined with Levonorgestrel Intrauterine Sustained-Release System on Pain Symptoms, Serum MMPs and Recurrence in Patients with Adenomyosis. Chinese Journal of Family Planning, 29(2): 266–270 + 274.

Guo A, Liu P, Ma Y, et al., 2021, Effects of GnRH-? Combined with Mirena on Ovarian Function, Sex Hormone Levels and Quality of Sexual Life in Patients with Adenomyosis. Journal of Hunan Normal University (Medical Science), 18(4): 75–78.