Objective: To compare and analyze the effects of myomectomy by laparotomy and laparoscopy for uterine fibroids. Methods: 60 patients with uterine fibroids treated in the past 3 years (January 2020 to December 2022) were randomly divided into two groups according to the surgical plans, with 30 cases in each group. Patients in the control group underwent laparotomy, whereas those in the observation group underwent laparoscopic surgery. The effects were compared and analyzed. Results: Compared with the control group, the observation group had shorter surgery, time to first passage of flatus, and hospital stay; less intraoperative blood loss; lower complication rate; and higher postoperative quality-of-life score (P < 0.05). Although there was no significant difference between the two groups in terms of substance P (SP), interleukin 6 (IL-6), and prostaglandin E2 (PGE2) before surgery (P > 0.05), there was an increase in each index after surgery, but the increase in the observation group was less, as compared to the control group; the observation group had significantly lower levels of each index (P < 0.05). Conclusion: There are two common surgical approaches for myomectomy, laparotomy and laparoscopy. In comparison, the laparoscopic approach, a minimally invasive procedure, can optimize surgery-related indicators, reduce surgical trauma response, and reduce complications. It benefits patients by delivering favorable surgical outcomes and improving postoperative quality of life.
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