Keywords
Chemotherapy-induced myelosuppression
Kidney-tonifying
Essencereplenishing
Marrow-fortifying therapy
Submitted : 2025-12-10
Accepted : 2025-12-25
Published : 2026-01-09
Abstract
Chemotherapy-induced myelosuppression is a common dose-limiting toxicity of chemotherapy for malignant tumors, and its core mechanism is closely related to hematopoietic stem cell homing disorder. Chinese medicine attributes chemotherapy-induced myelosuppression to the category of “medullary labor” and believes that “deficiency of kidney essence and drying up of the medulla oblongata” is the main pathogenesis of chemotherapy-induced myelosuppression, which is precisely the same as that of hematopoietic stem cell homing disorders revealed by modern medicine, which involves chemokines such as CXCL12/CXCR4 axis, adhesion molecules such as very late antigen-4 (VLA-4)/vascular cell adhesion molecule (VCAM), and other factors such as the CXCL12/CXCR4 axis, and the CXCL4/VCAM axis. This is highly compatible with modern medicine’s revelation of hematopoietic stem cell homing disorder. By activating signaling pathways such as PI3K/Akt and Wnt/β-catenin, up-regulating chemokine expression, enhancing cell adhesion, improving extracellular matrix remodeling, and alleviating oxidative stress, the method of tonifying the kidneys and filling in the marrow promotes the homing of hematopoietic stem cell through multiple pathways, which provides a new idea for the integration of Chinese and Western medicine in the treatment of chemotherapy-induced myelosuppression.
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