A Study on the Association Between Siglec-1 Gene Polymorphism and Susceptibility in Patients with Chronic Obstructive Pulmonary Disease in Luohe Area

Juan Cao, Chun'e Wang, Bing Zhao, Yi Zheng, Sensen Li — Mon, 10 Jun 2024 00:00:00 +0800

Objective: To analyze the association between Siglec-1 gene polymorphism and susceptibility to chronic obstructive pulmonary disease (COPD) in the population of the Luohe area. Methods: A case-control study (150 COPD patients and 150 healthy controls) was conducted to analyze the Siglec-1 allele in two groups of individuals using single nucleotide polymorphism (SNP) high-throughput detection technology, and the frequencies of each allele were compared. Results: The frequency of rs611847 heterozygous A/G genotype in COPD patients was significantly lower in females than in healthy controls (OR = 0.282, 95% CI = 0.085–0.938, P = 0.039); among smokers, the frequency of rs3859664 and rs6084444 genotypes in COPD patients was significantly higher than that in the healthy control group (OR = 2.028, 95% CI = 1.111–3.704, P = 0.021; OR = 1.836, 95% CI = 1.033–3.262, P = 0.038). Conclusion: Among the COPD population in the Luohe area, there is a significant correlation between the genotypes of three SNPs loci, rs3859664, rs6084444, and rs611847 and susceptibility to COPD in different subgroups of the population. The rs3859664 A/G-A/A and rs6084444 A/G-G/G genotypes can increase the risk of COPD in smokers; the rs611847 heterozygous A/G genotype can reduce the risk of COPD in both female and smoking populations.

Research Progress on Clinical Nursing of Hypertension

Li Zhang, Shengjie Ji — Mon, 10 Jun 2024 00:00:00 +0800

High-quality nursing care can greatly reduce the occurrence of nursing accidents and help patients maintain better physical and mental health. For patients with hypertension, special attention should be given to clinical nursing. Providing scientific medication guidance, along with psychological support, can improve their medication compliance and establish a good doctor-patient relationship, aiding in their faster recovery. Based on a review of relevant literature and the author’s practical experience, this paper first analyzes the content and requirements of clinical nursing for hypertension, then discusses the main factors that restrict the effectiveness of clinical nursing for hypertension, and finally suggests improvements to the clinical nursing model for hypertension to serve as a reference for colleagues.

Journal of Clinical and Nursing Research

A Study on the Association Between Siglec-1 Gene Polymorphism and Susceptibility in Patients with Chronic Obstructive Pulmonary Disease in Luohe Area

Research Progress on Clinical Nursing of Hypertension