Journal of Clinical and Nursing Research

The Effect and Preliminary Exploration of Subcutaneous Immunotherapy with Dust Mites on Peripheral Blood Biomarkers in Children with Asthma

Thu, 30 Apr 2026 00:00:00 +0800

Objective: To analyze the differentially expressed genes in peripheral blood mononuclear cells (PBMCs) of asthmatic children before and after subcutaneous immunotherapy (SCIT), with the aim of screening potential biomarkers. Methods: This study collected clinical data and PBMCs from asthmatic children before and after treatment, and divided them into a differential gene screening group (7 cases) and a differential gene validation group (30 cases) for preliminary screening and subsequent validation, respectively. Transcriptome differential analysis was performed on PBMCs samples from 7 asthmatic children before and after treatment using RNA sequencing technology. After preliminary screening, candidate genes were validated by qReal-time PCR in the baseline group and the 16-week treatment group of 30 children undergoing SCIT. Spearman correlation analysis was used to investigate the correlation between the expression levels of candidate genes and clinical and pulmonary function indicators, and the biomarker efficacy was evaluated using ROC curves. Results: In the differential gene screening group, a total of 317 differentially expressed genes (166 upregulated and 151 downregulated) were identified in the 16-week SCIT group compared to the baseline period. qReal-time PCR validation revealed that the expression of SERPINB2 gene was significantly decreased after treatment compared to the baseline group (p < 0.05). Spearman correlation analysis indicated a significant correlation between the gene expression changes and reduced ACQ scores, CSMS scores, and increased C-ACT scores; the ROC curve suggested that this gene had good efficacy evaluation and predictive value. Conclusion: SERPINB2 expression was significantly downregulated after 16 weeks of SCIT treatment and was closely correlated with clinical improvement, suggesting that SERPINB2 could serve as a potential biomarker for evaluating the efficacy of SCIT in pediatric asthma, but further experimental validation is required.

Content and Effects of Hand Function Exercises in Patients with Rheumatoid Arthritis: A Scoping Review

Yuqi Liu, Yuexian Tao, Siying Qiu — Thu, 30 Apr 2026 00:00:00 +0800

Objective: This study aimed to systematically review and synthesize the current research status, core components of intervention protocols, and outcome measures of hand function exercises in patients with rheumatoid arthritis, in order to provide references for healthcare professionals in developing and implementing related interventions. Methods: Following the scoping review framework, a systematic search was conducted in PubMed, Embase, Web of Science, the Cochrane Library, China National Knowledge Infrastructure (CNKI), VIP Database, WanFang Database, and China Biomedical Literature Database (CBM). The search period ranged from 1 August 2015 to 1 August 2025. The identified studies were screened and synthesized according to the inclusion criteria. Results: A total of 10 studies were included. The intervention content of hand function exercises comprised joint range-of-motion training, resistance training, and functional training for daily activities, among which joint range-of-motion training and resistance training were the most commonly used. The intervention delivery modes included offline interventions, online interventions, and hybrid interventions. Outcome measures involved three domains: clinical indicators, clinical efficacy, and hand function assessment tools. Conclusion: This scoping review analyzed the existing literature and found that hand function exercises can effectively improve hand symptoms and functional outcomes in patients with rheumatoid arthritis, with 12 weeks being a typical intervention duration. However, evidence remains limited regarding exercise duration and patient-reported outcomes. Therefore, further studies are needed to explore their effects on patient-reported outcomes and to consider patients’ exercise-related needs and goals.

Clinical Efficacy and Safety Analysis of Reversed Flap Turnover Layered Minimally Invasive Surgery for the Treatment of Bromhidrosis

Ye Tian, Guichuan Huang, Dequn Ren, Yan Gu — Thu, 30 Apr 2026 00:00:00 +0800

Objective: To explore the clinical efficacy and safety of reverse skin flap turnover and stratified minimally invasive surgery for the treatment of bromidrosis, and compare it with traditional bromidrosis excision surgery, providing a reference for optimizing clinical surgical plans for bromidrosis. Methods: A total of 100 patients with bromidrosis admitted to the Vascular Surgery Department of our hospital from January 2024 to December 2025 were selected as the study subjects. They were randomly divided into an observation group and a control group using a random number table method, with 50 cases in each group. The control group was treated with traditional fusiform excision surgery, while the observation group was treated with reverse skin flap turnover and stratified minimally invasive surgery. Surgical-related indicators, the overall clinical treatment response rate, the incidence of postoperative complications, scar scores at 6 months postoperatively, and recurrence rates were compared between the two groups. Patient postoperative satisfaction was also recorded. Results: The observation group showed significantly better results than the control group in terms of operative time, intraoperative blood loss, and incision healing time (all p < 0.001). The overall response rate in the observation group was significantly higher than that in the control group (χ² = 5.005, p = 0.025 < 0.05). The overall incidence of complications in the observation group was significantly lower than that in the control group (χ² = 6.353, p = 0.012 < 0.05). At 6 months postoperatively, the Vancouver Scar Scale (VSS) scores and recurrence rates in the observation group were significantly lower than those in the control group, while overall patient satisfaction was significantly higher in the observation group (all p < 0.05). Conclusion: Reverse skin flap turnover and stratified minimally invasive surgery is effective for the treatment of bromidrosis. Compared with traditional surgical methods, it offers advantages such as less trauma, reduced bleeding, faster healing, a lower incidence of complications, minimal scarring, and a lower recurrence rate. It is safer and more acceptable to patients, making it suitable for clinical promotion and application.

Research on Drug Resistance Mechanisms and Countermeasures of Targeted Therapy for Colorectal Cancer Based on Next-Generation Sequencing

Mengyi Li — Thu, 30 Apr 2026 00:00:00 +0800

Colorectal cancer, a malignant gastrointestinal tumor with high morbidity and mortality, has long been plagued by difficulties in treatment and high recurrence rates, seriously threatening patients’ lives and health. With the continuous development of molecular biology technology, targeted therapy has emerged and shown great value in improving the survival and prognosis of patients with colorectal cancer. However, drug resistance is common in clinical practice, which directly impairs therapeutic efficacy. Next-Generation Sequencing (NGS), a high-efficiency and high-throughput molecular detection technology, can deeply analyze the genomic characteristics of tumors, accurately identify relevant molecular targets, and provide important support for the study of drug resistance mechanisms and the formulation of individualized countermeasures. This paper discusses the drug resistance mechanisms of targeted therapy for colorectal cancer based on NGS and the corresponding countermeasures, aiming to provide reference for relevant practitioners.

A Visualization Study on the Nursing of Female Menopausal Syndrome Based on CiteSpace

Meng Zhao, Chunhui Ren, Weina Yan, Hong Liu — Thu, 30 Apr 2026 00:00:00 +0800

Background: With the accelerating global population aging, health issues related to menopausal syndrome in women are becoming increasingly prominent. Although related research and guidelines continue to enrich, problems such as fragmented knowledge and dispersed research efforts constrain the improvement of nursing quality.Objective: To analyze and summarize current research trends and hot topics in women’s health concerning menopausal syndrome, and to explore the forefront development directions in this field.Methods: Based on literature retrieved from the China National Knowledge Infrastructure (CNKI) and Web of Science (WOS) databases from their inception to December 2024, this study ultimately included 639 articles (256 in Chinese, 383 in English). Using CiteSpace software, a bibliometric and visual analysis was conducted to construct knowledge maps of countries, institutions, authors, and keywords. Results: The overall publication volume of both Chinese and English literature showed an upward trend. English publications reached 53 in 2024, while Chinese publications peaked at 30 in 2019. The United States led in publication output (117 articles, 21.91%). Among Chinese institutions, the highest publication count was only 2 articles. Keyword analysis revealed that “menopausal syndrome” and “psychological care” were hot topics in Chinese literature (frequencies 51, 40), whereas “symptoms” and “quality of life” were high-frequency keywords in English literature (frequencies 98, 78). The cluster structures were significant (Q > 0.53, S > 0.78), and burst term analysis indicated an evolution in research focus from symptomatic care towards personalized interventions. Conclusions: Knowledge graph visualization can clearly present the development context and hotspot differences in research on nursing care for women with menopausal syndrome, providing a reference for subsequent studies.

Prognostic Classification of Hepatocellular Carcinoma Under Incomplete Data Conditions Using a Public Reference Cohort: A Weakly Supervised Multi-Omics Study

Hanlin Lv, Xiao Wang, Kesong Wu, Lei Li, Lei Wang — Thu, 30 Apr 2026 00:00:00 +0800

Background: Prognostic stratification of hepatocellular carcinoma (HCC) remains difficult because the disease is highly heterogeneous and complete matched multi-omics data are not always available in clinical cohorts. Objective: To develop a weakly supervised multi-omics framework that derives prognostic subtype labels from a public reference cohort and transfers them to cohorts with incomplete data. Methods: This study has analyzed 363 patients in TCGA-LIHC with matched mRNA, miRNA, DNA methylation, and clinical data. Overall-survival-related features were selected by univariate Cox regression, integrated by similarity network fusion (SNF), and clustered by spectral clustering to generate pseudo-labels. TCGA-LIHC was then split 6:4 into training and test sets for supervised modeling. External validation used LIRI-JP, GSE14520, GSE54236, and GSE31384, with models rebuilt on features shared with each cohort. Prognostic performance was evaluated by Kaplan-Meier analysis, log-rank testing, and the concordance index (C-index). Results: A total of 3,890 mRNA features, 150 miRNA features, and 1,889 methylation features were retained. SNF plus spectral clustering identified two subtypes: S1 (n = 257) and S2 (n = 106). S2 had significantly worse overall survival than S1 (log-rank P = 3.891 × 10^-9; C-index = 0.866). In internal validation, XGBoost showed the highest AUC (0.983). In external validation, the predicted subtypes remained prognostically informative, with C-index values of 0.857 in LIRI-JP, 0.875 in GSE14520, 0.930 in GSE54236, and 0.883 in GSE31384. Conclusions: In the public datasets included in this study, this weakly supervised framework identified two prognostically distinct HCC subtypes and retained prognostic discrimination after transfer to external cohorts with incomplete data.

Construction and Use of a Predictive Model for the Risk of ICU-acquired Weakness

Yaling Li, Baoyi Yang, Zhenzhen Rao — Thu, 30 Apr 2026 00:00:00 +0800

Objective: To explore the risk factors of acquired weakness in ICU patients and construct a prediction model. Methods: Using convenience sampling method, 245 intensive care patients admitted to ICUs of three tertiary hospitals in Shiyan City from March 2022 to April 2023 were selected, of which 172 cases from March to December 2022 were used as the modeling group and 73 cases from January to April 2023 were used as the validation group. The predictive effect of the model was examined using the area under the curve (AUC) of the receiver operating characteristic curve (ROC) and Hosmer-Lemeshow goodness-of-fit, and the model column line graph was plotted. Results: The incidence of ICU-acquired weakness was 36.63% (63/172) and 38.37% (28/73) in the modeling and validation groups, respectively. Patient’s history of alcohol consumption, mode of admission to the ICU, treatment with CRRT, mechanical ventilation, restraint braking, use of analgesics, use of norepinephrine, use of glucocorticoids, and length of stay in the ICU were the independent influencing factors of acquired weakness in ICU patients (p < 0.05). The AUCs of the modeling and validation groups were 0.979 and 0.887, respectively. Conclusion: The risk prediction model constructed in this study can predict the risk of acquired weakness in ICU, which can provide a reference for healthcare professionals to formulate interventions at an early stage.

Ultrasonographic Findings of Low-Grade Myofibroblastic Sarcoma: A Case Report

Guoxin Huang, Dejuan Shen — Thu, 30 Apr 2026 00:00:00 +0800

Objective: To analyze the ultrasonographic features of low-grade myofibroblastic sarcoma (LGMS) and explore its preoperative diagnostic value and key points of differential diagnosis. Methods: A case of LGMS confirmed by surgical pathology was retrospectively analyzed. The ultrasonographic manifestations were combined with magnetic resonance imaging (MRI) and pathological results for comprehensive analysis, and relevant literature was reviewed. Results: The patient was a 41-year-old female with a hypoechoic mass (45 mm × 30 mm × 21 mm) in the muscle layer of the left lower leg. The mass had an irregular shape with lobulated margins, and some boundaries were unclear. A large hyperechoic area (8.0 mm × 1.6 mm) was seen inside. Color Doppler flow imaging (CDFI) showed rich blood supply around and within the mass, and a cord-like extension was visible at the lower edge. MRI showed an isointense signal on T1-weighted images and a long T2 signal, with high signal intensity on diffusion-weighted imaging (DWI) and significant enhancement on contrast-enhanced scans. Postoperative pathology confirmed LGMS. Conclusion: The ultrasonographic manifestations of LGMS have certain characteristics, but a definite diagnosis still depends on pathological examination. Ultrasonography can provide important imaging evidence for preoperative assessment.

Application and Effect Evaluation of Smart Blood Collection System in Outpatient Blood Collection in Oncology Specialty Hospitals

Thu, 30 Apr 2026 00:00:00 +0800

Objective: To explore the application effect of the intelligent blood collection system in the outpatient blood collection of cancer specialized hospitals, and to provide a basis for improving the quality of outpatient blood collection nursing and the medical experience of patients. Methods: 136,274 blood specimens collected using the traditional manual blood collection mode from January to June 2020 were selected as the control group, and 176,989 blood specimens collected using the intelligent blood collection system from January to June 2021 were selected as the observation group. The blood collection process time, blood specimen quality, incidence of adverse events and patient satisfaction of the two groups were compared. Measurement data were expressed as ± s and analyzed by t-test. Counting data were expressed as cases (%), and the χ² test was used. A p value < 0.05 was considered statistically significant. Results: The registration and number collection time, specimen submission time and total process time of the observation group were significantly shorter than those of the control group (p < 0.001). The total error rate of blood samples decreased from 0.374% to 0.050%, and the error rate of blood collection tube usage decreased from 3.8% to 0.7%. The patient satisfaction rate increased from 88% to 96%, and the differences were statistically significant (p < 0.05). Conclusion: The intelligent blood collection system can optimize the outpatient blood collection process, shorten the service duration, reduce the error rate of specimens, improve the efficiency of nursing and patient satisfaction, and has good application value in the outpatient blood collection management of tumor specialized hospitals.

Analysis of Specialized Nursing Practices During Anti-Infective Treatment for Pediatric Brain Abscess

Dandan Su, Xiujuan Fan, Lili Zhao, Lin Wang, Qiang Wang — Thu, 30 Apr 2026 00:00:00 +0800

Objective: This paper focuses on a comprehensive analysis of the overall framework and core operational points of specialized, systematic nursing interventions for children with brain abscesses undergoing complete antimicrobial therapy, and explores the practical effects of such structured nursing models on enhancing treatment compliance, preventing related complications, and improving long-term neurological recovery. Methods: A cohort analysis model incorporating both retrospective and prospective features was designed. The study subjects were identified as 76 pediatric patients admitted from early 2020 to the end of 2023, diagnosed with brain abscesses, and who completed the prescribed anti-infective treatment course. Based on different clinical nursing pathways adopted, all cases were equally divided into two groups: a control group receiving standard routine care (38 cases) and a practice group applying a specialized integrated nursing protocol designed for this study (38 cases). This specialized protocol systematically integrates four dimensions: precise monitoring of intracranial pressure changes, a full-process management strategy for antimicrobial drug use, neurological function maintenance measures, and a family-centered educational support plan. The study comprehensively recorded various clinical observation indicators for both groups during treatment. Results: Data analysis revealed that the practice group adopting the specialized nursing protocol demonstrated superiority across multiple evaluation indicators. The effective symptom control rate during treatment (94.7% vs. 78.9%, p < 0.05), the incidence of adverse events induced by treatment drugs (10.5% vs. 28.9%, p < 0.05), and the qualification rate of primary caregivers of the children in mastering relevant knowledge and skills (92.1% vs. 71.1%, p < 0.05) were all significantly better than those in the routine care group. Additionally, the practice group showed statistically significant reductions in time-sensitive indicators such as the average number of days required for fever resolution, the time for relief of meningeal irritation signs, and the overall length of hospital stay (all comparisons p < 0.05). In the follow-up Glasgow Outcome Scale scores conducted three months after treatment completion, the proportion of cases in the practice group achieving a good prognosis (scores of 4 to 5) reached 86.8%, significantly higher than the 68.4% in the control group (p < 0.05). Conclusion: A multi-component, interlinked specialized nursing practice developed around and deeply integrated with the anti-infective treatment mainline can clearly enhance the safety level and overall efficiency of clinical management for pediatric brain abscesses.

Investigation on the Vitamin D Nutritional Status of Neonates with Hyperbilirubinemia

Fuhong Yang, Jian Miao, Bojun Xu, Xinhua Yin — Thu, 30 Apr 2026 00:00:00 +0800

Objective: This study aims to investigate the vitamin D nutritional status of neonates with hyperbilirubinemia and provide clinical evidence for guiding the scientific and rational supplementation of vitamin D in these neonates. Methods: This study selected neonates diagnosed with neonatal hyperbilirubinemia without other diagnoses admitted to the neonatal ward of our hospital from December 2021 to December 2023 as the research subjects. One milliliter of peripheral venous blood samples was collected from the neonates before treatment and sent to Hangzhou Qlife Precision Medical Testing Technology Co., Ltd. (Dian Diagnostics) for testing. The Sciex4500MD mass spectrometer was used as the detection instrument, and the Dicesis reagent was used as the detection reagent. The concentration of 25(OH)D in peripheral blood, namely the sum of 25(OH)D2 and 25(OH)D3 concentrations, was quantitatively detected using high-performance liquid chromatography-tandem mass spectrometry (LC-MS). According to the criteria for assessing children’s vitamin D nutritional status proposed by the Institute of Medicine of the United States in 2011 and the Global Consensus on the Management of Nutritional Rickets in 2016, serum 25-(OH)D < 30 nmol/L (12 ng/mL) was defined as vitamin D deficiency; serum 25-(OH)D 30–50 nmol/L (12– < 20 ng/mL) was defined as vitamin D insufficiency; and serum 25-(OH)D ≥ 50 nmol/L (20 ng/ml) was defined as adequate. Results: A total of 76 neonates with hyperbilirubinemia who met the diagnostic criteria were included in this study, including 40 boys and 36 girls. The results showed that the distribution of 25-(OH)D concentrations did not conform to a normal distribution, with a median of 11.69 (8.46–14.04) ng/mL. Only 5 neonates had adequate vitamin D levels, 31 had insufficient levels, and 40 had deficient levels. The rates of adequate, insufficient, and deficient vitamin D were 6.6%, 40.8%, and 52.6%, respectively, with no statistically significant difference in vitamin D levels between boys and girls (p > 0.05). Additionally, there was no statistically significant difference in serum 25(OH)D levels among neonates with hyperbilirubinemia across different seasons (F value = 0.312, p > 0.05). Conclusion: Neonates with hyperbilirubinemia generally have low vitamin D levels. However, due to the small sample size and single-center nature of this study, further verification with more samples and studies are needed.

Research on Optimizing the Surgical Treatment Plan and Postoperative Refined Nursing Management of Keloids

Qiang Zhu — Thu, 30 Apr 2026 00:00:00 +0800

Surgical resection is the core treatment for large, medium-sized, and refractory keloids. However, the recurrence rate of simple surgery remains high, and the standardization of perioperative nursing and postoperative management directly affects the treatment effect. Combining clinical nursing practice, this paper summarizes the key points of perioperative nursing for keloids, the optimization path of surgical plans, and multi-mode anti-recurrence nursing strategies, focusing on the core links of preoperative evaluation, intraoperative cooperation, postoperative wound care, tension control, recurrence monitoring, and psychological intervention. Research shows that refined surgical cooperation based on skin tension lines, anti-recurrence intervention within 24 hours after surgery combined with standardized nursing, and long-term dynamic follow-up can control the postoperative recurrence rate within 10%. This paper also analyzes the bottlenecks in postoperative nursing diagnosis and treatment, proposes optimization measures, and provides evidence-based reference for constructing an integrated perioperative nursing plan.

Observation on the Therapeutic Effect of Budesonide Combined with Azithromycin in the Treatment of Mycoplasma Pneumoniae Pneumonia in Children

Yaowu Zhan, Yulian Dong, Bo Yuan, Xiao Tan, Dandan Su — Thu, 30 Apr 2026 00:00:00 +0800

Objective: To investigate whether adding budesonide inhalation to the azithromycin anti-infective regimen can enhance the therapeutic effect and ensure the safety of its application in the clinical management of Mycoplasma pneumoniae pneumonia in children. Methods: This study included 120 diagnosed children who were randomly divided into two parallel groups. Among them, 60 children in the reference group received a 3-day course of oral azithromycin (single daily dose of 10 mg/kg); the study group, consisting of 60 children, received an additional twice-daily budesonide suspension inhalation (0.5 mg each time) alongside the same azithromycin treatment. The total treatment period for all children was set at 7 days. This study systematically collected and compared the time spans required for the resolution of core symptoms (body temperature, cough, and pulmonary signs) between the two groups; analyzed changes in the concentrations of C-reactive protein and interleukin-6 in the blood before and after treatment; evaluated the absorption of inflammatory shadows on chest X-rays at the end of treatment; examined changes in pulmonary ventilation function indicators in some children; and recorded and compared all adverse events that occurred during the treatment phase. Results: The study data indicated that children in the study group experienced faster resolution of fever, cough, and pulmonary signs compared to the reference group, with differences being statistically significant. After the treatment course, the levels of inflammatory markers in the blood of children in the study group decreased more significantly. Imaging assessment showed that the overall effective rate of pulmonary inflammation absorption in the study group reached 96.7%, higher than the 83.3% in the reference group. In terms of pulmonary function improvement, the study group also demonstrated superior results. There was no significant difference in the reported rates of treatment-related adverse events between the two groups. Conclusion: For children with Mycoplasma pneumoniae pneumonia, combining azithromycin for etiological treatment with budesonide inhalation for local anti-inflammatory intervention can accelerate the clinical recovery process, effectively suppress systemic inflammation levels, promote pulmonary lesion repair, and improve pulmonary function.

Multivariate Logistic Regression Analysis of Risk Factors for Subacute Delirium Syndrome in ICU Patients

Xiangli Zhang, Qian Zhang, Bo Wen, Shumei Feng, Xingfeng Yu — Thu, 30 Apr 2026 00:00:00 +0800

Objective: This study aimed to identify risk factors for subsyndromal delirium (SSD) in adult intensive care unit (ICU) patients using a multivariate logistic regression model. Methods: A total of 252 ICU patients admitted to a Grade A tertiary hospital between January 2024 and December 2025 were included in the study. General characteristics, clinical conditions, treatments and laboratory test results were compared between 174 patients who developed SSD and 78 who did not. Univariate risk factors for SSD were identified, and multivariate logistic regression analysis was performed to determine the independent risk factors for SSD. Results: Multivariate logistic regression analysis revealed that patient age (OR = 1.465), Acute Physiology and Chronic Health Evaluation II (APACHE II) score (OR = 1.677), Critical Care Pain Observation Tool (CPOT) score (OR = 1.899), physical restraint (OR = 3.485), sepsis (OR = 2.452) and duration of mechanical ventilation (OR = 1.635) were identified as independent risk factors for SSD in ICU patients. Conclusion: Elderly ICU patients are at higher risk of developing sub-delirium syndrome; early screening and timely medical intervention can reduce the risk of SSD and improve patient prognosis.

Research on the Application Effect of Predictive and Targeted Nursing in Patients with Liver Cirrhosis Complicated with Upper Gastrointestinal Bleeding

Ni Zeng — Thu, 30 Apr 2026 00:00:00 +0800

Objective: To investigate the application effect of predictive and targeted nursing in patients with liver cirrhosis complicated with upper gastrointestinal bleeding, and to evaluate its impact on clinical indicators, psychological state, and quality of life of patients. Methods: A total of 102 patients with liver cirrhosis complicated with upper gastrointestinal bleeding who were hospitalized from January 2023 to December 2023 were selected and divided into a control group (51 cases) and an observation group (51 cases) according to the random number table method. The control group received routine care, while the observation group received further strengthening of preventive care and targeted care on the basis of routine care. Clinical indicators (time to stop bleeding, length of hospital stay, incidence of rebleeding), psychological states (Self-Rating Anxiety Scale (SAS), Self-rating Depression Scale (SDS) scores), and quality of life (Short Form SF-36 score) were compared between the two groups. Results: The hemostasis time and hospital stay in the observation group were shorter than those in the control group, and the incidence of rebleeding was also lower than that in the control group, which was statistically significant (p < 0.05). After the intervention, the SAS and SDS scores of the observation group were lower than those of the control group, and the scores of each dimension of the SF-36 scale were higher than those of the control group, and the differences were statistically significant (p < 0.05). Conclusion: The application of predictive and targeted nursing to patients with liver cirrhosis complicated with upper gastrointestinal bleeding can significantly shorten hemostasis and hospital stay, reduce the incidence of rebleeding, significantly improve patients’ anxiety and depression, improve patients’ quality of life, and has good clinical application value.

Research on the Construction of a Digital and Intelligent Nursing Simulation Teaching System Based on Best Practice Standards

Guanglin Yang — Thu, 30 Apr 2026 00:00:00 +0800

Objective: To construct a digital and intelligent nursing simulation teaching case library based on INACSL best practice standards, and to evaluate the effect of clinical teaching for nursing interns under this model. Method: The case library was established based on the best practice standards of INACSL. Sixty nursing interns were selected and divided into a control group and an experimental group. The control group received traditional teaching, while the experimental group received digital and intelligent case simulation teaching based on traditional teaching. The theoretical and operational assessment results, clinical practice ability, critical thinking ability, and teaching satisfaction of the two groups were compared. Results: The theoretical scores (86.52 ± 4.38) and operational scores (88.15 ± 3.96) of the experimental group were higher than those of the control group (79.63 ± 5.12, 80.24 ± 4.85) (p < 0.05). The total scores of clinical practice ability (178.65 ± 12.34) and critical thinking ability (298.42 ± 18.56) in the experimental group were higher than those in the control group (152.37 ± 15.68, 265.19 ± 20.43) (p < 0.05). The teaching satisfaction rate of the experimental group (96.7%) was higher than that of the control group (80.0%) (p < 0.05). Conclusion: The digital and intelligent nursing simulation teaching case library created based on INACSL best practice standards can improve the clinical practice ability, critical thinking ability and teaching satisfaction of nursing interns.

A Study on Evidence-Based Nursing Practice for Perioperative Pain Management in Thoracoscopic Lung Cancer Surgery

Jia Liu, Ruolian Wang — Thu, 30 Apr 2026 00:00:00 +0800

Objective: To evaluate the efficacy of a perioperative pain management protocol based on evidence-based nursing principles in patients undergoing thoracoscopic surgery for lung cancer. Methods: A total of 112 patients undergoing thoracoscopic lung cancer surgery in the Department of Thoracic Surgery at a specific hospital between August 2025 and March 2026 were selected and randomly assigned to either a control group or an observation group, with 56 patients in each group. The control group received standard pain management, while the observation group received a pain management protocol based on evidence-based nursing. Results: At various postoperative time points, the observation group demonstrated significantly lower pain scores, both at rest and during activity, compared to the control group. Furthermore, within the first 48 hours post-surgery, the observation group consumed fewer opioids, mobilized out of bed earlier, experienced shorter postoperative hospital stays, and had a lower overall incidence of complications than the control group; all these differences were statistically significant (p < 0.05). Conclusion: A perioperative pain management protocol established upon evidence-based nursing principles can effectively alleviate postoperative pain in patients undergoing thoracoscopic lung cancer surgery, reduce opioid consumption, facilitate postoperative recovery, lower the incidence of complications, and enhance patient satisfaction with nursing care.

Value Evaluation of Applying the Concept of Enhanced Recovery After Surgery in the Reengineering of Operating Room Service Processes

Lang Lin — Thu, 30 Apr 2026 00:00:00 +0800

Objective: To investigate the clinical value of the concept of enhanced recovery after surgery in the reengineering of operating room service processes. Methods: 260 patients scheduled for elective surgery in a tertiary grade A hospital from January 2023 to December 2023 were randomly divided into a control group and an observation group, with 130 cases in each group. The control group used the traditional operating room service process, while the observation group used the process reengineering plan integrated with the ERAS concept. Perioperative indicators, postoperative recovery, complication rates, and patient satisfaction were compared between the two groups. Results: The observation group had shorter preoperative fasting and fluid deprivation time, surgical waiting time, first postoperative ambulation time, first anal exhaust time and hospital stay than the control group, lower intraoperative hypothermia, postoperative nausea and vomiting and total complication rates than the control group, and higher patient satisfaction than the control group. The differences were statistically significant. Conclusion: ERAS concept for operating room service process reengineering can improve perioperative management, accelerate postoperative recovery speed, reduce the incidence of complications, enhance patients’ medical experience, and has good clinical application value.

Clinical Application and Research of Telemetry Electrocardiographic Monitoring in Pediatric Patients

Qiuling Yi — Thu, 30 Apr 2026 00:00:00 +0800

Pediatric patients have a wide age range, weak independent cooperation ability, rapid disease changes, and obvious individual differences in physiological indicators. Traditional bedside electrocardiographic monitoring has problems such as multiple wires, limited mobility, easy data interference, and poor patient compliance. Telemetry electrocardiographic monitors, with characteristics such as wireless transmission, continuous monitoring, real-time early warning, and portability, have been increasingly widely used in pediatric clinical practice.

Research Review on Early Diagnostic Markers and Intervention Strategies for Liver Fibrosis

Guodong Yu, Xuefeng Bai — Thu, 30 Apr 2026 00:00:00 +0800

Liver fibrosis represents a pivotal intermediate pathological stage in the progression from various chronic liver diseases to cirrhosis and hepatocellular carcinoma, characterized primarily by persistent hepatocyte injury leading to the activation of hepatic stellate cells, which subsequently results in excessive extracellular matrix deposition and hepatic tissue structural remodeling. Early-stage liver fibrosis is fully reversible; however, once it advances to late-stage fibrosis or cirrhosis, the difficulty of reversal significantly increases. Therefore, early and accurate diagnosis, coupled with timely intervention, is crucial for improving the prognosis of patients with chronic liver diseases and reducing mortality from end-stage liver diseases. This article systematically reviews current markers for the early diagnosis of liver fibrosis and summarizes mainstream intervention strategies, providing theoretical references and clinical practice evidence for the early diagnosis and treatment of liver fibrosis.

Analysis of the Effectiveness of Evidence-Based Multidimensional Nursing Interventions in Preventing Deep Vein Thrombosis in Patients with Lower Limb Fractures

Jianglin Hu — Tue, 19 May 2026 13:30:14 +0800

Lower limb fractures are common orthopedic injuries in clinical practice. Due to factors such as prolonged bed rest, immobilization, and vascular injury, patients are at a higher risk of developing deep vein thrombosis (DVT), which can lead to pulmonary embolism in severe cases, endangering their lives and affecting their prognosis and quality of life. Evidence-based nursing, guided by clinical problems, integrates high-quality clinical evidence, nursing expertise, and individual patient needs to develop scientific and standardized nursing plans, offering greater effectiveness compared to traditional empirical nursing. Evidence-based multidimensional nursing interventions break through the limitations of single nursing approaches by constructing a comprehensive prevention system from multiple dimensions, including physiology, medication, rehabilitation, psychology, and health education, precisely targeting the risk factors for DVT formation. This article reviews the implementation content of multidimensional nursing interventions for patients with lower limb fractures and analyzes their application effectiveness in DVT prevention, providing a reference for optimizing clinical DVT prevention nursing plans, improving nursing quality, and enhancing patient prognosis for those with lower limb fractures.

Research Progress on Nurse-Driven Warning Tools for Early Recognition of ICU Sepsis

Qianqian Guan, Xuan Shen, Yingzi Yuan, Ying Zhang — Thu, 30 Apr 2026 00:00:00 +0800

Sepsis is the primary cause of deterioration and death in patients in the intensive care unit (ICU). Early identification and timely intervention are crucial for improving prognosis. Nurses, as frontline personnel providing bedside continuous monitoring, play a pivotal role in the early recognition of sepsis. This article systematically reviews the evolution, research progress, current challenges and shortcomings of nurse-driven early warning tools for sepsis in the ICU, and looks forward to future development directions, aiming to provide a reference for related research and clinical practice.

Research on the Effect of Operating Room Nursing on Perioperative Body Temperature Protection of Patients and the Improvement Methods

Feng Ren — Thu, 30 Apr 2026 00:00:00 +0800

Objective: To investigate the application effect of comprehensive thermoprotective nursing strategies in preventing unplanned hypothermia in surgical patients during the perioperative period, and to analyze the weak links and improvement directions in the temperature management process. Methods: A total of 286 patients undergoing elective surgery in a tertiary grade A hospital from January 2024 to June 2025 were selected and randomly divided into an observation group and a control group, with 143 cases in each group. The control group received routine temperature care, while the observation group carried out comprehensive measures such as preoperative risk assessment and pre-insulation, intraoperative active insulation and dynamic monitoring, and postoperative continuous insulation on this basis. Core body temperature changes, incidence of hypothermia, incidence of shivering, intraoperative blood loss, postoperative recovery time, and incidence of surgical site infection were compared between the two groups. Results: The results showed that the core body temperature of the observation group was higher than that of the control group at 30 minutes, 60 minutes after the start of the operation, at the end of the operation and when entering the recovery room. The incidence of perioperative hypothermia and postoperative chills was significantly lower than that of the control group. The incidence of intraoperative blood loss, postoperative recovery time and surgical site infection was better than that of the control group, and the differences were statistically significant. Conclusion: Comprehensive body temperature protection nursing measures can effectively maintain stable body temperature during the perioperative period, reduce the occurrence of hypothermia and hypotheria-related complications, promote postoperative recovery of patients, and provide a reference for the optimization of the operating room body temperature management process.

Experience in Treating Atherosclerosis Based on Professor Guo Shuwen’s Theory of “Qi Deficiency and Turbid Stasis”

Dongmei Zang, Jing Wang, Shuwen Guo — Thu, 30 Apr 2026 00:00:00 +0800

Atherosclerosis is the pathological basis leading to various chronic internal diseases, such as peripheral atherosclerosis, coronary heart disease, cerebral infarction, etc. Professor Guo Shuwen, based on the pathophysiological characteristics of atherosclerosis and plaque formation, believes that the gradual decline in physical function and metabolic function in middle-aged and elderly people leads to the formation of pathological products, which in turn cause the occurrence and development of diseases. Therefore, clinical practice emphasizes the key pathological links of “gradual deficiency” or “intrinsic deficiency”. Qi deficiency is the root cause of the formation of pathological products such as turbidity, phlegm, blood stasis, and toxicity. That is, Qi deficiency does not circulate, turbid phlegm is diffuse, and blood stasis is the main pathological characteristics. The theory of “Qi deficiency, turbidity, and blood stasis” is proposed to treat atherosclerosis. Clinically, the method of nourishing Qi to resolve turbidity and promoting blood circulation to clear the meridians is applied, and the therapeutic effect is satisfactory.

Research Progress on the Mechanisms and Management Strategies of Pneumonia in Patients with Schizophrenia

Xiaohong Luo — Thu, 30 Apr 2026 00:00:00 +0800

Patients with schizophrenia are at high risk of developing pneumonia, with significantly higher incidenceand mortality rates than the general population, a public health issue that warrants urgent attention. This articlesystematically reviews the epidemiological characteristics of pneumonia susceptibility in schizophrenia patients, deeplyexplores the multifaceted risk factors, including disease-specific features, antipsychotic medication effects, behavioraland lifestyle factors, and immune dysfunction. Based on this, the article further analyzes the core pathophysiologicalmechanisms underlying this susceptibility and comprehensively summarizes strategies for pneumonia prevention, earlyidentification, and treatment. By integrating the latest research evidence, this review aims to provide a theoretical basisfor developing targeted comprehensive management strategies in clinical practice, thereby improving the physical healthstatus and long-term prognosis of patients with schizophrenia.

Research Advances in Return-to-Work Readiness Among Young and Middle-Aged Hospitalized Patients: A Review

Wenxin Li, Huiru Wang, Wenjie Wang — Thu, 30 Apr 2026 00:00:00 +0800

This review synthesizes current evidence on return-to-work (RTW) readiness among young and middleaged adults hospitalized for acute or chronic conditions. We clarify the conceptual foundations of RTW readiness, critically evaluate existing assessment instruments, including their psychometric properties and clinical applicability, and delineate the multilevel determinants shaping readiness: disease-related factors, individual attributes, workplace characteristics, and sociocultural supports. This study further assess the empirical basis and implementation feasibility of prevailing interventions, namely, integrated vocational rehabilitation, cognitive-behavioral support, and conditionspecific health literacy programs. While substantial progress has been made in identifying correlates of RTW readiness, critical gaps persist in longitudinal measurement, cross-cultural validation of tools, and theory-driven, scalable interventions. This synthesis aims to inform evidence-based practice and policy aimed at strengthening sustainable RTW outcomes in this high-need population.

Molecular Genetics Etiology Research on a Typical Case of Unexplained Sudden Death in Yunnan Based on Whole Exome Sequencing

Thu, 30 Apr 2026 00:00:00 +0800

Objective: To explore the etiology of a typical case of unexplained sudden death in Yunnan (referred to as “Yunnan sudden death”), correlate genotypes with phenotypes to identify high-risk populations, and provide a basis for intervention measures. Methods: Epidemiological and clinical investigation data, as well as blood biochemical test results, were collected from three cases of Yunnan sudden death. Whole exome sequencing (WES) was performed on blood samples, using GRCh38/HG19 as the reference sequence. Mutation sites were screened based on genetic heart disease-related gene variants and subjected to filtering, annotation, and analysis. Protein function prediction analysis of mutated genes was conducted using SIFT, Mutation Taster, and PolyPhen2 software. Results: After screening, harmful and ambiguous mutation sites were retained, involving 18 mutation site information from four genetic heart disease-related genes (DMD, SIDT1, CSRP3, DSG2). Among them, 17 were predicted by software to have harmful, harmful, or pathogenic protein functions. Deceased 2 carried six mutation sites in DMD, deceased 2 and deceased 4 jointly carried nine mutation sites in SIDT1, and deceased 3 carried two mutation sites in CSRP3. Conclusion: The causes of death in the three cases of Yunnan sudden death in this study are highly likely related to mutations in genetic heart disease-related genes.

The Application Effect of Nursing Interventions Based on Failure Mode and Effect Analysis in Non-invasive Positive Pressure Ventilation Therapy for Patients with Chronic Obstructive Pulmonary Disease Complicated by Type II Respiratory Failure

Lingling Liu, Yan Peng, Daidi Tang — Thu, 30 Apr 2026 00:00:00 +0800

Objective: To investigate the application effect of nursing intervention based on Failure Mode and Effects Analysis (FMEA) in Non-Invasive Positive Pressure Ventilation (NPPV) treatment for patients with Chronic Obstructive Pulmonary Disease (COPD) complicated by Type II respiratory failure. Methods: Eighty patients with COPD complicated by Type II respiratory failure admitted from January 2024 to December 2025 were selected and randomly divided into a control group receiving conventional nursing and a study group receiving FMEA-based nursing intervention, with 40 cases in each group. Blood gas indicators, the incidence of adverse events, and quality of life scores were compared between the two groups after intervention. Results: After intervention, the blood gas indicators in the study group [PaO₂ (69.58 ± 5.21) mmHg, PaCO₂ (46.83 ± 4.56) mmHg, SaO₂ (93.87 ± 2.75) %] were significantly better than those in the control group [PaO₂ (63.12 ± 5.07) mmHg, PaCO₂ (52.15 ± 4.89) mmHg, SaO₂ (90.36 ± 2.89) %] (p < 0.05). The incidence of adverse events in the study group was significantly lower than that in the control group (p < 0.05). After intervention, the scores of all dimensions of the St. George’s Respiratory Questionnaire (SGRQ) in the study group were significantly lower than those in the control group (p < 0.05), indicating a more significant improvement in quality of life. Conclusion: The FMEA-based nursing intervention constructed in this study can effectively improve blood gas indicators during NPPV treatment for patients with COPD complicated by Type II respiratory failure, reduce the incidence of adverse events, and significantly improve patients’ quality of life, providing a widely applicable prospective risk prevention and control plan for specialized nursing management in clinical NPPV treatment.

An Empirical Study on the Quality Assessment and Improvement of Outpatient Prescriptions in Tertiary-Grade Class-A Hospitals under Multi- Policy Coordination

Bin Liu, Meiling Shao, Jun Liang, Fang Ye, Li Chen — Wed, 20 May 2026 09:31:59 +0800

Objective: To evaluate the quality of outpatient prescriptions for Western and proprietary Chinese medicines in a tertiary hospital under the coordinated implementation of DRG/DIP payment reform, the Tertiary Hospital Evaluation Standards (2025 Edition), and the National Performance Assessment of Tertiary Public Hospitals, and to examine the effectiveness of a policy-embedded management model. Methods: A triple stratified random sampling approach (disease category–department–month) was used to collect 4,996 outpatient prescriptions from January 2024 to September 2025. A four-dimensional framework (compliance, economy, efficacy, and risk) was established. Prescription quality was assessed using a risk-scoring model and Apriori association rule analysis. Results: The overall qualification rate was 96.2% (4,807/4,996). The mean number of drugs per prescription was 2.6 ± 0.8; antimicrobial use rate was 16.8%; essential medicines accounted for 62.5%; and drug cost proportion for key DRG/DIP disease groups was 28.3%, all meeting policy targets. Among 189 unqualified prescriptions, inappropriate medication use (38.5%) and minor omissions (48.7%) were the main issues. Association rules identified junior physicians in chronic disease management as a key risk factor (confidence > 40%). Conclusion: The policy-embedded model effectively improved core prescription quality indicators to required standards. Further optimization is needed for special populations, junior physician prescribing, and intelligent system support. The proposed Assessment–Insight–Intervention closed-loop model provides a practical framework for advancing refined prescription management.

Differential Diagnosis and Treatment of Medical Acute Abdomen

Qiuxiang Xiao — Thu, 30 Apr 2026 00:00:00 +0800

Acute abdomen is one of the most common emergencies in clinical emergency departments, characterized mainly by acute abdominal pain. It involves multiple disciplines including internal medicine, surgery, obstetrics and gynecology, and pediatrics, with complex etiologies and rapid progression. Misdiagnosis or delayed treatment can easily worsen the condition and even endanger the patient’s life. With the development of medical technologies and diagnosis-treatment models such as artificial intelligence and precision medicine, the system for differential diagnosis and treatment of medical acute abdomen has been continuously improved, providing new ideas and methods for clinicians. Based on clinical practice, this paper summarizes the key points of differential diagnosis and standardized treatment of medical acute abdomen, and discusses the development trend of its clinical diagnosis and treatment, so as to provide a reference for clinical practice.

Application of PBL Combined with Role-Play in Group Cooperative Teaching Mode in Nursing Education

Yue Xin — Thu, 30 Apr 2026 00:00:00 +0800

Objective: To explore the application effect of a group cooperative teaching mode combining PBL and roleplay in the teaching of “Fundamentals of Nursing”. Methods: A controlled experimental design was adopted. Two nursing classes from the same university were selected. The experimental group adopted the PBL combined with roleplay group cooperative teaching mode, while the control group used traditional teaching. After teaching, theoretical exam scores, operational skills scores, and teaching effects were compared. Results: The experimental group’s theoretical scores, operational skills scores, and teaching effects were significantly higher than those of the control group, with statistically significant differences (p < 0.05). Conclusion: The group cooperative teaching mode combining PBL and role-play aligns with the characteristics of “Fundamentals of Nursing” teaching, effectively compensates for the shortcomings of traditional teaching, and optimizes teaching outcomes.

Application of an Integrated Medical-Nursing Fast-Track Surgery Program in Patients After Oral Cancer Surgery

Li Wang, Li Zhang — Thu, 30 Apr 2026 00:00:00 +0800

Objective: To investigate the efficacy of an integrated medical-nursing fast-track surgery (FTS) program in patients undergoing oral cancer surgery. Methods: A total of 80 patients with oral cancer who underwent surgical treatment at our hospital from January 2024 to October 2025 were enrolled and randomly divided into an observation group (n = 40) and a control group (n = 40) using simple random sampling. The control group received conventional perioperative care, while the observation group was managed with the integrated medical-nursing FTS program. Postoperative recovery time, complication rate, flap survival rate, pain intensity, negative emotions, and quality of life were compared between the two groups. Results: The time to drain removal, first oral intake, bed rest, infusion, and hospital stay were significantly shorter in the observation group than in the control group (p < 0.05). The overall complication rate was lower (15.00% vs. 32.50%) and the flap survival rate was higher (98.75% vs. 90.00%) in the observation group (p < 0.05). At 7 days postoperatively, the VAS, SAS, and SDS scores were significantly lower in the observation group (p < 0.05). One month after surgery, the observation group had higher scores in most items of the EORTC QLQ-H&N35 scale except for illness perception, social relations, and weight change (p < 0.05). Conclusion: The integrated medical-nursing FTS program effectively accelerates physical recovery, improves flap survival, reduces complication risks, and significantly ameliorates psychological status and long-term quality of life in patients after oral cancer surgery.

Application Status and Progress of Artificial Intelligence in Clinical Nursing

Lingjie Feng, Binbin Chen — Thu, 30 Apr 2026 00:00:00 +0800

Objective: With the intensification of global population aging, diversified upgrading of clinical nursing demands, and the prominent contradiction of nursing human resource shortage, artificial intelligence (AI) has become a core driving force for the reform of clinical nursing models. This paper systematically reviews the application status of AI in clinical nursing, analyzes the core challenges in its development, and proposes optimization strategies, so as to provide evidence-based references for the deep integration of AI and clinical nursing. Methods: Core research findings on AI in nursing at home and abroad were systematically integrated, covering key research directions including clinical technology implementation, nursing service optimization, humanistic nursing innovation, talent training, and R&D and application of intelligent equipment, followed by comprehensive analysis and critical review. Results: AI technologies have been implemented in full scenarios of clinical nursing, showing significant value in improving nursing efficiency, ensuring patient safety, and optimizing nursing outcomes. However, core problems remain, such as insufficient clinical translation of technologies, gaps in AI literacy among nurses, imperfect ethical and normative systems, and inadequate industrial standards and evidence-based support. Conclusion: The future integration of AI and nursing should adhere to the patient-centered core philosophy, build a nursing-led technology R&D system, lifelong career talent training, sound ethical norms and industrial standards, so as to promote the high-quality development of nursing in China.

Research Progress on Myasthenia Gravis

Thu, 30 Apr 2026 00:00:00 +0800

Myasthenia gravis (MG) is a chronic autoimmune disease characterized by impaired transmission at the neuromuscular junction. Conventional clinical treatments show unsatisfactory efficacy and severe adverse reactions, while traditional Chinese medicine (TCM) presents unique advantages in its management. From the perspective of integrated traditional Chinese and Western medicine, this paper investigates the effects of Qishen Dihuang Granules on patients with MG based on modern understandings of the pathogenesis of MG and TCM theories. The pharmacological mechanisms and theoretical basis of the granules are elaborated from four aspects: regulating immune function, protecting the structure and function of the neuromuscular junction, improving TCM syndromes and clinical symptoms, and enhancing efficacy while reducing toxicity. The results show that Qishen Dihuang Granules can effectively correct immune imbalance, alleviate damage to the neuromuscular junction, improve clinical symptoms and TCM syndromes, assist in enhancing therapeutic effects and reducing drug toxicity. It demonstrates favorable clinical application value and provides an important theoretical basis for the integrated treatment of MG with traditional Chinese and Western medicine.

Application Effect of Psychological Nursing Combined with Humanistic Care in Obstetrics

Yue Wang, Chanjuan Liu, Fan Li — Thu, 30 Apr 2026 00:00:00 +0800

The application of psychological nursing combined with humanistic care in obstetrics has become an inevitable trend in the future development of obstetric nursing. Based on the current development needs of the obstetric nursing field, this paper first conducts an in-depth analysis of the application effect of psychological nursing combined with humanistic care in obstetrics, and then proposes effective application paths, aiming to lay a solid foundation for improving the level of obstetric nursing work.

Research Progress of Plasma Biomarkers in Auxiliary Diagnostic Models for Alzheimer’s Disease

Wenjie Yuan, Xiang Yu — Thu, 30 Apr 2026 00:00:00 +0800

The early identification of Alzheimer’s disease requires efficient and non-invasive detection methods. Plasma biomarkers, with their convenient sampling, repeatable detection, and suitability for large-scale application, have become core elements in the construction of auxiliary diagnostic models. Indicators such as β-amyloid-related ratios, phosphorylated tau181, phosphorylated tau217, neurofilament light chain, and glial fibrillary acidic protein in plasma can stably reflect the core pathological processes in the brain. The diagnostic efficacy of single-indicator and multi-indicator combined models continues to improve. The correlation between plasma biomarkers and changes in brain structure and function, as well as cognitive assessment, is becoming increasingly clear, driving the development of auxiliary diagnostic models towards precision and intelligence. This provides stable support for early screening, risk stratification, and disease progression monitoring.

Motor Success and Reoperation After Surgery for Adult Intermittent Exotropia: A Systematic Review and Meta-analysis

Zhe Tao, Qijin Qian — Thu, 30 Apr 2026 00:00:00 +0800

Objective: To estimate pooled motor success and reoperation rates in adult intermittent exotropia (IXT), evaluating the impact of surgical technique, follow-up, and success definitions. Methods: We searched PubMed, Embase, and Scopus (inception–March 2026) for adult (≥ 18 years) intermittent exotropia surgery outcomes. Proportions were Freeman-Tukey transformed and pooled via a random-effects model. We assessed MINORS quality and performed subgroup/sensitivity analyses. Results: This study included 14 studies (18 arms, 793 patients). Pooled motor success was 78.3% (95% CI 72.4–83.8%; I² = 65.0%). Success definition was the sole significant modifier: 83.1% for ≤ 10 prism diopters (PD) exodeviation vs. 67.6% for ≤ 10/5 PD (P = 0.029). Reoperation rates (5 studies) ranged from 0–25%. Conclusion: Adult IXT surgery yields about 78% motor success, with variability primarily driven by inconsistent outcome definitions. Standardizing strict criteria and extending follow-up are essential to accurately characterize long-term outcomes.

Correlation between Dynamic Changes of Serum Tumor Markers and Recurrence Risk in Patients after Thyroid and Breast Surgery

Xinwei Chen — Thu, 30 Apr 2026 00:00:00 +0800

Objective: To explore the correlation between the dynamic changes of serum tumor markers and the risk of recurrence in postoperative patients undergoing breast surgery. Method: Sixty postoperative patients of breast surgery from January 2024 to December 2025 were selected and divided into an experimental group (malignant, 30 cases) and a control group (benign, 30 cases). Detect serum CEA and CA15-3/Tg levels at multiple time points before and after surgery, and record recurrence events during a 12-month follow-up. Result: The CEA and CA15-3/Tg levels in the experimental group were significantly lower than those before surgery at 1, 3, 6, and 12 months postoperatively (p < 0.05). The increase of CEA (HR = 2.84, p = 0.008) and CA15-3/Tg (HR = 3.12, p = 0.004) in the third month after surgery was significantly correlated with recurrence, and the combined prediction AUC was 0.913. Conclusion: The dynamic changes of serum CEA and CA15-3/Tg in the third month after surgery can effectively predict the risk of postoperative recurrence in breast surgery, and the combined detection value is higher.

The Role of Comprehensive Community-Based Rehabilitation Service Model in the Holistic Management of Patients with Severe Mental Disorders: A Randomized Controlled Trial Study

Ying Chen, Yanqiu Zhang, Yuan Li, Mingbing Su, Min Gao — Thu, 30 Apr 2026 00:00:00 +0800

Objective: To investigate the clinical efficacy, improvement in social functioning, prevention of relapse, and health economic value of a comprehensive community-based rehabilitation service model in the holistic management of patients with severe mental disorders, providing empirical evidence for the standardized promotion of community rehabilitation. Methods: A parallel-group randomized controlled trial (RCT) was conducted, involving 200 patients with severe mental disorders in a stable phase. They were randomly assigned at a 1:1 ratio to an intervention group (comprehensive community rehabilitation, n = 100) and a control group (routine community management, n = 100), with continuous intervention for 12 months. The Positive and Negative Syndrome Scale (PANSS) and the Personal and Social Performance Scale (PSP) were used as primary outcome measures to compare differences in symptom improvement, social functioning, relapse rate, medication adherence, hospitalization status, and medical expenses between the two groups. Results: After 12 months of intervention, the PANSS total score in the intervention group (43.0 ± 6.8) was significantly lower than that in the control group (47.9 ± 7.5), while the PSP score (66.0 ± 8.0) was significantly higher than that in the control group (60.8 ± 7.3), with statistically significant differences (p < 0.001). The relapse rate in the intervention group (10.0%) was significantly lower than that in the control group (22.0%), while the medication adherence rate (83.0%) was significantly higher than that in the control group (68.0%). The hospitalization rate, number of hospitalization days, and annual total medical expenses were all significantly lower in the intervention group than in the control group (p < 0.05). Conclusion: The comprehensive community-based rehabilitation service model can effectively improve psychiatric symptoms and social functioning in patients with severe mental disorders, reduce the risk of relapse and hospitalization, and save medical costs. It represents an efficient and promotable core intervention strategy for the holistic management of severe mental disorders.

Relationship Between Healthy Lifestyles and Cognitive Impairment in the Elderly

Xiao Shan, Yubo Xing, Yudie Zhang, Lingqian Bao, Ying Qian — Thu, 30 Apr 2026 00:00:00 +0800

Objective: To explore the influence of healthy lifestyles on cognitive function in the elderly population in China, and to provide a reference basis for the prevention and management of cognitive impairment. Methods: Based on cross-sectional data from the 2018 Chinese Longitudinal Healthy Longevity Survey (CLHLS), research subjects with samples below 60 years old and missing key variables were excluded. Ultimately, 8,687 elderly people were included. Descriptive statistics and binary logistic regression analysis were performed using SPSS 27.0 software. A restricted cubic spline model was constructed to analyze the dose-response relationship between healthy lifestyles and cognitive impairment. Results: Among the participants, 2072 individuals (23.85%) were identified with cognitive impairment. The results of the binary logistic regression analysis, after adjusting for covariates, lack of exercise, low social participation, abnormal sleep duration, and unhealthy diet, were all risk factors for cognitive impairment in older adults. A linear dose-response relationship was observed between the number of healthy lifestyles practiced by the elderly and cognitive impairment (Poverall < 0.0001, Pnon-linearity = 0.7318). Conclusion: Healthy lifestyles of the elderly are closely related to their cognitive function. Encouraging the elderly to change unhealthy lifestyles and increase the number of healthy lifestyles can effectively improve their cognitive function. This finding provides an important basis for formulating targeted health intervention strategies, emphasizing that appropriate measures should be taken to carry out multidimensional education on healthy lifestyles among the elderly, so as to prevent and delay the progression of cognitive impairment.

Research on the Intervention Effect of the Recovery Period of Pediatric Bronchopneumonia Based on the “Medical-Education Collaboration” Model

Jiuwei Dong, Wenling Zhu, Xiaohua Jiang, Yuxiang Ma — Thu, 30 Apr 2026 00:00:00 +0800

Objective: To explore the application effect of rehabilitation management strategies based on the “medical-education collaboration” model in the recovery period of pediatric bronchopneumonia, providing evidence-based support for optimizing the management of pediatric respiratory diseases during the recovery period. Methods: A total of 100 children aged 3–5 years who were discharged from Zhifu District Maternal and Child Health Hospital in Yantai City between June 2025 and March 2026, were in the recovery period of bronchopneumonia, and were enrolled in cooperative kindergartens were selected as the study subjects. They were randomly divided into a control group (n = 50) and an intervention group (n = 50) using a random number table method. The control group received routine discharge guidance and regular kindergarten care; the intervention group received a 3-month “medical-education collaboration” rehabilitation management model on this basis, including establishing an information-sharing platform, formulating personalized rehabilitation plans (covering medication, diet, environment, exercise, and prevention of re-infection), and forming a “medical-education-family” linkage team. The disappearance time of clinical symptoms, re-infection rate of respiratory diseases, health behavior compliance, and parental satisfaction were compared between the two groups. Results: After the intervention, the disappearance times of cough and nasal congestion in the intervention group were shorter than those in the control group, with statistically significant differences (p < 0.05). During the 3-month follow-up, the incidence of re-infection with respiratory diseases in the intervention group (14.0%) was significantly lower than that in the control group (34.0%), with a statistically significant difference (p < 0.05). The health behavior compliance scores of the intervention group in terms of diet, exercise, and psychology were higher than those of the control group (p < 0.05). The parental satisfaction score of the intervention group was significantly higher than that of the control group (p < 0.05). Conclusion: The rehabilitation management strategy based on the “medical-education collaboration” model can effectively promote the recovery process of children in the recovery period of bronchopneumonia, reduce the risk of re-infection, improve their health behaviors, and enhance parental satisfaction. This model achieves the effective integration of medical resources and educational settings, possessing significant clinical promotion value.

Research Progress on Risk Assessment Tools and Interventions for Dementia in the Elderly

Dan Wang, Yaqi Niu, Yuting Su, Man Zhang, Jing Kang, Yu He — Thu, 30 Apr 2026 00:00:00 +0800

Dementia in the elderly has emerged as a critical public health issue both in China and globally. The substantial and annually increasing number of elderly individuals with dementia poses not only significant challenges to economic and social sustainability but also exerts immense pressure on family economic ethics and social culture. In light of this, this study reviews assessment tools, risk and protective factors, and the current state of interventions for dementia in the elderly, aiming to provide insights for the identification, prevention, and intervention nursing of dementia in the elderly.

Effect of Clinical Pathway-Based Airway Management on Early Rehabilitation in Patients with Severe Traumatic Brain Injury

Wei Zhu, Ziqing Hua, Yaqin Xu — Thu, 30 Apr 2026 00:00:00 +0800

Objective: To investigate the effect of clinical pathway-oriented airway management on early rehabilitation in patients with severe traumatic brain injury (sTBI) undergoing tracheotomy. Methods: A total of 146 sTBI patients were randomly divided into observation group (n = 73) and control group (n = 73). The control group received routine nursing care, while the observation group was implemented with clinical pathway-based airway management. All patients were evaluated for outcome indicators, airway humidification and complications after 8 weeks of intervention. Results: After intervention, the observation group had significantly higher airway humidification satisfaction (87.5%, p < 0.05), lower incidence of pulmonary infection (30.0%, p < 0.05) and lower incidence of airway bleeding (27.5%, p < 0.01) than the control group. The sputum aspiration frequency [2 (1,2), p < 0.01], single-patient tracheotomy care time [4 (3,5) min, p < 0.01], and tracheostomy cannula indwelling time (35.80 ± 18.22 d, p < 0.01) in the observation group were significantly lower or shorter than those in the control group. The successful decannulation rate was significantly higher (47.5%, p < 0.05). Conclusion: Clinical pathwaybased airway management can effectively improve sputum characteristics, reduce pulmonary infection and airway bleeding, shorten tracheostomy cannula indwelling time, improve decannulation success rate and promote prognosis in sTBI patients with tracheotomy.

Prevalence and Risk Factors of Hypertension Among College Students in a University in Qujing

Lu Han, Meng Zhang, Dandan Wan — Thu, 30 Apr 2026 00:00:00 +0800

Objective: To understand the prevalence of hypertension and prehypertension among ethnic minority college students in a university in Qujing, compare ethnic differences, and analyze risk factors, so as to provide a basis for blood pressure intervention in young people. Methods: A total of 1,834 college students were selected by cluster sampling. Indicators such as blood pressure, height, weight, and abdominal circumference were measured, and statistical analysis was performed using chi-square test and multivariate Logistic regression. Results: Using 140/90 mmHg as the standard, the prevalence of hypertension was 3.9% and prehypertension was 26.0%; there was no statistically significant difference in the prevalence between Han and ethnic minority students (p > 0.05). According to the 130/80 mmHg standard, the prevalence of hypertension increased to 23.7%. Male gender and high-salt diet were risk factors, while non-abdominal obesity and non-smoking were protective factors. Conclusion: The detection rate of hypertension and prehypertension among college students in this university is relatively high, and the prevalence scale increases significantly after the downward adjustment of the diagnostic standard. Early screening and lifestyle intervention should be strengthened.

Application Prospects of Robots in the Field of Clinical Nursing Under the Background of Embodied Intelligence

Hui Qin — Thu, 30 Apr 2026 00:00:00 +0800

With the acceleration of the aging population and the increasingly prominent contradiction between the supply and demand of medical resources, the field of clinical nursing is also facing new challenges and opportunities. Embodied Intelligence (EI) is a cutting-edge branch of artificial intelligence, emphasizing that intelligent agents achieve the unity of cognition and action through dynamic interaction between physical carriers and the environment, which has injected vivid vitality into the development of clinical nursing robots. Based on this, this paper will briefly analyze the core connotation and technical characteristics of embodied intelligence, as well as the application scenarios of nursing robots in the field of clinical nursing, and look forward to the application prospects of nursing robots in the field of clinical nursing under the background of embodied intelligence, aiming to promote the deep integration of embodied intelligence technology and the field of clinical nursing.

Problems and Solutions in the Training of Pediatric Clinical Skills for Undergraduate Medical Students

Changbo Zhao — Thu, 30 Apr 2026 00:00:00 +0800

Undergraduate students majoring in clinical medicine are one of the important reserve forces of clinical doctors in China, and their pediatric clinical skills are directly related to their future clinical practice quality and the diagnosis and treatment safety of children. At present, there are still some deficiencies in the training of pediatric clinical skills for undergraduate medical students, which restrict the effect of skill training and are difficult to meet the needs of pediatric clinical diagnosis and treatment positions. Focusing on four dimensions—teaching model, teaching resources, student learning, and assessment and incentive—this paper analyzes the existing problems in the training of pediatric clinical skills for undergraduate medical students and puts forward targeted solutions, aiming to provide references for optimizing the pediatric clinical skill training system and improving the pediatric clinical practice ability of undergraduate medical students.

Clinical Study on Traditional Chinese Medicine Syndrome Differentiation-Based Comprehensive Regimen for Migraine Treatment: Observation of Clinical Efficacy and Exploration of 5-HT/CGRP Regulatory Mechanism

Xueyun Zeng, Caidie Li — Thu, 30 Apr 2026 00:00:00 +0800

This study systematically investigates the clinical efficacy of traditional Chinese medicine (TCM) syndrome differentiation intervention for migraine and its neuroendocrine regulatory mechanism, aiming to provide evidence-based medical support for optimizing clinical diagnosis and treatment strategies for this disease. A total of 120 migraine subjects meeting the inclusion criteria were randomly assigned in a 1:1 ratio to the experimental group and the control group (60 cases each). The experimental group received individualized TCM compound prescription combined with filiform needle acupuncture based on four types identified by four diagnostic methods: hyperactivity of liver Yang, deficiency of both Qi and blood, internal obstruction of phlegm-turbidity, and obstruction of collaterals by blood stasis. The control group was treated with oral flunarizine hydrochloride capsules. The intervention period was 12 weeks, and follow-up observations were extended to the end of the 9th month, with dynamic collection of efficacy endpoints and safety indicators in both groups. Efficacy data showed that the total effective rate of the TCM intervention group was 91.67%, which was significantly higher than 76.67% of the control group, with a statistically significant difference (p < 0.05). At 3 and 6 months of treatment, the TCM treatment group exhibited more significant improvements in Numerical Rating Scale (NRS) scores, migraine attack frequency, and single attack duration; the increase in serum 5-hydroxytryptamine (5-HT) level and the decrease in calcitonin gene-related peptide (CGRP) level were also significantly superior to those in the control group (p < 0.05). The study concludes that TCM treatment based on syndrome differentiation for migraine has definite and reliable clinical efficacy, which can effectively relieve clinical symptoms and reduce attack frequency. Its mechanism of action may be related to regulating 5-HT/CGRP balance, improving vascular function, and inhibiting neurogenic inflammation. This treatment regimen has good clinical safety with no obvious adverse reactions and possesses practical value for extensive promotion.

Dyslipidemia in Kidney Transplant Recipients: Implications for Graft Prognosis and Lipid Management

Jingru Chen, Jianghua Chen — Thu, 30 Apr 2026 00:00:00 +0800

Dyslipidemia is a common metabolic complication after kidney transplantation, affecting 75-95% of recipients. Increasing evidence links post-transplant lipid abnormalities to graft dysfunction and eventual graft loss. However, studies on conventional lipid markers have reported inconsistent associations with transplant outcomes. Emerging lipid indicators may better reflect the burden of atherogenic lipoproteins and provide additional value for risk stratification after transplantation. This review summarizes current evidence on the epidemiology, mechanisms, graft outcome associations, and management of dyslipidemia in kidney transplant recipients, with a focus on postoperative monitoring and prognostic assessment.

Application Effect of Emotional Nursing Combined with Comfort Nursing in the Perioperative Period of Percutaneous Coronary Intervention in Patients with Coronary Heart Disease

Jingyan Shan, Yutan Tang — Thu, 30 Apr 2026 00:00:00 +0800

Objective: To explore the effect of applying emotional nursing combined with comfort nursing in the perioperative period of percutaneous coronary intervention (PCI) in patients with coronary heart disease. Methods: A total of 84 patients with coronary heart disease who underwent PCI treatment from January 2024 to December 2025 were selected and randomly divided into a control group receiving routine perioperative care and a study group receiving emotional nursing combined with comfort nursing, with 42 cases in each group. The intervention effects of the two groups were compared. Results: After the intervention, the GCQ score of the study group was significantly higher than that of the control group (p < 0.05); the SAS and SDS scores of the study group were significantly lower than those of the control group after the intervention (p < 0.05); the GCQ score of the study group was significantly better than that of the control group after the intervention (p < 0.05). Conclusion: Emotional nursing combined with comfort nursing can effectively improve negative emotions in patients with coronary heart disease during the perioperative period of PCI, enhance comfort, and improve the quality of life related to angina pectoris.

Research Progress of Intrathecal Morphine in Postoperative Analgesia

Xiaohui Wang, Zhongyu Wang — Thu, 30 Apr 2026 00:00:00 +0800

Postoperative pain is a common complication in the perioperative period of surgery. It not only reduces patients’ quality of life, but also easily induces adverse events such as pulmonary infection and deep vein thrombosis, hindering the clinical implementation of the concept of enhanced recovery after surgery. As a hydrophilic opioid, intrathecal morphine (ITM) has the advantages of long residence time in cerebrospinal fluid and high analgesic potency, which can achieve long‑term analgesia for 24–48 hours, especially with a significant effect on visceral pain control. It has become a core component of the multimodal analgesia system. This paper systematically reviews the development status, pharmacological basis and core advantages of ITM in postoperative analgesia, focuses on its clinical application optimization strategies and targeted application schemes in different types of surgery, analyzes the shortcomings of current research, and prospects future research directions, so as to provide accurate and comprehensive practice guidance for clinicians.

Research on the Construction Method of Famous TCM Physicians’ Academic Knowledge Graph Based on Multimodal Deep Learning — Application of the AGBAN Model

Huisi Hong, Yunchou Li, Yiming Yuan, Weihan Shen, Shiqi Luo, Jianlong Huang — Thu, 30 Apr 2026 00:00:00 +0800

Aiming at the problems of knowledge fragmentation and opaque reasoning in the digital inheritance of famous TCM physicians’ academic thoughts and diagnosis-treatment experience, a multimodal knowledge graph construction method based on the AGBAN model is proposed. Using more than 3,000 outpatient medical records of famous TCM physicians as the data source, multimodal information is integrated to construct a clinical knowledge graph through ontology design, entity-relationship extraction, and knowledge storage. The graph attention network and reinforcement learning mechanism of the AGBAN model are introduced to optimize the diagnosis-treatment path. The results show that the knowledge graph contains 3,089 entities and 1,461 relationships, with an average degree of 2.49; the average reciprocal rank of link prediction of the AGBAN model is 0.973, which is 165.4% higher than that of the TransE model, the diagnosis success rate is 59.19%, and the average reasoning path is 5 steps; cluster analysis verifies the core TCM principles such as “drug-syndrome correspondence”. The conclusion indicates that this method realizes the structured representation and intelligent reasoning of famous TCM physicians’ clinical experience, providing a feasible path for TCM academic inheritance and clinical decision support.

Real Experiences of Low Back Pain in Nursing Students During Nursing Operations: A Qualitative Study

Thu, 30 Apr 2026 00:00:00 +0800

Objective: To explore the authentic experiences of low back pain among nursing students during clinical practice and provide evidence for prevention and management. Methods: Twenty-three nursing students were recruited between November 1 and December 31, 2024. Semi-structured face-to-face focus group interviews were conducted, and data were analyzed using Colaizzi’s seven-step method. Results: Five main themes and five sub-themes were identified: influencing factors of low back pain; high-risk procedures exacerbating pain; insufficient preventive knowledge; dual impacts on learning and psychology; and expectations for equipment improvement. Conclusion: Optimizing the training environment, standardizing operation protocols, and strengthening ergonomic training can reduce occupational low back pain and improve health protection awareness among nursing students.

The Impact of Metabolic Equivalent-Based Exercise Rehabilitation Nursing Combined with Exercise-Psychological-Sleep Nursing on Mental Health and Cardiac Rehabilitation in Elderly Patients with Coronary Heart Disease and Heart Failure

Yuan Yuan, Xia Zhou — Thu, 30 Apr 2026 00:00:00 +0800

Objective: To explore the effects of integrating metabolic equivalent-based exercise rehabilitation with exercise-psychological-sleep nursing in elderly patients with coronary heart disease complicated by heart failure. Methods: A total of 70 patients meeting the inclusion criteria were selected and randomly divided into a control group (n = 35, receiving conventional cardiac rehabilitation nursing) and an observation group (n = 35, receiving metabolic equivalent-based exercise rehabilitation nursing combined with exercise-psychological-sleep integrated intervention) using a random number table method. Mental health indicators, cardiac rehabilitation indicators, and sleep quality indicators were observed and compared between the two groups before and after nursing. Results: After nursing, the observation group had significantly lower SAS scores, SDS scores, and PSQI scores, as well as higher 6MWT and METs levels compared to the control group (p < 0.05). Conclusion: Metabolic equivalent-based exercise rehabilitation nursing combined with exercise-psychological-sleep integrated intervention can effectively alleviate anxiety and depression in patients, promote cardiac function recovery, optimize sleep status, and demonstrate clear long-term effects, indicating significant value for clinical promotion.

Clinical Study of FGF8 as a Biomarker in Sepsis

Yanting Ruan, Yao Chen, Huali Ran, Fang Wang, Ran Pu, Rongrui Tang — Thu, 30 Apr 2026 00:00:00 +0800

Objective: To explore the application and predictive value of FGF8 as a biomarker in sepsis. Methods: A total of 44 patients with sepsis who were diagnosed and treated in our hospital from December 2024 to February 2026 were selected as the study subjects, and another 44 volunteers who underwent health check-ups in our hospital during the same period were selected as the control group. Clinical data and levels of FGF8, procalcitonin (PCT), C-reactive protein (CRP), white blood cell count (WBC), red blood cell count (RBC), hemoglobin (Hb), and platelet (PLT) in peripheral venous blood were collected from both groups. Univariate analysis was performed, and variables with statistical significance in the univariate analysis were included in the multivariate logistic regression analysis. ROC curves were plotted to explore the predictive value of FGF8 as a biomarker in sepsis. Results: Univariate analysis revealed that APACHE II score, SOFA score, FGF8 level, and PLT were statistically significant. After inclusion in the multivariate logistic regression analysis, APACHE II score, SOFA score, and FGF8 level were positively correlated with sepsis, while PLT was negatively correlated with sepsis. Subsequent ROC curve plotting showed that FGF8 had a sensitivity of 82.67%, a specificity of 78.50%, and an AUC of 0.840 in sepsis, indicating certain predictive value. Conclusion: FGF8, as a biomarker, has certain predictive value in sepsis, providing a potential new candidate marker for the auxiliary diagnosis of sepsis, which deserves clinical attention.

Research on the Construction of an Evaluation Index System for Nursing Quality in Patients with Diabetes Mellitus Complicated by Coronary Heart Disease Based on the Structure-Process-Outcome Three-Dimensional Quality Evaluation Model

Xia Zhou, Wang Xu — Thu, 30 Apr 2026 00:00:00 +0800

Objective: To construct an evaluation index system for nursing quality in patients with diabetes mellitus complicated by coronary heart disease based on the structure-process-outcome three-dimensional quality evaluation model. Methods: Using Donabedian’s three-dimensional quality evaluation model as the theoretical foundation, an initial index system was formed through literature analysis and interviews. The Delphi method was employed to solicit opinions from 24 experts over two rounds of correspondence to screen the indicators. Subsequently, the Analytic Hierarchy Process (AHP) was used to determine the weights of indicators at all levels, establishing an evaluation index system for nursing quality in patients with diabetes mellitus complicated by coronary heart disease. Results: The response rates for both rounds of expert correspondence were 100.00%. The expert authority coefficients were 0.873 and 0.892, respectively, with Kendall’s coefficients of concordance being 0.231 and 0.318 (p < 0.05). The final nursing quality evaluation system comprised 3 primary indicators, 11 secondary indicators, and 32 tertiary indicators. Among the primary indicators, process quality had the highest weight (0.467), followed by structural quality (0.284) and outcome quality (0.249). Within the secondary indicators, blood glucose management and cardiovascular risk management had relatively high weights. Conclusion: The constructed evaluation index system for nursing quality in patients with diabetes mellitus complicated by coronary heart disease demonstrates good scientific validity and systematicness, providing a reference basis for evaluating and continuously improving nursing quality in these patients.

Construction and Application of a Patient Journey Map-Based Comprehensive Care Model for Individuals Undergoing Hepatic Carcinoma Interventional Therapy

Na Bai, Hui Chen, Lili Tian, Wenting Li, Jing Wu — Thu, 30 Apr 2026 00:00:00 +0800

Objective: To establish a full-process management model for liver cancer patients undergoing interventional therapy based on the Patient Journey Map (PJM), and to evaluate its application effect. Methods: A non-synchronous controlled trial design was adopted. 120 liver cancer patients who underwent transcatheter arterial chemoembolization (TACE) in the Department of Infection of our hospital from January 2025 to December 2025 were selected. The control group included 60 patients (1–6 months) who received routine care, while the experimental group included 60 patients (7–12 months) who received the full-process management based on the Patient Journey Map. Through semi-structured interviews, the key touchpoints and needs of patients were clarified, and the Patient Journey Map was drawn. A three-stage full-process management plan of “hospitalization period - discharge preparation period - home rehabilitation period” was constructed. The satisfaction of patients, the incidence of postoperative complications, self-management ability, quality of life, and readmission rate were compared between the two groups. Results: The satisfaction rate of patients in the experimental group (96.67%) and the total score of self-management ability (86.35 ± 5.21) and the total score of quality of life (78.56 ± 6.42) were all higher than those in the control group (81.67%, 72.48 ± 6.35, 65.32 ± 7.18), respectively; the incidence of complications (13.33%) and the 30-day readmission rate (6.67%) were lower than those in the control group (30.00%, 18.33%), and the differences were statistically significant (P < 0.05). Conclusion: The full-process management model based on the Patient Journey Map can improve the satisfaction of liver cancer patients undergoing interventional therapy, reduce the incidence of complications and readmission rate, and improve self-management ability and quality of life, and has clinical application value.