Journal of Clinical and Nursing Research

Analysis of Ophthalmology Drug Clinical Trial Institutions in China: Challenges and Opportunities Under the Registration System

Rui Xu, Yurong Zhang, Yongxia Zhao, Li Wang — Mon, 09 Dec 2024 13:07:13 +0800

Objective: To analyze the status of ophthalmology drug clinical trial institutions in China following the implementation of the registration system and provide a reference for their development. Methods: An analysis was conducted using data from the Drug Clinical Trial Institution Registration Management Information Platform and the Drug Clinical Trial Registration and Information Publicity Platform of the National Medical Products Administration. The search period was up to April 19, 2024. Results: As of April 19, 2024, 314 ophthalmology-specific institutions were registered nationwide, comprising 274 comprehensive medical institutions and 40 specialized ophthalmology institutions, representing a 245% increase compared to the qualification certification phase. There were 965 major researchers in ophthalmology, accounting for 6.3% of the total number of researchers across all registered ophthalmology institutions. These institutions were predominantly located in economically developed areas such as Guangdong, Zhejiang, and Jiangsu Provinces, with the top five provinces and cities comprising 39.8% of the total registered institutions. Beijing had the highest number of major researchers (126), with their distribution positively correlated with the geographic spread of registered institutions. Furthermore, as of April 19, 2024, there were 216 clinical drugs related to eye diseases, with the top three provinces conducting 77.8% of national clinical trial projects. The number of institutions was directly proportional to the volume of clinical trials conducted. Conclusion: The implementation of the registration system has facilitated the release of ophthalmic medical resources. However, regional disparities remain in the number of ophthalmology-specific institutions, the availability of major investigators, and the distribution of clinical trial projects.

Analysis of the Effectiveness of a General Medicine Management Model in Treating Chronic Coronary Syndrome

Yingxin Zhao — Mon, 09 Dec 2024 17:29:26 +0800

Objective: To analyze the effects of a general medicine management model in the treatment of chronic coronary syndrome. Methods: The study included 100 patients with chronic coronary syndrome admitted to the hospital between April 2022 and May 2023. Patients were divided into an observation group and a control group to compare the outcomes of the general medicine-based management model with those of the conventional management model. Results: The incidence of adverse cardiovascular events in the observation group was significantly lower than in the control group (P < 0.05). Anxiety and depression scores in the observation group were also significantly lower than those in the control group (P < 0.05). Quality-of-life scores and patient satisfaction in the observation group were significantly higher than those in the control group (P < 0.05). Conclusion: Implementing a general medicine-based management model for patients with chronic coronary syndrome effectively reduces the incidence of adverse cardiovascular events, significantly improves patients’ emotional well-being and quality of life, and has notable clinical significance for wider adoption.

Impact of PDCA Cycle Combined with Instrument Mapping on Sterilization and Supply of Surgical Instruments

Zifeng Li, Li He — Mon, 09 Dec 2024 17:35:38 +0800

Objective: To explore the effect of applying the Plan-Do-Check-Act (PDCA) cycle combined with instrument mapping to manage surgical instruments in a hospital sterilization supply center. Methods: A total of 600 surgical instruments in a hospital’s surgical instrument sterilization and supply management center were sampled and grouped based on the introduction of the PDCA cycle combined with instrument mapping. The control group included 300 surgical instruments subject to routine sterilization management from November 2023 to January 2024. The observation group included 300 surgical instruments managed with the PDCA cycle combined with instrument mapping from February 2024 to April 2024. The quality of surgical instrument management, incidence of adverse events, and other indicators were compared between the two groups. Results: The observation group demonstrated significantly higher scores in management quality indices compared to the control group, with scores for disassembly and assembly (93.28 ± 1.57 vs. 87.41 ± 1.48), cleaning (95.04 ± 2.08 vs. 90.23 ± 2.12), disinfection and sterilization (95.33 ± 1.27 vs. 91.95 ± 1.39), waste disposal (93.26 ± 1.24 vs. 89.65 ± 1.18), packaging and traceability (94.35 ± 1.74 vs. 92.23 ± 1.65), and issuance and recycling (95.79 ± 1.72 vs. 90.22 ± 1.81) (all P < 0.05). The observation group reported two adverse events (one incomplete instrument specification and one case of instrument package overweight) with an incidence rate of 0.67%. Conversely, the control group reported six adverse events (including shortages, incomplete specifications, unqualified sterilization, defective instruments, untimely or incorrect delivery, and overweight instrument packages) with an incidence rate of 3%, demonstrating statistically significant differences between groups (P < 0.05). Conclusion: Applying the PDCA cycle combined with instrument mapping for surgical instrument management in hospital sterilization supply centers significantly improves management quality and reduces adverse events. Its application is recommended for wider adoption in hospital sterilization supply centers.

Effects of King’s Theory of Goal Attainment Combined with Teach-Back Method on Improving Patients’ Standardization Rate of Eye Drop Use

Qiuying Huang, Guilian Jie, Xiaohong Liu — Mon, 09 Dec 2024 09:15:03 +0800

Objective: To explore the effect of King’s Theory of Goal Attainment combined with teach-back method on improving the standardization rate of eye drop use in patients. Methods: A total of 200 patients who used more than two types of eye drops in the Department of Ophthalmology of our hospital were selected as the research subjects, and were randomly divided into an observation group and a control group. The control group was given routine health education, while the observation group was given King’s Theory of Goal Attainment combined with teach-back method on the basis of the control group. The standardization rate of eye drop use, knowledge awareness rate, and nursing satisfaction were compared between the two groups before and after the intervention. Results: After the intervention, the standardization rate of eye drop use, the awareness rate of eye drop knowledge, and the nursing satisfaction of the observation group were significantly higher than those of the control group (P < 0.05). Conclusion: King’s Theory of Goal Attainment combined with teach-back method can effectively improve the standardization rate of eye drop use in patients, increase their awareness of eye drop knowledge, and improve nursing satisfaction, which is worthy of clinical application.