Journal of Clinical and Nursing Research

The Efficacy of Flexible Negative Pressure Suction Sheath Combined with Flexible Ureteroscopy Lithotripsy in the Treatment of Upper Urinary Tract Calculi and Its Impact on Postoperative Quality of Life

Zhongcheng Zhu — Thu, 02 Apr 2026 00:00:00 +0800

Objective: To evaluate the therapeutic efficacy of Flexible Vacuum Suction Ureteral Access Sheath (FVSUAS) combined with Flexible Ureteroscopy Lithotripsy (FURL) for Upper Urinary Tract Calculi (UUTC). Methods: A total of 88 UUTC patients admitted between August 2024 and August 2025 were selected and equally divided using a random number table. The experimental group received FVSUAS combined with FURL treatment, while the reference group received conventional guide sheath combined with FURL treatment. The therapeutic effects of the two groups were compared. Results: The stone clearance rate in the experimental group was higher than that in the reference group, with shorter operative time and postoperative hospital stay, and lower postoperative pain scores (p < 0.05). The complication rate in the experimental group was lower than that in the reference group, with lower postoperative inflammatory factor levels and higher quality of life scores (p < 0.05). Conclusion: Implementing FVSUAS combined with FURL treatment for UUTC patients results in a high stone clearance rate, shorter operative time and postoperative hospital stay, alleviation of postoperative pain symptoms, fewer complications, mild postoperative inflammatory response, and a high quality of life.

Development of a Protection Motivation Theory–Based Health Education Program for Patients with Diabetes and Periodontitis

Mingjie Cai, Wenjuan Lai, Weiqun Peng, Jiaqi Chen, Pinmei Zou — Fri, 03 Apr 2026 09:52:45 +0800

Background: Diabetes mellitus (DM) is a metabolic disorder characterized by persistent hyperglycemia, with a prevalence of approximately 11.2% in China that continues to rise. Periodontitis is a microorganism-initiated, multifactorial infectious disease and is regarded as the sixth complication of diabetes. Nearly 90% of individuals with diabetes are affected by periodontitis. The relationship between these two conditions is bidirectional: periodontitis worsens glycemic control, increases insulin resistance, and contributes to the development of diabetic complications, including higher mortality from ischemic heart disease and diabetic nephropathy. Conversely, sustained hyperglycemia, longer disease duration, and inadequate self-management increase the risk of periodontitis. In addition, severe periodontitis and tooth loss impose a substantial social and economic burden. However, oral-health knowledge among diabetic patients remains limited. This study aimed to develop a Protection Motivation Theory (PMT)-based health education program for patients with diabetes and periodontitis. Objective: To develop a PMT-based health education program for patients with diabetes and periodontitis and provide a replicable intervention for clinical practice. Methods: Guided by PMT, this study used evidence synthesis and Delphi expert consultation. Literature retrieval, screening, quality appraisal, evidence extraction, and grading were conducted to develop a draft program, which was then refined through expert consultation on content, delivery, intervention cycle, and expected outcomes. Results: Of 448 records identified, 22 studies were included, yielding 31 best-evidence items. Evidence confirmed the bidirectional relationship between diabetes and periodontitis and the importance of health education in improving glycemic and periodontal outcomes. After two Delphi rounds, the final program included 7 primary and 48 secondary items. Expert participation was 100% in both rounds; the authority coefficient was 0.87; coefficients of variation ranged from 0.10 to 0.25; Kendall’s W values were 0.466 and 0.301 (p < 0.01), indicating good agreement. Conclusion: A structured PMT-based health education program with sound scientific basis and feasibility was developed for patients with diabetes and periodontitis.

Efficacy of Modified Baihe Dihuang Decoction Combined with Escitalopram in Treating Depression and Its Impact on Serum Levels of 5-HT and ACTH

Guofang Lv, Yuhong Ye — Fri, 03 Apr 2026 00:00:00 +0800

Objective: To evaluate the therapeutic effects of Modified Baihe Dihuang Decoction combined with Escitalopram (ESC) in treating depression. Methods: A total of 200 patients with depression admitted to the hospital from May 2023 to May 2025 were selected and randomly divided into two groups using a random number table. The experimental group received combined treatment with Modified Baihe Dihuang Decoction and ESC, while the control group received ESC monotherapy. The therapeutic effects of the two groups were compared. Results: The total effective rate of the Hamilton Depression Rating Scale (HAMD) and the total effective rate of traditional Chinese medicine (TCM) syndromes in the experimental group were higher than those in the control group (p < 0.05). After 6 weeks of treatment, the cortisol (Cor) level in the experimental group was lower than that in the control group. The HAMD scores after 2, 4, and 6 weeks of treatment were lower in the experimental group than in the control group. The levels of 5-hydroxytryptamine (5-HT), adrenocorticotropic hormone (ACTH), and corticotropin-releasing hormone (CRH) were better in the experimental group than in the control group, and the Treatment Emergent Symptom Scale (TESS) score was lower in the experimental group than in the control group (p < 0.05). Conclusion: Combined treatment with Modified Baihe Dihuang Decoction and ESC for patients with depression can improve clinical efficacy, alleviate TCM syndromes, reduce depressive symptoms, regulate neurotransmitter and hormone secretion, and exhibit high medication safety.

Analysis of Factors Influencing the Return of Spontaneous Circulation and Prognosis in Patients with In-Hospital Cardiac Arrest Under a Rapid Response System

Shuwen Ren, Mingming Wang, Zhengnan Wu, Peng Wang, Titi Li — Fri, 03 Apr 2026 11:31:15 +0800

Objective: To investigate the influencing factors and prognosis of the return of spontaneous circulation (ROSC) in patients with unexpected in-hospital cardiac arrest (IHCA) under the rapid response system. Methods: According to the Utstein template, a retrospective analysis was conducted on the clinical data of 263 patients with unexpected IHCA from a tertiary-level hospital in Zhenjiang City from May 2019 to May 2024. The primary outcomes were categorized into the ROSC group and the Non-ROSC group based on post-resuscitation outcomes, while the secondary outcomes were divided into the discharged alive group and the non-discharged alive group. Logistic regression analysis was employed to identify the influencing factors and prognosis of ROSC, and the Kaplan-Meier method was used to plot survival curves. Results: (1) A total of 263 patients with IHCA were included in this study, with 166 cases (63.5%) achieving ROSC and 54 cases (32.5%) surviving for 7 days, among whom 42 cases (15.9%) were discharged alive. (2) Multivariate regression analysis revealed that age, abnormal BMI, duration of cardiopulmonary resuscitation (CPR), ventilation method during resuscitation, and the initial cumulative dosage of epinephrine were independent influencing factors for Non-ROSC in IHCA patients (p < 0.05). The NRS2002 score, recurrent resuscitation events, initial cumulative dosage of epinephrine, and duration of CPR were independent influencing factors for non-discharge alive in IHCA patients (p < 0.05). Conclusion: The ROSC rate of IHCA under the rapid response system has improved, but the rate of discharged alive remains relatively low. The system plays a certain role in reducing in-hospital mortality; however, further strengthening of the links in each stage is necessary to enhance patient prognosis.

Current Status of Antidepressant Drug Research and Development in China: A Feature Analysis Based on Drug Clinical Trial Registration and Information Disclosure Platform

Zhe Liu, Yurong Zhang, Li Wang, Xin Wang, Rui Xu — Fri, 03 Apr 2026 11:41:47 +0800

Objective: To systematically review the clinical trial data of registered antidepressant drugs in China, conducted an in-depth analysis of their current status and development trends, and provided reference for the research and development of antidepressants. Methods: Clinical trials of registered antidepressant drugs registered from April 16,2013, to December 31,2025, were searched. The development status of antidepressant drug clinical trials in China was analyzed from various aspects, including drug types, indications, trial classification, phase, and design types. Results: A total of 675 trials were included, comprising 667 domestic multicenter trials and 8 international multicenter trials. Among them, chemical drugs accounted for 96.0%, while biological products were absent. There were 500 bioequivalence studies (74.1%), with Phase II and III trials employing parallel group, randomized, and double-blind designs. 501 (74.2%) clinical trials provided trial injury insurance for participants, and research resources were concentrated in leading psychiatric specialty hospitals. Conclusion: Although the overall development of antidepressant drug clinical trials in China has shown a steady trend, the number of international multicenter trials remains significantly low, while bioequivalence studies and early exploratory trials are more prevalent. Future efforts should focus on strengthening international cooperation and exchange, as well as innovative drug development, to accelerate the fulfillment of clinical needs for patients with depression in China.

Analysis of Reasons for Suspension of Drug Clinical Trials Between China and Other Countries

Jingwen He, Yurong Zhang, Ruizhong Wang — Fri, 03 Apr 2026 00:00:00 +0800

Objective: To analyze the various reasons for the suspension of drug clinical trials, provide suitable solutions to reduce the incidence of such suspensions, prevent wastage of resources, and enhance the completion rate of clinical trials. Method: Relevant information on drug clinical trials suspended in China and other countries was retrieved from “Drug Clinical Trial Registration and Information Disclosure Platform” and “ClinicalTrials.gov”. Various factors were statistically summarized, comparing the reasons for clinical trial suspensions between China and other countries, and analyzing differences among groups in various classification variables, including indications, years, trial phases, and types of drugs. Result: A total of 323,248 drug clinical trials were conducted internationally, with a suspension rate of 0.48% (1,564/323,248). Within this dataset, China reported 377 suspended clinical trials, constituting 1.66% (377/22,703) of its total studies, while other countries conducted a total of 300,545 clinical trials, resulting in a suspension rate of 0.39% (1,187/300,545). The primary cause of suspension in various countries was attributed to issues related to sponsors and funding. Notably, there existed a statistically significant difference in the number of suspended trials between China and other countries (p < 0.05). Conclusion: During the research preparation phase, sponsors should meticulously assess the feasibility of clinical trials and exercise prudence in development decisions. The clinical trial protocol design must prioritize safety and scientific validity. Research teams should be equipped with emergency risk control measures, adhere to pertinent laws and regulations governing clinical trial, and ensure adequate management. Thus, drug clinical trials can only be conducted with high quality, thereby ensuring the progression of drug marketing.

Research Progress on Ferroptosis in Ischemic Cardiomyopathy

Yichen Liu, You Peng — Fri, 03 Apr 2026 14:41:05 +0800

Ischemic cardiomyopathy (ICM) is the terminal manifestation of long-term myocardial ischemia, necrosis, and fibrosis caused by coronary artery disease, and its pathogenesis involves multiple modes of cell death. In recent years, the role of ferroptosis as an iron dependent, lipid peroxidation driven regulatory form of cell death in ICM has gradually been revealed. This article systematically reviews the molecular mechanisms of ferroptosis and its role in the occurrence and development of ICM, and explores potential therapeutic strategies targeting ferroptosis, aiming to provide new ideas for the prevention and treatment of ICM.

Construction and Empirical Study of a Standardized Nursing Protocol for CO2 Angiography in Patients with Lower Extremity Arteriosclerosis Obliterans Complicated by Renal Insufficiency

Yan Zhao, Chao Kong, Jie Cai, Fang Yang — Fri, 03 Apr 2026 00:00:00 +0800

Objective: To develop and empirically analyze a standardized nursing protocol for CO₂ angiography in patients with lower extremity arteriosclerosis obliterans (ASO) complicated by renal insufficiency. Methods: A standardized nursing protocol for CO₂ angiography was first established for patients with lower extremity ASO complicated by renal insufficiency. Subsequently, 30 patients who underwent interventional therapy for lower extremity ASO complicated by renal insufficiency in the interventional vascular surgery department of our hospital from October 2025 to December 2025, following the standardized protocol, were selected as the experimental group. Another 20 patients who received treatment without the standardized protocol from October 2024 to December 2024 were selected as the control group. Intraoperative cooperation time, hospital stay, cost-effectiveness indicators, complications, and patient satisfaction were analyzed. Results: Compared with the control group, the experimental group exhibited a reduction in intraoperative cooperation time and hospital stay (p < 0.05). Although the cost of surgical consumables in the experimental group decreased compared to the control group, this difference was not statistically significant (p > 0.05). However, the costs of medications and total hospitalization expenses significantly decreased in the experimental group (p < 0.05). The overall incidence of complications was lower in the experimental group than in the control group (p < 0.05), and patient satisfaction was higher in the experimental group. Conclusion: The development and application of a standardized nursing protocol for CO₂ angiography can effectively improve nursing quality, reduce the risk of complications, and enhance patient prognosis, demonstrating clinical value for widespread adoption.

Advances in Mechanisms and Clinical Applications of Lasers with Different Wavelengths in Medicine

Rongzhu Yu, Liwei Feng, Jing Guo, Xiaolin Bu — Sun, 05 Apr 2026 00:00:00 +0800

Since its inception, laser technology has undergone a leapfrog development from fundamental exploration to extensive clinical applications. In its early stages, lasers were mainly used for simple tissue cutting. With continuous technological innovation, their clinical value in precision therapy and minimally invasive intervention has become increasingly prominent. Lasers have evolved into an indispensable tool for the treatment of numerous diseases, driving a paradigm shift in diagnosis and treatment within the medical field. Lasers of different wavelengths exhibit significant differences in penetration depth and absorption characteristics within biological tissues. This wavelength selectivity enables lasers to act precisely on target tissues while minimizing damage to surrounding normal tissues. For instance, specific wavelengths can be selectively absorbed by chromophores such as melanin and hemoglobin, thereby achieving precise treatment of related diseases. This constitutes the fundamental mechanism underlying the precision of medical lasers. This review aims to systematically summarize recent advances in the working principles, expanded clinical applications, and cutting-edge research trends of various wavelengths of lasers in medicine. It is intended to provide comprehensive and up-to-date references for researchers and clinicians in related fields, and to promote the further development and application of medical laser technology.

Clinical Efficacy of Xiaochengqi Decoction Enema Combined with Conventional Therapy in Patients with Acute Simple Intestinal Obstruction

Xiujuan Guo, Hongfei Deng, Yanheng Zhang, Zhongjian Li — Sun, 05 Apr 2026 00:00:00 +0800

Objective: To evaluate the clinical efficacy of Xiaochengqi Decoction enema in the treatment of acute simple intestinal obstruction and to compare its effects with those of Gastrografin and soap water enema. Methods: This study was designed as a prospective randomized controlled study. A total of 150 patients diagnosed with acute simple intestinal obstruction and admitted to the Emergency Department of Linfen People’s Hospital between September 2023 and August 2025 were enrolled. Patients were randomly assigned into the Xiaochengqi Decoction group, the Gastrografin group, and the soap water group, with 50 patients in each group. All groups received conventional conservative management, including fasting, continuous gastrointestinal decompression, fluid resuscitation, and correction of water–electrolyte and acid–base imbalances. In addition, patients in the Xiaochengqi Decoction group received modified Xiaochengqi Decoction retention enema, those in the Gastrografin group received 76% Gastrografin via nasogastric tube, and those in the soap water group received soap water enema. Clinical efficacy, symptom relief time, length of hospital stays, and imaging improvement were compared among the three groups. Results: No statistically significant differences were observed among the three groups in baseline characteristics (p > 0.05). Overall clinical efficacy differed significantly among the groups (χ² = 11.429, p = 0.003). The total effective rate was highest in the Xiaochengqi Decoction group (90.0%), followed by the Gastrografin group (86.0%) and the soap water group (76.0%). Significant differences were also identified in abdominal pain relief time, time to first flatus, time to first defecation, and length of hospital stay (all p < 0.001), with the shortest durations observed in the Xiaochengqi Decoction group. Imaging improvement rates differed significantly among groups (χ² = 13.333, p = 0.001), with the highest rate in the Xiaochengqi Decoction group (98.0%). Conclusion: Xiaochengqi Decoction enema, when combined with conventional conservative therapy, may improve clinical outcomes in patients with acute simple intestinal obstruction, promote recovery of bowel function, and reduce hospital stay, demonstrating favorable clinical applicability.

A Study on the Correlation between Anxiety Levels, Family Resilience and Hope Levels in Patients after Benign Prostatic Hyperplasia Surgery

Juan Xiao, Shaoyan Yuan, Fang Xu, Weijuan Li — Sun, 05 Apr 2026 00:00:00 +0800

Objective: This study aims to explore the correlations between anxiety levels, family resilience, and hope levels in postoperative patients with benign prostatic hyperplasia, providing a theoretical basis for reducing anxiety in postoperative patients. Methods: Convenience sampling was used to conduct a questionnaire survey among 150 patients who underwent prostatic hyperplasia resection in our hospital from June 2024 to December 2025. The questionnaire included a general information questionnaire, an anxiety scale, a family resilience scale, and a hope level scale. Multiple linear regression was used to analyze the factors influencing anxiety after prostatic hyperplasia surgery. Results: A total of 140 questionnaires were retrieved, with an effective recovery rate of 93.33%. Patients scored 51.71 ± 16.49 in anxiety level, 29.67 ± 10.44 in family resilience, and 29.67 ± 11.44 in hope level. Anxiety level was negatively correlated with erectile function (r = -0.379, p < 0.001). Negatively correlated with family resilience (r = -0.380, p < 0.001), negatively correlated with hope level (r = -0.476, p < 0.001), The results of multiple linear regression showed that age, chronic disease status, smoking status, family resilience, and hope level were factors influencing anxiety levels in patients after benign prostatic hyperplasia surgery (p < 0.05). Conclusion: The anxiety level of patients after prostatic hyperplasia surgery is at a moderate level. The improvement of family resilience and hope level is of great significance in postoperative rehabilitation. It is recommended to strengthen psychological support and family intervention in clinical management, and pay attention to older patients, those with chronic diseases and smokers to improve the overall quality of life and treatment effect of patients.

Research on the Risk Classification Nursing Model in the Prevention of Pressure Injuries in Critically Ill Patients in ICU

Chuanmei Wang — Sun, 05 Apr 2026 00:00:00 +0800

Objective: The purpose of the study was to explore the application effect of the risk classification nursing model in the prevention of pressure injury in critically ill patients in the ICU. Methods: A total of 186 critically ill patients admitted to the ICU of our hospital from January 2024 to December 2024 were randomly divided into the control group and the observation group according to the time of admission, with 93 cases in each group. Conventional pressure injury prevention nursing measures were used in the control group, while risk classification nursing model was adopted in the observation group. The incidence, staging, time of occurrence, length of hospital stay and nursing satisfaction of pressure injury were compared between the two groups. Results: The results showed that the incidence of pressure injury in the observation group was 5.38%, significantly lower than 15.05% in the control group (p < 0.05); The proportion of stage I pressure injury in the observation group was higher than that in the control group, and the proportion of stage II and above was lower than that in the control group (p < 0.05); The occurrence time of pressure injury in the observation group was later than that in the control group, and the length of hospital stay was shorter than that in the control group (p < 0.05); The nursing satisfaction score of the observation group was higher than that of the control group (p < 0.05). Conclusion: The risk classification nursing model can effectively reduce the incidence of pressure injury in critically ill patients in the ICU, delay the occurrence time, shorten the length of hospital stay, and improve nursing satisfaction. It is worthy of clinical promotion and application.

Research Progress on Risk Perception of Skeletal-Related Events in Patients with Solid Tumors

Shaomei You, Yan Qiu, Yalian Fu, Jian Chen — Tue, 21 Apr 2026 00:00:00 +0800

Skeletal-related events are common complications in patients with advanced solid tumors and bone metastases, significantly affecting their quality of life and survival prognosis. Risk perception refers to an individual's recognition, judgment, and understanding of risky matters, which holds great significance in promoting healthy behaviors and improving preventive actions among patients. Understanding the level of risk perception for bone-related events in patients with solid tumors is a crucial approach to enhancing their subjective initiative and compliance in bone health management behaviors. This article provides a comprehensive review of the current status, measurement tools, influencing factors, and intervention strategies related to the risk perception of bone-related events in patients with solid tumors. The aim is to enhance the awareness of bone-related events among patients with solid tumors and clinical practitioners, providing references for promoting bone health management behaviors and improving patients' quality of life.

Visual Analysis of the Current Situation of Elderly Care for Empty-Nest Seniors in Rural China Based on CiteSpace

Fang Xu, Juan Xiao, Xiaofang Hu, Jianfeng Xu, Shaoyan Yuan — Sun, 05 Apr 2026 00:00:00 +0800

Objective：To analyze the hotspots and trends in the current state of care for rural empty-nest elderly in China over the past two decades, providing insights for future research on this topic. Methods: Chinese literature related to the care of rural empty-nest elderly was retrieved from the China National Knowledge Infrastructure (CNKI) database, covering the period from January 2005 to December 2024. Citespace software was employed to generate visualizations of publication volume, author collaboration patterns, keyword co-occurrence, clustering, and emergent themes. Results: A total of 808 articles were included. Publication volume exhibited a trend of “slow growth—rapid surge—gradual decline”, with room for improvement in author collaboration. Co-occurrence and clustering maps revealed that research hotspots primarily revolved around issues such as care provision, security, services, and influencing factors for rural empty-nest elderly. Conclusion: Research on elderly care for rural empty-nest elderly in China has transitioned from foundational conceptual studies to a stage of substantive development. Establishing a three-dimensional network integrating “care strategy innovation, technology empowerment, and policy coordination” is key to addressing

Implementation Path and Effect Evaluation of Health Education in Pediatric Nephrology Nursing

Manman Yang, Yan Wang — Fri, 10 Apr 2026 10:17:50 +0800

Objective: To explore the scientific implementation path of health education in pediatric nephrology nursing and evaluate its impact on children’s rehabilitation and parents’ nursing ability. Methods: A total of 80 children with pediatric nephropathy admitted to our hospital from January 2023 to December 2024 were randomly divided into an experimental group and a control group, with 40 cases in each group. The control group received routine health education, while the experimental group implemented a systematic health education path of “admission assessment– phased education–discharge guidance–follow-up reinforcement”. The parents’ mastery of nursing knowledge, children’s treatment compliance, and disease recurrence rate were compared between the two groups. Results: The parents’ nursing knowledge score in the experimental group (89.6 ± 5.3) was significantly higher than that in the control group (67.2 ± 7.1). The children’s treatment compliance rate in the experimental group was 95.0%, which was higher than 72.5% in the control group, and the recurrence rate was 7.5%, which was lower than 25.0% in the control group. All differences were statistically significant (p < 0.05). Conclusion: The systematic health education path can improve parents’ nursing ability, enhance children’s treatment compliance, and reduce the risk of disease recurrence, which is worthy of clinical promotion.

The Impact of HFHD on Calcium-Phosphorus Metabolism and Nutritional Indicators in Patients with Chronic Kidney Disease

Qian Lu, Yin Shi, Changhua Liu — Fri, 10 Apr 2026 10:51:45 +0800

Objective: To analyze the effects of high-flux hemodialysis (HFHD) on calcium and phosphorus metabolism and nutritional indicators in patients with chronic kidney disease (CKD). Methods: A total of 86 CKD patients diagnosed in our hospital’s Nephrology Department between January 2024 and December 2025 and undergoing HFHD were enrolled. Using a random number table, all patients were divided into a control group (n = 43, receiving conventional hemodialysis) and a study group (n = 43, receiving HFHD). SPSS 26.0 statistical software was used to compare calcium-phosphorus metabolism and nutritional indicators between the two groups. Results: After 6 months of treatment, the PTH level in the study group was significantly lower than that in the control group, while serum calcium and phosphorus levels were significantly higher (p < 0.05). The Alb and Hb levels in the study group were higher than those in the control group, but the difference was not statistically significant (p > 0.05). Conclusion: HFHD maintains calcium-phosphorus metabolism balance in CKD patients while significantly improving nutritional indicators.

Evaluation of Individualized Nursing Based on the IKAP Model on Cardiac Function Improvement in Patients with Chronic Heart Failure

Jia Luo — Fri, 10 Apr 2026 11:04:08 +0800

Objective: To investigate the impact of individualized nursing based on the IKAP model on cardiac function in patients with chronic heart failure. Methods: A total of 112 patients with chronic heart failure admitted from January 2024 to September 2025 were selected and grouped using the random number table method. The control group (56 cases) received conventional nursing, while the observation group (56 cases) received individualized nursing based on the IKAP model. Cardiac function and quality of life were compared between the groups. Results: After three months of nursing, the left ventricular ejection fraction (LVEF) in the observation group was significantly higher than that in the control group, while the left ventricular end-systolic diameter (LVESD) and left ventricular end-diastolic diameter (LVEDD) were significantly lower than those in the control group (p < 0.05). The quality-of-life score in the observation group was significantly lower than that in the control group (p < 0.05). Conclusion: Individualized nursing based on the IKAP model can effectively improve cardiac function and quality of life in patients with chronic heart failure, and is thus worthy of promotion.

Research Progress of Appropriate Traditional Chinese Medicine Nursing Techniques for Postpartum Urinary Retention

Xinyue Zhang, Li Li — Fri, 10 Apr 2026 13:41:18 +0800

This review summarizes the definition and classification, etiology and pathogenesis of postpartum urinary retention, as well as the application of Traditional Chinese Medicine (TCM) nursing techniques in its prevention and treatment. It also identifies the limitations and prospects of TCM nursing techniques in managing postpartum urinary retention, aiming to provide a reference for the clinical application and future research of TCM nursing techniques regarding this condition.

Research Progress on Functional Assessment of Non-specific Low Back Pain

Huiqian Yan, Qianli Wu — Fri, 10 Apr 2026 13:50:46 +0800

Nonspecific low back pain (NLBP) is a prevalent condition in daily life with a notably high recurrence rate. It is particularly common among athletes, especially those involved in sports such as weightlifting and ice hockey. Assessment is crucial both before and after rehabilitation therapy for NLBP to evaluate its effectiveness. Functional assessment, as a common evaluation method, plays a significant role in understanding patients’ functional impairments and quality of life, as well as guiding rehabilitation interventions and assessing treatment outcomes. There are numerous tools available for assessing NLBP. This paper summarizes recent domestic and international literature on nonspecific low back pain.

Application Research of Collaborative Decision-Making Nursing Intervention Based on Information Asymmetry Theory in Postoperative Limb Functional Rehabilitation of Patients with Lower Limb Fractures

Jianglin Hu — Fri, 10 Apr 2026 00:00:00 +0800

Lower limb fractures are a prevalent clinical orthopedic condition, primarily caused by factors such as trauma and osteoporosis. Surgical treatment serves as the main intervention method; however, the postoperative rehabilitation of limb function is characterized by a lengthy and challenging process. Patients often experience suboptimal rehabilitation outcomes due to a lack of rehabilitation knowledge and insufficient compliance. The information asymmetry theory elucidates the information imbalance between doctors and patients resulting from disparities in professional knowledge. Collaborative decision-making nursing intervention effectively alleviates information asymmetry by establishing a mechanism for information sharing between doctors and patients, thereby fully mobilizing patients’ initiative in rehabilitation. This paper synthesizes relevant domestic and international research in recent years to summarize the application methods and implementation effects of collaborative decision-making nursing intervention based on information asymmetry theory in the postoperative limb functional rehabilitation of patients with lower limb fractures. It aims to provide theoretical references and practical evidence for optimizing clinical rehabilitation nursing models and enhancing rehabilitation quality following lower limb fracture surgery.

Self-Management Experiences and Challenges in Patients with Metabolic Dysfunction-associated Steatotic Liver Disease: A Qualitative Study Guided by Pender’s Health Promotion Model

Haojie Hao, Danyang Guo, Yidan Quan, Han Fei, Jiayin Xu, Wei Zhang — Fri, 10 Apr 2026 00:00:00 +0800

Objective: The study aims to explore experiences of patients with metabolic dysfunction–associated steatotic liver disease (MASLD) in self-management, identify the challenges they encountered and their needs during the self-management process. Methods: This qualitative study was conducted at an integrated tertiary hospital between March and May 2025. Semi-structured interviews with 15 participants were analyzed using Colaizzi’s seven-step method, and the resulting themes were mapped onto the constructs of the Pender health promotion model (HPM). Result: Three themes and nine sub-themes were mapped onto the HPM as challenges and obstacles in the self-management process of patients with MASLD. The themes encompass individual characteristics and negative experiences (personal factors and previous experiences with weight loss and rebound), cognitive and emotional deficits in self-management behaviors (insufficient recognition of the benefits of self-management, lack of interpersonal and situational support, negative emotional impact related to behavior, and low self-efficacy), and temporary needs and compromises with hobbies (unhealthy dietary preferences and long-term dietary habits, behavioral compromises in social situations, and temporary needs conflicting with healthy behaviors). Conclusion: Healthcare professionals should comprehensively assess the individual characteristics of patients with MASLD and provide personalized dietary and exercise management tailored to their lifestyle and behavioral preferences, while also paying close attention to their psychological and emotional well-being. Addressing patients’ behavioral, psychological, and social needs enhance the feasibility and sustainability of lifestyle changes, thereby promoting more effective and long-term self-management.

Epidemiology and Demographic Patterns of Co-infections with Eight Respiratory Pathogens: A Large-Scale Retrospective Study

Fri, 10 Apr 2026 20:20:27 +0800

Background: Respiratory tract infections (RTIs) pose a significant global health burden, with etiology complicated by frequent pathogen co-infections. Comprehensive data on the epidemiology of co-infections across broad age and demographic spectra remain limited. Methods: This large-scale retrospective study analyzed 9,908 patients with suspected RTIs at a single hospital. Detection of IgM antibodies against eight common pathogens (Influenza A/B, Respiratory syncytial virus, Adenovirus, Mycoplasma pneumoniae, Parainfluenza virus, Coxsackievirus B, Chlamydia pneumoniae) was performed using rapid colloidal gold kits. Positivity rates, co-infection patterns, and their associations with age and gender were analyzed. Results: The overall pathogen detection rate was 33.1%. Influenza A was the most frequently detected pathogen overall, while Influenza B was most common among single infections. Notably, 33.1% of positive cases involved co-infections, with dual infections being most prevalent. The most frequent co-infection pattern was Influenza A with RSV. Age-stratified analysis revealed the highest proportion of co-infections in preschool children (48.3%) and older adults (40.3%), with adults having the lowest rate (28.5%). Significant gender-based differences were observed within specific age groups, such as higher Adenovirus rates in adult males and higher Mycoplasma pneumoniae rates in adult females. Conclusion: This study highlights the high frequency and specific demographic patterns of respiratory pathogen co-infections, underscoring the complexity of RTI etiology. The findings emphasize the need for considering multiple pathogens in clinical diagnosis and suggest that both age and gender may influence infection susceptibility and co-infection risk, informing future surveillance and management strategies.

Exploration on the Application of Airway Care Measures During the Coma Period in Pediatric Patients with Severe Craniocerebral Injury

Dandan Su, Fang Li, Meng Hao, Hua Yang, Qiang Wang — Tue, 21 Apr 2026 09:10:13 +0800

Objective: This study aims to systematically evaluate the practical effects of an integrated airway care protocol in the clinical management of pediatric patients with severe craniocerebral injury in a coma, with the core objective of reducing airway-related complications and optimizing treatment outcomes. Methods: A prospective study was conducted involving 76 pediatric patients with severe craniocerebral injury in a coma who were admitted to the PICU of our hospital from January 2022 to December 2023 and met the inclusion criteria. These patients were randomly divided into an intervention group and a conventional group, with 38 cases in each group. The conventional group received standard neurosurgical airway care, while the intervention group implemented a systematic care strategy encompassing precise humidification, programmed suctioning, individualized positioning adjustments, and early respiratory function intervention. The incidence of ventilator-associated pneumonia and airway mucosal injury, duration of invasive ventilation, length of stay in the PICU, and improvements in arterial oxygen and carbon dioxide partial pressures before and after intervention were recorded and compared between the two groups. Results: The incidence of ventilator-associated pneumonia in the intervention group was 13.16%, significantly lower than the 34.21% in the conventional group. The incidence of airway mucosal injury in the intervention group was 10.53%, also lower than the 28.95% in the conventional group. In terms of time indicators, the intervention group had shorter average durations of mechanical ventilation and PICU stay compared to the conventional group. Blood gas analysis results showed that the intervention group had greater increases in arterial oxygen partial pressure and decreases in carbon dioxide partial pressure than the conventional group, with statistically significant differences between the groups. Conclusion: Comprehensive and proactive airway care interventions during the coma period in pediatric patients with severe craniocerebral injury can effectively safeguard airway function integrity, significantly reduce the risk of major complications, accelerate the critical care process, and thereby provide more stable support conditions for neurological recovery. This protocol holds clinical practical value.

Construction of an Integrated Oral Care and Swallowing Stimulation Protocol for Comatose Patients with Cerebral Hemorrhage

Qiang Wang, Lu Pang, Jiting Yu, Tian Zhang, Ying Lv — Tue, 21 Apr 2026 00:00:00 +0800

Objective: This study aims to design and establish a comprehensive intervention protocol that combines oral care with swallowing stimulation for comatose patients with cerebral hemorrhage. The core objectives are to systematically control the risk of aspiration pneumonia, improve the oral health environment of patients, and explore its potential supportive role in the early awakening process. Methods: The study was conducted using a mixed-methods approach. The first phase involved integrating systematic literature reviews with Delphi expert consultations to establish the basic components and specific operational norms of the protocol. The second phase implemented a non-randomized concurrent controlled clinical trial, enrolling 112 eligible comatose patients with cerebral hemorrhage, evenly divided into an intervention group and a control group, with 56 patients in each group. The intervention group received a newly constructed integrated protocol of oral care and swallowing stimulation for four weeks, while the control group maintained standard oral care routines in the neurology department. The core observational indicators included the Clinical Pulmonary Infection Score (CPIS), Oral Assessment Scale (OAS) scores, changes in the Glasgow Coma Scale (GCS) scores, and analysis of microbial colony counts in saliva. Data were analyzed using SPSS 25.0 software, with continuous variables conforming to a normal distribution presented as mean ± standard deviation. Comparisons between groups were made using independent sample t-tests or non-parametric Mann-Whitney U tests, and repeated measures analysis of variance was used for repeated measurement indicators. Results: After the four-week intervention period, data analysis revealed that the CPIS values in the intervention group were significantly lower than those in the control group, with statistical significance. In terms of oral health assessment, the intervention group showed significantly greater improvement than the control group. The intervention group also demonstrated a more pronounced upward trend in consciousness level scores. Microbiological test results confirmed that the survival numbers of opportunistic pathogens in the saliva of the intervention group were effectively controlled. Conclusion: The integrated protocol of oral care combined with swallowing stimulation constructed and preliminarily validated in this study has been shown to effectively reduce the clinical probability of aspiration pneumonia in comatose patients with cerebral hemorrhage, optimize oral microecological balance, and potentially promote improvement in consciousness status. This protocol holds potential value for translation into routine clinical practice.

Discussion on the Current Situation and Implementation Models of Pharmaceutical Science Popularization Communication in China

Gaihong Xian, Junting Cai, Xingqiang Liu — Tue, 21 Apr 2026 09:17:18 +0800

At present, the general public has limited knowledge of pharmaceutical products, which to a certain extent increases the risk of medication. Strengthening pharmaceutical science popularization education is particularly important for promoting rational drug use, reducing medication risks, and improving national health literacy. Based on this, this paper analyzes the current situation and main implementation models of pharmaceutical science popularization communication in China, reveals the prominent challenges faced, and explores specific countermeasures on this basis. It is expected to provide useful references for the high-quality development of China’s pharmaceutical science popularization cause and contribute to the construction of Healthy China.

In Adults with Type 1 Diabetes, is the Artificial Pancreas System More Effective than Open-loop Systems in Controlling Blood Glucose?

Bo Liu — Wed, 22 Apr 2026 00:00:00 +0800

Background: Despite advances in continuous glucose monitoring (CGM) and insulin pump therapy, many adults with type 1 diabetes (T1D) do not consistently achieve recommended glycemic targets. Automated insulin delivery (AID), often referred to as the artificial pancreas (AP), integrates CGM, an insulin pump, and a control algorithm to adjust insulin delivery in real time. Objective: To summarize contemporary evidence comparing AP/AID (closed-loop or hybrid closed-loop) with open-loop approaches (e.g., sensor-augmented pump therapy or user-directed insulin dosing) for glycemic control in adults with T1D. Methods: We synthesized evidence from recent randomized controlled trials (RCTs) and meta-analyses in adults with T1D, focusing on clinically meaningful CGM-derived metrics (time in range [TIR], time below range), HbA1c, and safety outcomes. Reporting principles align with PRISMA 2020 where applicable. Results: Across modern RCTs and meta-analyses, AP/AID consistently improves TIR and reduces hyperglycemia compared with open-loop strategies, without increasing hypoglycemia. Key trials in older adults show clinically relevant gains in TIR with closed-loop systems versus sensor-augmented pump therapy. Meta-analytic evidence supports improved TIR and modest HbA1c reductions with closed-loop compared with open-loop approaches. Conclusion: In adults with T1D, AP/AID systems are more effective than open-loop regimens in improving glycemic control, offering better TIR and comparable or improved hypoglycemia safety profiles.

Efficacy of Laparoscopic Choledochojejunostomy Reconstruction for Anastomotic Stenosis After Choledochojejunostomy

Xin Zhang, Maitao Hu, Zhiwei Jiang, Peng Jiang, Zili He — Tue, 21 Apr 2026 09:30:34 +0800

Objective: To evaluate the safety, feasibility, and key surgical techniques of laparoscopic choledochojejunostomy reconstruction for anastomotic stenosis following biliary-enteric internal drainage surgery. Methods: The clinical data of 5 patients with anastomotic stenosis after biliary-enteric internal drainage surgery, admitted to The First Affiliated Hospital of Hunan Normal University between March 2025 and August 2025, were retrospectively reviewed and analyzed. All patients provided written informed consent, and the study was conducted in compliance with medical ethics standards. There were 3 males and 2 females, with an age range of 10–45 years and a median age of 17 years. Outcome measures included operation time, intraoperative blood loss, postoperative anal exhaust time, postoperative hospital stay, and perioperative complications. Results: All 5 patients successfully underwent laparoscopic choledochojejunostomy reconstruction without conversion to open surgery. The operation time ranged from 220 to 380 minutes (median, 235 minutes), and the intraoperative blood loss was 20–80 mL (median, 50 mL), with no blood transfusion required in any case. T-tube drainage was performed in 2 patients. The postoperative anal exhaust time was 1–2 days (median, 2 days), and the postoperative hospital stay was 5–7 days (median, 6 days). No perioperative complications occurred in any patient. Conclusion: Laparoscopic choledochojejunostomy reconstruction is a safe and feasible surgical approach for anastomotic stenosis after biliary-enteric internal drainage surgery, offering advantages of minimal invasiveness and a low incidence of perioperative complications.

Determination of the Plasma Concentrations of Amygdalin and Paeoniflorin in Rat Serum Using Liquid Chromatography-tandem Mass Spectrometry

Kang Li — Tue, 21 Apr 2026 09:38:30 +0800

Objective: To establish a liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method to determine amygdalin and paeoniflorin in rat blood serum. Method: After protein precipitation by acetonitrile, a gradient elution procedure was performed to separate the samples by using acetonitrile and ammonium acetate buffer as the mobile phase. The quantitative determination was based on an HPLC-MS/MS in negative electron spray ionization mode and in multiple reaction monitoring (MRM) mode. The precursor to product ion transitions for amygdalin and paeoniflorin were 456.2 to 323.1 and 479.2 to 121.0, respectively. Results: The linear ranges of amygdalin and paeoniflorin were 1–300 ng/mL (rAmy = 0.9994，rPae = 0.9993) with the lowest limits of quantification were 0.3 ng/ml. The extract recovery of amygdalin and paeoniflorin were 91.1%, 94.2%, 92.0% and 90.3%, 93.7%, 94.1% at concentrations of 3, 20, 100 ng/mL, respectively. All the intra and inter day precisions of analysis were less than 15%, and the RE were in the range of ± 15%. Conclusion: The method is specific, sensitive, accurate, and suitable for determination of amygdalin and paeoniflorin in rat blood serum．

Research on the Application Effect of Digital Pathology-Assisted Technology in the Differential Diagnosis of Left and Right Hemicolon Cancer

Jiaxin Qin, Xiong Du, Jie Ai — Tue, 21 Apr 2026 09:48:04 +0800

Objective: To explore the application value of digital pathology-assisted technology in the differential diagnosis of left and right hemicolon cancer, compare the efficacy differences between conventional pathological diagnosis and digital pathology-assisted diagnosis, and provide a basis for clinical precise differential diagnosis. Methods: A total of 200 patients with colon cancer who underwent surgery in our hospital from October 2024 to October 2025 were selected as the study subjects. They were divided into a control group (100 cases) and an observation group (100 cases) according to the random number table method. The control group was diagnosed manually using conventional pathological sections, while the observation group was diagnosed with the assistance of digital pathological sections. Both groups clearly identified the lesion sites in the left and right hemicolon. The general data, diagnostic time consumption, diagnostic accuracy, and consistency in interpreting pathological features were compared between the two groups. Results: There were no statistically significant differences in general data such as gender, age, and disease duration between the two groups (p > 0.05). The average diagnostic time consumption in the observation group was significantly shorter than that in the control group, the diagnostic accuracy rate was significantly higher, and the misdiagnosis rates were significantly lower (all p < 0.05). There was no statistically significant difference in the missed diagnosis rate (p = 0.088 > 0.05). The consistency rates in interpreting the four indicators of tumor differentiation degree, infiltration depth, lymph node metastasis, and pathological morphology in the observation group were higher than those in the control group (all p < 0.05). Conclusion: The application of digital pathology-assisted technology in the differential diagnosis of left and right hemicolon cancer can significantly shorten the diagnostic time, improve the diagnostic accuracy rate, reduce the risks of misdiagnosis and missed diagnosis, and enhance the consistency in interpreting pathological features. It is suitable for promotion and application in clinical pathological diagnosis.

The Impact of Bidirectional Quality Feedback Nursing Model on the Quality of Life and Self-Management Ability of Patients with Chronic Obstructive Pulmonary Disease (COPD)

Daidi Tang, Chengjin Sheng, Lingling Liu — Tue, 21 Apr 2026 09:55:58 +0800

Objective: To explore the intervention effect of the bidirectional quality feedback nursing model on the quality of life and self-management ability of patients with chronic obstructive pulmonary disease (COPD). Methods: A total of 60 COPD cases in the stable phase of the disease admitted to our hospital from January to December 2024 were included. Using a random number table method, they were divided into a control group and an observation group, with 30 cases in each group. The control group received the standard nursing protocol, while the observation group underwent a three-month bidirectional quality feedback nursing intervention in addition to the standard protocol. The quality of life and self-management ability scores of the two groups were compared before and after the intervention. Results: After the intervention, compared with the control group, the observation group showed lower scores in all dimensions of the St. George’s Respiratory Questionnaire (SGRQ) and higher scores in all domains and the total score of the Self-Care of Chronic Illness Inventory-Modified for COPD (SCMMS) (p < 0.05). Conclusion: The bidirectional quality feedback nursing intervention can significantly improve the self-care level and quality of life of patients with COPD, demonstrating clinical application value.

Evaluation of the Effectiveness of Oral Care Intervention Programs for Adult Mechanically Ventilated Patients in the ICU

Xiaoshan Lin, Zhenjiang Chen — Tue, 21 Apr 2026 10:05:06 +0800

Objective: To evaluate the application effect of an individualized comprehensive oral care intervention program in adult mechanically ventilated patients in the ICU an evidence-based basis for clinical oral care. Methods: A total of 80 adult mechanically ventilated patients in the ICU of a tertiary hospital from January to December selected and randomly divided into a control group and an observation group, with 40 cases in each group. The control group received routine oral care, while the observation group received incomprehensive oral care. The intervention continued until the patients were extubated or transferred out of the ICU. SPSS 26.0 software was used for analysis. Measure was expressed as (± s) and analyzed using t-tests; count data were expressed as [n(%)] and analyzed using χ² tests. p < 0.05 was statistically significant. Results: After the intervention, the oral hygiene score (2.15 ± 0.62), VAP incidence rate (7.50%, 3/40), and total incidence rate of oral complications (5.00%, 2/40) in the observation group were significantly lower than those in the control group (4.82 ± 0.95, 25.00%, 10/40, and 22.50%, 9/40, respectively) (all p < 0.05). The duration of mechanical ventilation (6.82 ± 2.15 days) and ICU length of stays (10.35 ± 3.26 days) in the observation group were significantly shorter than those in the control group (p < 0.001). Conclusion: Individualized comprehensive oral care improves oral hygiene in adult mechanically ventilated patients in the ICU, reduce the incidence of VAP and oral complications, and shorten the duration of mechanical ventilation and ICU length of stay, demonstrating clinical value.

Impact of Early Shoulder Joint Functional Exercise Program on Quality of Life of Survivors after Modified Radical Mastectomy

Tiantian Sun, Mary Ann Bayani — Tue, 21 Apr 2026 10:12:53 +0800

This study aimed to evaluate the effects of an early shoulder joint functional exercise program on shoulder joint function and quality of life among breast cancer survivors who underwent modified radical mastectomy. Breast cancer remains the most prevalent malignancy among women worldwide. With advances in early detection and comprehensive treatment, survival rates among breast cancer survivors have markedly improved. Consequently, the focus of postoperative care has shifted from disease control to long-term functional recovery and quality of life enhancement. However, shoulder joint dysfunction following modified radical mastectomy (MRM) remains a common and debilitating complication, significantly affecting upper limb function, daily activities, and overall quality of life. Although early shoulder joint functional exercises have been reported to be beneficial, their systematic integration into routine postoperative nursing care and their effects on both shoulder function and quality of life require further empirical investigation. A quantitative, quasi-experimental, non-equivalent control group design was employed. Sixty female breast cancer survivors who underwent unilateral MRM were recruited from a tertiary hospital in Shandong Province, China, and were allocated into an experimental group (n = 30) and a control group (n = 30) using sequential recruitment and sealed draw assignment. The experimental group received a structured, phase-based early shoulder joint functional exercise program beginning 1–3 days postoperatively, while the control group received routine postoperative functional exercise guidance. Shoulder joint function was assessed using the Constant–Murley Score (CMS) at baseline (preoperative), postoperative day 10, and postoperative day 30. Quality of life was measured using the Functional Assessment of Cancer Therapy–Breast (FACT-B) at postoperative day 30. Data were analyzed using descriptive statistics, independent and paired t-tests, and correlation analysis. Baseline comparisons revealed no statistically significant differences in demographic characteristics or shoulder function scores between the experimental and control groups of breast cancer survivors (p > 0.05), indicating that the two groups were well-matched at the outset of the study. Following the intervention, shoulder function improvement in the experimental group was significantly greater than that in the control group. For instance, assessments using the Constant–Murley Shoulder Score (CMS) demonstrated that the experimental group exhibited statistically significant increases in shoulder function scores at both postoperative day 10 and day 30 compared to baseline levels (p < 0.05), with a consistent upward trend. In contrast, although the control group also showed improvement at the same time points, the extent of improvement was markedly smaller. Intergroup comparisons further confirmed that CMS scores in the experimental group were significantly higher than those in the control group at both postoperative day 10 and day 30 (p < 0.05). With respect to quality of life, as evaluated by the Functional Assessment of Cancer Therapy–Breast (FACT-B) scale, the experimental group exhibited significantly higher total quality-of-life scores than the control group at postoperative day 30 (p < 0.05). Improvements were particularly notable in the physical well-being and functional well-being domains. Further correlation analysis indicated a significant positive relationship between shoulder function scores and overall quality-of-life scores among breast cancer survivors who received early shoulder rehabilitation interventions (p < 0.05). This suggests that greater improvement in shoulder function is associated with better self-perceived quality of life in this population. Early shoulder joint functional exercise significantly improved shoulder joint function and quality of life among breast cancer survivors after modified radical mastectomy. The findings support the systematic incorporation of structured early shoulder joint functional exercises into routine postoperative nursing care to promote functional recovery and enhance overall quality of life.

Application Effect of Hierarchical Nursing Management Model in Hospital Nursing Management

Meirong He, Qiongying Tang — Tue, 21 Apr 2026 00:00:00 +0800

Objective: To explore the implementation plan of the hierarchical nursing management model and its application effect in actual hospital work, and propose more effective and guaranteed management measures to provide reference for the improvement of modern medical and nursing service quality. Methods: Based on a controlled experiment, 68 nursing staff from our hospital from March 2024 to February 2025 were enrolled and randomly divided into two groups with 34 cases in each group. The control group adopted conventional management, while the observation group implemented the hierarchical nursing management model to form a new working mode. Finally, their performance in work enthusiasm, nursing quality, as well as patient satisfaction and assessment scores were discussed. Results: The data of the observation group showed that it was superior to the control group in multiple indicator dimensions (patient satisfaction, work enthusiasm, work efficiency, nursing quality, and assessment scores), and the difference was statistically significant (p < 0.05). Conclusion: In hospital nursing management work, there is an urgent need to implement modern and effective management models, and the hierarchical nursing management model is one of them. It has truly reversed the concept of nursing staff, making them realize the importance of maintaining work enthusiasm and fulfilling their duties. Moreover, through the penetration of modern management concepts, it has effectively improved the level of professional nursing services and patient satisfaction, and contributed to the harmony of doctor-patient relations.

Clinical Application Study of Airway Management Team Applying Evidence-Based Nursing Model in Early Rehabilitation Treatment of Elderly Patients with ARDS

Yan Wang, Han Liang, Xueping Ji, Shaowei Ma, Panpan Zhang, Huaping Wei — Tue, 21 Apr 2026 10:32:13 +0800

Objective: To explore the application effect of the airway management team combined with the evidence-based nursing model in the early rehabilitation of patients with acute respiratory distress syndrome (ARDS). Methods: A total of 76 elderly patients with ARDS admitted from January 2024 to January 2025 were selected and randomly divided into a control group (receiving conventional nursing) and an observation group (receiving airway management team combined with evidence-based nursing). Blood gas indicators such as arterial partial pressure of oxygen (PaO₂) and oxygenation index (PaO₂/FiO₂) before and after intervention were compared between the two groups. The quality of life of patients after intervention was evaluated using the Short Form Health Survey (SF-36), and satisfaction with nursing services was assessed using a self-made questionnaire. Results: After intervention, both PaO₂ and PaO₂/FiO₂ in the observation group were significantly higher than those in the control group (both p < 0.05). The scores of the observation group in the 11dimensions of physical functioning, role-physical, role-emotional, and social functioning on the SF-36 scale were significantly higher than those of the control group (p < 0.05). The overall satisfaction rate with nursing services in the observation group was 94.74%, significantly higher than the 76.32% in the control group (p < 0.05). Conclusion: The intervention model of the airway management team combined with evidence-based nursing can effectively improve the oxygenation status and quality of life of elderly patients with ARDS and enhance their satisfaction with nursing services. It is an optimized critical care nursing plan worthy of clinical promotion.

Summary of the Best Evidence for Treatment and Management of Drooling in Children with Cerebral Palsy Based on Evidence-Based Approach

Qinghuan Zhou, Hui Liu, Lingli Zhou, Zhoujing Hu, Xingqin Tian — Tue, 21 Apr 2026 10:44:01 +0800

Objective: Literature review on the treatment and management of drooling in children with cerebral palsy was conducted. The literature was screened, evaluated, and compiled into an optimal evidence table to provide evidence-based reference for the treatment and management of drooling in children with cerebral palsy. Methods: A systematic search was conducted in the following databases for relevant evidence on the treatment and management of drooling in children with cerebral palsy: BMJ Best Practice, CINAHL, Cochrane Library, Clinical Trials, Embase, PubMed, UpToDate, Web of Science, GIN (Global Institution for Instruction), NGC (National Center for Health and Care Excellence), NICE (National Institute for Health and Care Excellence), JBI (Journal of the Institute of Evidence-Based Healthcare), Ontario Registered Nurses Association, SIGN (Scotland Institute of Instructions), Med live, CNKI (China National Knowledge Infrastructure), Chinese Medical Association, China Biomedical Research Center, Wan fang Data, and VIP (VIP Database). The literature types included guidelines, expert consensus, best clinical practice, evidence summaries, systematic reviews and randomized controlled trials. The search period was from database inception to July 30, 2025. All evidence related to the treatment and management of drooling in children with cerebral palsy was compiled, identified, and summarized to form the best evidence system. Results: A total of 22 articles were included, comprising 5 guidelines, 9 systematic reviews and systematic summaries, 3 expert consensus statements, and 5 randomized controlled trials. The optimal evidence framework contained 28 pieces of best evidence covering 10 aspects, including multidisciplinary team collaboration, comprehensive step-by-step assessment, overall treatment principles, behavioral therapy, physical therapy, drug therapy, intraglandular botulinum toxin injection, surgical treatment, radiotherapy, and dynamic follow-up. Conclusion: The best evidence summarized in this study is scientific and systematic. Healthcare professionals can use this best evidence to develop targeted interventions to alleviate drooling symptoms, reduce complications, and improve treatment efficacy and quality of life in children with cerebral palsy. Furthermore, when developing treatment plans, it is crucial to comprehensively consider the specific clinical context of the child with cerebral palsy, treatment effectiveness, follow-up adjustment results, and the wishes of both the child and caregivers.

Analysis of the Effect of Gua Sha Combined with Cupping Therapy in TCM Nursing for Patients with Shoulder Periarthritis

Xiaoting Ma — Tue, 21 Apr 2026 00:00:00 +0800

Shoulder periarthritis is a common disease characterized by shoulder joint pain and dysfunction, which seriously affects patients’ quality of life. In the clinical treatment of shoulder periarthritis, external therapies of Traditional Chinese Medicine (TCM) have unique advantages. This paper focuses on the TCM nursing model of Gua Sha combined with cupping therapy. By systematically elaborating on the operational process and detailed requirements of this nursing model, it further compares with conventional nursing to analyze its clinical effects in relieving pain, improving shoulder joint mobility, and enhancing quality of life. The results show that Gua Sha combined with cupping TCM nursing can effectively dredge the meridians and Qi-blood in the shoulder, dispel cold and dampness, and relieve muscle spasm. Its analgesic and functional recovery effects are significantly superior to simple conventional nursing, with high safety, and it is worthy of popularization and application in clinical nursing.

Exploration of the Application of Humanistic Care in High-Quality Nursing Services of Gastroenterology Department

Dongying Zhou — Tue, 21 Apr 2026 10:59:35 +0800

Objective: To explore the application effect of humanistic care in high-quality nursing services of the gastroenterology department. Methods: A total of 40 patients in the gastroenterology department admitted to our hospital from July 2024 to July 2025 were randomly divided into two groups. The experimental group (20 cases) received high-quality nursing services integrated with humanistic care, while the control group (20 cases) only received high-quality nursing services. Results: The scores of depression (SDS) and anxiety (SAS) in the control group were significantly higher than those in the experimental group; the understanding and mastery of dietary health knowledge in the control group were significantly lower than those in the experimental group; the satisfaction degree of the control group was significantly lower than that of the experimental group, and the differences between the groups were statistically significant (p < 0.05). Conclusion: The application of humanistic care in high-quality nursing services of the gastroenterology department can not only promote the rapid recovery of the body, but also improve patients’ compliance, effectively alleviate their negative emotions, guide patients to develop good dietary and living habits, and effectively improve their quality of life. Therefore, it has high clinical application value and is worthy of vigorous promotion and active reference.

LncRNA MALAT1 as a Competitive Endogenous RNA in Osteoarthritis: Mechanisms and Therapeutic Prospects

Junhao Hu — Tue, 21 Apr 2026 00:00:00 +0800

Osteoarthritis (OA) is a complex degenerative joint disease characterized by articular cartilage degeneration, synovial inflammation, and osteophyte formation, with its exact pathogenesis not yet fully elucidated. In recent years, competing endogenous RNA (ceRNA) regulatory networks, particularly the role of long non-coding RNAs (LncRNAs) within them, have garnered increasing attention. This review focuses on LncRNA MALAT1, summarizing its ceRNA mechanism in the initiation and progression of OA. The article systematically elaborates on how MALAT1 acts as a molecular sponge to adsorb specific microRNAs (miRNAs), thereby relieving the inhibition of downstream target genes, and consequently regulating key pathological processes such as chondrocyte metabolism, extracellular matrix homeostasis, inflammatory response, and cell apoptosis. Furthermore, this review summarizes the potential value and latest research progress in targeting the MALAT1-ceRNA axis for early OA diagnosis, disease monitoring, and the development of novel therapeutic strategies, aiming to provide a new theoretical basis and perspective for the precise diagnosis and treatment of OA.

Research on the Construction and Application of a Homogeneous Training and Management Program for Nursing Interns in Primary-Level Hospitals

Xiaoxiao Liu, Xuefang Liu, Kaixin Wang, Chao Lin, Fenxiu Wang — Tue, 21 Apr 2026 14:55:03 +0800

Objective: To construct a homogeneous training and management program for vocational nursing interns suitable for primary-level hospitals and explore its application effects in improving the quality of nursing intern training, providing practical evidence for the reform of nursing internship teaching in primary-level hospitals. Methods: Vocational nursing students who interned at Zhucheng People’s Hospital from June 1, 2022, to May 30, 2024, were selected as the research subjects. They were divided into a control group and an experimental group using convenience sampling. The control group continued with the traditional one-on-one teaching model, while the experimental group implemented a homogeneous training and management program in addition to traditional teaching. The training effects of the two groups were compared using six indicators: theoretical assessment, skill operation, bedside comprehensive ability, nursing student satisfaction, teaching instructor satisfaction, and the occurrence of adverse events. Data were analyzed using SPSS 25.0. Results: The experimental group scored significantly higher than the control group in theoretical assessment, skill operation, and bedside comprehensive ability. Satisfaction among nursing students and teaching instructors in the experimental group was also significantly higher than that in the control group. Additionally, the incidence of adverse events in the experimental group was significantly lower than that in the control group, with all differences between the two groups being statistically significant (p < 0.005). Conclusion: Implementing a homogeneous training and management program for vocational nursing interns in primary-level hospitals can effectively improve nursing students’ theoretical knowledge, operational skills, and clinical comprehensive abilities, enhance satisfaction among both students and instructors, and reduce the occurrence of nursing adverse events. It holds significant practical value for comprehensively improving the quality of nursing intern training and optimizing nursing internship teaching in primary-level hospitals.

Exploration of Optimizing Hospital Nursing Work in the New Era

Jing Zhou — Tue, 21 Apr 2026 15:28:02 +0800

Under the background of the new era, with the continuous advancement of the Healthy China strategy, the general public has put forward higher requirements for hospital nursing work. As a bridge between medical services and patient needs, nursing work directly affects medical quality and safety, patients’ medical experience, and the sustainable development of the medical and health cause. Based on this, this paper briefly analyzes the connotation and development requirements of hospital nursing work in the new era, as well as the current situation of hospital nursing work, and discusses the optimization paths of hospital nursing work in the new era, aiming to provide certain theoretical support and practical guidance for the improvement of hospital nursing work.

Establishment of Physiological Therapy: A New Health Preservation Strategy Based on the Quantum Decoherence Theory of Aging

Wed, 22 Apr 2026 08:56:06 +0800

Objective: To establish the theoretical system and technical specifications of Intentional Physiological Therapy (IPT), and explore its application value in anti-aging health preservation. Methods: Based on interdisciplinary research of quantum biology, neuroscience, aging biology and systems medicine, an intention-quantum-physiology coupling model was constructed by integrating microtubule quantum computing theory, mitochondrial quantum metabolism theory and biophoton communication mechanism; the technical system and evaluation standards of IPT were established through literature analysis, theoretical deduction and preliminary experimental verification. Results: (1) The quantum decoherence theory of aging was proposed, holding that aging is the gradual loss of quantum coherence at cell-tissue-system level driven by environmental perturbations and internal metabolic noise. (2) A four-level intention regulation model (molecular-gene, cell-tissue, organ-system, whole-integration) was established to realize multi-scale quantum state regulation. (3) The core technical system of IPT was designed, including quantum awareness training, mitochondrial intention regulation, biofield resonance and environment-assisted quantum ecology, forming a closed-loop regulation system. (4) Quantum optimization strategies for anti-aging were proposed for different age groups and physiological states. Conclusion: IPT provides a new quantum biological paradigm for anti-aging health preservation, breaking the limitations of traditional molecular biology research, with significant theoretical innovation, technical feasibility and broad application prospects, worthy of further in-depth research and clinical verification.

Research Progress on Functional Exercise Nursing Interventions for Elderly Patients with Alzheimer’s Disease

Yuan Wang; Yan Li; Panjia Xu — Wed, 22 Apr 2026 09:20:42 +0800

Alzheimer’s Disease (AD) is a degenerative disorder of the central nervous system characterized primarily by progressive cognitive decline, behavioral abnormalities, and a decrease in daily living abilities. It is predominantly observed in the elderly population, with its incidence rising annually alongside the aging demographic, posing a significant public health threat to the physical and mental well-being and quality of life of older adults. Currently, clinical treatment primarily relies on pharmacological interventions to alleviate symptoms, whereas functional exercise nursing interventions, as a core non-pharmacological approach, can effectively delay cognitive decline, improve physical motor function, enhance self-care abilities in daily life, and reduce the caregiving burden on families and society. This article systematically reviews the main types, implementation methods, influencing factors, and intervention effects of functional exercise nursing interventions for elderly patients with AD, aiming to provide theoretical foundations and practical references for the clinical implementation of standardized and individualized functional exercise nursing interventions.

Observation on the Therapeutic Effect of Modified Major Bupleurum Decoction in Treating Elderly Patients with Type 2 Diabetes Mellitus Complicated by Constipation

Yaru Zhou — Wed, 22 Apr 2026 00:00:00 +0800

Objective: To observe the clinical effect of modified Major Bupleurum Decoction in treating elderly patients with type 2 diabetes mellitus (T2DM) complicated by constipation, particularly its role in alleviating constipation symptoms. Methods: A clinical study was conducted on 60 elderly patients with T2DM complicated by constipation who were hospitalized in the geriatrics department of our hospital from January 2024 to December 2025. The patients were divided into groups based on the order of their visits. The control group (n = 30) received Western medicine treatment, while the treatment group (n = 30) received a combination of Western medicine and modified Major Bupleurum Decoction. Differences in traditional Chinese medicine (TCM) syndrome scores, constipation scale scores, glycemic and lipid metabolism indicators, treatment efficacy, and the incidence of adverse reactions were compared between the two groups before and after treatment. Results: Compared with the control group, the treatment group showed a significant reduction in TCM syndrome scores and CCS scores after treatment, along with an increase in treatment efficacy, with statistically significant differences (p < 0.05). Compared with the control group, the treatment group also demonstrated a significant reduction in glycemic and lipid metabolism indicators after treatment, with statistically significant differences (p < 0.05). Conclusion: Modified Major Bupleurum Decoction can actively improve constipation symptoms in elderly patients with T2DM complicated by constipation, with a definite therapeutic effect. Additionally, it exerts a certain auxiliary regulatory effect on the glycemic and lipid metabolism health of patients.

Intervention Study of Solution-Focused Approach on Negative Emotions and Self-Management in Patients with First-Episode Acute Ischemic Stroke

Xingyue Liu, Tingting Chen, Dongxue Sun, Peng Zhang — Wed, 22 Apr 2026 00:00:00 +0800

Objective: To evaluate the intervention effect of the Solution-Focused Approach (SFA) on negative emotions, emotional self-management ability, and self-efficacy in patients with first-episode acute ischemic stroke (AIS). Methods: A quasi-experimental study design was adopted. A total of 64 first-episode AIS patients with negative emotions were randomly divided into a control group and an intervention group. The control group received routine psychological nursing, while the intervention group received structured psychological intervention based on SFA in addition to routine nursing. Before the intervention and after the last intervention, the Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS), Emotional Self-Management Behavior Scale, and Stroke Self-Efficacy Questionnaire (SSEQ) were used for effect evaluation. Results: After the intervention, the decrease in anxiety and depression scores, as well as the increase in emotional self-management behavior and self-efficacy scores in the intervention group, were significantly better than those in the control group (p < 0.05). Conclusion: SFA can effectively alleviate anxiety and depression symptoms in patients with first-episode AIS, improve their emotional self-management ability and self-efficacy, and is a clinically valuable empowering psychological intervention method.

Gut Microbiota and Liver Health: The Role of Resistant Starch in Ameliorating Metabolic Dysfunction-Associated Fatty Liver Disease

Sitian Zhao, Di Meng, Junping Shi — Wed, 22 Apr 2026 00:00:00 +0800

With lifestyle changes, the prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD), which accompanied by obesity, has been steadily increasing rising and has become the most common chronic liver disease. MAFLD is a multisystem condition that heightens the risk of liver disease and is concomitantly linked to an increased risk of other metabolic disorders, including cardiovascular and renal diseases. Research indicates that resistant starch (RS), a natural compound, influences MAFLD by dietary intervention, regulation of blood glucose and lipids, and reduction of inflammation. These studies augment our comprehension of the processes through which RS ameliorates MAFLD related disorders. This article examines recent research on the role of gut microbiota in enhancing the condition and progression of MAFLD, along with the therapeutic effects of RS. This study also analyzes the prospective advantages and obstacles of employing RS to treat MAFLD patients. Overall, the available evidence suggests that RS significantly improves MAFLD via the gut microbiota. However, these effects vary depending on the type of RS, the patient population, and gender. We recommend that future studies refine RS classification and usage conditions to optimize its application in MAFLD treatment.

Design and Application of a New Four-party Collaborative Management Model in the Intelligent Scheduling System for Operating Room

Lihong Xie, Chuxing Hong, Shufen Liao, Donghua Long, Youzhen Su, Fengqiu Gong — Wed, 22 Apr 2026 10:53:16 +0800

This study targets issues in traditional manual operating room scheduling, including unbalanced resource use, low efficiency, poor inter-departmental communication, and ignored nursing staff personal needs. It developed an integrated surgical scheduling platform to achieve refined, intelligent operating room management while balancing medical quality and humanistic care. Built on the existing Hospital Information System (HIS) with Caché database and Vue + .Net B/S three-tier architecture, the platform integrates five core functions: standardized surgical application, intelligent scheduling, staff rostering, dynamic dispatching, and information collaboration. It combines multi-objective optimization algorithms and Answer Set Programming (ASP) for precise matching of personnel, procedures, time and demands. Comparative analysis was conducted between 66,300 manually scheduled surgeries in 2024 (observation group) and 79,000 surgeries under intelligent scheduling in 2025 (control group). Results showed significant improvements: elective surgery scheduling time reduced by 78.1%, operating room golden time utilization increased by 31.18%, nursing workload balance rose by 27%, nursing emotional exhaustion positive rate decreased by 23%, and nursing turnover reached 0, with enhanced patient experience and staff satisfaction (p < 0.05). The platform forms a four-party collaborative management system, realizing efficient resource allocation and providing replicable experience for intelligent operating room management in tertiary hospitals.

Clinical Application of Guizhi Longgu Muli Decoction Combined with Traditional Chinese Medicine Foot Bath and Five-Tone Therapy in the Treatment of Insomnia

Zhigang Xu — Wed, 22 Apr 2026 11:03:37 +0800

Objective: To evaluate the therapeutic effect of Guizhi Longgu Muli Decoction combined with traditional Chinese medicine (TCM) foot bath and five-tone therapy on insomnia. Methods: A total of 99 patients with insomnia admitted to the hospital from October 2023 to October 2025 were selected and equally divided using a random number table. Group A received Guizhi Longgu Muli Decoction treatment, Group B received Guizhi Longgu Muli Decoction combined with TCM foot bath treatment, and Group C received Guizhi Longgu Muli Decoction combined with TCM foot bath and five-tone therapy. The therapeutic effects among the groups were compared. Results: The total effective rate in Group C was higher than that in Groups A and B. The sleep quality score and TCM syndrome score after treatment in Group C were lower than those in Groups A and B, and the scores in Group B were lower than those in Group A (p < 0.05). There was no significant difference in the adverse reaction rates among the three groups (p > 0.05). Conclusion: Administering Guizhi Longgu Muli Decoction combined with TCM foot bath and five-tone therapy to patients with insomnia can improve insomnia symptoms, enhance sleep quality, and demonstrate high treatment safety and definite efficacy.

A Study on the Management of Sedation and Analgesia in ICU Patients Based on Fault Tree Analysis and the eCASH Concept

Qian Zhang, Xiangli Zhang, Wenting Li, Qing Xu, Yang Yang, Jun Wang — Wed, 22 Apr 2026 11:31:14 +0800

Objective: To investigate the efficacy of combining fault tree analysis with the eCASH (early Comfort using Analgesia, Sedation, and delirium monitoring) concept in the management of sedation and analgesia for ICU patients. Methods: A total of 90 patients admitted to the ICU of a certain hospital between January and December 2025 who required sedation and analgesia were selected as subjects. Using a random number table, they were divided into a control group and an observation group, comprising 45 patients each. The control group received conventional sedation and analgesia nursing management, whilst the observation group was managed using fault tree theory combined with the eCASH concept. Indicators such as RASS scores for sedation levels, pain intensity (NRS and FPS-R scores), and PSQI scores for sleep quality were compared between the two groups before and after intervention. Results: Compared with pre-intervention levels, RASS, NRS, FPS-R and PSQI scores were significantly reduced in both groups; however, the observation group showed lower scores than the control group, with statistically significant differences (p < 0.05). Conclusion: The application of fault tree theory combined with the eCASH concept in the management of sedation and analgesia for ICU patients can effectively standardise the management process and improve the efficacy of sedation and analgesia, and is worthy of clinical promotion and application.

Effect Evaluation under the Control of Connotation Construction of Antimicrobial Use Density after Multiple Strategic Interventions

Gende Li, Liqun Zhang, Hua Cao, Shihua Yang, Geng Chen — Wed, 22 Apr 2026 13:37:54 +0800

Objective: To evaluate the effect of connotation construction control on antimicrobial use density (AUD) after the application of multiple strategic interventions. Methods: The experimental subjects were discharge data from Dehong Prefectural People’s Hospital, with the scope of this study spanning from January 2024 to December 2025. Comprehensive data from 2024 were included in the pre-intervention group, while comprehensive data from 2025 were included in the post-intervention group. A set of antimicrobial management systems was constructed, characterized by precision, standardization, and systematization, and multiple measures were implemented (including organizational system restructuring, information-based precise control, personalized indicator management, dynamic authorization and training of prescription rights, and multidisciplinary collaboration (MDT), etc.). The following indicators before and after the intervention were statistically analyzed and compared: AUD, antimicrobial use rate, etiological examination submission rate, and irrational prescription rate. Results: The post-intervention AUD was significantly lower than that before the intervention [(39.46 ± 2.08) DDDs/(100 person-days) vs (36.79 ± 0.22) DDDs/(100 person-days)], and the post-intervention antimicrobial use rate, proportion of special-grade antimicrobials used, and irrational prescription rate showed a lower trend compared to those before the intervention (p < 0.05); the etiological examination submission rate for therapeutic medications showed a higher trend compared to that before the intervention (p < 0.05). Conclusion: By focusing on connotation construction and implementing multiple strategic interventions, a shift from simple indicator control to precise diagnosis and treatment and rational medication use was achieved, significantly reducing the antimicrobial use density and improving the rationality of medication use.

Application Progress of 3D Printing in Orthopedic Clinical Practice

Xuanting Ye, Zhaochang Ye — Wed, 22 Apr 2026 13:48:56 +0800

In recent years, 3D printing technology has been widely applied in the field of orthopedics, covering preoperative planning, surgical simulation, personalized implants, and surgical guides, all demonstrating broad application prospects. This article systematically elaborates on the basic principles, methods, and materials of 3D printing technology, as well as its current application status, technological progress, and clinical effects in orthopedics. It also briefly outlines future directions such as artificial intelligence-assisted design and bio-printing. In the future, the combination of 3D printing and artificial intelligence will further reduce printing costs and simplify clinical operation procedures, enabling more patients to benefit from personalized and precise treatments. This will become an important direction for the next stage of orthopedic research.

A Competency-Mapping-Based Instructional Model for Health Assessment Education in Nursing

Xiuying Guo, Luyan Gu, Ruoling Mo, Yang Liu, Shiyu Liu — Wed, 22 Apr 2026 00:00:00 +0800

Health assessment represents a fundamental component of professional nursing practice and forms the starting point of the nursing process. As healthcare systems become increasingly complex and patient needs more diverse, nursing education has gradually shifted toward competency-based training models. International professional organizations, including the International Council of Nurses (ICN), the American Association of Colleges of Nursing (AACN), and the American Nurses Association (ANA), have proposed competency frameworks that define the knowledge, skills, and professional attributes required of registered nurse. However, translating these broad competency standards into specific curriculum structures and teaching strategies remains a challenge in nursing education. Drawing on the AACN Essentials framework and incorporating elements from the ICN competency framework and ANA practice standards, this study develops a competency-mapping-based instructional model for health assessment education. The model integrates the Knowledge–Skill–Attitude (KSA) structure and a progressive competency development pathway. Three levels of competency are described: foundational assessment and data collection, integrated analysis and preliminary clinical judgment, and advanced clinical reasoning in complex clinical situations. Previous studies have suggested that nursing competence develops progressively through education and clinical experience. The proposed model aligns learning activities with competency outcomes through a mapping matrix linking curriculum content, teaching strategies, and evaluation approaches. Simulation training, case-based learning, standardized patient encounters, and clinical observation are incorporated to facilitate competency development. By clarifying how competency standards can be translated into teaching practice, the model contributes to bridging the gap between competency frameworks and nursing curriculum implementation. The framework may provide a useful reference for curriculum development, clinical training design, and competency evaluation in nursing education. Future research should further examine the effectiveness of this instructional model through empirical studies and longitudinal assessment of student competency development.

The Impact of Therapeutic Communication Based on Humanistic Care on Nursing Satisfaction and Negative Emotions in Patients with Acute Renal Colic

Baoguo Fu, Yan Zheng, Yuan Zhou, Cheng Hu, Li Wang — Wed, 22 Apr 2026 00:00:00 +0800

Objective: To analyze the nursing effect of therapeutic communication guided by humanistic care on patients with acute renal colic. Methods: A total of 84 patients with acute renal colic admitted to the observation room from November 2022 to November 2024 were selected and evenly divided using a random number table. The experimental group received therapeutic communication guided by humanistic care, while the reference group received routine nursing care. Nursing indicators were compared between the two groups. Results: The experimental group exhibited higher nursing satisfaction than the reference group, lower scores for negative emotions after nursing, higher scores for knowledge mastery, lower scores for disease uncertainty, and superior scores for coping strategies (p < 0.05). Conclusion: Implementing therapeutic communication guided by humanistic care for emergency patients can enhance their nursing satisfaction, improve negative emotions, increase their knowledge mastery, reduce disease uncertainty, and correct inappropriate disease coping strategies.