Journal of Clinical and Nursing Research

Efficacy and Safety of Drug-Coated Balloon in Revascularization of Patients with Acute Myocardial Infarction: A Single-Center Retrospective Cohort Study

Tue, 03 Mar 2026 17:03:53 +0800

Background: Drug-coated balloons (DCBs) are receiving increasing attention in interventional therapy for coronary artery disease. However, evidence regarding their application in acute myocardial infarction (AMI), particularly in high-risk AMI patients, is limited, leading to significant clinical concerns. This study aims to compare the efficacy and safety of DCBs versus standard drug-eluting stents (DESs) in AMI patients and explore their efficacy differences in patients with ST-segment elevation myocardial infarction (STEMI), non-ST-segment elevation myocardial infarction (NSTEMI), and different risk stratifications. Methods: A single-center, retrospective cohort study was conducted, involving 86 patients who underwent percutaneous coronary intervention (PCI) for AMI between January 2023 and July 2025. Patients were divided into a DCB group (n = 26) and a DES group (n = 60) based on the treatment modality. According to the Killip classification of myocardial infarction at admission, patients were categorized into a low-risk group (Killip Class I, n = 68) and a high-risk group (Killip Classes II–IV, n = 18). The primary efficacy endpoint was targeting lesion restenosis as shown by coronary angiography follow-up (6–12 months). Safety endpoints included acute in-stent thrombosis during hospitalization (ARC criteria) and long-term coronary slow flow. A multivariate logistic regression model was used to evaluate the associations between intervention modality, risk stratification, infarction type, and endpoint events, and to test for interactions. Results: The DCB and DES groups were generally balanced in terms of baseline traditional risk factors. During hospitalization, three cases (5.0%) of acute in-stent thrombosis occurred in the DES group, all requiring urgent re-intervention, while no such events occurred in the DCB group (0%). Acute in-stent thrombosis formation was significantly associated with high-risk stratification (χ² test, p = 0.047). The overall restenosis rate was 22.1% (19/86). Multivariate analysis showed no statistically significant difference in restenosis risk between the intervention modalities (DCB vs. DES) (adjusted odds ratio [OR] = 1.07, 95% confidence interval [CI] 0.27–4.21, p = 0.920), and no statistical differences were found in subgroups based on risk stratification (p = 0.382) or infarction type (p = 0.484). There was a trend toward increased restenosis risk in high-risk patients (OR = 12.34), but the difference was not statistically significant (95% CI 0.28–542.75, p = 0.193). The incidence of long-term coronary slow flow was significantly higher in the DES group than in the DCB group (16.7% vs. 3.8%, Fisher’s exact test, p = 0.048), with a statistically significant difference. Conclusion: For AMI patients, DCBs demonstrate similar efficacy to DESs in preventing restenosis. However, DESs are associated with a higher risk of acute thrombosis during hospitalization, especially in high-risk patients, and a higher risk of long-term slow coronary flow. DCBs exhibit superior perioperative and long-term safety compared to DESs. Given the limited sample size, particularly the small number of high-risk patients and those treated with DCBs, the conclusions require validation through larger-scale prospective studies.

Research Progress of Insulin-like Growth Factor-1 in the Diagnosis and Efficacy Prediction of Sarcopenia in the Elderly

Yang Liao, Shujin Guo — Tue, 10 Mar 2026 13:12:17 +0800

Sarcopenia in the elderly is a syndrome characterized by age-related progressive loss of muscle mass, decline in muscle strength, and deterioration of muscle function. Its high incidence significantly increases the risk of falls, fractures, disability, and mortality among the elderly, posing a global public health challenge for geriatric health. Insulin-like growth factor-1 (IGF-1), a key cytokine regulating muscle growth, repair, and metabolism, exhibits a progressive decline in serum levels with aging and is closely associated with the onset and progression of sarcopenia in the elderly. This study reviews the research progress of IGF-1 in the diagnosis and efficacy prediction of sarcopenia in the elderly, providing theoretical references for precise diagnosis, treatment, and prognosis assessment of sarcopenia in the elderly.

The Application Progress of Traditional Chinese Medicine Nursing Appropriate Techniques in Patients with Insomnia

Xuling Li — Tue, 10 Mar 2026 13:22:32 +0800

This paper elaborates on the concept of Traditional Chinese Medicine (TCM) nursing appropriate techniques, selects techniques including moxibustion, auricular seed pressing, acupoint application, massage and Tuina, Chinese herbal foot bath, five-tone therapy, and aromatherapy, and summarizes the application mechanisms, methods, and clinical effects of these techniques in patients with insomnia. It also analyzes the existing problems in their application and discusses future development and practice directions, aiming to provide references for establishing more standardized and scientific nursing plans for patients with insomnia.

Research Progress on Patient Journey Mapping in the Field of Nursing

Fei Chen — Tue, 10 Mar 2026 13:30:11 +0800

In recent years, improving patients’ medical experience has become increasingly prominent in medical activities, and patient experience has become the core of medical service models. As an emerging visualization tool for exploring patient experience, patient journey mapping has been increasingly applied in the field of medical and health services, with unique advantages in exploring patient experience. This study reviews the overview, content and types, application and effects in the nursing field, and presentation methods of results of patient journey mapping, aiming to provide reference for improving patient experience.

The Application of Health Education Based on the Transtheoretical Model on Self-Management and Vascular Crisis in Patients Undergoing Finger Replantation Surgery

Hongxia Cheng, Wenjie Wang — Tue, 10 Mar 2026 13:39:02 +0800

Objective: To investigate the effects of health education based on the Transtheoretical Model (TTM) on self-management and vascular crisis in patients undergoing finger replantation surgery. Methods: A total of 106 patients who underwent finger replantation surgery between January 2025 and December 2025 were randomly divided into control and intervention groups using a random number table method (control group, n = 52; intervention group, n = 54). The control group received standard perioperative nursing care, while the intervention group received TTM-based health education in addition to standard care. Self-management levels and incidence of vascular crisis were compared between the two groups. Results: After intervention, the Adult Health Self-Management Skills Rating Scale (AHSMSRS) scores in both groups increased significantly compared with baseline (control: 91.26 ± 5.49 to 116.97 ± 8.15; intervention: 90.39 ± 6.72 to 136.38 ± 9.36, p < 0.001). The intervention group showed significantly higher AHSMSRS scores than the control group (136.38 ± 9.36 vs. 116.97 ± 8.15, p < 0.001). Similarly, general self-efficacy scores increased significantly in both groups, with the intervention group demonstrating superior improvement (36.73 ± 4.78 vs. 28.49 ± 4.11, p < 0.001). The incidence of vascular crisis was significantly lower in the intervention group (5.5%) compared with the control group (19.23%, χ² = 3.421, p < 0.05). Conclusion: Health education based on the Transtheoretical Model effectively enhances self-management abilities and self-efficacy in patients undergoing finger replantation surgery, and significantly reduces the incidence of postoperative vascular crisis.

Networked Cognitive Training on Negative Emotions for People with Mild Cognitive Impairment: A Systematic Review and Meta-analysis

Liaozhi Zhang, Shiqi Yang — Tue, 10 Mar 2026 00:00:00 +0800

Purpose: Individuals with mild cognitive impairment (MCI) frequently experience negative emotions, which are closely correlated with an accelerated rate of cognitive decline and the subsequent transition to a state of dementia. Despite networked cognitive training has been demonstrated to enhance cognitive function in MCI, its effectiveness for negative emotions is still unknown. This review aimed to exam the influences of networked cognitive training on negative emotions and quality of life in people with MCI. Methods: Searches for eligible studies were conducted using PubMed, Web of Science, EMBASE, Cochrane Library, Psyc INFO, CNKI, Wanfang database, VIP database, and Sinomed. The retrieval time limit was set from their inception to 17 December 2025. The articles were reviewed and extracted by two researchers, and their quality was evaluated using the Cochrane risk-of-bias assessment tool. Subsequently, a meta-analysis was carried out utilizing RevMan 5.4 software. Results: The review comprised 13 randomized controlled trials with 626 individuals. The meta-analysis demonstrated that networked cognitive training significantly improved depression (SMD = -0.36; 95% CI [-0.73, -0.00]; p = .050), anxiety (SMD = -0.32; 95% CI [-0.57, -0.06]; p < .050), and quality of life (MD = 2.54; 95% CI [0.98, 4.10]; p < .001). In terms of the comparison of apathy, the effect of intervention was unclear. Conclusions: From these meta-analysis results, networked cognitive training may help patients for MCI with their anxiety, depression, and overall quality of life. However, because there are so few randomized controlled trials available, the evidence regarding apathy is still ambiguous. More thorough randomized controlled trials with larger samples are necessary to verify the significance of networked cognitive training on apathy and to consolidate the findings. Registered number on PROSPERO: CRD42024593710.

A Case Report and Analysis: Hereditary Hemochromatosis Caused by a Splice Site Mutation in the HFE Gene

Qian Yan, Yaling Wang, Zhaoqiang Xiang, Xiaomin Chen, Chunlan Huang — Tue, 10 Mar 2026 14:05:54 +0800

Hereditary hemochromatosis (HH) is defined as an autosomal recessive iron metabolism disorder, typically characterized by excessive iron absorption leading to iron overload in multiple organs, particularly the liver, heart, and endocrine glands. Clinical manifestations commonly include diabetes, skin pigmentation, cirrhosis, abdominal pain, arthralgia, and fatigue. Mutations in the HFEgene, located on chromosome 6p22, have been identified as the primary genetic basis of HH. This gene encodes a protein critical for iron absorption and metabolism. Studies indicate that HH is most prevalent in European populations but rare in Asians. Due to reduced iron accumulation from menstrual blood loss in females, the disease predominantly affects adult males, with females often developing symptoms post-menopause. This article reports a rare case of HHin a premenopausal Chinese female caused by a homozygous HFE gene mutation (c.340 + 4T > C). The patient presented with chronic fatigue, abdominal pain, and lower limb petechiae. Diagnosis was confirmed via clinical evaluation, laboratory tests, and genetic analysis. This study identifies a novel pathogenic mutation in the Chinese population, contributing to early diagnosis and treatment of HH.

Survey Analysis of Traditional Chinese Medicine Constitution Among Night Shift Nurses in a Public Grade A Tertiary Hospital

Ting Li, Jia Jiang, Wendan Sun — Tue, 10 Mar 2026 00:00:00 +0800

Objective: To investigate the distribution of Traditional Chinese Medicine (TCM) constitution among night-shift nurses at a public tertiary-level Class A hospital, thereby identifying new approaches for developing effective interventions to enhance their health status. Methods: A total of 601 nurses employed at a public tertiary-level Class A hospital from August 2024 to August 2025 participated in the survey. Analysis was conducted using the Traditional Chinese Medicine Constitution Questionnaire. Results: The most prevalent TCM constitution types among night-shift nurses were Yang Deficiency Constitution (50.4%), Yin Deficiency Constitution (49.8%), Qi Deficiency Constitution (45.4%), and Phlegm-Dampness Constitution (45.1%). Conclusion: A high proportion of clinical night-shift nursing staff exhibit imbalanced constitution types, severely impacting their physical and mental health. Nursing administrators should implement targeted TCM constitution-based health maintenance and regulation to improve the health status of nursing personnel.

Mitophagy Pathways and Therapeutic Applications in Renal Fibrosis

Xinyue Yang, Longhao Jia, Jing Gao, Li Wang, Jian Liu, Ruizhi Tan — Tue, 10 Mar 2026 00:00:00 +0800

Chronic kidney disease (CKD), a global health burden, progresses through renal fibrosis driven by mitochondrial dysfunction in metabolically active renal cells. As the kidney harbors exceptionally high mitochondrial density, defective mitophagy, a quality control mechanism for clearing damaged mitochondria have emerged as a central pathological trigger. Environmental toxins, such as perfluorinated compounds, disrupt lysosomal-mitochondrial crosstalk, exacerbating fibrotic pathways via metabolic reprogramming and sustained activation of pro-fibrotic signaling axes like FGF9/PI3K/Akt. Impaired PINK1/Parkin-mediated mitophagy permits accumulation of fragmented mitochondria, fueling oxidative stress and TGF-β/Smad3-driven epithelial-mesenchymal transition (EMT) and fibroblast activation. Recent therapeutic advances focus on restoring mitophagic flux to counteract fibrosis. Small-molecule activators (UMI-77) enhance mitochondrial clearance, attenuating NF-κB-mediated inflammation and collagen deposition. Nanotechnology-augmented mesenchymal stem cells offer targeted delivery of mitophagy modulators to damaged tubules, synergizing mitochondrial repair with anti-inflammatory effects. While preclinical studies highlight promising agents like SS-31 and MitoQ, challenges persist in achieving tissue-specific mitochondrial targeting and ensuring long-term genomic safety. This review synthesizes molecular insights into mitophagy dysregulation in fibrosis, explores innovative intervention strategies, and underscores the need for multi-omics approaches to optimize mitochondrial therapeutics. Bridging translational gaps through advanced delivery systems and patient-specific mitochondrial profiling may unlock precision therapies for halting CKD progression.

Clinical Study on Auricular Thumbtack Needle Therapy in the Treatment of Diabetic Neurogenic Bladder in Elderly Patients with Type 2 Diabetes Mellitus

Chunyan Xu, Qinmei Lai, Wei Yan — Tue, 10 Mar 2026 00:00:00 +0800

Objective: To investigate the clinical efficacy and safety of auricular acupressure therapy in elderly patients with type 2 diabetic neurogenic bladder, and to provide a feasible external treatment intervention plan based on traditional Chinese medicine (TCM) for such patients. Methods: A randomized controlled study was conducted, selecting elderly patients with type 2 diabetic neurogenic bladder who met the inclusion criteria and randomly dividing them into a control group and an observation group. The control group received conventional comprehensive diabetes management and bladder function training, while the observation group additionally received auricular acupressure therapy, involving continuous stimulation of relevant auricular points such as Shenmen, Subcortex, Sympathetic, Kidney, Bladder, and Urethra, for a treatment duration of two courses. Changes in maximum urinary flow rate, bladder residual urine volume, TCM syndrome scores, and quality of life index (QOL) were compared between the two groups before and after treatment, and adverse reactions during treatment were recorded and analyzed. Results: After treatment, the observation group demonstrated superior improvement in clinical symptoms such as dysuria and urinary retention compared to the control group, with a significant increase in maximum urinary flow rate, a notable decrease in bladder residual urine volume and TCM syndrome scores, and a concurrent improvement in quality-of-life scores. The differences between the groups were statistically significant (p < 0.05). No serious adverse events occurred during treatment, and minor local discomfort resolved spontaneously after management, indicating overall good safety. Conclusion: As a simple and persistent TCM external treatment method, auricular acupressure therapy can further improve urinary function and quality of life in elderly patients with type 2 diabetic neurogenic bladder when combined with conventional treatment, with high safety and certain clinical promotion value.

Correlation between Optical Coherence Tomography Images and Histological Features in Female Reproductive Tract Lesions

Xianlin Yuan, Yunmiao Chen, Rutong Lin — Tue, 10 Mar 2026 00:00:00 +0800

Female reproductive tract lesions are diverse, ranging from benign inflammation to malignant tumors, all of which seriously threaten women’s health. Early accurate diagnosis is crucial for improving prognosis. As the “gold standard” for diagnosis, histopathological examination is difficult to meet the needs of clinical screening and dynamic monitoring due to limitations such as invasiveness and sampling restrictions. Optical Coherence Tomography (OCT), as a non-invasive, real-time, and high-resolution imaging technology, can clearly display the microstructure of biological tissues, known as “optical biopsy”, and shows promising application prospects in the diagnosis of female reproductive tract lesions. This article systematically reviews the basic principles of OCT technology, the research progress on the correlation between OCT image features and histological features in lesions of different parts of the female reproductive tract such as the cervix and endometrium, analyzes the diagnostic efficacy, advantages and limitations of OCT technology, and prospects its future development direction, aiming to provide a reference for the clinical application of OCT technology in the diagnosis of female reproductive tract diseases.

Kinesiophobia in Primary Caregivers of Patients with Chronic Heart Failure: A Scoping Review

Jiaqi Chen, Wenjuan Lai, Yumei He, Mingjie Cai, Pinmei Zou, Hui Xu — Tue, 10 Mar 2026 15:18:11 +0800

Objective: To conduct a scoping review of kinesiophobia among primary caregivers of patients with chronic heart failure (CHF). Methods: Following a scoping review methodological framework, PubMed, Web of Science, Embase, Cochrane Library, CINAHL, CNKI, SinoMed, Wanfang, and VIP were searched from inception to 30 June 2025. Relevant studies on kinesiophobia in primary caregivers of CHF patients were identified, summarized, and analyzed. Results: A total of 24 studies were included. Caregivers generally showed insufficient exercise-related knowledge, particularly regarding appropriate exercise intensity and risk recognition. At the cognitive–affective level, caregivers exhibited a pronounced “substitutive” kinesiophobia, characterized by excessive worry about potential adverse events induced by patients’ physical activity. At the behavioral level, this was reflected in restricting patients’ activities and avoiding assisting with exercise, which in turn reduced patients’ adherence to cardiac rehabilitation. Conclusion: Kinesiophobia among primary caregivers of CHF patients arises mainly from cognitive deficits and protective psychological mechanisms. Individualized education and professional guidance are needed to enhance caregivers’ exercise management competence and thereby optimize patients’ rehabilitation outcomes.

Analysis of the Effectiveness and Teaching Satisfaction of Diversified Teaching Methods in Clinical Instruction for Operating Room Nursing Interns

Jie Gao, Yuanrong Luo — Tue, 10 Mar 2026 15:27:40 +0800

Objective: To analyze the advantages of diversified teaching methods in the clinical instruction of operating room nursing interns. Methods: Twenty-one nursing interns who underwent internships in the operating room from March 2023 to March 2024 were selected as the control group and received conventional teaching methods. Another twenty-one nursing interns who underwent internships in the operating room from April 2024 to April 2025 were selected as the experimental group and received diversified teaching methods. The teaching effects of the two groups were compared. Results: The experimental group scored higher than the control group in assessments, teaching satisfaction, and teaching quality evaluations, as well as in post-instruction professional identity scores (p < 0.05). Conclusion: Diversified teaching methods can enhance the professional competence of operating room nursing interns, cultivate their professional identity, and yield high teaching satisfaction, thereby improving teaching quality.

From Traditional Use to Modern Pharmacology: Research Progress on the Multi-target Mechanisms of Potentilla discolor Bunge

Tue, 10 Mar 2026 00:00:00 +0800

Potentilla discolor Bunge, a traditional Chinese medicinal herb, has been extensively utilized for treating diverse ailments including diabetes, bacterial infections, viral diseases, and inflammatory disorders. Modern phytochemical investigations have identified over 200 bioactive compounds, predominantly flavonoids, tannins, triterpenoids, and phenolic acids. Pharmacological studies demonstrate that P. discolor exerts multi-target therapeutic effects through antioxidant, anti-inflammatory, antimicrobial, antiviral, antidiabetic, and anticancer activities. Its mechanisms involve modulation of key signaling pathways including PI3K/Akt, MAPK, NF-κB, and Nrf2/HO-1, alongside regulation of glucose-lipid metabolism and gut microbiota. This review systematically summarizes the phytochemistry, traditional applications, and contemporary pharmacological advances of P. discolor, emphasizing its multi-target characteristics and molecular mechanisms. Furthermore, current research limitations and future perspectives are discussed to provide scientific evidence for its clinical development and therapeutic applications.

Advances in Research on Procedural Pain Management in Neonates

Na Wang, Wenjie Wang — Tue, 10 Mar 2026 15:51:14 +0800

Neonatal procedural pain is one of the most frequent clinical challenges in the NICU. It not only causes acute physiological stress but also possibly has long-term neurodevelopmental adverse effects. In recent years, with a change in pain concept and advancement in evidence-based medicine, strategies for managing neonatal procedural pain have been becoming increasingly systematic and individualized. By reviewing domestic and international research progress, this article summarizes the current status of procedural pain occurrence, pain assessment tool application and timing, and non-pharmacological and pharmacological interventions in clinical practice, including healthcare professional education and training; it aims to provide a reference for clinical practice and further improve the quality of neonatal pain management.

Research on the Impact of High-Quality Nursing on the Nursing Effect of Patients with Hepatic Encephalopathy

Xiaofang Peng, Kaiyu Yang, Dan Zhang — Tue, 10 Mar 2026 16:04:32 +0800

Objective: To explore the impact of high-quality nursing on the nursing effect of patients with hepatic encephalopathy, and provide a basis for optimizing clinical nursing plans. Methods: A total of 80 patients with hepatic encephalopathy admitted to a hospital from April 2023 to April 2024 were selected and randomly divided into a conventional group (37 cases, receiving conventional nursing) and an observation group (43 cases, receiving high-quality nursing) using a blind selection method. The incidence of complications, nursing satisfaction, changes in quality of life (SF-36 scale) and liver function indicators (ALT, AST, TBIL, ALB) before and after nursing were compared between the two groups. Results: The incidence of complications in the observation group (6.98%) was significantly lower than that in the conventional group (24.32%), and the nursing satisfaction (97.67%) was significantly higher than that in the conventional group (81.08), with statistically significant differences (p < 0.05); after nursing, the scores of each dimension and total score of the SF-36 scale, and the improvement range of liver function indicators in the observation group were significantly better than those in the conventional group, with statistically significant differences (p < 0.05). Conclusion: High-quality nursing can effectively reduce the risk of complications in patients with hepatic encephalopathy, improve nursing satisfaction and quality of life, and enhance liver function, which has important clinical promotion value.

A Study on the Correlation between Peer Caring Behavior and Empathy among Undergraduate Nursing Students

Fang Xu, Juan Xiao, Xiaofang Hu, Jianfeng Xu, Shaoyan Yuan — Tue, 10 Mar 2026 00:00:00 +0800

Objective: To understand the current status of peer caring behavior and empathy among undergraduate nursing students and to explore the relationship between the two. Method: Using the convenience sampling method, a questionnaire survey was conducted among 292 nursing students from a medical college in Jiangxi Province, using the Peer Caring Behavior Scale and the Jefferson Scale of Empathy. Results: The score for peer caring behavior among undergraduate nursing students was 85.00 (78.00–92.00), and the score for empathy was 101.00 (92.00–110.00). A positive correlation was found between the two (r = 0.362, p < 0.05). Conclusion: The level of peer caring behavior among undergraduate nursing students is above average, while their empathy level is moderate, with a positive correlation between the two. This suggests that nursing educators should strengthen the development of peer caring behavior, which may help enhance the empathy of undergraduate nursing students.

Application of Improved Emergency Integrated Nursing in the Treatment Effect and Safety of Emergency Trauma Patients

Jiangning Zhao, Xiaoli Su, Wei Gong, Na Luo, Wei Huang — Tue, 10 Mar 2026 16:33:50 +0800

Objective: To analyze the impact of improved emergency integrated nursing on the treatment effectiveness and safety of emergency trauma patients. Methods: Study duration: December 2024 to December 2025. Observation target: emergency trauma patients in our hospital. Sample size: 92 cases. Using computer-based grouping, the 92 patients were divided into two equally sized groups: a control group of 46 patients who received conventional emergency nursing care, and an observation group of 46 patients who underwent an improved emergency integrated nursing model. The treatment-related indicators, treatment effectiveness, and incidence of adverse events were evaluated in both groups. Results: After intervention, the pre-hospital emergency care time, emergency diagnosis time, total emergency rescue duration, and examination waiting time in the control group were all longer than those in the observation group (p < 0.05); the treatment effectiveness in the control group (effective rate: 82.61%) was worse than that in the observation group (effective rate: 95.65%), p < 0.05; compared with the control group, the observation group had a lower incidence of adverse events, p < 0.05. Conclusion: Implementing an improved emergency integrated nursing model for emergency trauma patients helps streamline the treatment process, enhance treatment effectiveness, and reduce the incidence of adverse events.

Application of Moxibustion Combined with Sihuang Anti-inflammatory Lotion in a BMT Patient with Herpes Zoster

Suling Chen, Zhongren Chen, Jiaqian Cai — Tue, 10 Mar 2026 16:45:20 +0800

Objective: To explore the application effect of moxibustion combined with Sihuang Anti-inflammatory Lotion in patients with herpes zoster after bone marrow transplantation (BMT). Methods: One patient with herpes zoster after BMT was selected and treated with moxibustion combined with Sihuang Anti-inflammatory Lotion in addition to conventional antiviral drugs. Results: The patient’s pain disappeared within 48 hours after the intervention (NRS score decreased from 6 to 2), large-scale crusting of herpes occurred within 72 hours, and complete shedding occurred within 10 days. No infection or other adverse reactions occurred, and the patient had high nursing satisfaction. Conclusion: Moxibustion combined with Sihuang Anti-inflammatory Lotion can safely and effectively improve the symptoms of herpes zoster after BMT, which is worthy of clinical promotion.

Research on Automatic Identification of Colorectal Cancer Cells Based on Machine Learning Strategies and Analysis of their Morphological Heterogeneity and Prognostic Value

Yanna Ding — Tue, 10 Mar 2026 00:00:00 +0800

In the fast-paced living environment, changes in dietary patterns have led to a continuous increase in the incidence and mortality rates of colorectal cancer (CRC), making it a prevalent malignant tumor of the digestive system worldwide. Currently, CRC clinical diagnosis and treatment face challenges such as high costs and persistently high recurrence rates. Traditional quantification of tumor-infiltrating lymphocytes (TILs) relies on manual analysis and judgment, resulting in low diagnostic efficiency and susceptibility to subjective factors, leading to missed or misdiagnosed cases. To enhance the efficiency and quality of CRC clinical diagnosis and treatment, this study explores domestic and international research on the automatic identification of CRC cells using machine learning strategies. It analyzes the morphological heterogeneity and prognostic value in the application of this strategy, aiming to deepen the understanding of intelligent tool applications in precise diagnosis, treatment, and prognostic evaluation of colorectal cancer, comprehend the current research status and development trends, and provide references for addressing and addressing the gaps in related research.

Application of Pulmonary Rehabilitation Nursing Intervention in Patients with Stable Chronic Obstructive Pulmonary Disease and Evaluation of Nursing Satisfaction

Xiaoyan Wang — Tue, 10 Mar 2026 17:06:39 +0800

Objective: To explore the application effect of pulmonary rehabilitation nursing intervention in patients with stable chronic obstructive pulmonary disease (COPD) and evaluate its impact on nursing satisfaction. Methods: A total of 120 patients with stable COPD admitted to our hospital from February 2023 to February 2025 were selected and divided into a control group and an observation group according to the order of admission, with 60 cases in each group. The control group received routine nursing care, while the observation group received systematic pulmonary rehabilitation nursing intervention on this basis. Pulmonary function indicators, 6-minute walk test (6MWT) distance, COPD Assessment Test (CAT) scores, incidence of acute exacerbations, and nursing satisfaction were compared between the two groups after nursing. Results: After nursing, the FEV1, FVC, and FEV1/FVC in the observation group were significantly higher than those in the control group, the 6MWT distance significantly increased, and the CAT scores significantly decreased, with statistically significant differences (p < 0.05). The incidence of acute exacerbations in the observation group was lower than that in the control group, and the nursing satisfaction score was higher (p < 0.05). Conclusion: Pulmonary rehabilitation nursing intervention can effectively improve pulmonary function, exercise tolerance, and symptom control in patients with stable COPD, and significantly enhance nursing satisfaction, making it worthy of further clinical promotion.

A Study on the Intervention Effect of Whole-Process Blood Glucose Management for Patients with Diabetes Complicated with Cataract During the Postoperative Period

Ying Chen, Siyu Zhou, Zhonglian Zhou, Yangyang Wang, Fen Liu, Shuhu Feng — Tue, 10 Mar 2026 00:00:00 +0800

Objective: To explore the intervention effect of comprehensive perioperative blood glucose management on patients with diabetes complicated with cataract surgery. Method: A total of 68 patients in our hospital from July 2024 to July 2025 were selected and randomly divided into the experimental group and the control group, with 34 cases in each group. The control group received routine blood glucose management, while the experimental group, on this basis, implemented individualized intervention 3 days before the operation, real-time regulation during the operation, dynamic management 7 days after the operation, and self-management training. Result: The blood glucose control in the experimental group was more stable 7 days after the operation. The total incidence of complications (2.9%) was significantly lower than that in the control group (38.2%), and the average hospital stay (5.1 ± 1.0 days) was shorter than that in the control group (7.3 ± 1.4 days). One week after the operation, the proportions of uncorrected visual acuity and visual acuity ≥ 0.6 (67.6%) were both better than those of the control group (p < 0.001). Conclusion: The whole-course management of perioperative blood glucose can enhance the stability of blood glucose control, reduce the risk of complications, shorten the length of hospital stay, promote visual recovery, and has high clinical promotion value.

Metaviromics Study on Populations in Areas Affected by Unexplained Sudden Death in Yunnan Province

Wed, 11 Mar 2026 08:54:54 +0800

Objective: To investigate the correlation between the occurrences of unexplained sudden death in Yunnan Province and the pathogen spectrum by using real-time fluorescent quantitative reverse transcription PCR, metagenomic next-generation sequencing (mNGS), and virus isolation techniques to test autopsy samples from cases of unexplained sudden death and fecal specimens from populations in affected areas. Methods: Real-time fluorescent quantitative reverse transcription PCR and Sanger sequencing were performed on 101 fecal samples collected from populations in affected areas. Virus isolation was conducted on fecal and gastric content samples from individuals who died suddenly. Additionally, metavirome sequencing and pathogen spectrum abundance detection were performed on 50 autopsy organ samples. Results: No specific fragments of enteroviruses were detected in 101 fecal samples from the population in the affected wards, and no viruses were isolated from fecal and gastric content samples of sudden death victims. Among the 50 autopsy organ samples, 29 were successfully sequenced. High-throughput sequencing revealed low-abundance enterovirus reads in 11 samples (relative abundance ≤ 0.91% in all cases); Enterovirus A114 was detected in 6 samples (with relative abundances of 0.211%, 0.571%, 0.910%, 0.013%, 0.002%, and 0.0000263%, respectively); Coxsackievirus A2 in 9 samples (with relative abundances of 0.111%, 0.192%, 0.051%, 0.291%, 0.007%, 0.00019%, 0.00342%, 0.000551%, and 0.0000368%, respectively); and Coxsackievirus B3 in 9 samples (with relative abundances of 0.312%, 0.486%, 0.120%, 0.765%, 0.001%, 0.001%, 0.001%, 0.0000999%, and 0.00000848%, respectively). Coexistence of 2-3 types of enteroviruses was observed in some samples. Genomic annotation results indicated that high-abundance bacteria were primarily Paeniclostridium sordellii and Escherichia coli, while viral species could not be successfully assembled due to their low abundance. Conclusion: Enterovirus infection may be one of the causes of some unexplained sudden deaths in Yunnan, and the possibility of varying degrees of enterovirus infection cannot be ruled out in some populations in the affected areas. The detection of bacteria may be attributed to the normal intestinal flora of the human body or contamination during the autopsy sampling process.

Observation on the Efficacy of Non-Invasive Positive Pressure Ventilation in Respiratory Support Treatment for Severe Pneumonia

Baoshan Liu — Wed, 11 Mar 2026 09:06:44 +0800

Objective: To evaluate the efficacy of noninvasive positive pressure ventilation (NIPPV) in respiratory support for severe pneumonia. Methods: Data were analyzed from 74 patients with severe pneumonia undergoing respiratory support at our hospital between May 2024 and April 2025. Patients were randomly assigned using a random number table to two groups (n = 37 each): the experimental group received NIPPV, while the control group underwent conventional invasive mechanical ventilation. Intergroup differences were compared. Results: Compared with the control group, the experimental group demonstrated significantly higher PaO₂ and oxygenation index, significantly lower PaCO₂, significantly reduced levels of WBC, CRP, and PCT, significantly higher overall efficacy rate, and significantly lower incidence of adverse reactions after treatment (p < 0.05). Pre-treatment PaO₂, oxygenation index, PaCO₂, WBC, CRP, and PCT levels showed no significant differences between groups (p > 0.05). Conclusion: Non-invasive positive pressure ventilation demonstrates favorable outcomes in respiratory support for severe pneumonia.

Physical Fitness Development of Preschool Children in Chongqing: An Analysis of Tests in Different Region, Age and Gender

Xulin Yang, Xin Zhong — Wed, 11 Mar 2026 00:00:00 +0800

This study evaluated the physical development levels of preschool children across different districts of Chongqing, considering variations in age and gender, with the aim of proposing a differentiated physical education curriculum implementation plan tailored to the differences in age, gender, and physical fitness levels among this population. A total of 1209 preschool children (46.89% girls) aged 3–6 years were tested on eight items: height, weight, standing long jump, 10 m toss, seated forward bend, tennis ball toss, continuous jump on both feet and walking the balance beam. One-way variance, multiple comparisons and t-tests were used to calculate and express differences in their results. Overall, preschoolers (City) performed better than preschoolers (Country) in height and standing long jump, and preschoolers (Country) performed better than preschoolers (City) in continuous jumping on both feet. With the exception of the seated forward bend test, there were significant differences in the fitness levels of preschoolers by grade, with preschoolers of different genders (Boys) performing better than preschoolers (Girls) in height, weight, standing long jump and tennis throw. Preschoolers (Girls) performed better than preschoolers (Boys) in the 10 m toss and bend in a sitting position, and the gender differences were more pronounced with increasing age.

Efficacy and Safety Evaluation of Dexmedetomidine in Sedation of Neurosurgical Intensive Care Patients: A Retrospective Cohort Study

Binbin Zhu, Weilong Zhong — Wed, 11 Mar 2026 09:32:03 +0800

Objective: To investigate the effect of dexmedetomidine (DEX) on the incidence of delirium and clinical prognosis in patients with neurosurgical ICU. Methods: This study was a retrospective cohort study that enrolled patients admitted to the Neurosurgery ICU of our hospital between January 2021 and December 2023 who required mechanical ventilation (duration > 48 hours). Based on sedation protocols, patients were divided into a dexmedetomidine group (DEX group, n = 60) and a midazolam routine sedation group (control group, n = 60). The primary endpoint was the incidence of delirium during ICU stay, while secondary endpoints included mechanical ventilation duration, ICU length of stay, 28-day mortality rate, and adverse events. Results: The incidence of delirium in the DEX group was significantly lower than that in the control group (31.7% vs. 58.3%, p = 0.004). Additionally, the duration of mechanical ventilation in the DEX group was significantly shorter than that in the control group [(7.2 ± 2.5) days vs. (9.8 ± 3.4) days, p < 0.001], and the ICU stay was also significantly reduced [(13.5 ± 4.2) days vs. (16.8 ± 5.7) days, p = 0.002]. There were no statistically significant differences in the 28-day mortality rate (DEX group: 13.3% vs. control group: 16.7%, p = 0.59) or the rate of unintended extubation (DEX group: 3.3% vs. control group: 5.0%, p = 0.64) between the two groups. In terms of safety, the incidence of bradycardia was significantly higher in the DEX group than in the control group (15.0% vs. 3.3%, p = 0.03). Conclusion: In neurosurgical patients on mechanical ventilation, dexmedetomidine sedation can effectively reduce the incidence of delirium and shorten the duration of mechanical ventilation and ICU stay, but the potential risk of bradycardia should be monitored.

Application of Allergen Subcutaneous Immunotherapy in Patients with Allergic Rhinitis

Xiaorong Yang, Bingyue Bai, Zhiquan Peng, Na Zhou, Tingting Jiang — Wed, 11 Mar 2026 00:00:00 +0800

Objective: To analyze the efficacy of allergen subcutaneous injection immunotherapy in patients with allergic rhinitis. Methods: Fifty patients with allergic rhinitis admitted from May 2023 to May 2025 were selected as study subjects and randomly divided into a control group and an observation group, with 25 patients in each group. The control group was treated with budesonide nasal spray, while the observation group received allergen subcutaneous injection immunotherapy in addition to the control treatment. The treatment efficacy, adverse reactions, symptom improvement time, and immune indicators were compared between the two groups. Results: The observation group showed a higher disease treatment efficacy than the control group (p < 0.05); the incidence of adverse reactions in the observation group was not statistically significant compared to the control group (p > 0.05); the observation group had a shorter symptom improvement time for nasal obstruction, rhinorrhea, and sneezing than the control group (p < 0.05); before treatment, there was no statistical significance in immune indicators between the two groups (p > 0.05); after treatment, CD3⁺ and CD4/CD8⁺ in the observation group were higher than those in the control group (p < 0.05). Conclusion: Allergen subcutaneous injection immunotherapy in patients with allergic rhinitis can improve disease treatment efficacy, alleviate clinical symptoms, and enhance immune function. This therapy is safe and has clinical application value.

Exploratory Practice of Online Group Psychological Counseling with Narrative Painting Therapy

Pai He, Liang Yue, Wenxin Guo, Siyao Xu, Xinling Wu — Wed, 11 Mar 2026 10:03:38 +0800

To explore effective paths for improving college students’ mental health, this study integrates narrative therapy and painting therapy to design a 7-week online group psychological counseling program. A total of 121 volunteer college students participated as subjects, and themed painting counseling was conducted via Tencent Meeting. Five scales, including the General Self-Efficacy Scale, Self-Esteem Scale, and Self-Rating Depression Scale, were used for pre-test and post-test comparisons. The results show that after the intervention, students’ self-efficacy (t = -5.528, p = 0.000) and self-esteem level (t = -2.153, p = 0.033) significantly improved statistically, and depression and anxiety showed a positive improvement trend. The research indicates that online narrative painting therapy can effectively release students’ psychological pressure, promote in-depth self-cognition and interpersonal connection construction, providing an operable innovative paradigm for college mental health education. Its interactivity and effectiveness are compatible with the psychological needs and internet usage habits of contemporary college students.

Clinical Characteristics Analysis of Hypertension Complicated with Diabetes Mellitus

Yang Li, Yuanmei Liao — Wed, 11 Mar 2026 10:28:30 +0800

Objective: For patients with hypertension complicated with diabetes mellitus, their health risks are not a simple sum but present complex interactive effects. Clarifying the clinical characteristics of such patients is the key to solving this medical problem. Methods: From June 2023 to June 2024, this study conducted a comparative study on 100 patients with hypertension complicated with diabetes mellitus and 100 patients with hypertension alone. By retrospectively analyzing clinical data of patients, the differences in disease manifestations, complication occurrence, and treatment effects between the two groups were explored in depth, and the unique challenges and treatment difficulties faced by patients with hypertension complicated with diabetes mellitus were identified. Results: Hypertensive patients with concurrent diabetes had more difficult blood glucose and blood pressure control, and were more prone to severe complications such as cardiovascular lesions and renal damage. Conclusion: The clinical characteristics and treatment needs of patients with hypertension complicated with diabetes mellitus are different from those with hypertension alone, and disease management should be more refined and personalized.

Correlation Analysis of Anatomical and Pathological Characteristics of the Respiratory-Circulatory System

Min Li — Wed, 11 Mar 2026 00:00:00 +0800

The respiratory-circulatory system, including organs such as the nose, pharynx, larynx, trachea, bronchi, and heart, is an organic community responsible for ventilation and gas exchange. The integrity of its anatomical structure directly affects the evolution of pathological processes, and the analysis of their correlation is a core entry point for clinical disease diagnosis, treatment, and mechanism research. Based on this, this paper mainly explores the correlation between the anatomical and pathological characteristics of the respiratory-circulatory system, aiming to provide anatomical and pathological theoretical support for clinical accurate diagnosis, targeted therapy, and prognosis evaluation.

Application of Whole-Process Nursing in the Rescue of Emergency Critically Ill Patients

Xiaojing Wang — Wed, 11 Mar 2026 10:49:52 +0800

Objective: To analyze the impact of whole-process nursing on the rescue of emergency critically ill patients by setting a control group and an experimental group and comparing their experimental results. Methods: A total of 50 critically ill patients admitted to the Emergency Department from October 2022 to October 2023 were randomly divided into the experimental group (25 cases) and the control group (25 cases). The control group received routine nursing, while the experimental group received whole-process nursing. The rescue success rate and nursing satisfaction were compared between the two groups. Results: In the experimental group, 24 patients were rescued successfully, with a success rate of 96%; in the control group, 19 patients were rescued successfully, with a success rate of 76%, showing a significant difference (χ² = 4.1528, p = 0.0415 < 0.05). The nursing satisfaction was 92% in the experimental group and 68% in the control group. Conclusion: Whole-process nursing can effectively improve the rescue success rate of critically ill patients, enhance the satisfaction of patients and their families, and improve patients’ quality of life.

Liu Shaowu’s “Exterior Region” Theory and Clinical Cases of Treating Cold-Damp Type Allergic Rhinitis with Ephedra-Based “Diaphoresis Method”

Huixia Ji, Xiaoxu Liu, Gao Liu — Wed, 11 Mar 2026 11:08:15 +0800

Based on Liu Shaowu’s “Exterior Region” theory in the “Three Regions and Six Diseases” doctrine, combined with Zhang Zhongjing’s therapeutic principle of “diaphoresis method”, this paper explores the TCM pathogenesis and treatment methods of cold-damp type allergic rhinitis. It points out that the core pathogenesis of the disease is the invasion of wind-cold-damp pathogens into the exterior region, leading to stagnation of defensive Yang and obstruction of orifices and collaterals. Through three typical clinical cases (involving symptoms such as nasal itching, nasopharyngeal tube obstruction, nasal congestion with headache), modified ephedra-based formulas such as Mahuang Decoction, Maxing Shigan Decoction, and Xiaoqinglong Decoction are used, combined with drugs for inducing resuscitation, resolving dampness, and promoting blood circulation, to expel pathogens through diaphoresis. Clinical observations show that expelling pathogens with the “diaphoresis method” can effectively relieve symptoms with significant curative effect. This study provides new ideas and methods for expanding the application of the “diaphoresis method” in the treatment of sinusitis.

Current Status of Inheritance and Development of Community-Level Traditional Chinese Medicine Practices: A Cross-Sectional Survey in Linfen, China

Ruifen Zhang, Hongfei Deng, Yukai Cui — Wed, 11 Mar 2026 00:00:00 +0800

Objective: To investigate the current status of inheritance and development of folk traditional Chinese medicine in Linfen City, analyze practitioner characteristics, inheritance modes, and social acceptance, and to provide references for standardized management and rational development of folk traditional Chinese medicine. Methods: A questionnaire-based survey was conducted from January to December 2025 among folk traditional Chinese medicine practitioners, medical staff, and urban and rural residents in Linfen City. The survey content included basic characteristics of practitioners, inheritance modes, practice status, and levels of recognition of folk traditional Chinese medicine among different population groups. An Excel database was established, and descriptive statistical analysis was performed using SPSS version 26.0. Results: A total of 349 participants were surveyed, including 99 folk traditional Chinese medicine practitioners, 100 medical staff members, and 150 urban and rural residents. Most practitioners were middle-aged or elderly, had more than 10 years of practice experience, primarily inherited their skills through apprenticeship or family transmission, and had a relatively low proportion of systematic theoretical training in traditional Chinese medicine. Residents showed a high level of acceptance of folk traditional Chinese medicine, whereas medical staff demonstrated a relatively cautious attitude. Conclusion: Folk traditional Chinese medicine in Linfen City has a certain social foundation and practical value; however, further improvements are needed in standardized inheritance, management mechanisms, and sustainable development.

Research on the Anti-Alcohol Effect of Mulberry Juice

Weishuang Tong — Wed, 11 Mar 2026 00:00:00 +0800

Alcohol culture has a long history in China, often appearing in scenarios such as business banquets, social gatherings, and family parties. With the expansion of the drinking population, the health problems caused by alcohol consumption have attracted widespread social attention. Excessive drinking can lead to alcohol poisoning in mild cases, damage to the stomach and liver in severe cases, and even induce alcoholic hepatitis and pancreatitis. Against this background, finding raw materials containing anti-alcohol substances and developing products to replace traditional anti-alcohol drugs have become important directions in the development of food science and nutrition. Based on existing theoretical and empirical research results, this paper systematically explores the anti-alcohol value of mulberry juice from aspects such as its biological components, anti-alcohol mechanism, relevant experimental verification, and application prospects. It aims to promote the development of natural anti-alcohol products, provide references for accelerating human alcohol metabolism, alleviating post-drinking discomfort, and meeting people’s pursuit of a healthy life.

Research Progress on the Association Between Children’s Sleep and Oral Diseases

Na Yu — Wed, 11 Mar 2026 00:00:00 +0800

This paper systematically reviews epidemiological empirical studies on the association between children’s sleep problems (such as insufficient sleep, sleep-disordered breathing, and circadian rhythm disorders) and common oral diseases (dental caries, malocclusion, periodontal diseases, etc.). Starting from potential biological mechanisms, it deeply analyzes the correlation from dimensions including salivary secretion rhythm disturbance, oral microbiota imbalance, abnormal inflammatory response, and abnormal circadian rhythm gene regulation. The limitations of existing research and future development directions are discussed, providing references for clinical interventions and subsequent studies on children’s sleep and oral health.

Innovation and Practice Research on the Modern Apprenticeship Training Model for Nursing Talents Integrating General-Specialty Integration, Moral-Technical Fusion, and Specialty-Innovation Union

Yuan Yuan, Ling Shen, Lei Yin — Wed, 11 Mar 2026 00:00:00 +0800

Modern apprenticeship emphasizes strengthening school-enterprise cooperation, deepening the integration of production and education, and promoting the combination of work and study to achieve seamless connection between professional education and industrial needs, thereby improving the quality of talent training. This paper analyzes the current problems in the nursing talent training system, elaborates on the significance of cultivating nursing talents based on modern apprenticeship, and proposes new ideas for constructing a modern apprenticeship training model for nursing talents from the perspectives of “integrating general and specialized education, merging virtue and skills, and linking specialization and innovation”. The aim is to further promote the organic combination of nursing talent training goals and post needs, for reference only.

Research on Children’s Oral Health Management in the Era of “Digital Intelligence”

Na Yu — Wed, 11 Mar 2026 13:49:04 +0800

At present, the caries rate of deciduous teeth in Chinese children remains high, and there is a huge gap with the actual consultation rate, indicating that children’s oral health management has a long way to go. Against this background, doctors should comply with the development of the “digital intelligence” era and actively explore the innovative application of digital intelligence technology in children’s oral health management to solve the practical dilemmas of children’s oral health. Based on this, this paper will briefly analyze the importance of children’s oral health management in the era of “digital intelligence” and the current status of children’s oral health management, and discuss the improvement strategies of children’s oral health management in the era of “digital intelligence”.

The Effect of “72-Hour Proactive Follow-up” Led by Respiratory Specialist Nurses on Reducing 30-Day Readmission Rates for Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD) after Hospital Discharge

Yaran Li, Xinyi Ye, Jiao Chen, Wei Yuan — Wed, 11 Mar 2026 14:03:09 +0800

Objective: To investigate the effect of “72-hour proactive follow-up” led by respiratory specialist nurses on reducing the 30-day readmission rate in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) after hospital discharge. Methods: A randomized controlled trial was conducted involving 60 patients with acute exacerbation of COPD admitted from September 2024 to September 2025. The participants were divided into a control group and an observation group, with 30 individuals in each group. The control group received routine discharge guidance nursing measures, including instructions on medication use, key points for condition monitoring, and scheduling of follow-up appointments. The observation group implemented “72-hour proactive follow-up” nursing measures, which included telephone follow-up within 72 hours after discharge, quantitative assessment of respiratory symptoms, dynamic adjustment of medication regimens, and personalized health education. The 30-day readmission rate, mMRC dyspnea index, CAT quality of life score, and other parameters were compared between the two groups. Results: The 30-day readmission rate in the observation group was significantly lower than that in the control group (p < 0.05). The mMRC dyspnea index (1.8 ± 0.5) in the observation group was significantly lower than that in the control group (2.5 ± 0.7) (p < 0.05). The CAT quality of life score (18.2 ± 3.1) in the observation group was significantly higher than that in the control group (22.4 ± 4.2) (p < 0.05). The patient satisfaction score (92.5 ± 4.3) in the observation group was higher than that in the control group (85.6 ± 5.8) (p < 0.05). Conclusion: The “72-hour proactive follow-up” nursing intervention demonstrates a favorable effect in reducing readmission rates, exhibiting significant clinical practical value. It can optimize the allocation of medical resources, effectively enhance patients’ self-management efficacy, and holds prominent value for clinical promotion and application.

Analysis of the Impact of Evidence-Based Nursing on Postoperative Complications and Stress Responses in Patients with Ureteral Calculi Undergoing Holmium Laser Lithotripsy

Yanying Huang — Wed, 11 Mar 2026 14:16:37 +0800

Objective: To explore the application effect of evidence-based nursing in the postoperative care of patients with ureteral calculi undergoing holmium laser lithotripsy, analyze its impact on the incidence of postoperative complications, the degree of stress response, and nursing satisfaction, and provide evidence-based support for optimizing clinical nursing practices. Methods: A total of 100 patients with ureteral calculi who underwent holmium laser lithotripsy in our hospital from January 2023 to June 2025 were selected and divided into an observation group (50 cases) and a control group (50 cases) using a random number table method. The control group received routine nursing interventions, while the observation group adopted an evidence-based nursing model. The incidence of postoperative complications (hematuria, urinary tract infection, renal colic, ureteral stricture), stress response indicators (heart rate, systolic blood pressure, diastolic blood pressure, Self-Rating Anxiety Scale (SAS) score, Self-Rating Depression Scale (SDS) score) before surgery and 24 hours after surgery, and nursing satisfaction were compared between the two groups. Results: The total incidence of postoperative complications in the observation group was significantly lower than that in the control group (p < 0.05). At 24 hours after surgery, the heart rate, systolic blood pressure, diastolic blood pressure, SAS score, and SDS score in the observation group were significantly lower than those in the control group (all p < 0.01). Nursing satisfaction in the observation group was significantly higher than that in the control group (p < 0.01). Conclusion: Evidence-based nursing can effectively reduce the incidence of postoperative complications in patients with ureteral calculi undergoing holmium laser lithotripsy, alleviate patients’ stress responses, and improve nursing satisfaction, demonstrating significant clinical application value.

Evaluation of the Effectiveness of Multi-dimensional Protective Care Interventions in Reducing Occupational Exposure Risks to Hydrofluoric Acid in Dental Practice

Cunxi Li — Wed, 11 Mar 2026 14:42:45 +0800

Objective: To investigate the efficacy of multidimensional protective nursing interventions in reducing occupational exposure risks to hydrofluoric acid in dental departments. Methods: The study was conducted between January 2024 and January 2025, involving 60 healthcare workers who were randomly assigned to groups. The control group (n = 30) received conventional occupational protective nursing care, while the observation group underwent multidimensional protective nursing interventions. Results: Following intervention, the observation group demonstrated significantly higher scores than the control group in knowledge of hydrofluoric acid occupational exposure, occupational exposure risk perception, and protective skill operation (p < 0.05). Emergency response capability scores and protective behavior implementation scores were also higher in the observation group (p < 0.05). Compared to the control group, the observation group exhibited higher occupational health satisfaction rates and lower occupational exposure incidence rates (p < 0.05). Conclusion: Multidimensional protective nursing interventions effectively enhance dental healthcare personnel’s awareness and protective capabilities regarding hydrofluoric acid occupational exposure, improve compliance with protective measures, and significantly reduce occupational exposure risks. This approach warrants promotion and application in occupational protective nursing interventions within dental departments.

Research on the Construction and Application of an Integrated Teaching Platform Combining Virtual Simulation and High-End Simulators in Practical Obstetrics and Gynecology Teaching

Shuo Feng, Ao Li, Chao Wang, Hui Wang, Yingui Sun — Wed, 11 Mar 2026 14:56:32 +0800

Objective: To analyze the effectiveness of an integrated teaching platform combining virtual reality (VR) technology and high-end simulators in practical obstetrics and gynecology teaching. Methods: A total of 39 interns who underwent obstetrics and gynecology internships from March 2023 to March 2024 were included in the reference group and received conventional practical teaching methods. Another 39 interns who underwent internships from April 2024 to April 2025 were included in the observation group and received the integrated teaching platform combining VR and high-end simulators. The teaching effects of the two groups were compared. Results: The observation group achieved higher assessment scores than the reference group, with higher scores in self-directed learning ability and clinical thinking ability after teaching, as well as higher teaching satisfaction (p < 0.05). Conclusion: The integrated teaching platform combining VR and high-end simulators can improve the assessment scores of obstetrics and gynecology interns, cultivate their self-directed learning ability and clinical thinking ability, and achieve high teaching satisfaction.

Diagnostic Efficacy of Musculoskeletal Ultrasound in Rotator Cuff Injuries and Analysis of the Extent of Damage

Haiyun Tong — Wed, 11 Mar 2026 15:07:51 +0800

Objective: To analyze the effectiveness of musculoskeletal ultrasound in diagnosing rotator cuff injuries. Methods: A total of 80 patients with suspected rotator cuff injuries who were admitted and diagnosed between January 1, 2020, and December 31, 2024, were selected. Musculoskeletal ultrasound was performed on these patients, and the diagnostic efficacy of musculoskeletal ultrasound was evaluated by comparing the results with those of MRI. Results: The detection rates of musculoskeletal ultrasound for the location and extent of injury were similar to those of MRI (p > 0.05). Based on the MRI diagnosis results, the diagnostic accuracy rate of musculoskeletal ultrasound was 92.50%, with a sensitivity of 93.06% and a specificity of 87.50%. The morphological and signal characteristics, as well as ultrasound indicators, of patients with positive musculoskeletal ultrasound results differed significantly from those of patients with negative results (p < 0.05). Conclusion: Musculoskeletal ultrasound can effectively detect the location and extent of rotator cuff injuries, comprehensively assess the damage, and demonstrate high diagnostic efficacy. Furthermore, the morphological and signal characteristics, as well as ultrasound indicators, of musculoskeletal ultrasound can serve as diagnostic criteria for rotator cuff injuries, improving disease detection efficiency.

Holistic Hierarchical Predictive-Integration Theory (HHPIT): An Exploration of AI-Empowered Innovation and Empirical Research in Traditional Chinese Medicine Meridian Theory

Jiren Zhang, Yang Zhang, Bingna Hao, Junjie Hao, Leiming Wang, Fengtian Lao — Wed, 11 Mar 2026 00:00:00 +0800

By 2025, research on Traditional Chinese Medicine (TCM) meridians has generated 12–15 macro-level theories and over 20 specific hypotheses, manifesting a highly fragmented research landscape. Objective: This paper proposes the “Holistic Hierarchical Predictive-Integration Hypothesis” (HHPIT) to construct a unified theoretical framework that integrates the rational components of existing meridian hypotheses. Methods: The HHPIT hypothesis systematically reviews current meridian theories, employs interdisciplinary methodologies, integrates artificial intelligence technology, and establishes a three-tier architecture encompassing structural, functional, and systemic layers. Results: HHPIT successfully integrates diverse meridian theories, proposes a computable algorithmic pipeline, and provides specific application protocols for chronic disease treatment, anti-aging, and enhancement of Zang-fu organ functions. Conclusion: HHPIT offers a novel, computable, and verifiable research paradigm for meridian studies, promoting the modernization and internationalization of TCM theory.

Research on the Influence of Professional Identity of Specialized Nurses on Core Competency Development and Enhancement Pathways

Alima, Khulan Gaalan, Solongo Dashnyam, Baasanjav Nachin — Wed, 11 Mar 2026 15:42:53 +0800

Within contemporary healthcare systems, professional identity among specialized nurses serves as a pivotal intrinsic factor influencing the development of their core competencies. This review synthesizes existing research, revealing that professional identity positively impacts the development of core competencies through multiple pathways, including psychological drive, behavioral facilitation, teamwork, and career stability. Building on this analysis, this paper proposes systematic enhancement strategies from four dimensions: education and training, organizational environment, cultural development, and individual growth, aiming to provide a reference for nursing practice and professional development.

Firsekibart in the Treatment of Acute Gout Attack in a Patient with Chronic Kidney Disease and Progressive Renal Dysfunction: A Case Report

Jing Hu — Wed, 11 Mar 2026 00:00:00 +0800

Currently, glucocorticoids are the only treatment option for acute gout attacks in patients with chronic kidney disease (CKD) and progressive renal dysfunction. Management becomes particularly challenging when steroid therapy is contraindicated, poorly tolerated, or ineffective. IL-1β monoclonal antibodies offer potent, targeted anti-inflammatory effects and have been approved for the treatment of gout, providing new therapeutic hope for this population. Here, we report a case of a patient with CKD and progressively worsening renal function who experienced an acute gout attack requiring dialysis. Treatment with the IL-1β monoclonal antibody Firsekibart produced rapid and remarkable anti-inflammatory and analgesic effects, effectively controlling the gout attack, improving renal function, and allowing discontinuation of dialysis.

The Impact of Free Lens Anterior Capsular Disc on Corneal Endothelial Cells in Femtosecond Laser-Assisted Cataract Surgery

Yongchang Tan, Bo Wu, Yingdong Luo, Xiaoling Huang — Fri, 13 Mar 2026 00:00:00 +0800

Objective: To investigate whether attaching a free lens anterior capsular disc to the corneal endothelial surface during femtosecond laser-assisted cataract surgery (FLACS) can effectively reduce postoperative corneal endothelial cell loss. Methods: This prospective study included 97 cataract patients. Among them, 33 patients served as the experimental group, where a free lens anterior capsular disc was applied for corneal endothelial protection during FLACS. The remaining 64 patients formed the control group and underwent conventional FLACS. Changes in corneal endothelial cell density were compared between the two groups before surgery and one month postoperatively. Results: One month after surgery, corneal endothelial cell counts in both groups were lower than preoperative levels. However, the experimental group exhibited higher corneal endothelial cell counts than the control group, with a smaller reduction in cell counts (p < 0.05). The corneal endothelial cell loss rate in the experimental group was lower than that in the control group one month postoperatively (p < 0.05). At the one-month follow-up, there were no significant differences in LogMAR visual acuity or non-contact intraocular pressure between the two groups compared to preoperative values (p > 0.05). Additionally, no significant differences were observed between the experimental and control groups in terms of LogMAR visual acuity, non-contact intraocular pressure, improvements in LogMAR visual acuity, or changes in non-contact intraocular pressure (p > 0.05). Conclusion: Attaching a free lens anterior capsular disc to the corneal endothelial surface during FLACS can effectively reduce intraoperative corneal endothelial cell loss.

Research on the Mechanism of Dahuang Mudan Decoction in Treating IBD Based on Metabolomics

Zhanzhan Jia, Jiahe Zhang, Jiliang Li — Fri, 13 Mar 2026 16:19:52 +0800

Objective: This study aims to systematically explore the mechanism of Dahuang Mudan Decoction in treating inflammatory bowel disease through metabolomic analysis, revealing its therapeutic effects and potential pathways in mice, and providing a scientific basis for clinical treatment. Methods: An acute colitis model in mice was established by administering dextran sodium sulfate (DSS) in drinking water continuously for 7 days. After successful modeling, the mice were randomly divided into an ulcerative colitis model group, a mesalazine group, and low-, medium-, and high-dose Dahuang Mudan Decoction groups. The intervention was administered via continuous gavage for 7 days. Body weight changes and colon length were recorded, and the disease activity index (DAI) and fecal occult blood status were monitored. Colon length was measured, and colon tissue was subjected to HE staining and pathological scoring to assess inflammatory damage. Intestinal tissue samples were collected for metabolomic analysis to screen for differential metabolites and perform pathway enrichment analysis. Results: The experimental results indicated that, compared with the model group, intervention with Dahuang Mudan Decoction significantly improved the colitis phenotype induced by DSS, as evidenced by alleviated weight loss, reduced DAI scores, decreased colon shortening, and mitigated histopathological damage, along with improved inflammatory cell infiltration and crypt structure destruction. Metabolomic analysis revealed a clear separation in metabolic profiles between the model and normal groups. Conclusion: Dahuang Mudan Decoction induced a holistic shift in the metabolic phenotype of the model mice, partially reverting/remodeling it toward the normal state.

Evidence-Based Plan for Environmental Cleaning of Operating Room: Impact on High-Frequency Contact Surfaces

Fri, 13 Mar 2026 16:36:14 +0800

Objective: To develop an evidence-based plan for cleaning operating room and evaluate the impact on high-frequency contact surfaces. Method: The evidence application model of the JBI Evidence-Based Nursing Center was utilized to create a strategy, which was implemented in a tertiary-level hospital in Yunnan Province. The adenosine triphosphate (ATP) biological biofluorescence detection method was used to assess the quality of cleaning before and after the intervention. Results: A total of 17 quality review indicators were established in this study. Following the application of evidence, the implementation rate for 16 quality review indicators increased significantly, from a range of 0–71.6% to 85.3–100%. Moreover, the pass rate of ATP bioluminescence detection on high-frequency contact surfaces increased from 14.07% to 47.10%, with significant difference (p < 0.05). Conclusion: The evidence-based environmental cleaning program proved to enhance the overall cleanliness of operating room and reduce the risk of surgical infections. This strategy holds promise for effective cleaning of operating room.

Analysis of the Efficacy of Short-Term Intensive Insulin Pump Therapy Combined with Alogliptin and Canagliflozin in Elderly Patients with Type 2 Diabetes Mellitus

Hui Dai — Fri, 13 Mar 2026 16:45:37 +0800

Objective: To investigate the effects of switching to either Prandilin 25R monotherapy or Prandilin 25R combined with alogliptin and canagliflozin tablets after short-term intensive insulin pump therapy during hospitalization in elderly patients with type 2 diabetes mellitus on glycemic control, glycometabolic indicators, and cardiovascular risk factors, and to evaluate the safety of the two regimens. Methods: A total of 78 elderly patients with type 2 diabetes mellitus admitted to our hospital from January 2025 to September 2025 were selected and randomly divided into a control group and an observation group, with 39 cases in each group. The control group received monotherapy with insulin lispro protamine recombinant injection (Prandilin 25R) after intensive insulin pump therapy, while the observation group received Prandilin 25R combined with alogliptin and canagliflozin tablets. Continuous glucose monitoring (CGM) was performed for 14 days during the intensive insulin pump therapy phase in the hospital, followed by routine fingertip blood glucose monitoring after 14 days. Glycemic control indicators, glycometabolic indicators, and the incidence of adverse reactions were compared between the two groups. Results: After treatment, the mean amplitude of glycemic excursions and the 24-hour blood glucose standard deviation were significantly lower in the observation group than in the control group, while the time spent within the target blood glucose range was significantly higher (p < 0.05). The levels of glycated hemoglobin, fasting blood glucose, and 2-hour postprandial blood glucose were better in the observation group than in the control group; moreover, the body mass index, systolic blood pressure, and blood lipid levels improved more significantly in the observation group than in the control group (p < 0.05). There was no statistically significant difference in the incidence of hypoglycemia between the two groups. Conclusion: Combination therapy with alogliptin and canagliflozin tablets after short-term intensive insulin pump therapy can effectively improve glycemic variability in elderly patients with type 2 diabetes mellitus, with good safety. This suggests that alogliptin and canagliflozin tablets have a hypoglycemic advantage in the combination regimen and possess high clinical promotional value.

The Impact of Motivational Nursing under a Focus-Resolving Model on the Health Behaviors of Bladder Cancer Surgery Patients

Ying Chen, Qiaoyan Zhao — Fri, 13 Mar 2026 16:54:05 +0800

Objective: To analyze the impact of motivational nursing under the solution-focused approach on health behaviors in surgical care for bladder cancer patients. Methods: A sample of 72 bladder cancer patients who underwent surgical treatment from September 2024 to September 2025 was randomly divided into groups using a random number table. Group A received motivational nursing under the solution-focused approach, while Group B received conventional nursing. Health behavior scores and complication indicators were compared between the two groups. Results: Group A had higher scores on the Health-Promoting Lifestyle Profile II (HPLP-Ⅱ) than Group B, with p < 0.05. The postoperative complication rate in Group A was lower than that in Group B, with p < 0.05. Conclusion: For bladder cancer patients undergoing surgery, receiving motivational nursing under the solution-focused approach can improve health behaviors, alleviate negative emotions, and is highly feasible and effective.

Research Progress on Novel Surrogate Indicators of Insulin Resistance in Type 2 Diabetic Kidney Disease

Jingjing Liang, Yuanyuan Jia, Chang Tian, Ge Wu — Fri, 13 Mar 2026 17:06:11 +0800

Diabetic kidney disease (DKD)is one of the most common and severe microvascular complications of type 2 diabetes mellitus (T2DM). It is also a major cause of end-stage renal disease (ESRD), making early identification and intervention crucial. Insulin resistance (IR)is a key pathophysiological mechanism of T2DM and plays a central role in the progression of DKD. In recent years, a series of novel surrogate indicators of IR, such as the triglyceride-glucose (TyG)index, TyG-body mass index (TyG-BMI), triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C), and metabolic score for insulin resistance (METS-IR), have attracted widespread attention due to their simplicity and cost-effectiveness. This article reviews the research progress of novel surrogate indicators of insulin resistance (IR) in type 2 diabetic kidney disease (DKD), aiming to provide references for the early prevention and improved prognosis of DKD.

Analysis of the Effect of Pain Nursing Combined with Exercise and Posture Intervention on Postoperative Patients with Kidney Stones and Improvement in VAS Scores

Lu Hua, Jin Chen — Mon, 16 Mar 2026 16:32:32 +0800

Objective: To analyze the effect of pain nursing combined with exercise and posture intervention on improving Visual Analogue Scale (VAS) scores in patients after kidney stone surgery. Methods: A sample of 80 patients who underwent kidney stone surgery from October 2024 to October 2025 was randomly divided into groups using a random number table. Group A received pain nursing combined with exercise and posture intervention, while Group B received conventional nursing. Postoperative recovery time, VAS scores, and postoperative complications were compared between the two groups. Results: The postoperative recovery time in Group A was shorter than that in Group B, with p < 0.05. The VAS scores at 12 hours, 24 hours, and 72 hours postoperatively in Group A were all lower than those in Group B, with p < 0.05. The postoperative complication rate in Group A was lower than that in Group B, with p < 0.05. Conclusion: Pain nursing combined with exercise and posture intervention in postoperative nursing for kidney stone patients can shorten postoperative recovery time and alleviate pain scores.

Analysis of Nursing Satisfaction in Patients with Kidney Stones Undergoing Percutaneous Nephrolithotomy with Holmium Laser Lithotripsy Under the Impact of High-Quality Nursing Intervention

Jing Yang, Jiahui Qian — Mon, 16 Mar 2026 16:46:30 +0800

Objective: To analyze the value of high-quality nursing care for patients with kidney stones undergoing percutaneous nephrolithotomy with holmium laser lithotripsy (PCNL). Methods: A total of 72 patients with kidney stones treated with PCNL from November 2024 to November 2025 were selected as samples and randomly divided into groups using a random number table. Group A received high-quality nursing care, while Group B received conventional nursing care. Indicators such as pain, anxiety, nursing satisfaction, and complications were compared between the two groups. Results: The Visual Analog Scale (VAS) scores for pain and Self-Rating Anxiety Scale (SAS) scores for anxiety in Group A were lower than those in Group B (p < 0.05). The nursing satisfaction rate in Group A was higher than that in Group B (p < 0.05). The complication rate of PCNL in Group A was lower than that in Group B (p < 0.05). Conclusion: For patients with kidney stones treated with PCNL, receiving high-quality nursing care can alleviate anxiety, relieve pain, and reduce the risk of postoperative complications.

Analysis of the Preventive Effects of Shoulder Dystocia Midwifery Techniques and Predictive Nursing on Shoulder Dystocia

Wei Li, Aiming Wang — Mon, 16 Mar 2026 00:00:00 +0800

Objective: To evaluate the preventive effect of shoulder dystocia midwifery techniques combined with predictive nursing on shoulder dystocia. Methods: A total of 82 high-risk pregnant women with shoulder dystocia admitted for childbirth from January 2022 to January 2025 were selected and equally divided using a random number table. The experimental group received shoulder dystocia midwifery techniques combined with predictive nursing, while the reference group received routine midwifery care. Indicators such as the preventive effect on shoulder dystocia were compared between the two groups. Results: The incidence of shoulder dystocia in the experimental group was lower than that in the reference group, the duration of labor was shorter, the amount of intra-partum bleeding was less, the incidence of adverse delivery outcomes was lower, and the score for fear of childbirth after intervention was lower than that in the reference group (p < 0.05). Conclusion: Implementing shoulder dystocia midwifery techniques combined with predictive nursing for high-risk pregnant women with shoulder dystocia can prevent shoulder dystocia and other adverse delivery outcomes, shorten the duration of labor, reduce intra-partum bleeding, and alleviate pregnant women’s fear of childbirth, demonstrating high nursing value.

Comparative Study on the Efficacy of Closed Reduction and Kirschner Wire Fixation versus Open Reduction and Plate Fixation in the Treatment of Hand Surgery Fractures

Weishun Wang — Tue, 17 Mar 2026 00:00:00 +0800

Objective: To investigate the therapeutic advantages of closed reduction and Kirschner wire fixation versus open reduction and plate fixation in patients with hand surgery fractures. Methods: The sample was collected from May 2021 to May 2025, consisting of 80 patients with hand surgery fractures. These patients were randomly divided into two groups using the red and blue ball method: the plate fixation group (40 cases, treated with open reduction and plate fixation) and the Kirschner wire fixation group (40 cases, treated with closed reduction and Kirschner wire fixation). The therapeutic effects between the two groups were randomly compared. Results: The Kirschner wire fixation group outperformed the plate fixation group in all indicators except for hand function scores (p < 0.05). There was no statistically significant difference in hand function scores between the two groups (p > 0.05). Conclusion: Compared with open reduction and plate fixation, closed reduction and Kirschner wire fixation for patients with hand surgery fractures achieves a more pronounced therapeutic effect, with advantages such as less trauma, shorter operation time, less bleeding, and a lower incidence of complications. It is suitable for hand surgery fractures with good stability. Open reduction and plate internal fixation have greater advantages in complex fractures and cases requiring high stability, and are worthy of promotion and application.