Journal of Clinical and Nursing Research

A Case of A Middle-Aged Woman with Cor Triatriatum Dexter and Sick Sinus Syndrome: Comprehensive Cardiovascular Evaluation

Jun Wang — 2024-10-28

This case study discusses a 51-year-old woman with a complex cardiovascular condition, cor triatriatum dexter, complicated by sick sinus syndrome. The patient presented with a history of bradycardia, dizziness, and amaurosis, and was admitted to the emergency department due to numbness in her right limb. Diagnostic examinations, including computed tomography (CT) and cardiac color-ultrasound screening, revealed cor triatriatum dexter along with an enlarged left atrium and ventricle. Additional findings included the absence of the inferior vena cava and polysplenic syndrome. Based on these results, double-chamber pacemaker surgery was recommended, supported by cardiac and thoracic-abdominal CT angiography and three-dimensional vascular reconstruction. This case underscores the importance of comprehensive examinations in identifying associated cardiovascular abnormalities.

Observation of the Clinical Effects of Detail-oriented Nursing in Health Checkups at a Health Management Center

Qian Chen — 2024-10-28

Objective: To observe the clinical effects of detail-oriented nursing in health checkups at a health management center. Methods: A total of 240 individuals undergoing health checkups at the hospital’s health management center from June 2023 to June 2024 were enrolled and randomly divided into two groups according to a random number table method. The control group received routine nursing care, while the observation group received detail-oriented nursing care, with 120 cases in each group. Differences in checkup quality and nursing risk incidence were compared. Results: The form submission rate, project completion rate, and one-time checkup completion rate in the observation group were higher than those in the control group, while the checkup time was shorter (P < 0.05). The incidence of nursing risks such as item loss, falls, and patient-nurse disputes was lower in the observation group compared to the control group (P < 0.05). Conclusion: Applying detail-oriented nursing in health checkups at a health management center can effectively improve checkup quality and reduce the occurrence of nursing risks.

Application of TCT to Research on Value in Screening for Cervical Cancer in Postmenopausal Women

Lixia Liu — 2024-10-24

Objective: To study the screening for cervical cancer in postmenopausal women in liquid-based cell test (TCT) application value. Methods: From January 2023 to March 2024 hospital check-ups and outpatient reached 400 cases of postmenopausal women, and they were TCT and HPV detection, during the study period to pathological diagnosis of numerical results as the standard, analysis of TCT detection application of screening for cervical cancer in postmenopausal women and the effect. Results: After the TCT detection, the inflammation group and normal group by use of HPV testing positive rate higher than other groups (P < 0.05). Hospital after pathological diagnosis and research, after the screening system found CIN Ⅰ level and above cases about 39 cases, the TCT and HPV detection rate of positive difference is not obvious, and there is no statistical significance (P > 0.05). Joint test analysis, the sensitivity and specificity were higher than that of TCT and HPV testing positive (P < 0.05). Conclusion: TCT detection screening for cervical cancer in postmenopausal women is of great importance to the application, if you can join HPV testing, help to improve the detection sensitivity, avoid missed diagnosis of problems, and then for treatment and later restore to lay a solid foundation.

Deciphering the Role of EPPK1 in the Development of Colon Adenocarcinoma by Integrated Bioinformatics Approach

Muhammad Akram — 2024-10-24

The role of Epiplakin1 (EPPK1) in colon adenocarcinoma (COAD) was analyzed through a comprehensive evaluation of its expression, methylation, genetic mutations, and prognostic implications. A significant up-regulation of EPPK1 expression in COAD malignant cells compared to normal control samples was observed using data from the UALCAN database. EPPK1 expression was found to be elevated across different cancer development stages, racial groups, genders, and age groups, emphasizing its crucial role in cancer proliferation. Validation of EPPK1 expression through the GEPIA2.0 dataset further confirmed its overexpression in COAD when compared to normal samples. The analysis revealed dysregulation across all four stages of cancer development, with the highest expression in stage IV and the lowest in stage II. Additionally, promoter methylation analysis demonstrated a fundamental relationship between COAD samples and normal controls, revealing significant methylation patterns across different clinical parameters, including cancer stages, race, gender, and age. Overall survival (OS) and disease-free survival (DFS) analysis using the KM plotter showed a strong association between high EPPK1 expression and worse survival outcomes in COAD patients. Conversely, low EPPK1 expression was linked to better OS and DFS. Genetic mutation analysis using cBioPortal identified minimal EPPK1 mutations in COAD, predominantly truncating and missense mutations, highlighting their relevance to EPPK1 dysregulation in COAD. These findings underscore the important role of EPPK1 in COAD development and proliferation, suggesting its potential as a therapeutic target and prognostic marker. Further exploration of EPPK1’s molecular mechanisms and its involvement in the COAD microenvironment may reveal new pathways for targeted treatments and precision medicine strategies against this challenging disease.

Application and Research of Big Data Technology in Intelligent Ward

Yuhan Li — 2024-10-24

With the rapid development of information science and technology and the progress of the health service industry, the integration of medical services and new technologies such as big data technology has become more in-depth, and the construction of smart hospitals and smart wards has received more and more attention and application. This article conducts in-depth research and analysis on the application and exploration of big data technology in smart wards and explores the role of big data technology in improving the quality, efficiency, and cost of medical services in smart wards, as well as the application prospects and challenges of big data technology in patient monitoring, disease prevention, and diagnosis and treatment processes in smart wards. The focus is on analyzing and studying the use of big data technology to assist in the construction of smart neonatal surgery wards. This article aims to provide useful references and lessons for the construction and development of smart wards.

The Relationship Between Social Isolation, Psychological Resilience, and Psychological Well-Being Among Older People in the Community

Lijing Wang — 2024-10-28

Objective: To explore the relationship between social isolation, psychological resilience, and psychological well-being in community-dwelling older adults. Methods: A questionnaire survey was conducted with 265 community-dwelling older adults using the Social Isolation Scale for the Elderly (C-SIS), the 10-item Brief Psychological Resilience Scale, and the Comprehensive Happiness Questionnaire (MHQ). The results were statistically analyzed using SPSS 27.0. Results: The highest score on the Social Isolation Scale for Community Elderly was 23, with a mean entry score of 2.36 ± 0.62. A score of 14 was the cut-off point, with scores of ≤ 14 classified as social isolation. There were 136 cases with scores below 14, resulting in a social isolation incidence rate of 51.3%. The median (P50) psychological resilience score was 27, indicating a higher level of resilience. The total score on the Psychological Well-being Scale was 161, suggesting a moderate to slightly higher level of well-being. Social isolation had a direct negative effect on psychological well-being, while psychological resilience had a positive effect. Conclusion: Older adults should be supported in reducing the incidence of social isolation and increasing psychological resilience to enhance psychological well-being and promote successful aging.

Effect of Social Skill Training on Social Function in Patients with Schizophrenia

Wanyi Zhao — 2024-10-25

Objective: To explore the effect of Social Skills Training (SST) on the social function of inpatients with schizophrenia. Methods: A total of 40 patients with schizophrenia (20 in the intervention group and 20 in the control group) were selected from a psychiatric hospital in Shanghai for 10 times (once a week) of social skills training. The control group was treated with routine hospitalization (drug therapy and routine hospitalization nursing) for 10 weeks. Social Disability Screening Schedule before and after intervention for patients enrolled in the intervention group (Social Disability Screening Schedule, SDSS and Scale of Social Function in Psychosis Inpatients, SSPI). Conclusion: The results of social skills training on SDSS and SSPI were different between the two groups, and there was no statistical value (P > 0.05). Observation of patients in this group, when undergoing social skills training, SSPI score was significantly better than the control group (P < 0.01) and SDSS score was significantly lower than the control group (P < 0.01), the differences were statistically significant. Social skills training and social work group intervention can improve psychiatric symptoms and further enhance social function in hospitalized patients with schizophrenia.

Application of Endovenous Laser Treatment Combined with Foam Sclerotherapy for the Minimally Invasive Treatment of Great Saphenous Vein Varicosity

Peng Liu — 2024-10-28

Objective: To evaluate the efficacy of endovenous laser treatment (EVLT) combined with foam sclerotherapy (FS) in the treatment of great saphenous vein varicosity (GSVV). Methods: A total of 50 patients with GSVV, treated between March 2021 and March 2024, were selected and randomly divided into two groups using a random number table. The combination group (25 cases) underwent EVLT combined with FS, while the conventional group (25 cases) underwent EVLT alone. The total effective rate, complication rate, disease severity score, and serological indicators were compared between the two groups. Results: The total effective rate in the combination group was higher, and the complication rate was lower compared to the conventional group (P < 0.05). One week after surgery, the disease severity score in the combination group was lower, coagulation function indicators were better, and inflammatory factor levels were lower compared to the conventional group (P < 0.05). Conclusion: EVLT combined with FS can improve the clinical efficacy in GSVV patients, prevent postoperative complications, reduce disease severity, protect patients’ coagulation function, and alleviate postoperative inflammatory responses, showing significant advantages in combined surgery.

A Review on Emerging Contaminants: Effects on Human Health and Cancer Risks

Hamza Khaliq — 2024-10-24

Emerging contaminants are growing health concerns that pose potential threats to the environment and human health globally. They originate from multiple sources, including rapid industrial processes, agriculture, households, and wastewater treatment plants. Despite efforts to reduce the levels of such pollutants, these harmful elements remain a serious problem for public health and the overall quality of life. Exposure to emerging contaminants can lead to various health problems, including cardiovascular diseases, brain and developmental disorders, and cancer. These contaminants can harm aquatic life, disrupt ecosystems, and contaminate drinking water sources. Cancer, a complex heterogeneous disease, can be triggered by multiple causes, including genetic and environmental factors. The rapid increase in emerging contaminants has contributed significantly to the development and proliferation of cancer. This review highlights the dangerous effects of exposure to these contaminants and explores future directions in research. Additionally, it summarizes the emerging roles of inorganic contaminants, such as engineered nanoparticles, and biological contaminants, including pathogenic bacteria, antibiotic-resistant bacteria and resistance genes, viruses, protein contaminants, microplastics, and nanoplastics, in cancer progression and treatment.

Research Progress of Intracardiac Electrogram Localization Technology in PICC Tip Localization

Lingyu Li — 2024-10-24

As a safe, accurate and radiation-free method of catheter tip positioning, intracardiac electrogram positioning technology (IC-ECG) has shown significant advantages in the field of peripherally inserted central catheter (PICC), and has been increasingly concerned and welcomed by clinical operators at home and abroad in recent years. This article reviews the technical principle, clinical progress, advantages and limitations of IC-ECG, aiming to provide a reference for further clinical research and application of this technology.

Analysis of the Emergency Rescue Nursing Intervention Effect and Rescue Success Rate for Patients with Traumatic Hemorrhagic Shock

Lingli He — 2024-10-28

Objective: To analyze the value of emergency rescue nursing intervention in the care of patients with traumatic hemorrhagic shock and its impact on the success rate of rescue efforts. Methods: A total of 80 patients with traumatic hemorrhagic shock were selected as samples, with the timeframe from July 2022 to July 2023. The patients were randomly divided into two groups using a random number table method. Group A received emergency rescue nursing, while Group B received routine nursing care. The success rate of rescue, rescue indicators, complication rates, and family satisfaction with nursing care were compared between the two groups. Results: The rescue success rate in Group A was higher than in Group B (P < 0.05); the total blood loss in Group A was less, and the rescue time, full transportation time, and hospitalization time were shorter than in Group B (P < 0.05); the complication rate of patients with traumatic hemorrhagic shock in Group A was lower than in Group B (P < 0.05); the family satisfaction with emergency nursing care in Group A was higher than in Group B (P < 0.05). Conclusion: Emergency rescue interventions for patients with traumatic hemorrhagic shock can reduce blood loss, shorten rescue times, and improve the success rate of shock rescue, providing a safe and effective approach.

Application Status and Future Prospects of Traditional Chinese Medicine Nursing Technology

Dan Wang — 2024-10-25

In recent years, the nursing technology of traditional Chinese medicine (TCM) has developed rapidly in the country. TCM nursing technology mainly refers to the application of TCM therapy in clinical nursing practice, such as acupoint massage, cupping, ear point pressure beans, scraping, wet compress of traditional Chinese medicine, etc. Its application can not only effectively reduce the pain of patients, but also can promote the treatment effect, help patients recover early, but also help to further improve the quality of service of nursing staff. In clinical nursing practice, however, the application of TCM nursing technology still has some problems, such as the theory of traditional Chinese medicine nursing quality to promote, “Internet + TCM nursing” is still in the exploratory stage, etc. This article mainly discusses the application status and existing problems of Chinese medicine nursing technique, coping strategies and its future prospects for related analysis and research, hope to be able to improve the quality of TCM nursing technology application in China to provide some reference and reference.

Research Progress on Acute Kidney Injury in Patients with Cardiogenic Shock Undergoing Venoarterial Extracorporeal Membrane Oxygenation

Tuohong Wang — 2024-10-28

Cardiogenic shock (CS) is a life-threatening syndrome characterized by peripheral hypoperfusion and organ dysfunction caused by primary heart disease. Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is a temporary mechanical circulatory support device for CS, used in cases of profound shock, biventricular failure, respiratory failure, and cardiac arrest that require urgent maximal support. While VA-ECMO provides effective tissue perfusion and ensures oxygen supply to organs, it is also associated with severe complications, among which acute kidney injury (AKI) is one of the most common and serious. To date, no comprehensive review has been conducted on the pathophysiology, influencing factors, and treatment of AKI associated with VA-ECMO. This paper aims to elaborate on the pathophysiological mechanisms, influencing factors, and treatment options for AKI in patients with CS undergoing VA-ECMO, providing clinical and nursing references.

Exploring the Application of Health Education During Pregnancy in Clinical Nursing of Obstetrics and Gynecology

Rongjie Liu — 2024-10-24

Objective: To study the methods and effects of health education during pregnancy in the clinical nursing work of obstetrics and gynecology. Methods: Between January 2022 and January 2024 in the hospital 140 cases of pregnant women, can be divided into two groups, an observation group and a control group, respectively, between groups of 70 people. The observation group was given health pregnancy education, while the control group was given routine nursing. Results: After intervention compared two groups of natural childbirth, postpartum breast feeding rate and postpartum bleeding, observation group is better than the control group. The results of the two groups have statistical significance (P < 0.05). Conclusion: The application of health education during pregnancy in the nursing of obstetrics and gynecology has a good effect, can be widely welcomed and has clinical value.

Analysis of the Status Quo and Influencing Factors of Advanced Lung Cancer Patients’ Quality of Life

Xuehong Tang — 2024-10-29

Objective: To investigate the quality of life and related influencing factors of patients with advanced lung cancer. Methods: A cross-sectional survey was conducted on 51 patients with advanced lung cancer who were hospitalized in the Department of Oncology from January 2023 to December 2023, and the influencing factors of patients’ quality of life were analyzed. Results: Among the five functional scales (physical, role, cognitive, emotional, and social functioning) of the QLQ-C30 scale, the social and emotional function scores were the lowest, respectively 16.7 (IQR: 0, 33.3) points, and 16.7 (IQR: 8.3, 25), and among the three symptom scales (fatigue, pain, nausea and vomiting), the fatigue symptom score was the highest: 77.7 (IQR: 66.7, 88.9) points. The results of Spearman correlation analysis showed that the anxiety score of patients with advanced lung cancer was positively correlated with depression score (P < 0.01), while the quality of life of patients with advanced lung cancer was not correlated with anxiety and depression score (P > 0.1). The self-care ability, the nature of the disease, and whether the patient was treated for chemotherapy were the independent influencing factors of the patient’s quality of life, and the difference was statistically significant (P < 0.001). Conclusion: Patients with advanced lung cancer have different degrees of anxiety and depression, and their quality of life is affected by many factors, which are mainly related to the patient’s self-care ability, the nature of the disease, and whether they received chemotherapy.

The Effect of Seated Baduanjin Exercise on Psychological State, Fatigue Symptoms, and Quality of Life in Maintenance Hemodialysis Patients

Jun Li — 2024-10-28

Objective: To evaluate the intervention effects of seated Baduanjin exercise on patients undergoing maintenance hemodialysis (MHD). Methods: A total of 108 MHD patients admitted between July 2022 and July 2023 were selected. They were randomly assigned into two groups: the experimental group, with 55 patients, who received seated Baduanjin exercise combined with leg exercises during dialysis; and the control group, with 53 patients, who only performed leg exercises during dialysis. The psychological state, fatigue symptoms, quality of life, and sleep quality scores were compared between the two groups, and exercise endurance was recorded. Results: After the intervention, the psychological state scores in the experimental group were lower than those in the control group, the fatigue symptom scores were lower, the quality of life scores were higher, the sleep quality scores were lower, and the exercise endurance was higher (P < 0.05). Conclusion: Seated Baduanjin exercise can improve the negative psychological state and fatigue symptoms of MHD patients, enhance their quality of life and sleep quality, and effectively increase their exercise endurance.

The Clinical Application of Quality Nursing Service in Urological Nursing

Zuohui Yi — 2024-10-24

Objective: To explore and analyze the clinical application effect of high-quality nursing service in urology nursing. Methods: 400 patients who received treatment in the urology department of our hospital were selected as the study object and randomly divided into two groups. The control group and nursing group, had 200 patients in each group. The control group received the usual nursing mode, while the nursing group received high-quality nursing services. Results: Through comparative analysis, the complication rate of the nursing group was significantly lower than that of the control group, and the satisfaction rate was significantly higher. Conclusion: The application of high-quality nursing service in the nursing of urological patients is remarkable.

Clinical Study on the Effect of Continuity of Care in CICU on Improving Cognitive Function and Psychological State in Patients with Heart Failure

Jin Sang — 2024-10-24

Objective: To analyze the effect of continuity of care in the cardiac intensive care unit (CICU) on improving cognitive function and psychological state in patients with heart failure (HF). Methods: A total of 112 chronic HF patients admitted to the CICU of Xuzhou Traditional Chinese Medicine Hospital from July 2022 to August 2024 were selected and randomly divided into two groups using the red and blue ball method: a control group (n = 56) and a study group (n = 56). The control group received routine CICU nursing management, while the study group received routine CICU nursing combined with continuity of care management. Cognitive function (using the Montreal Cognitive Assessment, MoCA), psychological state (using the Self-Rating Depression Scale, SDS, and Self-Rating Anxiety Scale, SAS), and quality of life (using the Minnesota Living with Heart Failure Questionnaire, MLHFQ) were compared between the two groups. Results: After the intervention, the cognitive function scores of the study group were significantly higher than those of the control group (P < 0.05). The SDS and SAS scores of the study group were significantly lower than those of the control group after the intervention (P < 0.05). The quality of life in the study group was also significantly better than in the control group (P < 0.05). Conclusion: CICU continuity of care can effectively improve cognitive function and psychological state in patients with HF, while also enhancing their quality of life.

Effect of Prone Position Ventilation in Patients with Severe Craniocerebral Injury Complicated with Pulmonary Infection

Xiaoqiong Huang — 2024-11-01

Objective: To investigate the effects of prone ventilation in patients with severe traumatic brain injury combined with pulmonary infection. Methods: A total of 100 patients with severe traumatic brain injury combined with pulmonary infection in the hospital were randomly divided into a prone ventilation group and a conventional ventilation group, with 50 patients in each group. The Glasgow Coma Scale (GCS) score, APACHE II score, sputum culture results, oxygenation indicators, and prognosis were compared between the two groups. Data were processed using SPSS 25.0 statistical software, and t-tests and chi-square tests were used to compare continuous and categorical variables, respectively. Results: The experimental group showed better oxygenation indicators, a lower positive rate of sputum cultures, and reduced intracranial pressure compared to the control group (all P < 0.05). Multivariate Cox regression analysis indicated that GCS score, APACHE II score, and prone ventilation were independent risk factors affecting patient prognosis (all P < 0.05). Conclusion: Prone ventilation can improve oxygenation, reduce the risk of pulmonary infection, and decrease intracranial pressure in patients with severe traumatic brain injury combined with pulmonary infection, thereby improving patient prognosis. GCS score and APACHE II score can serve as important indicators for prognostic evaluation.

A Meta-Analysis of the Effect of Modified Gastric Tube Length on Enteral Nutrition in Stroke Patients

Xuehong Tang — 2024-10-29

Objective: To systematically evaluate the effect of modified length of gastric tube implantation in stroke patients. Methods: Randomized controlled studies on the effect of narrative therapy on negative emotions of malignant tumor patients were published in PubMed, EMbase, Web of Science, Cochrane Library, CNKY. Wanfang Data, VIP Database and CBM disc from database establishment to May 2021. RewMan 5.2 software was used for the meta-analysis. Results: Ten articles were included, involving 1140 patients in total. Results of meta-analysis showed that improved length of gastric tube implantation could reduce the incidence of aspiration pneumonia in stroke patients with enteral nutrition [OR = 0.18, 95% CI (0.10, 0.31), P < 0.00001], reduce gastroesophageal reflux rate (OR = 0.13, 95% CI (0.04, 0.38), P < 0.0002], the incidence of aspiration (OR = 0.23, 95% CI (0.11, 0.38), P < 0.00001], the incidence of abdominal distension and diarrhea (OR = 0.13, 95% CI (0.06, 0.28), P < 0.00001], the incidence of choking cough (OR = 0.20, 95% CI (0.07, 0.61), P < 0.005], but no difference between the two groups in terms of reducing gastric residual (OR = 0.10, 95% CI (2.40, 2.60), P = 0.94]. Conclusions: The modified length of the gastric tube can replace the traditional length of the gastric tube in the application of stroke patients, can reduce the complications of enteral nutrition, is safe and feasible. However, due to the limitation of the quality and quantity of the included studies, we should be cautious about the results of this meta-analysis and expect to carry out more large-sample and high-quality randomized controlled trials for demonstration.

The Respiratory Rehabilitation Effect and Mechanism of Action of Oscillating Positive Expiratory Pressure Devices

Xiao Yang — 2024-10-24

Chronic respiratory diseases are one of the major global health problems, and their treatment and management impose a huge burden on both patients’ quality of life and healthcare resources. Respiratory rehabilitation, as a non-pharmacological treatment, has received increasing attention in recent years. Oscillating positive expiratory pressure (OPEP) devices, as a new type of respiratory rehabilitation device, show good application prospects in improving respiratory function, promoting sputum expectoration, and improving quality of life. The purpose of this paper is to review the effect and mechanism of OPEP in respiratory rehabilitation.

Advancements and Applications of Convolutional Neural Network Models in Cardiovascular Disease: A Comprehensive Review

Lu Wang — 2024-10-30

In recent years, artificial intelligence (AI) has demonstrated remarkable advancements in the field of cardiovascular disease (CVD), particularly in the analysis of electrocardiograms (ECGs). Due to its widespread use, low cost, and high efficiency, the ECG has long been regarded as a cornerstone of cardiological examinations and remains the most widely utilized diagnostic tool in cardiology. The integration of AI, especially deep learning (DL) technologies based on convolutional neural networks (CNNs), into ECG analysis, has shown immense potential across several cardiological subfields. Deep learning methods have provided robust support for the rapid interpretation of ECGs, enabling the fine-grained analysis of ECG waveform changes with diagnostic accuracy comparable to that of expert cardiologists. Additionally, CNN-based models have proven capable of capturing subtle ECG changes that are often undetectable by traditional methods, accurately predicting complex conditions such as atrial fibrillation, left and right ventricular dysfunction, hypertrophic cardiomyopathy, acute coronary syndrome, and aortic stenosis. This highlights the broad application potential of AI in the diagnosis of cardiovascular diseases. However, despite their extensive applications, CNN models also face significant limitations, primarily related to the reliability of the acquired data, the opacity of the “black box” processes, and the associated medical, legal, and ethical challenges. Addressing these limitations and seeking viable solutions remain critical challenges in modern medicine.

Endoscopic Treatment of 14 Cases of Small Subepithelial Lesions in the Gastrointestinal Tract Using a Combined Snare, Long Lucency Cap, and Argon Plasma Coagulation Technique

Jian Pang — 2024-10-24

Subepithelial lesions (SEL) of the digestive tract refer to a series of benign and malignant subepithelial masses that appear smooth or rough under gastrointestinal endoscopy. Endoscopic resection of subepithelial lesions in the digestive tract is widely recognized due to its advantages of minimal trauma and rapid recovery. This paper reports and summarizes the experiences of using the combined snare, long lucency cap, and argon plasma coagulation technique to remove small subepithelial lesions in 14 patients.

Exploring the Effects of Health Education and Chronic Disease Management Nursing in the Management of Hypertension in Elderly Patients in the Community

Yuhong Lin — 2024-10-24

Objective: To explore the effects of health education and chronic disease management nursing in elderly community patients with hypertension, in order to provide scientific evidence for improving the health management level of these patients. Methods: Sixty-four elderly hypertension patients treated at this hospital between March 2022 and March 2024 were selected and randomly divided into two groups, with 32 patients in each group. One group received conventional management, designated as the control group, while the other group received a combined management strategy involving health education and chronic disease management, designated as the experimental group. The study compared the management outcomes of the two groups to evaluate the value of the combined management approach in elderly hypertensive patients in the community. Results: The study found that the experimental group showed significantly lower systolic blood pressure (SBP), diastolic blood pressure (DBP), and scores on the Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) compared to the control group, with statistically significant differences (P < 0.05). Additionally, the experimental group demonstrated significantly higher scores in disease cognition levels regarding awareness of normal blood pressure ranges, prevention of complications, identification of high-risk factors, and healthy lifestyle practices, with statistically significant differences (P < 0.05). Moreover, the experimental group showed significantly better rates of self-management behaviors, such as quitting smoking and alcohol, self-monitoring of blood pressure, dietary control, regular medication adherence, and consistent exercise, compared to the control group, with statistically significant differences (P < 0.05). Conclusion: This study indicates that a combined management model integrating health education and chronic disease management effectively improves the emotional state of elderly hypertensive patients in the community, significantly enhances their disease cognition levels, and boosts their self-management abilities. Furthermore, this model can effectively lower patients’ blood pressure, thereby achieving better health management outcomes for elderly hypertensive patients in the community.

Effects of Acupuncture and Tuina Combined with Rehabilitation Therapy on Oxidative Stress Response and Motor Function in Stroke Hemiplegia Patients

Xiaojing Luo — 2024-10-24

Objective: To explore the effects of acupuncture and tuina combined with rehabilitation therapy on oxidative stress response and motor function in stroke hemiplegia patients. Methods: Sixty stroke hemiplegia patients were randomly divided into observation and control groups, with 30 cases each. The control group received conventional rehabilitation therapy, while the observation group also underwent acupuncture and tuina. After 8 weeks of treatment, oxidative stress indicators [malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px)], neurological deficit scores (NIHSS), Fugl-Meyer motor function scores (FMA), and activities of daily living (Barthel Index) were compared between the two groups. Results: Before treatment, there were no significant differences in MDA, NIHSS scores, FMA scores, and Barthel Index between the two groups (P > 0.05). After 8 weeks, the observation group had lower MDA and NIHSS scores, but higher SOD, GSH-Px, FMA scores, and Barthel Index compared to the control group, with statistically significant differences (P < 0.05). Conclusion: Acupuncture and tuina combined with rehabilitation therapy can effectively improve oxidative stress levels, promote neurological recovery, enhance motor function, and improve daily living activities in stroke hemiplegia patients. This combined therapy is recommended for clinical application.

Clinical Observation of the Therapeutic Effects of Wenzhong Hewei Formula in Treating Spleen and Stomach Qi Deficiency Syndrome in Internal Medicine Diseases

Silin Song — 2024-10-28

Objective: To observe the clinical efficacy and safety of Wenzhong Hewei Formula in treating spleen and stomach qi deficiency syndrome in internal medicine diseases. Methods: Sixty patients with spleen and stomach qi deficiency syndrome admitted to the hospital from April 2022 to June 2023 were randomly divided into observation and control groups, with 30 patients in each group. The control group received conventional internal medicine treatment, while the observation group was additionally treated with Wenzhong Hewei Formula on the basis of conventional treatment. Both groups were treated for 4 weeks. Results: The total effective rate of treatment in the observation group was higher than that of the control group (P < 0.05). After treatment, the traditional Chinese medicine syndrome scores of both groups were significantly lower than before treatment, with the observation group showing a more pronounced reduction (P < 0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion: Wenzhong Hewei Formula can effectively improve clinical symptoms in patients with spleen and stomach qi deficiency syndrome, enhance clinical efficacy, and have a high level of safety, making it worthy of clinical promotion.

Evaluation of the Effectiveness of the Competency Model for Nursing Managers in the Training of Newly Appointed Head Nurses

Kexiong Cui — 2024-10-28

Objective: To explore the effectiveness of the competency model for nursing managers in the training of newly appointed head nurses. Methods: Eighteen newly appointed head nurses from Yichang Central People’s Hospital, selected between August 2023 and July 2024, were chosen as the research subjects. Based on the nursing manager competency model, corresponding training programs were developed, and these 18 head nurses were trained accordingly. Results: After the training, all newly appointed head nurses passed the theoretical assessments, with a pass rate of 100.00%. The pass rates for two rounds of assessment were 100.00% and 94.54%, respectively. There was no significant difference in the performance evaluation scores between new and senior head nurses in terms of standardized services, nursing quality, nursing research and teaching, and patient satisfaction (P > 0.05). Conclusion: The competency model for nursing managers has a significant effect on the training of newly appointed head nurses. It effectively enhances management awareness, facilitates role transition, and, to some extent, improves the management and leadership capabilities of head nurses. It holds high value for broader implementation.

Clinical Study on the Treatment of Senile Alzheimer’s Dementia with Sodium Oligomannate Combined with Memantine Hydrochloride

Jian Zhao — 2024-10-28

Objective: To analyze the clinical effects of sodium oligomannate combined with memantine hydrochloride in the treatment of senile Alzheimer’s dementia. Methods: Sixty-eight cases of Alzheimer’s dementia treated at the Second People’s Hospital of Fujian University of Traditional Chinese Medicine from March 2020 to March 2022 were selected as the study subjects. The patients were divided into two groups based on different treatment methods: the control group (treated with memantine hydrochloride, 34 cases) and the treatment group (treated with sodium oligomannate + memantine hydrochloride, 34 cases). Cognitive function, activities of daily living, neurotransmitters, serum intestinal flora metabolic markers, inflammatory factors, neurotrophic factors, and adverse reactions were compared between the two groups. Results: The treatment group showed better cognitive function, quality of life scores, and levels of relevant metabolic markers in the body compared to the control group, with statistically significant differences (P < 0.05). The incidence of adverse reactions between the two groups (treatment group: 2%; control group: 4%) was not statistically significant (χ² = 0.731, P = 0.393). Conclusion: Sodium oligomannate combined with memantine hydrochloride has better efficacy than the control group for treating senile Alzheimer’s dementia. It significantly improves and restores cognitive function and daily living abilities, benefits neurotransmitter secretion and internal regulation, upregulates the expression of neurotrophic factors, and has fewer adverse reactions, making it a treatment worthy of further clinical promotion and application.

Evaluating the Impact of Transcutaneous Electrical Nerve Stimulation on Patients Undergoing Inguinal Hernia Surgery: A Meta-Analysis of Randomized Controlled Trials

Junfeng Li — 2024-10-25

Objective: A comprehensive meta-analysis based on the latest randomized controlled trials (RCTs) was conducted to investigate the effects of transcutaneous electrical nerve stimulation (TENS) on patients undergoing treatment after inguinal hernia surgery. Methods: A detailed search of Embase, PubMed, Web of Science, and the Cochrane Library was performed for RCTs investigating the use of TENS during inguinal hernia surgery up to September 28, 2021. The Cochrane tool was applied to assess the risk of bias in the included studies. Results: Seven eligible RCTs with a total of 379 cases were included. The meta-analysis showed a mean difference (MD) in VAS of -1.61 [95% CI: -2.20 – -1.02, P < 0.00001] at 2 hours post-operation, VAS MD = -1.33 at 4 hours post-operation [95% CI: -2.84 – -0.18, P = 0.09], VAS MD = -2.36 at 8 hours post-operation [95% CI: -4.04 – -0.69, P = 0.006], and VAS MD = -1.75 at 24 hours post-operation [95% CI: -2.64 – -0.85, P = 0.0001]. The cortisol level MD at 24 hours post-operation was -52.56 [95% CI: -168.8 – -63.76, P = 0.38]. Conclusion: TENS significantly reduces postoperative pain following inguinal hernia surgery and promotes patient recovery. TENS is recommended for patients undergoing inguinal hernia surgery. However, further high-quality studies are needed to confirm additional effects.

Identification and Antibacterial Activity Study of a Terrestrial Strain of Brevibacterium aureus 431

Jiedan Liao — 2024-10-25

This study isolated and purified strain 431 from an animal probiotic product. Through staining and microscopic examination, colony morphology analysis, biochemical reaction tests, and 16S rDNA sequence alignment, the strain was identified and named Brevibacterium aureus 431. The study focused on the production of biosurfactants by strain 431, and antibacterial activity tests were conducted on the strain and its secondary metabolites. The results showed that strain 431 exhibited no resistance to 10 commonly used drugs, and its concentrated secondary metabolites were highly sensitive to the indicator bacterium Escherichia coli. Oral administration of strain 431 to BALB/c mice resulted in normal mental state, diet, and bowel movements, with no signs of illness or death, indicating that strain 431 is highly safe and non-pathogenic to mice. The study suggests that Brevibacterium aureus 431 has significant research value as a new source of actinomycetes and that its secondary metabolites have potential application value in the development of antibacterial drugs.

Treatment Analysis of Limb Fractures Combined with Traumatic Shock

Mingwei Wang — 2024-10-28

Objective: To evaluate the treatment regimen and efficacy for limb fractures combined with traumatic shock (TS). Methods: A total of 88 patients with limb fractures combined with TS, admitted between January 2021 and December 2023, were selected. Patients were divided randomly using a numerical grouping method. The observation group underwent restricted fluid resuscitation combined with comprehensive treatment, while the reference group received conventional fluid resuscitation combined with comprehensive treatment. Recovery time, fracture prognosis, complications, severity of the condition, and post-fracture joint function were compared between the two groups. Results: The observation group showed shorter symptom recovery times, a higher rate of anatomical fracture reduction, and a lower complication rate compared to the reference group (P < 0.05). After one week of treatment, the severity score of the condition in the observation group was lower than that of the reference group, and all joint function scores were higher in the observation group (P < 0.05). Conclusion: Restricted fluid resuscitation combined with comprehensive treatment for limb fractures with TS can alleviate symptoms, improve fracture prognosis, reduce related complications, decrease the severity of trauma, and enhance joint function. The therapeutic effect is excellent.

Exploring the Role of Narrative Medicine in the Cultivation of Humanistic Spirit among Respiratory Medicine Interns

Yanhua Chen — 2024-10-28

Objective: To explore the role of narrative medicine in cultivating the humanistic spirit of respiratory medicine interns. Methods: Thirty interns were selected, all of whom were received by the respiratory department of our hospital from September 2023 to June 2024 and underwent narrative medicine teaching. Scores on narrative medicine knowledge, empathy ability, humanistic care ability, and teaching recognition were compared before and after the internship. Results: Compared to before the internship, the interns’ scores on narrative medicine knowledge were significantly higher after the internship, as were their empathy and humanistic care scores (P < 0.05). Among the 30 interns, 25 expressed interest in narrative medicine, and 29 were willing to continue with the narrative medicine teaching model. Conclusion: The application of narrative medicine in respiratory medicine internship teaching is highly effective. It cultivates the humanistic spirit of interns, improves their empathy and humanistic care abilities, and is worthy of wider implementation.

Comprehensive Analysis of CXCL6 Biological Significance in Head and Neck Squamous Cell Carcinoma

Muhammad Umair Abid — 2024-10-24

This study investigates the role of CXCL6 in head and neck squamous carcinoma (HNSC) through comprehensive expression and methylation analyses, genetic mutation analysis, and prognostic assessment. Utilizing the UALCAN dataset, CXCL6 expression analysis revealed a significant overexpression in HNSC cells compared to normal control samples, indicating its role in HNSC proliferation. Furthermore, an analysis of CXCL6 expression across different clinical parameters showed substantial up-regulation in various cancer stages, racial groups, gender, and age groups, underscoring its fundamental role in cancer progression. Validation of CXCL6 expression using the GEPIA2.0 online tool confirmed that CXCL6 was highly expressed in HNSC development compared to control samples. An analysis of CXCL6 expression across different stages of cancer revealed dysregulation in all four stages, with the highest expression in stage II and the lowest in stage III. This study also explored the promoter methylation levels of CXCL6, establishing a significant association between HNSC samples and normal controls. Examining promoter methylation across different clinical parameters revealed considerable variations, with distinct methylation patterns observed across cancer stages, racial groups, gender, and age. Overall survival (OS) and disease-free survival (DFS) analyses using the KM plotter tool demonstrated that high CXCL6 expression was associated with poorer OS compared to low expression levels. Similarly, DFS analysis showed that patients with low CXCL6 expression experienced better DFS outcomes compared to those with high CXCL6 expression. Finally, mutational analysis using cBioPortal revealed no significant mutations in HNSC samples. These findings highlight the complex involvement of CXCL6 in HNSC pathogenesis, underscoring its potential as a prognostic biomarker and therapeutic target in HNSC management.

Research Progress of Continuous Nursing for Patients with Chronic Wounds After Discharge

Zixuan Han — 2024-10-24

The research status of continuous nursing of patients with chronic wounds is reviewed. Since the research on continuous nursing of chronic wound patients in China is still in the initial stage, if necessary, learn from foreign experience, improve relevant systems, develop corresponding evaluation tools, actively implement telemedicine, and carry out hospital-community linkage models, etc. to provide high-quality nursing services for patients with chronic wounds.

Current Status of Diabetes Prevention and Control in China and Early-Stage Intervention Strategies

Yilin Zhao — 2024-10-28

In recent years, the prevalence of diabetes in China has continued to rise, with the adult prevalence expected to reach 12.8% by 2023. To control this trend, the government has introduced several policies and invested substantial funds in the prevention and treatment of diabetes, achieving certain results. Prediabetes is a stage where blood glucose metabolism can still be restored. For individuals in this stage, dietary and exercise intervention programs are recommended to prevent or delay the onset of diabetes, improve quality of life, and reduce the burden of disease on individuals, families, and society.

Study on the Application Effect of Enhanced Recovery After Surgery (ERAS) in Patients Undergoing Spinal Fracture Surgery

Yanan Niu — 2024-10-24

Objective: To study the application effect of the Enhanced Recovery After Surgery (ERAS) model in patients undergoing spinal fracture surgery. Methods: A randomized controlled trial was designed, and 86 patients undergoing spinal fracture surgery were randomly divided into the ERAS group and the conventional care group. Postoperative recovery outcomes of the two groups were compared. Results: The ERAS group showed better outcomes in terms of postoperative pain scores, activities of daily living, length of hospital stay, and adherence to rehabilitation training compared to the conventional care group, with shorter hospital stays and lower medical expenses (P < 0.05). Conclusion: The ERAS model significantly improves the postoperative recovery quality of patients undergoing spinal fracture surgery, reduces hospital stay and medical costs, and increases patient satisfaction.