Journal of Clinical and Nursing Research

Observation on the Clinical Effect of Traditional Chinese Medicine Fuzheng Quxie Tea Drinking Package in Treating Cancer of Zhengxu Xielian Type

Yongfu Dai — 2025-04-18

Objective: To explore the clinical efficacy of traditional Chinese medicine Fuzheng Quxie tea drinking package in the treatment of Zhengxu Xielian type cancer. Methods: In this study, 50 cases of Zhengxu Xielian type cancer admitted to our hospital from January 2020 to December 2021 were selected. They were divided into a control group (n = 25) and a treatment group (n = 25) according to the random number table method. The control group received conventional symptomatic treatment plus adjuvant therapy for cancer while the treatment group received traditional Chinese medicine Fuzheng Quxie tea drinking package plus conventional symptomatic treatment and adjuvant cancer therapy. Tumor marker indexes, quality of life scores, and fatigue scores before and after treatment were compared and analyzed between the two groups. Results: After treatment, the CEA, CA125, and NSE indexes in the treatment group were lower than those in the control group, and the differences were statistically significant (P < 0.05). After treatment, the quality of life scores of the treatment group were better, and the data between the two groups were statistically significant (P < 0.05). After treatment, the fatigue score of the observation group was significantly lower at 67.56 ± 4.69 compared to 110.59 ± 10.59 in the control group (t = 18.576, P < 0.05). Conclusion: The treatment of Zhengxu Xielian type cancer patients with traditional Chinese medicine Fuzheng Quxie tea drinking package can significantly reduce tumor marker indexes, improve patients’ quality of life, and reduce fatigue, which has clinical significance.

Correlation of Serum 25-hydroxyvitamin D Levels with Senile Hypertension and Its Stroke

Shasha Zang — 2025-04-29

Objective: Correlation of serum 25-hydroxyvitamin D level with senile hypertension and its stroke. Methods: Two hundred hypertensive patients admitted to the hospital from February 2022 to December 2023 were classified as study subjects. They were divided into grade 2 hypertension group and grade 3 hypertension group, and 100 healthy medical checkups admitted during the same period were analyzed as study subjects. Results: Comparison of diagnostic results between grade 2 hypertension and grade 2 hypertensive stroke patients, there was a difference in 25(OH)D, (P < 0.05). Comparison of test results between grade 3 hypertension and grade 3 hypertensive stroke patients, there was a difference in age, BMI, 25(OH)D, GLU, LDL-C, (P < 0.05). Serum 25-hydroxyvitamin D level is a high-risk factor for the occurrence of stroke in elderly hypertensive patients, so the probability of risk is higher, where 25(OH)D (ng/mL), GLU (mmol/L), there is a difference, (P < 0.05). Conclusion: There is a greater relationship between the occurrence of stroke and serum 25-hydroxyvitamin D level in elderly hypertensive patients. The occurrence of the disease has a greater relationship with this indicator in patients and is also a high-risk factor that affects the patients’ morbidity, so it is necessary to pay attention to the monitoring of this indicator after the onset of the disease in patients.

Observation on the Preventive Effect of Traditional Chinese Medicine Sachets on Influenza

Baijing Guo — 2025-04-29

Objective: To analyze the preventive effect of traditional Chinese medicine sachets on influenza. Methods: A total of 100 subjects meeting the inclusion criteria were recruited in a certain area based on population characteristics (age, occupation, gender). The subjects were divided into a sachet group (50 cases) and a control group (50 cases). The sachet group was given traditional Chinese medicine sachets with epidemic prevention and infection prevention effects (recommended to carry along or sniff intermittently, at least 3 times a day, each time not less than 1 minute. Replace the sachet medicine after one month when the scent disappears, and continue to use for 2 months). The control group did not receive any intervention measures. After the experiment, subjects filled out a questionnaire and an efficacy evaluation form. Results: Comparing the baseline data of the two groups, there was no statistical significance (P > 0.05). Comparing the symptoms of colds between the two groups, there was no significant difference in nasal congestion, rhinorrhea, and fatigue symptoms between the two groups (P > 0.05). However, the possibility of fever in the sachet group was much lower than that in the control group (P < 0.05). Comparing the immunoglobulins (IgA, IgM, and IgG) of the two groups before and after intervention, it was found that before the intervention, P > 0.50; after the intervention, the immunoglobulin levels of both groups increased, and the increase in the sachet group was much higher than that in the control group (P < 0.05). Comparing the occurrence of side effects in the two groups, it was found that the incidence of allergies in the sachet group was 4.00%. Due to allergies, two subjects withdrew from the study halfway (P > 0.05). Conclusion: In influenza, wearing traditional Chinese medicine sachets can effectively prevent colds and reduce the incidence of colds, but those who are allergic to sachets should use them with caution.

Study on the Correlation Between Night ECG Parameters and Sleep Quality in Elderly Patients with Atrial Premature Beat

Yaqian Huang — 2025-04-29

Objective: To explore the correlation between night ECG parameters and sleep quality in elderly patients with atrial premature beat (PAC). Methods: A total of 307 elderly patients with PAC were selected from March 2022 to March 2024. The parameters of room morning load and heart rate variability (HRV) at night (22:00–6:00) were collected by 24h holter electrocardiogram, and the sleep quality of PAC patients was evaluated by Pittsburgh Sleep Quality Index (PSQI). Multiple regression analysis was used to explore the correlation between night ECG parameters and sleep quality. Results: The incidence of sleep disorder in 307 elderly PAC patients was 62.54%. Univariate analysis showed that there were no statistically significant differences in gender, BMI and education level (P > 0.05), but there were statistically significant differences in age, disease course, underlying diseases, atrial morning load, SDNN, RMSSD, LF, HF, LF/HF and TP (P < 0.05). Multivariate Logistic regression analysis showed that atrial morning load, SDNN, RMSSD, LF and LF/HF were independent influencing factors of sleep disorder in elderly PAC patients (P < 0.05). Patients with sleep disorders were divided into mild group, moderate group and severe group according to PSQI score, and there were statistically significant differences in the indexes of atrial morning load, SDNN, LF, LF/HF and TP among the three groups (all P < 0.05). Spearman correlation analysis showed that room morning load, LF, LF/HF and TP were positively correlated with the degree of sleep disorder, while SDNN parameters were negatively correlated with the degree of sleep disorder (all P < 0.05). Conclusion: There is a significant correlation between night ECG parameters and sleep disorders in elderly patients with PAC. It is possible to prevent and treat sleep disorders by monitoring ECG abnormalities and improve the reliability of treatment.

Analysis of Adverse Reactions Caused by Antibiotics and Rational Drug Use in Clinical Practice

Hongyan Zhang — 2025-04-29

Objective: To explore the adverse reactions associated with antibiotics and analyze strategies for their rational use. Methods: A retrospective analysis was conducted on 60 patients who experienced adverse reactions to antibiotics between August 2021 and August 2023. The types of antibiotics that caused adverse reactions were analyzed, and the symptoms of adverse reactions and measures for rational use of antibiotics were summarized. Results: Among the analyzed cases of adverse reactions to antibiotics, the highest rate was observed in patients aged 61–75 years, accounting for 38.33%, followed by patients aged 51–60 years, accounting for 20.00%. In terms of the types of antibiotics that caused adverse reactions, cephalosporins were the most common, accounting for 40.00%, followed by penicillins, accounting for 18.33%. Analysis of the systems involved in adverse reactions showed that skin and appendage disorders were the most common, accounting for 36.67%, followed by the digestive system, accounting for 28.33%. Conclusion: Irrational use of antibiotics can lead to adverse drug reactions. Therefore, it is necessary to analyze strategies for the rational use of antibiotics to reduce adverse drug reactions and ensure the safety of antibiotic use.

In-depth Analysis of the Pathogenesis and Research Progress in Cutting-edge Treatment of Type III Acute Acquired Comitant Esotropia

Ling Jin — 2025-04-29

Type III acute acquired comitant esotropia (AACE) is a special type of binocular coordination disorder with sudden onset characteristics, but its pathogenesis and treatment strategies remain unclear. This article analyzes the incidence and classification characteristics of Type III AACE, and explores its pathogenesis from multiple perspectives including clinical medicine, neuroscience, and neuro-ophthalmology. It is found that this disease is associated with factors such as decompensation of phoria, dysfunction of the visual center, abnormalities in the physiological and anatomical structure of extraocular muscles, accommodative factors, and disorders of convergence and divergence. The prognosis of Type III AACE is excellent with treatments such as botulinum toxin injection and surgery, and adjunctive therapies like prism adaptation test and visual function training can enhance the management effect. This article provides an in-depth analysis of the pathogenesis and cutting-edge treatment techniques for patients with Type III AACE, which can offer guidance for the subsequent diagnosis and treatment of such patients.

Parameter Estimation of a Tumor Growth Model under Data-driven Approach and Its Numerical Solution in Matlab

Zhuo Chen — 2025-04-28

This paper focuses on the numerical solution of a tumor growth model under a data-driven approach. Based on the inherent laws of the data and reasonable assumptions, an ordinary differential equation model for tumor growth is established. Nonlinear fitting is employed to obtain the optimal parameter estimation of the mathematical model, and the numerical solution is carried out using the Matlab software. By comparing the clinical data with the simulation results, a good agreement is achieved, which verifies the rationality and feasibility of the model.

Empirical Study and Optimization Strategies of Psychological Support Measures for Psychiatric Medical Staff

Fengxia Qu — 2025-04-28

Objective: This study adopts empirical research methods to analyze the impact of intervention measures such as psychological counseling, team building, and stress management training on the mental health of psychiatric medical staff. Methods: This study selected 211 medical staff (including doctors, nurses, and psychotherapists) from the psychiatric department of a tertiary hospital as research subjects. They were divided into an experimental group (receiving psychological support measures) and a control group (not receiving psychological support measures) according to whether they received psychological support measures. Among them, the experimental group was divided into a total of 106 patients, while the control group was divided into a total of 105 patients. After the implementation of psychological support measures, the work efficiency of both groups of patients was evaluated from three aspects: psychological health level, occupational burnout level, and job satisfaction. Results: After intervention with psychological support measures, the experimental group patients showed significantly higher levels of mental health, occupational burnout, and job satisfaction than the control group, and the above differences were statistically significant (P < 0.05). Conclusion: For psychiatric medical staff, the regular implementation of psychological support measures can significantly improve their mental health level, and on the basis of psychological support, the professional enthusiasm and job satisfaction of medical staff have been significantly improved.

New Theories for Dental Disease Prevention and Treatment and Innovative Oral Products

Zhigang Hu — 2025-04-28

Dental diseases, especially dental caries, are significant issues affecting population health worldwide. Dental caries has been listed by the World Health Organization as one of the three key diseases to be prevented and treated, following cardiovascular diseases and cancer. It has a high incidence rate and a wide distribution, posing a serious threat to people’s oral health and quality of life^[1–5]. With the intensification of the global aging population and changes in dietary habits, the incidence of dental diseases is on the rise, becoming a public health problem that cannot be ignored. Therefore, exploring new theories for dental disease prevention and treatment, such as the bioelectrochemical theory and the mineralization and anti-electricity new theory, and discussing their application prospects can provide more effective scientific bases and methods for the prevention and treatment of dental diseases, which is of great practical significance, especially for children and the elderly.

An Investigation of the Effect of Visceral Acupressure Technique Combined with Physical Training on Improving Physical Anxiety in Adolescents

Jie Zheng — 2025-04-28

Purpose: To investigate the clinical effects of improving adolescents’ form anxiety after the intervention of visceral massage technique and form training. Methods: A total of 80 adolescent patients with scoliosis abnormalities were selected for this experiment, and they were intervened with form and body training and form and body training + visceral body acupressure techniques, and the anxiety and depression scores, spinal Cobb angle, vertebral body rotation of the parietal vertebrae, and the treatment efficiency were compared between the groups after the clinical interventions. Results: The anxiety and depression scores of patients in the form group were significantly higher than those of the combined group, P < 0.05; the improvement of the Cobb angle and vertebral rotation of the parietal vertebrae of patients in the combined group was better than that of the form group, P <0 .05; and the total effective rate of the treatment of patients in the form group was significantly lower than that of the combined group, P < 0.05. Conclusion: After intervening in adolescents’ abnormalities of form, patients were treated with a combination of the internal organs and body acupressure techniques and form training methods, and the results were compared between groups. After the joint intervention of the visceral massage technique and physical training, the patients’ scoliosis and other physical problems were positively improved, and the psychological status of the patients was relatively adjusted to ensure their physical and mental health.

Treatment of One Case of Pediatric Hand-Foot-Mouth Disease with Spleen Dampness-Heat Syndrome Using Acupoint Application Therapy to Disperse Dampness, Expel Heat, and Unblock the Fu Organs

Wangsen Zhao — 2025-04-28

The high incidence of hand, foot, and mouth disease (HFMD) in children, coupled with improper management, can lead to complications, causing significant distress to both patients and their parents. This article reports on the successful treatment of a case of HFMD with dampness-heat accumulation in the spleen type using a therapeutic approach of applying herbal patches to acupoints to disperse dampness, promote heat dissipation, and unblock the fu organs. The herbs selected primarily include honeysuckle, Forsythia, and mint to relieve the exterior and promote heat dissipation; Agastache and magnolia bark to transform and dry dampness; Scutellaria, blackberry lily, and licorice to clear heat, detoxify, and benefit the throat; and magnolia bark and bitter orange to unblock the fu organs and purge heat. The flexible combination of these herbs with acupoints such as Shenque, Zhongwan, Tiantu, and Feishu fully leverages the synergistic effects of both the herbs and acupoints, resulting in a significant therapeutic effect. This approach provides valuable insights and methodologies for the prevention and treatment of HFMD in children.

Research on the Pre-test Time Variable in Peripheral Blood Routine Analysis

Wei Li — 2025-04-30

Objective: To explore the accuracy and stability of the results of peripheral blood routine tests at different time points after anticoagulation and standing, providing a scientific basis for actual clinical work. Methods: In this study, 30 patients who visited the hospital in October 2023 were randomly selected and divided into two groups (15 cases in each group). The same collection method was used for routine blood tests. The tests were performed after anticoagulation and standing for 5 minutes, 1 hour, and 5 minutes, 2 hours respectively, and the routine blood test indicators at different time points were compared. Results: After comparison, there were no significant differences in the results of routine blood tests at 5 minutes after mixing, anticoagulating, and standing peripheral blood and those at 1 hour and 2 hours (P > 0.05). Conclusion: The results of peripheral blood after mixing, anticoagulating, and standing for 5 minutes are stable compared with those after standing for 1 hour and 2 hours. In actual work, the pre-test turnaround time can be appropriately extended.

Application of Modified Endoscopic Mucosal Resection and Endoscopic Submucosal Dissection in Treating Rectal Neuroendocrine Tumors and Prognostic Analysis

Yan Chen — 2025-04-28

Objective: To analyze the application value of modified endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) in rectal neuroendocrine tumors, with a view to providing new clinical options for the early diagnosis and treatment of patients with such tumors, and thus improving their prognosis. Methods: Seventy-two patients with rectal neuroendocrine tumors who underwent surgical treatment in a hospital between October 2023 and September 2024 were selected and divided into a control group and an observation group using the mean score method, each with 36 cases. In the control group, traditional foreign body forceps combined with laparoscopic resection were performed, and in the observation group, modified EMR and ESD were performed as needed. The mass resection rate, histologically intact resection rate, postoperative serum vascular endothelial growth factors (VEGFA, VEGFB, VEGFC levels) in the postoperative period of 7d, and indicators of the rate of related complications of the two groups of patients were compared. Results: The mass resection rate of 91.67% and histological complete resection rate of 94.44% in the observation group were significantly higher than those of 72.22% and 66.67% in the control group; the VEGFA, VEGFB, and VEGFC levels of the observation group were 82.08 ± 7.94 ng/ml, 168.89 ± 16.53 ng/ml, and 121.07 ± 10.75 ng/ml, respectively, in the postoperative period of 7 d after surgery; the levels were significantly higher than those of the control group: 68.39 ± 6.82 ng/ml, 141.06 ± 14.12 ng/ml, and 98.45 ± 9.87 ng/ml, respectively, and the difference was statistically significant (P < 0.05); the patients in the observation group had a lower rate of surgical complications than those in the control group (2.78% vs 8.33%), the difference was not statistically significant (P > 0.05). Conclusion: Modified EMR and ESD in rectal neuroendocrine tumors are effective, not only can it effectively improve the rate of mass resection and histological integrity of the resection rate, but it can also further improve the level of serum vascular endothelial growth factor (VEGFA, VEGFB, VEGFC); thus, it is recommended to be promoted for use in clinical practice.

Research on the Application Value of the Extended Nursing Intervention Model in Senile Dementia Patients

Fang Yu — 2025-04-30

Objective: To explore the application value of the extended nursing intervention mode in senile dementia patients. Methods: A total of 60 cases of Alzheimer’s disease patients were selected as the research subjects and divided using the random number table method into the control group and the observation group, each with 30 cases. The control group adopted conventional nursing, while the observation group adopted the extended nursing model of this study. The self-care ability, quality of life, cognitive function, and the frequency of unsafe behaviors were compared between the two groups. Results: After 6 months of intervention, the results showed that the scores of all dimensions in the relevant data tables such as the activity of daily living (ADL) scale, simple intelligence scale, and health survey scale in the observation group were higher than those in the control group, and the differences were statistically significant (P < 0.05). The incidence of unsafe behaviors in the observation group was lower than that in the control group, and the difference was statistically significant (χ² = 5.963, P < 0.05). Conclusion: Extended nursing plays a positive role in the nursing of Alzheimer’s patients, including improving their cognitive function and restoring their self-care ability, so as to significantly improve their quality of life and reduce the occurrence of unsafe behaviors. It can be seen that the extended nursing intervention mode can be vigorously promoted in clinical practice.

Evaluation of the Efficacy of Endoscopic Submucosal Dissection for the Treatment of ≥ 40 mm Protruding Colorectal Tumors

Yan Chen — 2025-04-28

Objective: To explore the effectiveness and safety of endoscopic submucosal dissection (ESD) in the treatment of ≥ 40 mm protruding colorectal tumors. Methods: Sixty-five patients with colorectal tumors who underwent surgical treatment in the Department of Anorectal Surgery of a hospital from July 2023 to June 2024 were selected and grouped according to the type of surgery, with 33 cases of endoscopic mucosal resection (EMR) patients included in the control group, and 32 cases of ESD patients included in the observation group. The surgical characteristics, adverse events, as well as the fasting time, postoperative hospital stay, and hospital costs of the two groups were compared. Results: The whole resection rate of the control group and the observation group was 100% and 69.70%, respectively, and the difference was statistically significant (P < 0.05); there was no incidence of intraoperative hemorrhage, delayed hemorrhage, and perforation adverse events in the observation group, and the intraoperative hemorrhage rate of the control group was 9.09%, the delayed hemorrhage rate was 6.06%, and the perforation rate was 3.03%, and the difference was statistically significant (P < 0.05); postoperative fasting time in the control group and observation group was 1.13 ± 0.32 d vs 1.22 ± 0.33 d, postoperative hospital stay was 4.1 ± 1.3 d vs 4.6 ± 1.5 d, and total hospitalization cost was 9,639.8 ± 1,303.5 yuan vs 9,978.6 ± 1,506.8 yuan, with statistically significant differences (P > 0.05). Conclusion: The efficacy of endoscopic submucosal dissection for the treatment of ≥ 40 mm protruding colorectal tumors is precise, with a high rate of whole resection, which can significantly reduce the risk of intraoperative bleeding, delayed bleeding, perforation, and other adverse events.

Exploring the Effectiveness of a Rapid Diagnostic Kit for Identifying Snake Venom Types in Blood Tests

Linfeng Zheng — 2025-04-29

Objective: To develop a rapid diagnostic kit for identifying snake venom types, aimed at providing a basis for clinical diagnosis and laying a foundation for early treatment through quick blood testing of injured patients. Methods: Anti-snake venom immunoglobulin (IgG) was prepared, biotinylated specific IgG was screened, detection enzyme-labeled strips were produced, and rapid identification of snakebites was performed. Pre-experimental verification was conducted to establish standard curves and confirm specificity. The kit was tested on clinical samples and the results were analyzed. Repeatability and stability were evaluated through multiple repeated tests and experiments under different storage conditions. Finally, sensitivity and specificity were calculated, receiver operating characteristic curves (ROC curves) were drawn, and statistical analysis software was used for data analysis to ensure the reliability and effectiveness of the kit. Results: The test showed high sensitivity and specificity. Conclusion: The rapid diagnostic kit for identifying snake venom types in blood tests demonstrates high reliability and effectiveness in clinical diagnosis.

Correlation between Disease Uncertainty and Psychological Distress in Hospitalized Patients with Primary Liver Cancer

Dezhen Cui — 2025-04-29

Objective: To explore the correlation between disease uncertainty and psychological distress in hospitalized patients with primary liver cancer, providing a basis for clinical nursing interventions. Methods: A convenient sampling method was used to select 82 patients with primary liver cancer from a tertiary first-class hospital in Guangzhou from September 2023 to March 2024 as the research subjects. General information questionnaires, the Mishel Uncertainty in Illness Scale-Adult Version (MUIS-A), and the Kessler Psychological Distress Scale (K10) were used for investigation. Pearson correlation analysis and linear regression analysis were performed to explore the relationship between the two. Results: The total score of disease uncertainty in hospitalized patients with primary liver cancer was (99.20 ± 8.79), and the total score of psychological distress was (22.87 ± 9.46), both at a medium level. There was a positive correlation between disease uncertainty and psychological distress (r = 0.360, P < 0.01), and the ambiguity dimension had the strongest correlation with psychological distress (r = 0.399, P < 0.01). Regression analysis showed that the ambiguity dimension had a significant predictive effect on psychological distress (β = 0.399, P < 0.01). Conclusion: There is a close correlation between disease uncertainty and psychological distress in patients with primary liver cancer. In clinical nursing, it is necessary to pay special attention to patients’ ambiguity regarding disease symptoms and prognosis. Targeted health education should be carried out to reduce their uncertainty, thereby improving their psychological state.

Exploration of the Application of Remote Ischemic Conditioning in Nursing of Cardiac Arrest

Yi-maizi Xu — 2025-04-29

Cardiac arrest (CA) is a major global public health challenge, and its high morbidity and low survival rate pose severe tests for emergency and critical care. Although modern CPR techniques significantly improve the immediate resuscitation success rate in CA patients, poor outcomes such as neurological impairment still significantly increase the long-term care burden and reduce the quality of survival. In recent years, the application of remote ischemic conditioning (RIC) has attracted much attention in the field of cardiac arrest through its unique myocardial-nerve dual protection mechanism against the heart. This paper summarizes the conceptual connotation, physiological mechanism, operation method, and its application progress in CA and explores the potential of this technology in the field of CA care in order to provide reference for the research and application of RIC in the field of emergency care.

Predictive Modeling of Comorbid Anxiety in Young Hypertensive Patients Based on a Machine Learning Approach

Haiyan Xiao — 2025-04-28

Objective: To analyze the risk factors of anxiety in young hypertensive patients and build a prediction model to provide a scientific basis for clinical diagnosis and treatment. Methods: According to the research content, young hypertensive patients admitted to the hospital from January 2022 to December 2024 were selected as the research object and at least 950 patients were included according to the sample size calculation. According to the existence of anxiety, 950 patients were divided into control group (n = 650) and observation group (n = 300), and the clinical data of all patients were collected for univariate analysis and multivariate Logistic regression analysis to get the risk factors of hypertension patients complicated with anxiety in. All patients were randomly divided into a training set (n = 665) and a test set (n = 285) according to the ratio of 7:3, and the evaluation efficiency of different prediction models was obtained by using machine learning algorithm. To evaluate the clinical application effect of the prediction model. Results: (1) Univariate analysis showed that age, BMI, education background, marital status, smoking, drinking, sleep disorder, family history of hypertension, history of diabetes, history of hyperlipidemia, history of cerebral infarction, and TC were important risk factors for young hypertensive patients complicated with anxiety. (2) Multivariate Logistic regression analysis showed that hypertension history, drinking history, coronary heart disease history, diabetes history, BMI, TC, and TG are important independent risk factors for young hypertensive patients complicated with anxiety. (3) Extra Trees has the highest predictive power for young people with hypertension complicated with anxiety, while Decision-Tree has the lowest predictive power. Conclusion: Hypertension history, drinking history, coronary heart disease history, diabetes history, BMI, TC, and TG are important independent risk factors that affect the anxiety of young hypertensive patients. Extra Trees model has the best prediction efficiency among different groups of models.

The Effect of the Medical and Nursing Integration Model in the Care of Patients Undergoing Inguinal Hernia Surgery

Qian Sun — 2025-04-28

Objective: To explore the application effect of the care of patients with inguinal hernia surgery, medical and nursing integration model with a view to providing help for the optimization of clinical surgical care program. Methods: Seventy-eight inguinal hernia patients who underwent surgical treatment in a hospital during the period of December 2023 to November 2024 were selected and divided into a control group and a study group, each with 39 cases, using the mean score method. The control group was given the usual clinical surgical care model, and the observation group was given the medical and nursing integration model, and the nursing effects of the two groups were compared. Results: The postoperative pain level score of patients in the observation group (2.23 ± 0.52) was lower than that of the control group (3.86 ± 1.02); the gastrointestinal recovery time of patients in the observation group (23.12 ± 4.06h), and the time to get out of bed (15.42 ± 4.19d) were shorter than that of the control group (29.53 ± 3.47 h) and (20.85 ± 3.08 d), and the differences were statistically significant (P < 0.05); postoperative sleep efficiency score (the observation group 5.12 ± 1.14), sleep disorder score (6.42 ± 1.29), time to sleep score (7.56 ± 1.57), and daytime function score (6.25 ± 1.19) in were significantly lower than those in the control group [(7.46 ± 1.29), (8.63 ± 1.41), (10.37 ± 1.38), and (8.49 ± 1.24), respectively], with the differences being statistically significant (P < 0.05).; the incidence of complications such as urinary retention, local hematoma, and incision infection during the treatment period of the patients in the observation group (2.56%) was significantly lower than that of the control group (20.51%), and the difference was statistically significant (P < 0.05); in the observation group, the patient care satisfaction (97.44%) was significantly higher than that of the control group (76.92%), and the difference was statistically significant (P < 0.05). Conclusion: The integrated model of medical care has significant advantages in the care of patients undergoing inguinal hernia surgery, which can effectively alleviate postoperative pain, shorten the gastrointestinal recovery time and the time to get out of bed, and at the same time significantly improve the quality of patient’s sleep, and reduce the risk of complications such as urinary retention, local hematomas, and incisional infections, to obtain a higher degree of satisfaction from patients, and it is recommended that it should be popularized and applied in other medical departments.

Research on the Role of Ezrin in Glucose and Lipid Metabolism

Ruyuan Zhang — 2025-04-29

Ezrin, as a key connecting protein between the cytoskeleton and cell membrane, plays an important role in various cellular physiological processes. In recent years, people have gradually attached importance to its research in the field of glucose and lipid metabolism. Based on relevant research materials, this article elaborates the structure and function of Ezrin, and focuses on its role and potential mechanism in the diseases related to abnormal glucose and lipid metabolism, such as diabetes and its complications, to provide new ideas and theoretical basis for in-depth understanding of the regulation of glucose and lipid metabolism and the prevention and treatment of related diseases.

Application Value of Bundle Management in Safe Nursing Care for Patients with Autoimmune Encephalitis

Ying Cui — 2025-04-29

Objective: To explore the application effect of bundle management in the safe nursing of patients with autoimmune encephalitis. Methods: Seventy-five patients with autoimmune encephalitis who met the inclusion criteria in our hospital from January 2024 to June 2024 were randomly divided into two groups: an observation group of 39 patients and a control group of 36 patients. The control group received routine nursing care, while the observation group implemented a bundle management strategy based on routine nursing care. Safety nursing outcomes, clinical symptom improvement time, hospital stay, and neurologic function recovery were observed in both groups. Results: The incidence of adverse events in the observation group was 12.82%, significantly lower than the 33.33% in the control group, with a statistically significant difference (P < 0.05). There was no statistically significant difference in restraint usage and ICU transfer rates between the two groups (P > 0.05). The clinical symptom improvement time, hospital stay, and neurologic function recovery in the observation group were significantly better than those in the control group, with a statistically significant difference (P < 0.05). Conclusion: Through the bundle management model, effective connections can be ensured in various aspects of treatment and rehabilitation for patients with autoimmune encephalitis, providing patients with comprehensive and multi-level nursing services and improving their overall satisfaction and treatment effectiveness.

Real-world Clinical Study of Recombinant Human Growth Hormone in the Treatment of Idiopathic Short Stature

Jianhua Liu — 2025-04-29

Objective: To investigate the clinical efficacy and safety evaluation of Polyethylene Glycol Recombinant Human Growth Hormone Injection (PEG-rhGH) in the treatment of idiopathic short stature. Methods: A total of 1402 patients were enrolled from March 21, 2024 to January 13, 2025, including 778 males and 624 females, with ages mainly ranging from 5 to 13 years old. Follow-up visits were completed by 488 patients for the first time, 174 patients for the second time, and 81 patients for the third time. All patients were treated with PEG-rhGH (Jin Sai Zeng) as the main therapy after admission. The changes in height information, IGF-1, and thyroid examination results of each patient at the initial diagnosis, 6, 9, and 12 months after treatment were observed and analyzed. Results: There was no statistical difference between the baseline and the initial diagnosis, as well as the second follow-up visit (P < 0.05), while there was a statistical difference between the baseline and the first and third follow-up visits (P > 0.05). There was a statistically significant difference in IGF-1 between the initial diagnosis and the first follow-up visit (P < 0.05), but no statistical difference between the first, second, and third follow-up visits (P > 0.05). Additionally, IGF-1 levels increased with time. There was no statistical difference in TSH between the initial diagnosis and the first, second, and third follow-up visits (P > 0.05). There was a statistical difference in free T3 between the initial diagnosis and the first and second follow-up visits (P<0.05), but no statistical difference between the second and third follow-up visits (P>0.05). There was no statistical difference in free T4 between the initial diagnosis and the first and second follow-up visits (P > 0.05), but there was a statistical difference between the second and third follow-up visits (P < 0.05). Conclusion: PEG-rhGH (Jin Sai Zeng) is significantly effective in improving height and IGF-1 levels in patients with idiopathic short stature.

Nursing Effects of Routine Care and Specialized Nursing Intervention on Patients with Dysphagia during Acute Stroke

Dandan Shi — 2025-04-29

Objective: To compare the nursing effects of routine care and specialized nursing intervention on patients with dysphagia during acute stroke. Methods: A total of 188 patients with acute stroke and dysphagia who received treatment at our hospital from May 2022 to December 2024 were selected as study subjects. The patients were randomly divided into a control group and an observation group, with 94 patients in each group. The control group received routine nursing intervention, while the observation group received specialized nursing intervention. The general information, swallowing function, quality of life, and nursing satisfaction were compared between the two groups. Results: There was no statistically significant difference in general information between the two groups (P > 0.05). The SAS score of the observation group after nursing was significantly lower than that of the control group (t=19.463, P = 0.000 < 0.001). After intervention, the number of patients with lung infection in the observation group was significantly lower than that in the control group (χ2=7.309, P = 0.007 < 0.01). The overall quality of life score of the observation group was significantly better than that of the control group after intervention (P < 0.001). The nursing satisfaction of the observation group was significantly higher than that of the control group (χ² = 15.865, P = 0.000 < 0.001). Conclusion: Compared with routine care, specialized nursing intervention can effectively improve the swallowing function of patients with dysphagia during acute stroke, enhance their quality of life, and increase nursing satisfaction.

A Study on Balancing the Demands of Patients’ Families and the Responsibilities of Medical Staff in Medical Emergencies: Starting from the Xiao Zhijun Case and the Yulin Pregnant Woman Case

Yuji Lin — 2025-04-29

Through analyzing the cases of Xiao Zhijun and the Yulin maternal jumping incident, the authors found significant disputes between the requests for non-indicated cesarean section and medical risk prevention, as well as between the psychology of avoiding childbirth pain and surgical responsibility. Currently, based on people’s current awareness and the responsibility orientation of expert opinions in disputes, medical institutions tend to satisfy family members’ surgical requirements after fulfilling their obligation to fully inform about risks, to reduce the risk of losing disputes. This phenomenon actually reflects the contradiction between the demands of patients’ families and the responsibilities of medical staff in medical decision-making. To balance the responsibilities of medical staff and the demands of patients’ families, the authors believe that multiple governance paths need to be constructed: first, optimizing the level of medical staff’s communication; second, strengthening medical risk science popularization relying on modern information technology to improve patients’ risk cognition ability; and third, raising society’s correct understanding of cesarean section through multiple channels. These measures can help to enhance patients’ trust in hospital diagnosis and treatment results and promote harmonious development of doctor-patient relationships.

Progress in Interventional and Surgical Treatment of Obstructive Hypertrophic Cardiomyopathy

Youjin Qiao — 2025-04-29

To improve the treatment effect of obstructive hypertrophic cardiomyopathy, this article focuses on the treatment of obstructive hypertrophic cardiomyopathy and conducts a comprehensive analysis of the disease. It highlights the limitations of traditional treatment methods and elaborates on interventional and surgical treatments. Additionally, this article compares the indications, risks, treatment effects, and costs of the two different treatment methods, providing a reference for doctors and patients in selecting clinical treatment plans.

The Clinical Application Value of Bundled Nursing Care in Postoperative Recovery of Lung Cancer Patients

Cuifang Liu — 2025-04-29

Objective: To investigate the clinical application value of bundled nursing care in postoperative recovery of lung cancer patients. Methods: Eighty lung cancer patients who underwent surgical treatment from October 2022 to May 2024 were selected as the study subjects. Their clinical data were retrospectively analyzed and grouped by nursing methods. The bundled nursing care group (n = 40) received bundled nursing care, while the conventional nursing care group (n = 40) received routine nursing care. Lung function, immune function, complication rate, pain level, exercise tolerance, and quality of life were compared between the two groups. Results: Before nursing, there were no statistically significant differences in lung function, immune function, pain level, exercise tolerance, and quality of life between the bundled nursing care group and the conventional nursing care group (P > 0.05). After nursing, both groups showed improvement in lung function, immune function, pain level, exercise tolerance, and quality of life, but the bundled nursing care group had better results and a lower complication rate, with statistical significance (P < 0.05). Conclusion: The bundled nursing care has a higher clinical application value in postoperative recovery of lung cancer patients and is worthy of widespread clinical use.

Study on Synergistic Effect of Eye Care and Drug Therapy in Patients with Dry Eye

Hui Guo — 2025-04-29

Objective: The aim of this study was to evaluate the synergistic effect of eye care and drug therapy in patients with dry eye. Methods: A total of 59 patients with dry eye diagnosed and treated in our hospital were randomly divided into the reference group (29 cases) and the experimental group (30 cases). Patients in the reference group received only the usual medication, while the experimental group received additional eye care. The treatment response and the improvement of quality of life were evaluated by comparing the treatment excellence rate, quality of life score, and nursing satisfaction score of the two groups. Results: The rate of excellent treatment in the experimental group was 93.33%, which was significantly higher than that in the reference group (68.97%) (P = 0.013). The quality of life scores in social function, psychological function and physiological function of the experimental group were significantly higher than those of the reference group (P < 0.003), the nursing satisfaction score and symptom score were also improved more significantly (P < 0.003), and the SAS score was decreased more (P < 0.003). Conclusion: The synergistic effect of comprehensive eye care and drug therapy on patients with dry eye can significantly improve the rate of good treatment and quality of life score, increase the nursing satisfaction of patients, and have potential benefits to improve psychological status, providing an effective way for the management of dry eye.

Exploring the Relationship between Obesity, Body Fat Percentage, Abnormal Blood Lipid Levels, and Prediabetes

Zhuangzhuang Luo — 2025-04-29

Objective: To explore the relationship between obesity, body fat percentage (BF%), blood lipid levels, and prediabetes. Methods: A total of 91 patients with prediabetes who visited the hospital from February 2024 to February 2025 were included in the observation group, and 90 healthy individuals with normal blood glucose levels during the same period were included in the control group. Physical examination, body fat percentage, and biochemical indicators were checked, and the relationship between these indicators and prediabetes was analyzed. Results: The observation group had higher body weight (BW), waist circumference (WC), body mass index (BMI), fat mass (FM), total cholesterol (TC), low-density lipoprotein (LDL), triglycerides (TG), fasting blood glucose (FBG), and 2-hour postprandial blood glucose (2hPG) compared to the control group, with P < 0.05. The detection rates of obesity, abnormal WC, abnormal body fat percentage (BF%), abnormal TC, abnormal TG, and abnormal LDL were higher in the observation group than in the control group, with P < 0.05. Multivariate logistic regression analysis showed that WC, TC, TG, BF%, and BMI were independent high-risk factors for prediabetes, with P < 0.05. Conclusion: Obesity and dyslipidemia are high-risk factors for prediabetes. Scientific dietary planning and weight management should be implemented to reduce the incidence of diabetes.

Advances in Research on the Use of ICU Diaries in Post-ICU Syndrome

Mingyue Yang — 2025-04-29

This article reviews the concept of ICU diary and the related contents of post-ICU syndrome, focuses on the current application status of ICU diary in post-ICU syndrome, problems faced, and suggestions for improvement, aiming to provide a reference basis for improving the physical and mental health of ICU patients and their families.

Investigation and Analysis of Professional Identity and Research on Influencing Factors of Nursing Students before and after Clinical Practice

Junfan Liu — 2025-04-29

Objective: To analyze the related factors affecting the professional identity of nursing students before and after clinical practice, hoping to provide reference for the career development and education of nursing students. Methods: A total of 393 undergraduate nursing students of grade 2020 from the Department of Nursing of a university in Shanxi Province were selected. The professional choice motivation, educational attainment expectation, future career planning, professional practice, and employment prospect expectation of nursing students before clinical practice, and the willingness to upgrade educational attainment, professional experience, career development expectation, and employment planning of nursing students after clinical practice were investigated. Through statistical analysis of the survey data, the related influencing factors affecting the professional identity of nursing students before and after clinical practice were explored. Results: The observation of general data showed that the proportion of female students in the survey sample was higher than that of male students, and the proportion of those whose family residence was in rural areas was slightly higher than that in urban areas. The analysis of students’ own situation showed that nursing students chose the nursing major because of the high expected employment rate, but they were generally anxious about the employment prospect before the internship, showing a contradictory mentality. The analysis of students’ professional ability showed that nursing students believed that their professional ability was mainly reflected in the vocational adaptability. The analysis of the social environment showed that the educational attainment expectations of nursing students were mainly undergraduate and master’s degrees, and they preferred to engage in clinical nursing work rather than nursing research. The analysis on the selection of internship hospitals shows that nursing students’ choice of internship hospitals is mainly influenced by the duration of the internship, and they consider the correlation between the selection of internship hospitals and future employment decisions to be low. The analysis on the surrounding environment such as family and school shows that the professional identity of nursing students is mainly influenced by the opinions of school teachers and parents, but the occupations of most of the family members of nursing students are not related to medicine. Conclusion: Targeted intervention strategies should be formulated based on the relevant influencing factors that affect the professional identity of nursing students before and after clinical internship, to enhance the professional identity and employment confidence of nursing students, and promote the healthy and sustainable development of nursing education and the medical service industry.

Visual Analysis of Postoperative Nursing Research of Ureterocutaneostomy based on CiteSpace

Yan Lu — 2025-04-29

Objective: To conduct a visual analysis of the current status and hotspots in the postoperative nursing of ureterocutaneostomy based on CiteSpace, in order to provide an evidence-based basis for the research direction and thinking in this field. Methods: In this study, the subject words and free words were used to search the China National Knowledge Infrastructure (CNKI), Wanfang Database, VIP Database, and Web of Science Core Database as the literature sources. The search time limit was from January 1, 1999 to December 31, 2024. CiteSpace 6.3. R2 software was used to conduct a visual analysis of the publication volume, authors, and keyword clusters of the literature related to ureterocutaneostomy nursing. Results: A total of 129 Chinese literary works were finally included. The results showed that 2019 was the peak year of publication volume (20 domestic articles); the First Affiliated Hospital of Nanchang University was the institution with the highest publication volume (13 articles); the high-frequency keywords included “bladder cancer” (42 times), “nursing” (29 times), and “quality of life” (16 times); the keyword cluster analysis showed that the research hotspots were concentrated in complication management, continuous nursing, and the application of intelligent technology. Conclusion: The nursing of ureterocutaneostomy has developed from a single technical operation to a multi-dimensional comprehensive intervention system, and the nursing shows a trend of multidisciplinary integration. In the future, it is necessary to strengthen the research and development of intelligent technology, the promotion of standardized nursing processes, and the balanced allocation of regional resources.

Application and Practice of Characteristic Traditional Chinese Medicine Nursing Techniques in the Colorectal Department

Xifeng Li — 2025-04-29

Objective: To explore the application effect and value of characteristic traditional Chinese medicine (TCM) nursing techniques in the colorectal department in clinical practice, in order to provide references for improving the nursing quality of patients and promoting their rehabilitation. Method: The colorectal department of Hospital A began to implement characteristic TCM nursing techniques in January 2023. Therefore, 100 patients admitted to the colorectal department from September 2022 to December 2022 were set as the control group, and 100 patients admitted from January 2023 to April 2023 were taken as the experimental group. The experimental group adopted characteristic TCM nursing techniques, including comprehensive measures such as herbal enema therapy, TCM hip bath, acupoint massage and application, and emotional care; the control group adopted conventional Western medicine nursing methods. The application effect and value of characteristic TCM nursing techniques in the clinical practice of the colorectal department were evaluated by comparing indicators such as the frequency of use, the proportion of treated patients, the number of types, and patient satisfaction between the two groups. Result: After using the characteristic TCM nursing techniques, the recovery speed of the patients in the experimental group was significantly accelerated, and the incidence of complications was significantly reduced. Specifically, the average hospital stay of the patients in the experimental group was shortened by approximately 20% compared with the control group. At the same time, the pain score of the patients in the experimental group was also significantly lower than that of the control group. In addition, the satisfaction rate of the patients in the experimental group with the nursing service was as high as 95%, significantly higher than 80% of the control group. Conclusion: The application and practice of the characteristic TCM nursing techniques in the colorectal department have shown significant advantages in improving the recovery speed of patients and the quality of nursing services, and can be further promoted in clinical practice.

Practical Analysis of the Matrix Medical Administration Model to Improve Medical Safety Level

Wei Yang — 2025-04-30

Objective: To analyze the effectiveness of the matrix medical administration model in enhancing medical safety management. Method: A total of 39 medical incidents in the hospital from September 2020 to September 2022 were selected as the reference group, implementing conventional medical administration. Another 39 medical incidents from October 2022 to October 2024 were chosen as the experimental group, adopting the matrix medical administration model. The practical indicators such as causes of medical disputes, dispute compensation, medical injury appraisal results, and diagnosis and treatment quality indicators were compared between the two groups. Results: In the experimental group, the primary reasons for medical disputes were patient-related, and most disputes resulted in no compensation. After medical injury appraisal, most cases were not considered medical injuries. The comparison between the two groups was statistically significant (P < 0.05). The diagnosis and treatment quality indicators of the experimental group were superior to those of the reference group (P < 0.05). Conclusion: The matrix medical administration model can reduce medical disputes caused by hospital factors, decrease the proportion of compensation and the incidence of medical injuries, and improve the quality of diagnosis and treatment, demonstrating high management effectiveness.

Application of Full Disease Course Management via Internet Platform in Rehabilitation Management of Patients with Depression

Yuqing Yao — 2025-04-30

Objective: To observe the application effect of full disease course management via an internet platform in the rehabilitation management of patients with depression. Methods: Eighty patients with depression meeting the inclusion criteria were selected as the study subjects and randomly divided into an experimental group and a control group, with 40 patients in each group. The control group was followed up every 4 weeks for 12 weeks after discharge. The experimental group underwent full disease course management via an internet platform for 12 weeks after discharge. The quality-of-life scores, depression scores, medication compliance, insight and treatment attitude questionnaire scores, and self-efficacy scores were compared between the two groups. Results: After 12 weeks of follow-up, the experimental group had higher quality-of-life scores, lower depression scores, higher medication compliance, higher insight and treatment attitude scores, and higher self-efficacy scores than the control group (P < 0.05). Conclusion: Full disease course management via an internet platform has a positive impact on the quality of life, medication compliance, self-efficacy, and disease stability of discharged patients with depression.

The Association between Cardiometabolic Multimorbidity and Frailty among Middle-Aged and Older Adults in China

Qinrou Yu — 2025-04-29

Objective: To explore the association between cardiometabolic multimorbidity and frailty among middle-aged and older adults in China. Methods: Data were derived from the 2013 wave of the China Longitudinal Healthy Longevity Survey, including a total of 6,179 individuals aged 45 years and above with complete follow-up records. Basic demographic information was collected, and frailty status was assessed using a physical frailty scale. Generalized linear models were employed to analyze the association between the number and combinations of cardiometabolic conditions—such as hypertension, diabetes, heart disease, and stroke—and frailty. Results: The prevalence of cardiometabolic multimorbidity among middle-aged and older adults was 14.23%. After adjusting for sociodemographic covariates, individuals with cardiometabolic multimorbidity had a significantly increased risk of frailty compared to those without such conditions (OR = 1.78, 95% CI: 1.45–2.19), along with higher frailty scale scores (β = 0.26, 95% CI: 0.19–0.34). Compared to individuals without cardiometabolic diseases, those with both hypertension and stroke (OR = 1.18, 95% CI: 1.06–1.31) and those with hypertension, heart disease, and stroke (OR = 1.46, 95% CI: 1.24–1.73) exhibited notably higher frailty risks. Conclusion: There is a significant association between cardiometabolic multimorbidity and frailty in middle-aged and older adults in China, particularly for comorbidity patterns involving hypertension. These findings provide evidence for developing targeted health interventions for aging populations.

Effects of 0.01% Atropine Eye Drops on Horizontal Meridian Choroidal Thickness Profile in Low to Moderate Myopic Children

Yun Tang — 2025-04-29

Purpose: To examine the changes in choroidal thickness (ChT) after 6-month topical treatment of 0.01% atropine eye drops in myopic children. Methods: A total of 46 low to moderate myopic children aged 8 to 12 years were recruited and received topical 0.01% atropine once a day for 6 months. Spherical equivalent (SE), axial length (AL), and ChT were measured at baseline, 3 months, and 6 months. Results: During the first and second 3-month treatment, there is no significant decrease in progression of SE and AL. Within the range of 3 mm from the temporal side of the fovea to the nasal side, no significant changes in ChT have been observed at any measuring points in low and moderate myopic participants. Changes in ChT were not significantly associated with gender or AL progression. Conclusion: A 6-month topical treatment of 0.01% atropine could not cause significant changes in ChT in myopic children.

Observation on the Intervention Effect of Emergency Rescue Capability Among College Students

Beiyan Zhang — 2025-04-29

Objective: To explore the application effect of emergency rescue capability intervention among students in a university in Beijing. Methods: A total of 900 students from a university in Beijing in 2023 were selected as the research objects. Emergency rescue capability training was conducted from March 2023 to June 2023, once a month. The students’ mastery of emergency rescue before and after the intervention was analyzed. Survey questionnaires were distributed to all college students to understand their channels and willingness to acquire emergency rescue knowledge. Results: A total of 886 valid questionnaires were collected in this study. The highest proportion of knowledge about China’s general emergency telephone number and how to dial the emergency rescue hotline was 100.00%. Among the strategies for dealing with cardiac arrest in CPR, the highest proportion was 336.34%. Among the four major first aid techniques of hemostasis, bandaging, fixation, transportation, the highest proportion of knowledge about the use of rubber band signs was 31.71%. Among the first aid techniques for heatstroke, poisoning, fire, and sharp instrument injuries, the principle of emergency treatment for severe gas poisoning had the highest proportion of 41.42%, showing significant differences. College students mainly acquire knowledge of emergency rescue capability through TV programs, health education lectures, and the internet. Around 61.40% of college students hope to learn more about prevention and control knowledge. Conclusion: After the intervention of emergency rescue capability, the emergency rescue capability of college students in this university has been significantly improved, showing a strong training effect, which is worthy of promotion.

Development of a Disposable Care Package for PICC Disinfection in Postoperative Clinical Surgical Patients

Peili Shi — 2025-04-28

Objective: To design a disposable care package for postoperative PICC disinfection for the daily maintenance of postoperative indwelling PICC catheter patients, save the operation time of nurses, reduce the operation difficulty of nurses, increase patient comfort and improve patient satisfaction. Methods: The items required for the routine maintenance of PICC catheter shall be packaged separately in a sterile manner, and all items shall be packaged as disposable care package for the maintenance of PICC catheter. Results: The use of a special PICC disinfection disposable care package, inside all the items after strict sterile treatment, simple and convenient, save time and effort. Conclusion: PICC disinfection disposable care package can reduce the operation difficulty of medical staff, shorten the operation time, increase patient comfort, and facilitate the use of medical staff.

Exploration on the Chemical Constituents and Pharmacological Effects of Korla Fragrant Pears

Ping Cheng — 2025-04-29

Korla fragrant pears are one of the “famous, excellent, and special” fruits in Xinjiang. They belong to the white pear variety in the genus Pyrus of the Rosaceae family. With a long-standing planting history and strong regional characteristics, they are mainly produced in southern Xinjiang. Due to unique natural conditions such as large temperature differences between day and night and sufficient sunlight, Korla fragrant pears have a crispy texture, a sweet but not cloying taste, and their flesh is delicate and juicy, with excellent quality. Korla fragrant pears contain a variety of bioactive substances, mainly including polysaccharides, polyphenolic compounds, flavonoid compounds, triterpenoids, and sterols. They have medical effects such as “moistening the lungs, calming the heart, reducing phlegm, anti-inflammation, relieving cough, and resolving carbuncle toxins”. Uyghur and Mongolian medicine often use them as a good dietary therapy product. Based on recent literature reports, this paper reviews the main chemical constituents and pharmacological effects of Korla fragrant pears, aiming to provide references for the research and utilization of the deep processing of Korla fragrant pears.

Integrating Ideological and Political Education into the Pathogen Biology Curriculum: Promoting the All-Round Development of Nursing Students through Diversified Teaching

Wenzhen Wang — 2025-04-28

In order to better implement the “Three-Dimensional Education” and cultivate high-quality nursing talents, the integration of ideological and political education into the pathogen biology curriculum promotes curriculum reform and application. This article explores the use of various teaching methods and means in the teaching process of pathogen biology under the guidance of ideological and political education, aiming to stimulate students’ learning interest, cultivate their autonomous learning ability, independent thinking, problem-analyzing and problem-solving abilities, and thus improve their comprehensive qualities and medical professional literacy.

Construction of a Clinical Path Discrimination Model for Stroke Patients Based on the XGBoost Integrated Learning Algorithm and Its Application Analysis in the MOP under the DIP Payment Model

Huisi Hong — 2025-05-06

Objective: Aiming at the problems of clinical pathway optimization and medical cost control for stroke patients, this study proposes a clinical pathway discrimination model based on the XGBoost integrated learning algorithm. Combined with the multi-objective programming (MOP) method, this study explores its application value under the Diagnosis-Intervention Packet (DIP) payment model. Methods: The data of stroke patients (ICD codes I60–I63) from 2018 to 2022 were obtained through the medical record statistical management system of medical institutions in Guangdong Province. Efficiency indicators (average length of hospital stay), health economics indicators (total cost), effectiveness indicators (mortality rate), and specific indicators (NIHSS score) were extracted. The XGBoost algorithm was used to construct the clinical pathway discrimination model, and the hyperparameters were optimized through grid search. Based on the DIP payment rules, the prediction results of the model were used as inputs to establish a dynamic programming model, aiming to minimize costs and maximize curative effects to obtain the optimal clinical pathway plan. Results: The goodness-of-fit (R²) of the XGBoost model on the test set reached 0.768, which was significantly better than that of the random forest (0.691) and the BP neural network (0.343). The total cost of the clinical pathway optimized by the dynamic programming model decreased by 12.7% (95% CI: 10.2–15.1%), the average length of hospital stay was shortened by 1.8 days, and the NIHSS improvement rate increased by 8.3%. Conclusion: The integrated model proposed in this study has high accuracy and robustness in clinical pathway discrimination. Combined with the MOP method, it can provide a scientific basis for the optimization of medical resources under the DIP model, helping medical institutions achieve the dual goals of precise cost control and curative effect improvement.

Clinical Observation on the Treatment of Brain Atrophy and Senile Dementia with Yizhi Xingnao Decoction Combined with Yizhi Pill

Jianzhong Tang — 2025-04-30

Objective: To analyze the therapeutic effect of Yizhi Xingnao Decoction + Yizhi Pill on cerebral atrophy and Alzheimer’s disease (AD). Methods: Ninety-two patients with cerebral atrophy and AD who were admitted to the hospital from September 2022 to September 2024 were selected and randomly divided into two groups using a random number table. The traditional Chinese medicine (TCM) group was treated with Yizhi Xingnao Decoction + Yizhi Pill, while the western medicine group was treated with Donepezil Hydrochloride. Indicators such as total effective rate, TCM syndrome score, dementia degree score, and cognitive function score were compared between the two groups. Results: The total effective rate of the TCM group was higher than that of the Western medicine group (P < 0.05). After treatment, the TCM syndrome score, dementia degree score, and cognitive function score of the TCM group were all lower than those of the Western medicine group (P < 0.05). Conclusion: Yizhi Xingnao Decoction + Yizhi Pill can improve the clinical efficacy of patients with cerebral atrophy and AD, reduce disease symptoms and dementia severity, and improve patients’ cognitive function.

Alleviative Treatments for Alzheimer’s Disease and Early Ecological Intervention Strategies in the Community

Peihua Zhuang — 2025-04-29

According to the data from the 7th national population census, the population aged 65 and above in China has reached 13.50%, indicating that the country has entered a deeply aging society. The health issues of the elderly have become a significant concern for society. Common brain diseases among the elderly, including cerebrovascular diseases, genetic factors, or long-term solitary living, can all lead to dementia, with Alzheimer’s disease (AD) being the most common. Early symptoms of AD mainly include memory loss and difficulty concentrating, which are often mistaken for normal aging or stress-related issues and thus overlooked. AD lacks specific biomarkers and effective auxiliary diagnostic methods, making it difficult to accurately diagnose with existing imaging and neuroprotein indicators. Therefore, early detection of AD is very challenging. This article explores community-based early detection and intervention strategies from the perspectives of existing mechanism research, clinical manifestations, modern drug treatments, innovative explorations in traditional medicine, and community-appropriate technologies, aiming to construct an ecological management strategy.

Research Progress of MAPK Signaling Pathway in Colorectal Cancer

Panpan Mao — 2025-04-30

Colorectal cancer (CRC) is one of the most common malignancies. In recent years, despite the widespread application of new endoscopic techniques and continuous advancements in treatment methods that have improved the early diagnosis rate of CRC, the disease often has an insidious onset. Many patients are already in the middle or late stages of the disease when diagnosed, leading to poor treatment outcomes and prognosis. Therefore, further investigation into the pathogenesis of CRC and exploration of new therapeutic targets remain hot topics of research. The mitogen-activated protein kinase (MAPK) signaling pathway belongs to the large family of serine/threonine kinases and is a crucial pathway for signal transduction in eukaryotes. The MAPK signaling pathway can be activated by various extracellular signals such as cytokines, growth factors, and oxidative stress, thereby influencing biological processes like cell cycle, differentiation, malignant transformation, metastatic potential, and apoptosis. It plays a significant regulatory role in the development and progression of malignancies ^[1]. The evolution of CRC involves abnormal regulation of multiple signaling pathways, among which dysregulation of the MAPK signaling pathway is a key molecular event. This article provides a comprehensive overview of the research progress on the MAPK signaling pathway in CRC.

Multidimensional Roles of Pears in Pear Paste: A Systematic Analysis from Molecular Mechanisms to Clinical Translations

Ping Cheng — 2025-04-29

Pear paste is a traditional preparation with both medicinal and nutritional functions. The “pear”, as its core ingredient, plays a crucial role in the efficacy of the preparation. This paper, through the interdisciplinary integration of evidence from traditional Chinese medicine, food chemistry, molecular biology, and clinical medicine, constructs a complete “raw material-component transformation-biological regulation” model for the first time. It is found that in pear paste, pears not only serve as a functional matrix. The polysaccharide-polyphenol-triterpene complex system forms a multi-target cough-relieving and anti-inflammatory network through dual regulation of TRPV1/TRPA1 ion channels, inhibition of the NLRP3 inflammasome, and metabolites of gut microbiota such as SCFAs. The research results provide a theoretical breakthrough for the modern development of pear paste and a scientific basis for the modernization of traditional preparations.

Research Report on Cell Quantum Medicine: Theory, Practice, and Prospects

Zhigang Hu — 2025-04-28

This paper is Taiji medicine based on the theory of traditional Chinese medicine and traditional medicine, and the core of Taiji medicine is “wave-particle duality of Qi and field”, which is a life science based on cellular quantum medicine. this paper makes an important pioneering exploration and research on cellular quantum medicine. The cellular quantum agents corresponding to the disease frequency were obtained through specially prepared aqueous solution containing living cell quantum matrix and frequency modulation of herbal medicines with different frequencies. This study of cellular quantum pharmacy makes it a useful exploration to effectively treat AIDS, cancer, tumor, coronavirus and other difficult diseases.

A Study on Modified Endoscopic Mucosal Resection in Rectal Neuroendocrine Tumors

Yan Chen — 2025-04-29

Objective: To explore the clinical feasibility and safety of modified endoscopic mucosal resection for rectal neuroendocrine tumors (R-NETs). Methods: Seventy cases of R-NETs treated with endoscopic mucosal resection in our hospital between April 2022 and March 2024 were selected and divided into the control group and the observation group using the mean score method, each with 35 cases. In the control group, traditional endoscopic mucosal resection (EMR) was performed, and in the observation group, modified EMR (endoscopic mucosal resection with ligation apparatus [EMR-L]) was performed. The operation time, hospitalization time, operation cost, and related complication rate of the two groups of patients were compared. Results: The operation time (20.36 ± 1.46 min) and hospital stay (3.37 ± 0.51 d) of patients in the observation group were shorter than those of the control group (31.44 ± 2.65 min and 4.73 ± 0.49 d). The cost of the operation in the observation group (7,695.85 ± 1,521.42 yuan) was lower than that of the control group (8,418.62 ± 1219.30 yuan), and the difference was statistically significant (P < 0.05). The total incidence of postoperative related complications in the observation group was observed to be 11.42%, which was significantly lower than that of 31.42% in the control group, and the difference was statistically significant (P < 0.05). Conclusion: The application of modified EMR in R-NETs is remarkable, which can not only effectively shorten the operation time and hospital stay, but also further reduce the risk of related complications, and indirectly save a large amount of hospital costs; thus, it is recommended to be promoted and applied clinically.

The Application Effect of Cardiac Rehabilitation Therapy in Patients with Chronic Heart Failure and Its Impact on Pulse Wave Velocity

Xin Huo — 2025-04-30

Objective: To evaluate the effectiveness of cardiac rehabilitation therapy in the treatment of patients with chronic heart failure (CHF). Methods: 76 patients with CHF who were treated in the hospital from January 2023 to December 2024 were selected and randomly divided into two groups using a random number table. The experimental group (38 patients) received cardiac rehabilitation therapy, while the reference group (38 patients) received conventional drug therapy. The total effective rate, cardiac function indicators, lung function indicators, and pulse wave velocity (PWV) were compared between the two groups. Results: The total effective rate was higher in the experimental group than in the reference group. After treatment, the cardiac and lung function indicators were better in the experimental group than in the reference group, and the PWV was lower in the experimental group (P < 0.05). Conclusion: Cardiac rehabilitation therapy for patients with CHF can improve treatment efficacy, enhance cardiopulmonary function, and regulate PWV levels, with high professionalism and feasibility.

Study on the Immune Activity of Mice In Vitro and In Vivo with Nano-Material Adjuvant

Qiran Wang — 2025-05-06

This paper investigates the effects of graphene quantum dots and mesoporous silica as nanomaterial adjuvants on immune activity in mice both in vitro and in vivo. The two materials have distinct properties; graphene quantum dots possess unique optical and electrical characteristics, while mesoporous silica features a regular pore structure. In vitro experiments show differences in their effects on immune cell activation and cytokine secretion; in vivo experiments reveal varying performances in antibody production and immune cell function regulation. Their mechanisms of action and safety profiles also differ, offering distinct advantages in application prospects. These two nanomaterial adjuvants provide new directions for the development of immunology, warranting further exploration.

Transcatheter Embolization Combined with Surgical Resection for Traumatic Middle Meningeal Artery-vein Fistula: A Case Report

Shengshan Li — 2025-04-30

Traumatic carotid-cavernous arteriovenous fistula (TCCAVF) is a rare but severe cerebrovascular disorder, often resulting from head trauma with temporal bone fractures. The pathogenesis involves vessel wall injury due to traction, frequently associated with fractures near the middle meningeal artery. This case highlights the typical clinical presentation, diagnostic approaches, and therapeutic management of TCCAVF, emphasizing the challenges in treating this condition. Transcatheter embolization proved effective in occluding the fistula, underscoring its role as a key intervention for traumatic meningeal arteriovenous fistulas.

Clinical Application of Imaging Navigation Technology in the Treatment of Pulmonary Tuberculosis

Yanju Su — 2025-05-06

Objective: To observe the clinical effect of targeted perfusion with DSA-guided bronchoscope in the treatment of multidrug-resistant pulmonary tuberculosis (MDR-TB). Methods: A total of 188 patients with multidrug-resistant pulmonary tuberculosis (MDR-TB) who were hospitalized for treatment between September 2023 and September 2024 were included. After random division, 94 cases were included in the control group and received systemic anti-tuberculosis chemotherapy; 94 patients were included in the treatment group. Based on digital subtraction angiography (DSA), targeted drugs were injected into the bronchoscope cavity to complete anti-tuberculosis treatment. The sputum and imaging changes were observed in both groups. Results: The sputum negative rate of the treatment group was significantly higher than that of the control group (86.2%; 70.2%) (u = 2.74, P < 0.01). The absorption rate of CT image lesion (significant absorption + partial absorption) was significantly higher than that of control group (83.0%; 50%) (u = 2.45, P < 0.05). The closure rate of chest CT cavity was significantly higher than that of control group (74.2%; 39.1%) (u = 2.20, P < 0.05). The improvement rate of clinical symptoms in the treatment group was statistically higher than that in the control group. There was no significant difference in the incidence of adverse reactions between the two groups (x = 0.434, P > 0.05). Conclusion: Based on inclusion in 20DSA, infusion of targeted drugs into bronchoscopy can significantly improve disease efficacy, with mild adverse reactions that patients can tolerate, and is worthy of promotion and application.

To Explore the Application Effect of Bird’s Nest Nursing in Neonatal Nursing

Xiaoling Liu — 2025-04-29

Objective: To observe and study the practical value of adopting nest nursing in neonatal nursing. Methods: From January 2023 to January 2024, a total of 382 newborns that were admitted to the hospital were selected to carry out this study. They were divided into two groups, the routine group and the observation group, with 191 cases in each group. Newborns in the routine group were given basic nursing intervention, while those in the observation group were given bird’s nest nursing intervention. The growth and development indexes, the occurrence of adverse reactions, the improvement of gastrointestinal function, and the nursing satisfaction rate of their families were analyzed and studied. Results: The growth and development indexes of newborns in the observation group were significantly better than those in the routine group (P < 0.05). The incidence of adverse neonatal reactions in the observation group was significantly lower than that in the routine group (P < 0.05). The improvement of gastrointestinal function of newborns in the observation group was significantly better than that in the routine group (P < 0.05). The nursing satisfaction rate of newborns’ families in the observation group was significantly higher than that in the routine group (P < 0.05). Conclusion: As for the key points of clinical newborn care, the actual effect of adopting the bird’s nest nursing intervention is more prominent, and its main function is to promote the growth and development of newborns. It can not only avoid the risk of adverse reactions in many aspects but also improve the gastrointestinal function of newborns, so that the nursing satisfaction rate of family members is obviously improved. It is recommended to be applied and popularized in clinical practice.