Journal of Clinical and Nursing Research

The Application of Formative Evaluation System in Clinical Laboratory Teaching

Guifen Wei — 2025-03-06

Theoretical education and practical education are very important in clinical laboratory teaching. The teaching evaluation system is one of the important means to test the quality of course teaching. The traditional summative evaluation needs to be improved in terms of scientificity and impartiality, and its guiding effect on teaching reform is limited. Therefore, this paper proposes to apply formative evaluation to clinical laboratory teaching to remobilize students’ learning enthusiasm and provide valuable guidance for the subsequent teaching reform, hoping to achieve the purpose of improving the quality of laboratory teaching.

The Molecular Mechanism of Weilingxian and Guizhi in the Treatment of Gout was Studied Based on Network Pharmacology

Dongrong Mo — 2025-03-10

Objective: To explore the mechanism of action of “Weilingxian-Guizhi” two drugs in the treatment of gout. Method: First obtain the 15 chemical components contained in the “Weilingxian-Guizhi” drug, predict its target points through the database, and then construct the gout-related protein-protein interaction network (PPI), and then construct the “Weiling,” the “Xian, Guizhi” drug pair “active ingredient-predicted target” network, the construction of the gout-related “Weilingxian-Guizhi” drug pair “active ingredient-potential target” network, based on the Kyoto Encyclopedia of Genes and Genomes (KEGG) biological pathway enrichment analysis and gene ontology (GO) functional enrichment analysis, to study the mechanism of action of the two drugs “Weilingxian-Guizhi” in the treatment of gout. Results: The gout-related “Weilingxian-Guizhi” drug pair “active ingredient-potential target” network contains 14 targets. KEGG pathway enrichment analysis yields 32 pathways, and GO functional enrichment analysis yields 517 GO entries. Among them, there are 468 items related to biological processes, 21 items related to molecular functions, and 28 items related to cell composition. Conclusion: The results of this study initially verified and predicted the mechanism of the “Weilingxian-Cinnamon Stick” medicine on the treatment of gout, and laid a good foundation for further revealing its mechanism of action.

The Application of Appropriate Traditional Chinese Medicine Techniques in the Rehabilitation Nursing of Neurogenic Bladder

Xiaojie Chen — 2025-03-06

The purpose of this study was to explore the application of TCM-appropriate technology in neurogenic bladder rehabilitation nursing. Firstly, the background and contents of the study were introduced. Then, it summarizes the definition and development of TCM-appropriate technology and expounds the main therapy and application of TCM-appropriate technology in the rehabilitation nursing field. Besides, the pathophysiological characteristics, rehabilitation nursing measures, and rehabilitation difficulties of the neurogenic bladder are described. Then, the application method, effect and prospect of TCM-suitable technology in rehabilitation nursing of neurogenic bladder are described. In addition, the object, method, result analysis, and conclusion of the experimental study are introduced, the main results of this study are summarized, and the future research direction is prospected. In summary, this study aims to provide effective TCM-appropriate technology for neurogenic bladder rehabilitation nursing and provide a reference for clinical practice and theoretical research in related fields.

Research on the Development of the Big Health Industry in the Context of Digitalization

Chao Qiu — 2025-03-06

This paper makes an in-depth study of the status quo and trend of the development of the big health industry under the background of digitalization, aiming to explore ways to promote the transformation, upgrading and sustainable development of the big health industry through technological innovation and policy guidance, and provide valuable references for the government, enterprises and universities and other stakeholders to promote the high-quality development of the big health industry in the digital era.

The Role of Central Inflammation in Postoperative Cognitive Dysfunction

Wenyuan Wang — 2025-03-06

Postoperative cognitive dysfunction is a typical complication, which can be referred to as POCD. This complication is common in elderly patients. Among them, POCD is mainly manifested in the function of patients with attention deficit and memory reduction after surgery, among which serious patients are prone to personality change, which affects their social behavior ability. In the context of the current era, the cause of POCD is not clear, combined with the results of most studies, it is found that central nervous inflammation, is a key factor affecting POCD. From the perspective of central inflammation, this paper analyzes the relationship between central inflammation and POCD, and discusses the mechanism of action, aiming at effectively preventing and treating POCD and providing a reference for subsequent research in related fields.

A Case of Head Posture Control Training Combined with Breathing Training in the Treatment of Dysarthria Brainstem Infarction Patient

Jingyi Li — 2025-03-07

This paper reports a case of cerebral stem infarction with quadriplegia and complete dependence on daily life. The course of the disease lasted more than 7 months. Frenchay’s improved articulation Disorder Assessment Form has been assessed as severe articulation disorder. The patient has significantly improved his speech function and quality of life after systematic head control training, respiratory function training, articulation motor training, and articulation training. In the course of treatment, emphasis was placed on head postural control training and respiratory function training, and emphasis was placed on the strength and coordination training of articulatory organs, and the results were remarkable. After the patient was discharged from the hospital, the follow-up of basic daily life communication was not limited.

A Study on the Impact of Filial Piety Values of Caregivers of Patients with Chronic Heart Failure on Their Caregiving Burden

Rongping Yin — 2025-03-10

Objective: To analyze the burden of caregivers of CHF patients in the current environment, to explore the related burden and influencing factors of caring for patients with chronic heart failure, and to explore the impact of filial piety values on the burden of caring for patients. Methods: 192 caregivers of CHF patients in the hospital were selected as the main objects of this study. The main method was convenient sampling. Through a questionnaire survey of 192 CHF patients’ caregivers, a unified investigation was conducted from the aspects of patient'’s general condition, objective burden, anxiety and depression degree and relationship quality, etc. The structural equation model was constructed and adjusted by analyzing data entry and variable correlation. Finally, path analysis was used to conduct inferential research on the direct and indirect influencing factors of control burden. Results: More than half of the patients’ caregivers had a caregiving burden, and the practical caregiving dimension had the highest score. The total effect values of patient-related factors, including anxiety degree, number of concomitant diseases and half-year readmission rate, were 0.36, 0.31 and 0.20, respectively (P < 0.05). The total effect values of filial piety, anxiety degree, average care time and understanding degree of disease directly derived from the caregivers themselves were -0.38, 0.29, 0.29 and -0.23, respectively (P < 0.05). In addition, the influence of filial piety values on the caregiver burden was more obvious, and the direct effect value of the value was -0.41 (P < 0.001). Conclusion: Most caregivers of CHF patients have a certain objective burden of care, and there are many factors that affect it, among which the degree of filial piety value is the most important. This finding provides a clear goal for caregivers to develop measures to improve the caregiver burden.

Prevention and Nursing Experience of Complications in Advanced Lung Cancer

Ting Yuan — 2025-03-10

Objective: To study the measures and effects of advanced lung cancer patients in terms of complication prevention and care. Methods: 50 cases of advanced lung cancer patients were selected for data study during January–December 2023, where the patients were divided into two groups. The study group used complication prevention and nursing care, while the control group used conventional care. The differences between the groups were compared. Results: Compared with the control group, the study group had significantly fewer complications, significantly lower psychological state scores, significantly higher quality of life scores, and significantly lower pain scores (P < 0.05). Comparing the psychological state scores, quality of life scores, and pain scores before care, both groups showed insignificant differences (P > 0.05). Conclusion: The results of patients with advanced lung cancer are ideal after the application of measures in the area of complication prevention and care.

Work Stressor and Turnover Intentions Among Chinese Obstetrical Nurses

Han Li — 2025-03-06

This study focuses on the relationship between job stress and intention to leave among obstetric (OB) nurses in the context of China‘s birth policy adjustment, and provides a scientific basis for policymakers and healthcare administrators. This study used a non-experimental descriptive correlation design with a purposive sampling of 230 OB nurses from three tertiary hospitals in Jinan, Shandong Province. Participants were surveyed using three questionnaires and descriptive analysis; ANOVA and correlation analyses were used to analyze the relationship between participants‘ stressor levels and turnover intention. Pearson‘s correlation coefficient analysis showed that there was a positive correlation between nurses‘ work stressors and turnover intention, with a correlation coefficient of r = 0.53, a moderate positive correlation (P < 0.001). Based on the survey data from three tertiary hospitals in Shandong Province, the obstetric nurses group has a medium level of work stressors, but a high turnover intention, highlighting the professional identity crisis.

The Value of Chinese Medicine Humanistic Nursing in Healthcare Integration

Jiale Lin — 2025-03-10

With the rapid development of medical and nursing combinations, the application of humanistic care in medical and nursing combination institutions is getting more attention. Elderly institutions are the main carrier of elderly services in China, and the demand for humanistic care among the elderly in elderly institutions is also getting higher and higher, but at present, the humanistic care ability of the nursing staff in China’s medical and nursing combined institutions is low. In recent years, the state vigorously promoted the development of traditional Chinese medicine, traditional Chinese medicine nursing contains a wealth of humanistic ideas, which can provide another solution for the lack of humanistic care in healthcare institutions. This paper discusses the ideological value, practical value and talent cultivation value of TCM humanistic nursing in medical care combination, aiming to provide a reference basis for improving the quality of humanistic nursing in medical care combination organizations.

Research Progress on the Mechanism of GSDMDInduced Pyroptosis in Macrophages

Zhaoru Wu — 2025-03-10

Pyroptosis is a form of programmed cell death. Excessive or uncontrolled pyroptosis and the production of pro-inflammatory cytokines can lead to organ damage, circulatory failure, and even death. Gasdermin D (GSDMD) is the primary executor of pyroptosis in macrophages. Upon cleavage, the N-terminal domain of GSDMD (GSDMD-N) is activated and oligomerizes to form pore-like structures in the plasma membrane, triggering pyroptosis and resulting in the release of pro-inflammatory cytokines such as interleukin-1β (IL-1β). As a key executioner molecule of pyroptosis, Gasdermin D plays a crucial role in pathogen-induced pyroptosis in macrophages. With in-depth research on the function and regulatory mechanisms of GSDMD, its role in pathogen-induced macrophage pyroptosis has gradually been revealed. This article elaborates on the mechanism of GSDMD in pathogen-induced macrophage pyroptosis, providing insights for exploring pyroptosis in the prevention and control of bacterial diseases, and identifying new therapeutic targets for bacterial infections.

Research Progress in Rehabilitation Nursing for Limb Dysfunction after Stroke

Jinhua Yang — 2025-03-06

Stroke, as a highly prevalent cerebrovascular disease, often leads to limb dysfunction in patients, severely affecting their quality of life. Seeking effective rehabilitation nursing methods is of great significance for patient recovery. This article deeply analyzes various aspects such as intelligent rehabilitation technology, traditional Chinese medical therapies, Western medical therapies, and rehabilitation training methods. It explores the characteristics, effectiveness, and application prospects of various rehabilitation nursing approaches, providing a reference for clinical rehabilitation nursing of limb dysfunction after stroke, and helping to improve the quality of patient recovery and enhance their self-care ability and quality of life.

A Preliminary Study on the Background of the Formation of the Meng Yao Zheng Dian

Hongying Wu — 2025-03-10

Meng Yao Zheng Dian is one of the three classics of Mongolian medicine. It was written by Zhanbra Dorje, who was a famous Mongolian physician. The book was not only related to the author’s origin, education and learning experience, but also closely related to the social development, cultural exchanges between Mongolian and Tibet, and people’s demand for Mongolian medicine at that time. The book in four languages indicates the name of Mongolian medicinal herbs, Mongolian, Tibet, Chinese, Manchu medicine academic and cultural exchanges played a positive role in promoting the cultural exchanges, is a vivid embodiment of the cultural exchanges between Chinese nationalities and exchanges and mingling.

Clinical Study on Treating Diarrhea-Predominant IBS with Liver Depression and Spleen Deficiency Using Shu Gan Jian Pi Yi Qi Prescription and Grain-Sized Moxibustion

Yamei Wang — 2025-03-06

Objective: To evaluate the therapeutic effect of Shu Gan Jian Pi Yi Qi prescription combined with grain-sized moxibustion on diarrhea-predominant irritable bowel syndrome (IBS-D) with liver depression and spleen deficiency syndrome. Methods: 60 patients with IBS-D (liver depression and spleen deficiency syndrome) treated in the outpatient clinic from January 2021 to December 2023 were selected and randomly divided into two groups using a random number table. The combined group was treated with Shu Gan Jian Pi Yi Qi prescription and grain-sized moxibustion, while the reference group was treated with western medication. The total effective rate, IBS symptom severity score (IBS-SSS), Bristol stool scale score, and IBS-specific quality of life questionnaire (IBSQOL) were compared between the two groups. Results: The total effective rate of the combined group was higher than that of the reference group (P < 0.05). Before treatment, there were no differences in IBS-SSS score, Bristol stool scale score, and IBSQOL score between the two groups (P > 0.05). After treatment, the IBS-SSS score and Bristol stool scale score of the combined group were lower than those of the reference group, while the IBSQOL score was higher (P < 0.05). Conclusion: Shu Gan Jian Pi Yi Qi prescription combined with grain-sized moxibustion can improve the symptoms of IBS-D patients, including stool characteristics, and enhance their quality of life.

Study on the Clinical Effect of Percutaneous Vertebroplasty in the Treatment of Old Unstable Osteoporotic Spinal Fractures

Hanpeng Zhang — 2025-03-06

Objective: To evaluate and analyze the actual efficacy of percutaneous vertebroplasty in the treatment of old unstable osteoporotic spinal fractures. Methods: From March 2023 to March 2024, 46 patients with old unstable osteoporotic spinal fractures in our hospital were included in this study. They were divided into the conventional group and the observation group based on treatment differences, with 23 patients in each group. The conventional group received conservative drug therapy, while the observation group underwent percutaneous vertebroplasty. The following indicators were compared and analyzed between the two groups: clinical treatment effect and improvement in physical function indicators. Results: The treatment efficiency of the observation group was 95.65% (22/23), while that of the conventional group was 69.57% (16/23). There was a significant difference between the groups, and the treatment effect of the observation group was significantly better (P < 0.05). After treatment, the scores of physical status, daily living ability, functional independence, and life obstacles in the observation group were (89.33 ± 4.08), (88.72 ± 4.08), (90.41 ± 2.89), (72.35 ± 3.22), respectively, while those in the conventional group were (68.54 ± 4.21), (67.42 ± 4.11), (73.48 ± 2.75), (72.35 ± 3.22). There was a significant difference between the groups, and the improvement in physical function indicators in the observation group was more pronounced (P < 0.05). Conclusion: For patients with old unstable osteoporotic spinal fractures, the basic value of percutaneous vertebroplasty is significant. It can not only improve clinical efficacy and safety but also promote the gradual recovery of patients’ physical function indicators. It is recommended for clinical reference and practical application.

Visual Analysis of Nursing Research on Children with Kawasaki Disease based on CiteSpace

Xiaoli Ma — 2025-03-06

Objective: This study aims to analyze the research hotspots and trends in nursing care for children with Kawasaki disease. Methods: The study utilized the CiteSpace 6.1.R6 software to visualize nursing-related research on Kawasaki disease in children, drawing from articles published in the CNKI and Web of Science core collection databases from January 1, 2014, to January 1, 2024. Key analysis components included authors, institutions, and keywords, supported by the creation of a corresponding knowledge map. Results: Literature Publications: Over the past decade, the analysis encompassed a total of 309 Chinese articles on nursing care for children with Kawasaki disease, with an average annual publication rate of 30.9 articles. Additionally, 251 foreign language articles were scrutinized, exhibiting an average annual publication rate of 25.1 articles. Author and Institution Analysis: In Chinese literature, the notable figure of Huang Rimei emerged as a prolific author, with the Children’s Hospital Affiliated with Zhengzhou University standing out as a high-yielding institution. Conversely, in English literature, the prolific authors Burns and Jane C were prominent, alongside the University of California, San Diego, which emerged as a high-yielding institution. Keyword and Research Hotspots Analysis: The focal points of research in Chinese literature revolved around continuous nursing, cardiovascular complications, clinical nursing pathways, rehabilitation effects, holistic nursing, and gamma globulin. Conversely, English literature emphasized research hotspots such as cardiovascular complications, treatment modalities, diagnostic approaches, long-term management strategies, gamma globulin therapy, steroid pulse therapy, and pediatric multisystem inflammatory syndrome. Conclusions: The quantity of Chinese literature concerning nursing care for children with Kawasaki disease appears comparatively scant, underscored by an uneven distribution of issuing institutions and a lack of influence. To address this, future endeavors should prioritize bolstering collaboration across diverse regions and institutions, conducting multi-center, cross-regional research, implementing clinical nursing pathways, and augmenting the continuity of care. Conversely, the upsurge in English literature publications regarding nursing care for children with Kawasaki disease signals a burgeoning interest, primarily concentrated on treatment modalities. This trend advocates for the integration of medical and nursing care and emphasizes the importance of remaining abreast of advancements in managing Kawasaki disease in children.

Analysis of the Effect of Continuous Nursing Pathway on Improving the Accuracy of Aerosol Use in Elderly Patients with Chronic Obstructive Pulmonary Disease

Jiao Chen — 2025-03-06

Objective: To explore nursing measures for elderly patients with chronic obstructive pulmonary disease (COPD) and analyze the effect of continuous nursing pathways on improving the accuracy of aerosol use. Methods: From April 2023 to April 2024, 76 elderly COPD patients admitted to our hospital were randomly selected for nursing research. They were divided into two groups using a computer double-blind method, with 38 patients in each group. The control group received routine nursing, while the observation group applied the continuous nursing pathway. The nursing effects of the two groups were investigated and compared, including (1) aerosol accuracy; (2) cardiopulmonary function; (3) subjective well-being and self-care ability; (4) quality of life; and (5) nursing satisfaction. Results: Compared with the control group, the observation group had a significantly higher accuracy rate of aerosol use (P < 0.05). Before nursing, there were no significant differences in cardiopulmonary function indicators, MUNSH scores, and ESCA scores between the two groups (P > 0.05). After nursing, the patient’s cardiopulmonary function improved significantly, and their subjective well-being and self-care ability increased. The observation group was significantly better than the control group in all the above indicators (P < 0.05). The quality of life scores of the observation group were significantly higher than those of the control group (P < 0.05). Conclusion: In the nursing of elderly patients with chronic obstructive pulmonary disease, the application of the continuous nursing pathway can effectively improve the accuracy of aerosol use and improve patients’ cardiopulmonary function.

Cross-sectional Survey of Volume Management in Peri-dialysis Patients in a Single Center

Yang Xu — 2025-03-10

Objective: To analyze the risk factors influencing volume overload in patients during the pre-dialysis and early post-dialysis period (peri-dialysis period) by investigating the current situation of volume management of such patients in our hospital, to reduce the incidence of volume overload during this period. Methods: A total of 86 patients in the peri-dialysis period (glomerular filtration rate eGFR less than 15 mL/(min·1.73 m²) to three months after dialysis) who received outpatient treatment, inpatient treatment, and hemodialysis in the hospital from June 2022 to December 2023 were selected as the research objects. General information, clinical symptoms, and laboratory data of the patients were collected. According to the disease evolution process of the patients, they were divided into the non-dialysis stage and the initial dialysis stage. The volume load index of the patients, namely the overhydration (OH) value, was measured by the multi-frequency bioelectrical impedance method. The relevant factors affecting the volume load of patients in the peri-dialysis period were compared and analyzed. Results: In the non-dialysis stage, 68 patients (86%) had volume overload, and 21 patients (21%) had normal volume load. In the initial dialysis stage, 53 patients (61%) had volume overload, and 33 patients (38%) had normal volume load. Among the patients with volume overload in the two stages combined, the primary diseases were diabetic nephropathy at 29%, hypertensive nephropathy at 29%, primary nephropathy at 34%, and other renal damage at 8%. Complications included heart failure at 29%, respiratory tract infection at 32%, coronary heart disease at 9%, and anemia at 21%. Among the patients with volume overload, 69% were male, 52% were over 60 years old, 53% had no family member accompaniment, 57% had insomnia, and 55% had an educational level of junior high school or below. Conclusion: More than half of the patients in the peri-dialysis period in the hospital are in a state of volume overload, which should arouse the attention of the department. For male patients, those with hypertension, diabetes, insomnia, respiratory tract infection, anemia, and without family member accompaniment, corresponding intervention measures should be taken to reduce the incidence of volume overload during the peri-dialysis period.

Analysis of Risk Factors for Delirium in Elderly Patients with Stanford-type B Aortic Dissection

Rong Wang — 2025-03-10

Objective: To investigate the incidence of delirium in elderly patients with Stanford-type B aortic dissection and analyze its risk factors. Methods: A convenience sample of 767 elderly patients with Stanford-type B aortic dissection admitted to the ICU from January 2020 to December 2023 was selected. Data were collected using a delirium-related questionnaire and the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Results: The incidence of delirium in elderly Stanford B aortic dissection patients was 23.73%. Logistic regression analysis showed that gender, length of stay in the ICU, and duration of sedative drug use were independent risk factors for delirium in elderly patients (P < 0.05). The model likelihood ratio test χ² = 28.462, P < 0.001; Hosmer-Lemeshow goodness-of-fit test χ²= 0.715, P = 0.878. Conclusion: The incidence of delirium in elderly patients with Stanford-type B aortic dissection is relatively low. Medical staff should conduct adequate and effective preoperative assessment according to the condition of elderly Stanford-type B aortic dissection patients, and use analgesic and sedative drugs reasonably to create a good treatment environment for patients, thereby minimizing the incidence of delirium in elderly patients with Stanford-type B aortic dissection as much as possible.

Exploring the Clinical Value of Combined Detection of Blood Lipids, Blood Glucose, and Liver Function in Non-alcoholic Fatty Liver Disease

Jinyuan Gong — 2025-03-10

Objective: To study the clinical value of combined detection of blood lipids, blood glucose, and liver function in non-alcoholic fatty liver disease. Methods: 105 patients with non-alcoholic fatty liver disease treated in our hospital from May 2022 to July 2024 were selected as the research subjects. All patients underwent a B-ultrasound examination. According to the severity of the disease, they were divided into group A (mild, n = 35), group B (moderate, n = 44), and group C (severe, n = 26). Another 30 healthy residents who came to the hospital for physical examination during the same period were selected as group D. The differences in blood lipids, blood glucose, and liver function indicators between groups were compared. Results: The triglyceride (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL) levels in groups A, B, and C were higher than those in group D, while the high-density lipoprotein cholesterol (HDL) level was lower (P < 0.05). The fasting plasma glucose (FPG) levels in groups B and C were higher than those in group D (P < 0.05). The TG, LDL, and FPG levels in groups B and C were higher than those in group A (P < 0.05). The TC level in group C was higher than that in group A, while the HDL level was lower (P < 0.05). The TC and FPG levels in group C were higher than those in group B (P < 0.05). The total bilirubin (TBil), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) levels in groups A, B, and C were higher than those in group D (P < 0.05). The TBil and ALT levels in groups B and C were higher than those in group A (P < 0.05). The AST level in group C was higher than that in group A (P < 0.05). The AST and ALT levels in group C were higher than those in group B (P < 0.05). Conclusion: Patients with non-alcoholic fatty liver disease have disordered glucose and lipid metabolism. Blood lipids, blood glucose, and liver function are closely related to the severity of the disease. Strengthening exercise and dietary intervention early on can help control the progression of simple fatty liver disease and reduce the risk of severe liver diseases such as steatohepatitis and cirrhosis.

Ambulatory Blood Pressure Characteristics and Risk Factors for Circadian Thythm Abnormalities in Elderly Patients with Hypertension

Yaqian Huang — 2025-03-10

Objective: To analyze the characteristics of ambulatory blood pressure in elderly patients with hypertension and find out the risk factors of abnormal circadian rhythm. Methods: According to the circadian rhythm of patients’ blood pressure, they were divided into Group A, Group B and Group C, and all the data of hypertension patients in this study were collected, including age, gender, BMI, smoking, drinking, basic diseases (diabetes, cerebrovascular disease, hyperlipidemia, etc.), fasting blood glucose, ambulatory blood pressure (24-hour mean systolic pressure, 24-hour mean diastolic pressure, daytime mean systolic pressure and daytime mean diastolic pressure). Results: There were significant differences in mean systolic blood pressure and mean diastolic blood pressure at night among Group A, Group B and Group C (P < 0.05). Age, hyperlipidemia and fasting blood glucose were risk factors for circadian rhythm abnormality (P < 0.05), and 24-hour urinary sodium was a protective factor for circadian rhythm abnormality (P < 0.05). Conclusion: Age, hyperlipidemia and fasting blood glucose are risk factors for circadian rhythm abnormality (P < 0.05), and 24-hour urinary sodium is a protective factor for circadian rhythm abnormality (P < 0.05).

Early Chest HRCT Findings and Dynamic Imaging Analysis of COVID-19 in Qinghai Province

Yingfang Yu — 2025-03-06

This study aimed to analyze the early high-resolution CT (HRCT) manifestations and dynamic imaging changes of coronavirus disease 2019 (COVID-19) in Qinghai Province. A total of 24 nucleic acid-positive COVID-19 patients admitted to our hospital between January 2020 and November 2021 were included. All patients underwent HRCT examinations, and lesion characteristics—including number, distribution, morphology, and surrounding involvement—were analyzed. Among the 24 patients, systemic and respiratory circulatory symptoms were more common than other symptoms (P < 0.05). There were no significant differences in the lung lobes, relative positions, quantity, size, and density of lesions across different stages of the disease course (P > 0.05). Within the same disease stage, lesions were primarily located in the lower lobes of both lungs, the peripheral lung fields, and a combination of peripheral and central regions, with single and multiple lesions being the most common. Lesion morphology varied significantly across disease stages (P < 0.05), including differences between patchy and striped lesions, striped and massive lesions (P < 0.05), and patchy and massive lesions (P < 0.05). The incidence of striped lesions was higher in the progressive and recovery stages than in the early stage, showing an upward trend. There were no significant differences in pleural thickening, pleural effusion, mediastinal lymph node enlargement, or pericardial effusion across different disease stages (P > 0.05). Common HRCT signs observed at all stages included air bronchograms, paving stone patterns, halo signs, subpleural lines, and grid-like patterns. The main patterns of lesion progression were an increase in lesion size (16/24, 66.67%), an increase in the number of lesions (17/24, 70.83%), changes in lesion density (20/24, 80.33%), and localized lesion increase and partial absorption (6/24, 25.00%). In conclusion, the HRCT manifestations and evolution of lung lesions in COVID-19 patients are complex and varied, with a progressive increase in striped lesions potentially serving as a characteristic imaging feature of the disease.