Journal of Clinical and Nursing Research

Effect of Acupuncture at Points of the Bladder Meridian of Foot-Taiyang on Serum Inflammatory Factors in Rabbit Models of Cervical Spondylosis

Wenrong Yang — 2026-01-09

Objective: Based on the theory of “Taiyang governs tendons”, to explore the effect of acupuncture at points of the Bladder Meridian of Foot-Taiyang on the expression of serum inflammatory factors in rabbit models of cervical spondylosis. Methods: Thirty New Zealand white rabbits were randomly divided into a blank group, a model group, and a treatment group, with 10 rabbits in each group. The models of cervical spondylosis in the model group and treatment group were established by long-term head-down flexion combined with cold-damp stimulation. After modeling, the treatment group received acupuncture at three points (Kunlun, Weizhong, and Feishu) on the Bladder Meridian of Foot-Taiyang, once a day for 20 minutes each time, for 14 consecutive days; the model group and blank group received no therapeutic intervention. After the intervention, cardiac blood was collected from all rabbits to detect the expression levels of serum inflammatory factors IL-6, TNF-α, and IL-1β. Meanwhile, cervical muscle tissue was collected, stained with HE, and the morphological changes of the posterior cervical muscle tissue in each group were observed under an optical microscope. Results: After modeling, the levels of inflammatory factors in the serum of rabbits in the model group and treatment group were significantly increased compared with those before modeling, with a statistically significant difference (p < 0.01). After intervention, the serum inflammatory factors in the treatment group decreased significantly compared with those in the model group, and the difference was statistically significant (p < 0.01). Conclusion: Acupuncture at points of the Bladder Meridian of Foot-Taiyang in rabbit models of cervical spondylosis can reduce the serum levels of inflammatory factors TNF-α, IL-1β, and IL-6.

Research on the Impact of Evidence-Based Predictive Nursing on Elderly Cataract Patients During the Perioperative Period

Weijian Ma — 2026-02-06

Objective: To explore the impact of evidence-based predictive nursing intervention on psychological stress and physiological indicator stability of elderly cataract patients during the perioperative period (1 day before surgery to 1 day after surgery), and to provide a basis for optimizing clinical nursing plans for elderly cataract surgery. Methods: A retrospective selection of 90 elderly patients (aged ≥ 60 years) who underwent cataract surgery in the Ophthalmology Department of our hospital from August 2024 to December 2024 was conducted. They were divided into an observation group (n = 45) and a control group (n = 45) using a random number table method. The control group received routine nursing for cataract surgery, while the observation group implemented evidence-based predictive nursing intervention (including the establishment of a multidisciplinary evidence-based team, hierarchical psychological intervention, perioperative environment optimization, intraoperative personalized cooperation, and video-based health education). Psychological stress indicators [Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS), General Self-Efficacy Scale (GSES)] on the 1st day before surgery and 1st day after surgery, and fluctuations of physiological indicators [Heart Rate (HR), Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP)] on the 1st day before surgery and during surgery were compared between the two groups. Results: Before intervention, there were no statistically significant differences in SAS, SDS, GSES scores, HR, SBP, or DBP between the two groups (p > 0.05); after intervention, the SAS score (33.62 ± 5.72) and SDS score (32.14 ± 4.86) of the observation group on the 1st day after surgery were significantly lower than those of the control group [(41.05 ± 5.56), (43.59 ± 4.75)], and the GSES score (31.15 ± 3.28) was significantly higher than that of the control group (24.84 ± 3.52) (all p < 0.05); during surgery, the fluctuations of HR (74.0 ± 6.0) beats/min, SBP (127.0 ± 15.8) mmHg, and DBP (75.0 ± 5.9) mmHg in the observation group were significantly smaller than those in the control group (all p < 0.05). Conclusion: Evidence-based predictive nursing intervention can effectively alleviate anxiety and depression in elderly cataract patients during the perioperative period, improve self-efficacy, stabilize intraoperative physiological status, and enhance surgical cooperation, which is worthy of clinical promotion.

Application of Whole Slide Imaging Technology in Clinical Pathological Diagnosis

Zhenjie Wang — 2026-02-09

Whole Slide Imaging (WSI) technology, as a revolutionary digital technology in the field of pathology, is gradually changing the traditional clinical pathological diagnosis model. By converting traditional glass pathological sections into complete digital images through high-resolution scanning, it provides a new method for pathological diagnosis. Based on this, this paper studies the application of WSI technology in clinical pathological diagnosis, elaborates on its application value, analyzes the current application status, and proposes corresponding application countermeasures, aiming to provide reference for the standardized and popularized development of this technology in clinical pathological diagnosis.

The Impact of Combined Health Education and Dietary Guidance on the Speed of Postoperative Recovery in Patients with Gastrointestinal Polyps

Jiyang Xie — 2026-02-03

This study aims to explore the impact of combined health education and dietary guidance on the speed of postoperative recovery in patients with gastrointestinal polyps. A specific number of patients who underwent gastrointestinal polyp resection were selected and randomly divided into a control group and an experimental group. The control group received routine nursing, while the experimental group implemented combined health education and dietary guidance on this basis. By comparing the recovery indicators of the two groups, it was found that the recovery speed of the experimental group was significantly faster than that of the control group, indicating that this combined intervention method can effectively promote patient recovery.

Research Progress on the Early Prevention and Control of Myopia in Children Using Mongolian Medical Moxibustion Therapy

Jingjing — 2026-02-09

Mongolian medicine posits that disruptions to the natural balance of the three roots and seven elements within the human body may lead to ocular disorders, vision impairment, and ultimately myopia. China’s children and adolescents not only exhibit high myopia rates but also face increasingly prominent issues of younger onset and severe progression, which critically impact the nation’s future and require urgent attention. Myopia prevention constitutes a systematic project. Traditional Mongolian moxibustion therapy works by applying heat stimulation to specific acupoints to warm meridians, harmonize Qi-blood circulation, regulate elemental balance, thereby enhancing immunity for disease prevention. This holistic approach features non-invasive application with minimal side effects. However, current interventions in myopia management through this method still face challenges including inconsistent operational protocols and insufficiently systematic collaborative research. This paper reviews recent advancements in early intervention using Mongolian moxibustion therapy for myopia, providing insights to optimize myopia prevention strategies.

A Review of Evidence-Based Research on Rehabilitation Nursing after Joint Replacement Surgery

Ying Wang — 2026-02-09

With the intensification of population aging, knee and hip joint replacement surgeries have become core methods for treating end-stage joint diseases, with over a million cases performed globally each year. Postoperative rehabilitation nursing, as a crucial aspect of enhancing surgical outcomes, reducing complications, and facilitating patients’ return to normal life, has its scientific and effective protocols directly influencing patient prognosis. This article systematically reviews the core research findings on rehabilitation nursing after joint replacement surgery based on the concept of evidence-based medicine, aiming to provide references for the formulation of standardized and personalized rehabilitation nursing plans in clinical settings.

The Impact of Personalized Nutritional Support on Complications and Pregnancy Outcomes in Advanced Maternal Age Women with Gestational Diabetes Mellitus

Jiaqi Xiong — 2026-02-09

Objective: To explore the clinical effect of personalized nutritional support in elderly women with gestational diabetes (GDM), and explore its impact on the incidence of maternal complications and pregnancy outcomes. Methods: A total of 90 elderly pregnant women with gestational diabetes who were delivered in our hospital from January 2023 to January 2024 were selected as the research objects. They were randomly divided into an observation group and a control group, with 45 cases in each group. The control group only received routine pregnancy care and basic nutrition guidance, while the observation group received personalized nutrition support on this basis. Compare the blood glucose control, incidence of pregnancy complications, pregnancy outcomes, and neonatal outcomes between two groups of parturient. Result: After intervention, the fasting blood glucose (FPG), 2-hour postprandial blood glucose (2hPG), and glycated hemoglobin (HbA1c) of the observation group were significantly lower than those of the control group, and the differences were statistically significant (p < 0.05); The incidence of complications such as gestational hypertension syndrome, polyhydramnios, premature rupture of membranes, and postpartum hemorrhage in the observation group was significantly lower than that in the control group, and the difference was statistically significant (p < 0.05); The cesarean section rate in the observation group was significantly lower than that in the control group, and the incidence of adverse neonatal outcomes such as fetal distress, macrosomia, neonatal asphyxia, and neonatal hypoglycemia in the observation group was significantly lower than that in the control group, with statistical significance (p < 0.05). Conclusion: Individualized nutritional support for elderly women with gestational diabetes can effectively improve the level of maternal blood sugar control, reduce the incidence of complications during pregnancy, and improve the outcome of pregnancy and neonatal outcomes, which is of high clinical value.

Progress in the Application of Digital Health Interventions in Oral Health Management

Li Li — 2026-02-09

Objective: To systematically sort out the application forms and effects of digital health intervention technologies in oral health management, and provide references for the digital development of stomatology. Methods: By reviewing relevant domestic and foreign studies and clinical practices, this paper summarizes and analyzes the main application forms of digital health interventions, including digital health education, intelligent detection equipment, telemedicine platforms, oral health big data platforms, and school-hospital collaborative screening robots. Results: Studies have shown that digital health interventions can effectively improve the public’s oral health knowledge level, optimize personal health behaviors, enhance clinical diagnosis efficiency, reduce overall medical costs, and promote the innovation and upgrading of oral health management models. Conclusion: Digital health intervention represents an inevitable trend in the future development of stomatology. In the future, it is still necessary to improve data security and privacy protection, technology adaptability and popularity, as well as relevant policies and norms, to give full play to its potential value.

Research on the Application of Digital Intraoral Scanning Impression Technique in Oral Implant Restoration for Periodontitis Patients and Its Impact on VAS Scores

Fei Chen — 2026-02-10

Objective: To explore the application effect of digital intraoral scanning impression technique in oral implant restoration for periodontitis patients and analyze its impact on patients’ Visual Analogue Scale (VAS) scores. Methods: A total of 80 periodontitis patients who received implant restoration in our hospital from May 2023 to May 2025 were selected as research subjects. They were randomly divided into an observation group and a control group using a random number table method, with 40 cases in each group. The observation group used the digital intraoral scanning impression technique to obtain impressions, while the control group used the traditional silicone rubber impression technique. The impression-taking time, the number of prostheses try-ins, implant survival rate, periodontal health indicators (probing depth, gingival index, bleeding index), and VAS scores (pain during treatment and comfort after restoration) were compared between the two groups. Results: The observation group was superior to the control group in terms of impression-taking time, the number of prostheses try-ins, and implant survival rate (p < 0.05). Six months after restoration, the improvement in periodontal health indicators in the observation group was significantly better than that in the control group (p < 0.05). In addition, the pain VAS score of the observation group during treatment was lower than that of the control group, and the comfort VAS score after restoration was higher than that of the control group (p < 0.05). Conclusion: Digital intraoral scanning impression technology can effectively enhance the efficiency and success rate of implant restoration in periodontitis patients, improve periodontal health, alleviate patients’ discomfort during treatment, and increase post-restoration comfort, demonstrating high clinical application value.

Application of Quantitative Assessment Intervention Based on the Kano Model in Postoperative Nursing Care Following Laparoscopic Radical Surgery for Patients with Early-Stage Ovarian Cancer

Jing Zhou — 2026-02-10

Objective: To analyze the impact of nursing interventions based on quantitative assessment using the Kano model on the quality of rehabilitation in patients with early-stage ovarian cancer following laparoscopic radical surgery. Methods: A prospective clinical study was conducted involving 96 patients with newly diagnosed early-stage ovarian cancer who underwent laparoscopic radical surgery from December 2023 to December 2025. Patients were randomly assigned to groups using a random number table method before surgery. After surgery, the control group (n = 48) received routine quantitative assessment nursing interventions, while the observation group (n = 48) received nursing interventions based on quantitative assessment using the Kano model. Both groups received continuous nursing care until discharge. Differences between the groups were compared in terms of negative emotions, quality of life scores before and after postoperative intervention, postoperative recovery indicators, and nursing satisfaction evaluations on the day of discharge. Results: After intervention, the observation group had lower scores on the Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS), as well as shorter recovery times for gastrointestinal function and food intake, and a shorter hospital stay compared to the control group. Additionally, the observation group had higher scores on the Quality-of-Life Instrument for Cancer Patients-Ovarian Cancer (QLICP-OV) than the control group, with statistically significant differences (p < 0.05). The overall satisfaction with nursing care in the observation group was also higher than that in the control group, with a statistically significant difference (p < 0.05). Conclusion: Implementing quantitative evaluation nursing interventions based on the Kano model for patients with early-stage ovarian cancer after laparoscopic radical surgery can, by addressing their postoperative basic health, disease awareness, and other intervention content needs to a comprehensive degree, actively promote postoperative recovery and improve their mental health and quality of life.

The Impact of Systematic Stepwise Rehabilitation Nursing Intervention on the Prognosis and Disease Uncertainty of Patients with Hypertensive Intracerebral Hemorrhage

Jing Zhang — 2026-02-10

Objective: To explore the impact of systematic stepwise rehabilitation nursing intervention on the prognosis and disease uncertainty of patients with hypertensive intracerebral hemorrhage, and to provide feasible strategies for clinical nursing. Methods: Eighty patients with hypertensive intracerebral hemorrhage admitted to our hospital from January 2023 to June 2025 were selected and randomly divided into an observation group (n = 40, receiving systematic stepwise rehabilitation nursing) and a control group (n = 40, receiving conventional nursing). The intervention effects were analyzed by comparing changes in the National Institutes of Health Stroke Scale (NIHSS) scores for neurological recovery, Short Form 36 Health Survey (SF-36) scores for quality of life, Exercise of Self-Care Agency Scale (ESCA) scores for self-management ability, compliance, and the Mishel Uncertainty in Illness Scale (MUIS) scores between the two groups. Results: All scores in the observation group were significantly better than those in the control group after the intervention (p < 0.05). Specifically, the NIHSS scores decreased more significantly, the total SF-36 scores increased, the ESCA scores increased significantly, while the MUIS scores decreased significantly, and compliance improved markedly, indicating a reduction in disease uncertainty among patients. Conclusion: Systematic stepwise rehabilitation nursing intervention can significantly improve neurological recovery, quality of life, self-management ability, and compliance in patients with hypertensive intracerebral hemorrhage, while effectively reducing disease uncertainty. It is worthy of clinical promotion and application.

The Application of Artificial Intelligence in Smart Education for Nursing Students

Yingdong Cao — 2026-02-10

Nursing education is undergoing a paradigm shift from skill training to clinical thinking cultivation. The integration of artificial intelligence technology offers technical possibilities for this transformation, but it also brings about a deep tension between the cultivation of humanistic qualities and a standardized training. Based on the analysis of the practical forms of nursing smart education, this paper examines the cognitive gap between the deterministic feedback of virtual simulation systems and the complexity of real clinical scenarios, reveals the potential narrowing effect of data-driven ability profiling on the all-round development of nursing students, and then proposes the design logic of intelligent teaching resources centered on real clinical problems, a hierarchical teaching model with clear human-machine division of labor, and a dynamic assessment mechanism for technology application led by professional nursing teachers, in an attempt to find a balance between technological empowerment and humanistic commitment in smart nursing education.

A Survey on the Current Status of Usage and Awareness of Out-of-Hospital Automated External Defibrillators in Deyang City

Chunyan Liao — 2026-02-10

Objective: To understand the current awareness and willingness to learn about the use of out-of-hospital automated external defibrillators (AEDs) in Deyang City, providing a basis for improving the success rate of rescue operations. Methods: A questionnaire survey was conducted among residents in Deyang City from January 2025 to October 2025, covering residents’ basic information, awareness of AED-related knowledge, and attitudes towards AED usage. Results: A total of 1,886 questionnaires were collected, with 1,823 valid questionnaires, yielding an effective rate of 96.66%. Among the 1,823 respondents, 692 (37.96%) had received cardiopulmonary resuscitation (CPR)-related learning or training, 619 (33.96%) could accurately describe the name of an AED, 417 (22.87%) could clearly describe the function of an AED, and 308 (16.89%) could accurately describe how to use an AED. Among them, 1,549 (84.97%) were willing to provide assistance to patients experiencing cardiac arrest; 1,731 (94.95%) were willing to provide assistance under the premise of knowing how to use an AED; and 1,750 (95.99%) were willing to learn about AED-related knowledge. Among the 91 individuals unwilling to provide rescue, 75 responded with reasons. Among them, 36 cases (48.00%) were reluctant to rescue due to a lack of relevant first aid knowledge, 32 cases (42.67%) expressed concerns about exacerbating the patient’s condition due to improper operation, and 4 cases (5.33%) were unwilling to interact with strangers due to personal reasons. Conclusion: Currently, residents in Deyang City have limited knowledge about AEDs but demonstrate a strong willingness to learn and apply them. Measures need to be taken to enhance their understanding and application of AEDs.

Evidence Summary for Discharge Preparation Services in Patients After Total Knee Arthroplasty

Jiapei Li — 2026-02-09

Objective: To systematically summarize and evaluate the evidence on discharge preparation services for patients undergoing total knee arthroplasty, providing an evidence-based foundation for developing scientific and standardized discharge preparation intervention programs in clinical practice. Methods: Following the “5S” evidence model, literature such as guidelines, expert consensuses, evidence summaries and randomized controlled trials related to discharge preparation services for total knee arthroplasty patients were retrieved from relevant websites and databases, both domestic and international, from database inception to August 31, 2025. Two researchers independently screened the literature, conducted quality appraisals, and extracted and synthesized the evidence. Results: A total of 15 articles were included, comprising 3 guidelines, 4 expert consensuses, 3 evidence summaries, 3 systematic reviews and 2 randomized controlled trials. Ultimately, 23 pieces of evidence were summarized across five aspects. Conclusion: This study synthesizes the evidence on discharge preparation services for patients undergoing total knee arthroplasty. It is recommended that healthcare professionals apply this evidence in clinical practice, considering specific circumstances and patient needs.

Research on the Clinical Efficacy of Integrated Medical-Nursing Comprehensive Care for Patients with Cerebral Infarction

Yaran Li — 2026-02-10

Objective: To analyze the application effectiveness of the integrated medical-nursing comprehensive care model in cases of cerebral infarction and clarify its clinical practical value for the patient rehabilitation process. Methods: A total of 60 patients with cerebral infarction admitted from June 2024 to December 2024 were selected as the research subjects and randomly divided into a control group and a research group, with 30 cases in each group. Patients in the control group received routine clinical nursing measures, while those in the study group underwent collaborative healthcare intervention in addition to routine nursing. The intervention included joint disease assessment, personalized rehabilitation training guidance, psychological counseling, and continuous nursing services after discharge. A comparative study was conducted by evaluating indicators such as the scores on adverse emotion scales, the extent of neurological recovery, the effectiveness rate of clinical rehabilitation treatment, and the level of satisfaction with nursing services between the two groups. Results: After the intervention, the scores on the Self-Rating Anxiety Scale (SAS) and the Self-Rating Depression Scale (SDS) in the study group decreased to (40.12 ± 5.01) and (41.36 ± 5.20), respectively, both significantly lower than those in the control group, which were (47.36±5.82) and (48.95 ± 5.63), respectively. The differences between the two groups were statistically significant (p < 0.05). The improvement in the neurological deficit scores of patients in the study group reached (9.18 ± 2.04), higher than that in the control group, which was (5.17 ± 1.82) (p < 0.05). The overall clinical rehabilitation effectiveness rate in the study group was 93.3%, significantly higher than that in the control group, which was 73.3%. The satisfaction rate with nursing services in the study group reached 96.7%, also higher than that in the control group, which was 83.3%. The differences between the two groups were statistically significant (p < 0.05). Conclusion: The integrated healthcare nursing model can effectively alleviate adverse emotional states in patients with cerebral infarction, facilitate the repair and reconstruction of neurological function, improve the effectiveness of clinical rehabilitation treatment and satisfaction with nursing services, and thus holds high value for clinical promotion and application.

Observation and Study on the Therapeutic Effect of Diuretics in Patients with Cirrhotic Ascites

Mengqin Zhou — 2026-02-06

Objective: This study aims to systematically evaluate the clinical efficacy and safety of diuretic therapy in patients with liver cirrhosis ascites. Method: 60 patients with liver cirrhosis ascites diagnosed from January 2024 to May 2025 were prospectively included and randomly divided into a furosemide monotherapy group (20 cases), a spironolactone monotherapy group (20 cases), and a combination therapy group (20 cases). The intervention period is 28 days, and the main observation indicators include 24-hour urine output, changes in abdominal circumference, weight loss, serum electrolyte levels, renal function indicators, and incidence of adverse reactions. All study subjects received standardized dietary management and sodium restriction intervention (daily sodium intake < 5 g). Result: The total effective rate (significant + effective) of the combination therapy group in reducing ascites was 95% (19/20), significantly higher than the 75% (15/20) of the furosemide group and the 70% (14/20) of the spironolactone group (p < 0.01). On the 28th day of treatment, the mean urine output in the combination group was 2450 ± 210 mL/d, which was higher than that in the monotherapy group (1850 ± 195 mL/d in the furosemide group); Spironolactone group 1560 ± 180 mL/d. The blood sodium levels of the three groups were maintained at 135–140 mmol/L, but the incidence of hypokalemia in the combination group (10%) was significantly lower than that in the furosemide group (35%). Conclusion: The combination of furosemide and spironolactone has a synergistic effect in the treatment of ascites in cirrhosis, with a 39.2% increase in diuretic effect and a reduction in the risk of electrolyte imbalance; Individualized dose adjustment combined with strict sodium restriction is the core strategy to ensure treatment safety.

Research on the Rehabilitation Treatment Effect of Sensory Integration Training Combined with Cognitive Training in Children with Mental Retardation

Chunhui Song — 2026-02-10

Objective: To analyze the clinical effect of sensory integration training combined with cognitive training in the rehabilitation treatment of children with mental retardation. Methods: A total of 120 children with mental retardation who received rehabilitation intervention in our hospital from January 2022 to December 2025 were selected and divided into a control group and an experimental group, with 60 children in each group. The control group adopted a conventional rehabilitation training program; the experimental group adopted a combined sensory integration training and cognitive training program. The sensory integration ability, cognitive function, and daily living skills of children in the two groups were compared. Results: The sensory integration ability score of the experimental group (85.3 ± 6.2) was significantly higher than that of the control group (72.1 ± 7.5) (p < 0.05); the cognitive function score (88.7 ± 5.8) was significantly improved compared with that of the control group (76.4 ± 6.9) (p < 0.05); the daily living skills score (90.2 ± 4.7) was significantly higher than that of the control group (80.5 ± 5.3) (p < 0.05). The social interaction ability of the experimental group reached 92.5%, which was significantly higher than that of the control group (81.3%) (p < 0.05). Conclusion: Sensory integration training combined with cognitive training demonstrates favorable outcomes in the rehabilitation treatment of children with mental retardation, exhibiting a notable neurofunctional remodeling effect. It can optimize the multidimensional rehabilitation process, effectively enhance the comprehensive developmental potential of children, and hold significant clinical application value.

The Application Value of Phased Nursing Model in Patients with Melasma Undergoing Laser Treatment

Miaomiao Wu — 2026-02-10

Objective: To analyze the application value of phased nursing care in patients undergoing laser treatment for melasma. Methods: A total of 68 patients with melasma who received laser treatment at the Dermatology Department of Yichang Central People’s Hospital from June 2023 to June 2025 were selected as the study subjects. According to differences in nursing plans, patients were randomly divided into two groups, with 34 patients in each group: the control group received routine nursing care, while the observation group received phased nursing care. The wound healing, negative emotions, and self-efficacy of the two groups before and after nursing were compared. Results: The duration of erythema in the observation group was shorter than that in the control group, and the area of pigmentation was smaller than that in the control group (p < 0.05). After nursing, the SAS and SDS scores of the observation group were lower than those of the control group (p < 0.05), and the GSES scores of the observation group were higher than those of the control group (p < 0.05). Conclusion: Phased nursing care can significantly improve wound healing in patients undergoing laser treatment for melasma, reduce negative emotions, and enhance self-efficacy.

Exploration and Practical Research on the Construction Model of the Emergency Care System Based on the Concept of “Linkage”

Yan Li — 2026-02-10

Against the backdrop of continuous social development and growing public health demands, the efficiency and scientific nature of the emergency care system are of paramount importance. This paper focuses on researching the construction of an emergency care system based on the concept of “linkage”, delving into its theoretical foundations, exploring innovative construction models, and analyzing practical cases. The study indicates that an emergency care system under the “linkage” concept can effectively integrate resources and enhance efficiency, providing new insights for improving the construction of the emergency care system. It aims to promote the development of the emergency care system towards a more scientific, efficient, and collaborative direction.

The Impact of Mother-Infant Separation on the Physical and Mental Health of Women with High-Risk Pregnancies and Corresponding Nursing Strategies

Qing Yang — 2026-02-10

Objective: To analyze the impact of maternal-infant separation on the physical and mental state of high-risk pregnancy patients and explore the clinical efficacy of targeted nursing interventions. Methods: A total of 80 high-risk pregnancy patients treated in our hospital from January 2023 to January 2024 were selected as the study subjects. These patients were randomly divided into an observation group and a control group (40 cases each) using a random number table. The control group received routine high-risk pregnancy nursing care, while the observation group received specialized maternal-infant separation nursing interventions in addition to routine care. The psychological and physiological states and nursing satisfaction of the two groups were compared before and after the intervention. Results: The SAS scores, SDS scores, and sleep quality scores of the observation group were significantly lower than those of the control group, with statistically significant differences (p < 0.05). The incidence of postpartum hemorrhage in the observation group was significantly lower than that in the control group, and the initiation time of lactation was significantly earlier than that in the control group, with both differences being statistically significant (p < 0.05). The nursing satisfaction of the observation group was significantly higher than that of the control group (80% vs. 32/40), with a statistically significant difference (p < 0.05). Conclusion: Maternal-infant separation exacerbates anxiety and depression in high-risk pregnancy patients, reduces sleep quality, increases the risk of postpartum hemorrhage, and delays the initiation of lactation. Specialized nursing interventions for maternal-infant separation can improve the physical and mental state of high-risk pregnancy patients, reduce the incidence of postpartum complications, and enhance nursing satisfaction, making them worthy of clinical application and promotion.

Forensic Evaluation of Blindness Following Ocular Bee Sting: A Case Report and Literature Review

Yongping Wei — 2026-02-09

This report presents a forensic evaluation of a case involving blindness (visual acuity grade 5) following a bee/wasp sting to the left eye. Through systematic analysis of the patient’s multiple hospital admissions, postoperative follow-up data, and a review of the pathological mechanisms of ocular injury caused by bee venom, this study comprehensively assesses the injury characteristics, treatment course, and visual outcomes. Bee venom induces severe complications such as corneal damage, uveitis, cataract, and secondary glaucoma through multiple mechanisms including direct cytotoxicity, immune-inflammatory responses, and enzymatic hydrolysis. Despite interventions including anterior chamber irrigation, phacoemulsification with intraocular lens implantation, and antiglaucoma surgery, the affected eye ultimately lost light perception. Forensic examination confirmed the absence of light perception in the left eye and abnormal visual pathway function, consistent with clinical observations. According to the relevant Chinese disability assessment standard (JR/T 0083-2013, Article 4.2.2), the injury was classified as grade 7 disability. This study provides an in-depth discussion of the mechanisms and key forensic identification points in bee-sting-induced blindness, offering a scientific reference for similar forensic clinical cases.

The Application of Frailty Prediction Model for Middle-aged and Elderly Patients with Upper Gastrointestinal Bleeding in Peri-inpatient Nursing Intervention

Chaoxiang You — 2026-02-10

Objective: To investigate the impact of targeted nursing interventions based on frailty prediction models on peri-hospitalization clinical outcomes in middle-aged and elderly patients with upper gastrointestinal bleeding (UGIB). Methods: A prospective cohort study was conducted, and 126 middle-aged and elderly patients with UGIB admitted from August 2024 to August 2025 were selected as the study subjects. The patients were divided into the intervention group (63 cases) and the control group (63 cases) based on whether they received nursing intervention based on frailty prediction models. The control group received routine care, while the intervention group, on the basis of routine care, used the FRAIL scale combined with laboratory indicators (albumin, hemoglobin, etc.) to establish a predictive model to evaluate patients within 24 hours of admission, and implemented multi-dimensional targeted nursing intervention for pre-frailty or frailty patients screened out. The incidence of frailty, rebleeding rate, average length of stay, hospitalization cost, and nursing satisfaction during hospitalization were compared between the two groups. Results: The incidence of frailty during hospitalization in the intervention group was 11.1% (7 cases /63 cases), significantly lower than 31.7% (20 cases /63 cases) in the control group, and the difference was statistically significant (p < 0.05). The rebleeding rate of 4.8% vs 12.7%, the average length of stay of (7.2 ± 1.5) days vs (9.1 ± 2.2) days, and the average hospitalization cost of (23,000 ± 6,000) yuan vs (28,000 ± 7,000) yuan in the intervention group were all lower than those in the control group (all p < 0.05). The nursing satisfaction score of the intervention group (93.5 ± 4.2) points was higher than that of the control group (86.3 ± 5.8) points (p < 0.05). Conclusion: The frailty prediction model applied to the peri-hospitalization care of middle-aged and elderly patients with UGIB can effectively identify frailty risk. Through early targeted intervention, the incidence of frailty and rebleeding rate can be reduced, the length of hospital stay can be shortened, medical expenses can be reduced, and nursing satisfaction can be improved, which has clinical promotion value.

Clinical Efficacy of Different Parameter Modes of Electrophysiological Therapy in Chronic Pelvic Pain Syndrome

Xiaoming Wang — 2026-02-06

Objective: To investigate the clinical efficacy of electrophysiological therapy under different parameter modes in chronic pelvic pain syndrome (CPPS). Methods: A total of 95patients with CPPS from the Department of Urology, First Affiliated Hospital of Jinan University, were selected and treated with electrophysiological therapy. They were randomly divided into three groups: the fixed-parameter AA7 treatment group, the P2 + P4 treatment group, and the precision treatment group (individualized parameter treatment). Pain scores of patients in each group were compared before and after treatment, with a pain score of 0 indicating cure. The cure rate of each group was observed. Results: The average ages of the AA7 group, P2 + P4 group, and precision treatment group were 34 ± 14.17 years, 35.58 ± 12.57 years, and 35.5 ± 11.27 years, respectively. There was no significant difference in age among the three groups (p > 0.05). Before treatment, the pain scores of the AA7 group, P2 + P4 group, and precision treatment group were 4.14 ± 1.74, 4.64 ± 1.72, and 3.50 ± 1.89, respectively, with no significant differences among the groups (p > 0.05). After treatment, the pain scores were 0.71 ± 0.99 for the AA7 group (cure rate: 57%), 0.49 ± 0.79 for the P2 + P4 group (cure rate: 67%), and 0.50 ± 0.77 for the precision treatment group (cure rate: 64%), with no significant differences among the groups (p > 0.05). The cure rates for different pain locations were as follows: 83% for lower abdominal pain, 74% for perineal pain, 62% for dysuria, 49% for testicular pain, and 75% for inguinal pain. Conclusion: The pathogenesis of CPPS is complex and diverse, with numerous treatment options and uncertain efficacy, posing significant challenges to clinical practice. This study showed that electrophysiological therapy under different parameter modes significantly reduced pain scores before and after treatment, indicating significant therapeutic effects on CPPS. All three modes demonstrated good cure rates. Individualized precision treatment and fixed-mode P2 + P4 or AA7 treatment were safe and effective in CPPS treatment and are worth promoting. Fixed-mode P2 + P4 and AA7, due to their easier standardization of parameters and patch modes, reduced the learning curve and had better potential for widespread application.

Application and Effectiveness Evaluation of Standardized Protective Care Procedures in Hydrofluoric Acid Operations within Dental Departments

Fengqun Yong — 2026-02-06

Objective: To evaluate the implementation effectiveness of standardized protective care procedures during hydrofluoric acid procedures in the dental department. Methods: This study was conducted from June 2023 to June 2025, selecting 90 patients who underwent hydrofluoric acid-related treatments in the outpatient dental department of this hospital during this period as subjects. Forty-five patients treated between June 2023 and June 2024 received conventional protective care (pre-intervention group), while 45 patients treated between June 2024 and June 2025 underwent the standardized protective care protocol (post-intervention group). Thirteen healthcare personnel participated in both pre- and post-intervention treatment phases. Based on the different nursing models, indicators such as the incidence of adverse events in patients and the exposure rate of healthcare personnel before and after implementation were compared to evaluate the effectiveness of the nursing intervention. Results: The incidence of oral mucosal irritation reactions in patients was lower after implementation, p < 0.05. Compared with the pre-implementation period, the incidence of procedure-related adverse events decreased after implementation, p < 0.05. There was a significant difference in the occupational exposure rate of healthcare personnel before and after implementation, with a higher rate observed before implementation (p < 0.05). Post-implementation, healthcare personnel achieved higher compliance scores for pre-procedure preparation, intra-procedure protection, and post-procedure handling (p < 0.05). Patient satisfaction with treatment was lower pre-implementation than post-implementation (p < 0.05). Conclusion: Adherence to standardized protective care procedures during hydrofluoric acid operations by dental department staff in outpatient settings standardizes practitioner techniques, effectively prevents oral mucosal irritation in patients, reduces occupational exposure risks for staff, minimizes adverse procedural events, and consequently enhances patient treatment satisfaction. This demonstrates significant practical value.

Integrated Predictive Nursing Care for a Case of Imported Severe Malignant Malaria with Spontaneous Splenic Rupture

Na Bai — 2026-02-06

A case of imported severe falciparum malaria with spontaneous splenic rupture was reported in this paper. The patient, an African migrant worker, developed hemolytic anemia, sepsis, thrombocytopenia, coagulation dysfunction, liver failure, renal insufficiency, electrolyte disturbance and other clinical manifestations after returning to the local area. Plasmodium falciparum was found by peripheral blood smearscopy and was diagnosed as severe falciparum malaria. After standardized anti-malaria treatment, plasma exchange + cytokine adsorption therapy, the establishment of “forewarning–forewarning–prevention–emergency” predictive nursing management model, the establishment of an integrated nursing team, the division of medical care is clear, professional knowledge is complementary, after three months of regular follow-up, the patient has no malaria recurrence, no refire, the function of all organs returned to normal.

Analysis of Sleep Quality Improvement in Patients with Lumbar Disc Herniation Following Auricular Acupuncture Combined with Chinese Herbal Medicine Packing Therapy

Wei Cai — 2026-02-11

Objective: To evaluate the nursing effects of auricular seed therapy combined with Chinese herbal poultice treatment for patients with lumbar disc herniation (LDH). Method: A total of 80 patients with LDH were randomly divided into two groups. The combined group received auricular acupuncture with seed application combined with Chinese herbal poultice therapy, while the reference group received auricular acupuncture with seed application alone. The therapeutic outcomes of both groups were compared. Results: The combined intervention group demonstrated decreased sleep quality scores, reduced pain neurotransmitter levels, and improved lumbar spine function scores post-intervention, with significant intergroup differences (p < 0.05). Conclusion: Auricular seed therapy combined with Chinese herbal poultice care effectively improves sleep quality and lumbar spine function while alleviating pain perception in patients with lumbar disc herniation, indicating superior therapeutic efficacy.

A Case of Ventilator-associated Pneumonia in Neonatology: Investigation and Analysis of the Source of Ralstonia mannitolilytica Infection

Huimin Yang — 2026-02-09

This study examined a case of ventilator-associated pneumonia caused by Ralstonia mannitolilytica in a neonatal department in order to determine the source of infection and mode of transmission. Symptoms of infection began to appear on day 16 of admission, and both sputum and catheter tip cultures revealed R. mannitolilytica. The infection control department of the hospital later sampled and identified R. mannitolilytica in the ventilator tube that was used by the patient with the exact gene sequence as the infecting strain. These findings indicate that ventilator tubing is a significant contamination source of this pathogen, and hospitals need to enhance their disinfection methods of ventilator-related devices.

A Case Report of Familial Episodic Pain Syndrome Type 3 in a 5-Year-Old Boy

Tianyi Hu — 2026-02-09

Medical history summary: The child has suffered from episodic joint pain in the lower extremities since childhood, with occurrences ranging from 1 to 3 times daily, predominantly during rainy, cold, and humid weather, as well as in the afternoons and evenings. Symptoms and signs: The primary manifestation is episodic pain in the distal extremities, predominantly in the lower limbs, knees, and ankles. Occasionally, the pain may ascend to the elbows, wrists, and palms, and may occasionally affect the proximal extremities and waist. Diagnostic methods: Nerve biopsy and related pathological examinations, along with whole exome sequencing, are helpful for diagnosis, particularly the detection of variants in the SCN11A gene. Treatment approaches: (1) Pharmacotherapy: Sodium channel blockers and nonsteroidal anti-inflammatory drugs such as ibuprofen and naproxen can alleviate pain. (2) Neuromodulation techniques: Techniques such as transcranial magnetic stimulation (TMS) and spinal cord stimulation (SCS) can be employed to improve symptoms. (3) Psychotherapy: Cognitive-behavioral therapy (CBT), relaxation training, or psychological counseling can enhance the patient’s coping abilities. Clinical outcome: Pain relief can be achieved with analgesic medication in children, and pain symptoms generally persist until adulthood, gradually diminishing or even disappearing. Patients can reduce the frequency of episodes by staying warm and avoiding cold and damp conditions.

Interventional Room Nursing for Patients with Ischemic Stroke Treated with Tirofiban Combined with Direct Thrombectomy

Yayun Xiong — 2026-02-11

Objective: To explore the interventional room nursing and its application effects in patients with ischemic stroke treated with tirofiban combined with direct thrombectomy. Methods: A total of 61 patients with ischemic stroke admitted to our hospital from June 2024 to June 2025 were selected and divided into two groups using the red and blue ball method: the control group (n = 30, receiving routine interventional room nursing) and the observation group (n = 31, receiving additional tirofiban medication-specific nursing + individualized interventional nursing on the basis of routine nursing). The cerebral hemodynamic indicators, adverse reactions, effectiveness of complication nursing, and nursing satisfaction were compared between the two groups. Results: After 7 days of treatment, the observation group had lower cerebrovascular peripheral resistance and higher mean blood flow velocity and mean blood flow volume compared to the control group (all p < 0.05). The observation group had a higher effectiveness rate of complication nursing than the control group, with a statistically significant difference (p < 0.05). The nursing satisfaction in the observation group (96.77%) was higher than that in the control group (80.00%), with a statistically significant difference (χ² = 4.223, p = 0.040 < 0.05). Conclusion: Tirofiban combined with direct thrombectomy can significantly improve cerebral hemodynamics, enhance the effectiveness of complication nursing, and increase patient satisfaction in patients with ischemic stroke.

Observation on the Effect of Combined Exercise Intervention Based on the Hospital-Community-Family Model on Intrinsic Capacity in Elderly Patients with Diabetes Mellitus Complicated by Chronic Kidney Disease

Meijie Zheng — 2026-02-11

Objective: To explore the application effect of combined exercise intervention based on the hospital-community-family model on intrinsic capacity in elderly patients with diabetes mellitus complicated by chronic kidney disease. Methods: Using convenience sampling, 100 elderly patients with diabetes mellitus complicated by chronic kidney disease who received treatment in the endocrinology department of a tertiary A-level hospital from May 2024 to May 2025 were selected as the study subjects. They were randomly divided into an experimental group (50 cases) and a control group (50 cases) using a random number table method. The control group received routine health education and telephone follow-up, while the experimental group, in addition to the control group’s interventions, underwent combined exercise intervention based on the hospital-community-family model. Remote medical guidance was utilized to monitor and study the application effect of exercise intervention on intrinsic capacity in elderly patients with diabetes mellitus complicated by chronic kidney disease. Fasting blood glucose, 2-hour postprandial blood glucose, glomerular filtration rate, 6-minute walk distance, and scores in five dimensions of intrinsic capacity (exercise, cognition, psychology, vitality, and sensation) were measured before the intervention, at 4 weeks of intervention, and at 12 weeks of intervention for both groups. Results: Before the exercise intervention, there were no statistically significant differences (p > 0.05) between the two groups in terms of fasting blood glucose, 2-hour postprandial blood glucose, glomerular filtration rate, 6-minute walk distance, and scores across five dimensions of intrinsic capacity: mobility, cognition, psychology, vitality, and sensation. After 12 weeks of intervention, the experimental group demonstrated significantly higher scores than the control group in glomerular filtration rate, 6-minute walk distance, and the dimensions of mobility, cognition, and vitality within intrinsic capacity, with all differences being statistically significant (p < 0.05). Conversely, the experimental group showed significantly lower scores than the control group in fasting blood glucose, 2-hour postprandial blood glucose, and the psychological dimension of intrinsic capacity, with these differences also being statistically significant (p < 0.05). Conclusion: Continuous nursing care utilizing telemedicine based on a hospital-community-family model combined with exercise intervention can effectively enhance exercise tolerance and intrinsic capacity in elderly patients with diabetes mellitus complicated by chronic kidney disease, thereby improving their quality of life. The effectiveness of the intervention is positively correlated with the duration of the intervention.

A Cross-sectional Analysis of Prenatal Bisphenol an Exposure and Pregnancy Characteristics in Northeastern Yunnan, China

Xuemei Ding — 2026-02-11

Objective: To assess prenatal Bisphenol A (BPA) exposure levels and explore their preliminary associations with maternal and fetal characteristics in a population from Northeastern Yunnan. Methods: A cross-sectional analysis was performed using data and urine samples from 70 pregnant women in their third trimester recruited at Qujing Central Hospital. Urinary BPA was measured by HPLC-MS/MS. Participants were stratified into high and low BPA exposure groups based on the median concentration. Results: BPA was detected in all samples (100%) with a median concentration of 2.41 μg/L (IQR: 0.68–4.96). The high BPA exposure group (≥ 2.41 μg/L) had a significantly higher proportion of gestational diabetes mellitus (GDM) (42.9% vs. 17.1%, p = 0.021) and a lower median fetal birth weight (3250 g vs. 3450 g, p = 0.048) compared to the low exposure group. Conclusion: This pilot study reveals ubiquitous BPA exposure in pregnant women from Northeastern Yunnan. The observed preliminary associations with GDM and reduced fetal birth weight warrant further investigation in larger, longitudinal studies.

Analysis of Management Strategies for Chronic Diseases in the Elderly with Cognitive Impairment

Yinchun Rui — 2026-02-11

With the intensification of population aging in China, the problem of cognitive impairment in the elderly has become increasingly prominent, attracting widespread attention from all sectors of society. Geriatric cognitive impairment is characterized by chronicity, which not only seriously threatens the health of the elderly and reduces their quality of life, but also imposes a heavy burden on families and society due to its long course. Attaching importance to and strengthening the chronic disease management of elderly cognitive impairment has profound significance for delaying disease progression, improving patients’ quality of life, and reducing the burden of family care. Therefore, this paper first comprehensively understands elderly cognitive impairment by briefly elaborating on its definition and characteristics; on this basis, it focuses on exploring effective strategies for the chronic disease management of elderly cognitive impairment, hoping to provide new ideas and methods for the management of this condition and offer useful references for relevant clinical research and practice.

Research on the Optimal Allocation of Community Elderly Care Service Resources Based on Big Data Technology

Shuying Li — 2026-02-11

With the accelerating aging process of China’s population, the demand for community elderly care services has shown diversified and personalized characteristics. However, problems such as insufficient total care service resources, uneven distribution, and prominent supply-demand contradictions have seriously affected service quality. Big data technology, with core advantages including data collection, analysis and mining, and accurate prediction, provides a new solution for the allocation of community elderly care service resources. This paper systematically studies the application value of big data technology in the allocation of community elderly care service resources from three aspects: resource allocation efficiency, service accuracy, and management intelligence. Combined with practical needs, it proposes optimal allocation strategies such as building a big data analysis platform and accurately grasping the elderly’s care needs, striving to provide operable path references for the construction of community elderly care service systems, promoting the early realization of the elderly care service goal of “adequate support and proper care for the elderly”, and boosting the high-quality development of China’s elderly care service industry.

Research on the Correlation Between Anesthetic Depth and Surgical Stress Response in Minimally Invasive Cardiothoracic Surgery Anesthesia

Liqun Zhao — 2026-02-11

Objective: To explore the relationship between anesthetic depth and surgical stress response in minimally invasive cardiothoracic surgery. Methods: A total of 89 patients who underwent thoracoscopic minimally invasive cardiothoracic surgery in our hospital from June 2024 to December 2024 were selected as the research objects. They were divided into the light anesthesia group (n = 45) and the deep anesthesia group (n = 44). The vital signs at different intraoperative nodes and perioperative stress status of the two groups were compared. Results: Before lesion resection and after surgery, the mean arterial pressure and heart rate of the deep anesthesia group were lower than those of the light anesthesia group, with statistically significant differences. Conclusion: In thoracoscopic minimally invasive cardiothoracic surgery, deep anesthesia can effectively control the patient’s surgical stress response, but the postoperative awakening time is longer; patients under light anesthesia have a shorter awakening time, but the intraoperative stress response is obvious.

An Analysis of the Role of Integrated Medical and Elderly Care in the Management of Chronic Diseases among the Elderly

Yinchun Rui — 2026-02-11

In recent years, with the accelerating aging process of the population, China has entered an aging society, and the number of elderly patients with chronic diseases has been increasing. The traditional medical and elderly care service models can no longer fully meet their needs. The integrated medical and elderly care model has emerged as the times require. It organically combines medical resources with elderly care resources to provide comprehensive and continuous health management services for the elderly, becoming an important approach to solving the problems of chronic disease management among the elderly. In this regard, this paper first elaborates on the role of integrated medical and elderly care in the management of chronic diseases among the elderly, and then puts forward application strategies of integrated medical and elderly care in the management of chronic diseases among the elderly, in order to provide certain reference for relevant researchers.

Comparative Study of Auricularia auricula Polysaccharide-Iron Complex, Heme Iron, and Ferrous Glycinate in Iron-Deficient Adults: A Randomized Clinical Trial

Nurfarih Hanna — 2026-02-11

Iron deficiency anemia affects approximately 1.62 billion people worldwide, yet traditional iron supplements present bioavailability limitations and gastrointestinal side effects. This randomized, double-blind clinical trial investigated a novel Auricularia auricula polysaccharide-iron complex (AAPIC) compared with heme iron and ferrous glycinate in 180 iron-deficient adults receiving 30 mg elemental iron daily for 12 weeks. AAPIC achieved comparable hemoglobin improvements (from 98.3 ± 8.7 to 126.5 ± 9.2 g/L) to heme iron (from 97.8 ± 9.1 to 128.3 ± 8.6 g/L) and was significantly superior to ferrous glycinate (from 98.6 ± 8.9 to 119.7 ± 10.3 g/L; p < 0.001). Iron absorption efficiency showed AAPIC at 23.7 ± 4.2%, heme iron at 25.1 ± 3.8%, and ferrous glycinate at 18.4 ± 5.1%. Toxicological assessments revealed no hepatotoxicity, nephrotoxicity, or mutagenicity. Gastrointestinal adverse events occurred in 8.3% of AAPIC recipients versus 15.0% with ferrous glycinate and 10.0% with heme iron. The polysaccharide component facilitates iron transport through enhanced intestinal uptake mechanisms. AAPIC represents a promising, well-tolerated alternative with clinical efficacy comparable to established iron formulations.

Application progress of Point-of-Care Ultrasound for Cannulation in Hemodialysis Patients with Difficult Arteriovenous Fistulae

Yuli Shi — 2026-02-09

The occurrence of difficult arteriovenous fistulas makes the use of vascular access in hemodialysis patients face great challenges. With the widespread application of point-of-care ultrasound, POCUS technology, it provides a new solution for clinical practice. This article reviews the principle, basic process, application status, current clinical challenges and development direction of difficult arteriovenous fistulas cannulation guided by POCUS technology, in order to provide reference for the standardized clinical application and future research direction of this technology.

Comparative Study on the Diagnostic Efficacy of Conventional MRI Sequences and T2 Mapping Sequences in Cartilage Injury

Wang Peng — 2026-02-11

Objective: To retrospectively evaluate the diagnostic efficacy of traditional MRI and T2 Mapping quantitative imaging technology for knee joint cartilage injury, clarify the differences in diagnostic value of the two imaging methods in different injury grades and different cartilage subregions, and provide evidence-based basis for the accurate diagnosis of clinical cartilage injury. Methods: Clinical and imaging data of 286 patients with knee joint lesions admitted to the Affiliated Hospital of Xiangtan Medicine and Health Vocational College from January 2020 to June 2023 were collected retrospectively. All patients underwent both traditional MRI sequences and T2 Mapping sequences. The knee joint cartilage was divided into 14 subregions. Two senior radiologists independently diagnosed the images of the two imaging technologies using a blind method and recorded the cartilage injury grades. The sensitivity, specificity, accuracy, positive predictive value, negative predictive value, and area under the receiver operating characteristic curve (AUC) of the two technologies for diagnosing cartilage injury were calculated and compared, and the differences in their diagnostic efficacy in different injury grades and different subregions were analyzed. Results: A total of 4004 cartilage subregions from 286 patients were included in the analysis, including 1836 injured subregions and 2168 normal subregions. The overall sensitivity (89.7%), accuracy (91.2%), and AUC (0.946) of T2 Mapping quantitative imaging for diagnosing cartilage injury were significantly higher than those of traditional MRI (76.3%, 82.5%, and 0.852 respectively), with statistically significant differences (p < 0.001); there was no significant difference in specificity between the two (93.5% vs 90.8%, p = 0.062). Subgroup analysis showed that T2 Mapping had the most significant diagnostic advantage in early cartilage injury (Grade 1), with sensitivity (78.5%) 33.2% higher than that of traditional MRI (45.3%) (p < 0.001). Conclusion: The diagnostic efficacy of T2 Mapping quantitative imaging for knee joint cartilage injury is significantly superior to that of traditional MRI, especially in the detection of early cartilage injury and accurate evaluation of weight-bearing area injury. Data verify its clinical applicability and reliability. It can be used as an important supplementary method to traditional MRI, and is recommended for the early diagnosis, grading evaluation, and clinical follow-up of cartilage injury.

Clinical Observation of TCM Constitution Theory-Based Intervention in the Critical Window of AECOPD

Xiaoyan Wang — 2026-02-11

Objective: To observe the efficacy and safety of TCM syndrome differentiation-guided herbal intervention for patients with five constitutions during the high-risk window period of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) based on TCM constitution theory. Methods: A total of 300 AECOPD patients in the high-risk window period (54–66 cases for each constitution) were randomly divided into two groups (150 cases each). The control group received fluticasone furoate/umeclidinium/vilanterol inhalation therapy, while the experimental group was additionally given constitution-specific TCM decoctions (e.g., Erchen Decoction combined with Sanzi Yangqin Decoction for Phlegm-Dampness constitution). The treatment course was 8 weeks with a 6-month follow-up. CAT score, TCM syndrome score, pulmonary function, 6-minute walking distance (6MWD), and levels of CRP and IL-6 were observed. Recurrence and safety indicators were recorded. Results: After treatment, all indicators improved significantly in both groups (p < 0.05), with the experimental group showing superior improvements in CAT score, TCM syndrome score, FEV1, 6MWD, and inflammatory indicators (p < 0.01). The recurrence rate was lower in the experimental group during follow-up (p < 0.05). No severe adverse reactions or abnormalities in liver/kidney function were observed in either group. Conclusion: TCM syndrome differentiation treatment guided by constitution theory can improve symptoms, quality of life, and pulmonary function, reduce inflammatory levels and recurrence rate in AECOPD patients during the high-risk window period, with good safety.

Composite Deep-Learning Model for 90-Day mRS Prediction in Post-Stroke Patients

Shihan Dong — 2026-02-11

To counteract small sample size, severe class imbalance and high feature redundancy in 90-day mRS prediction after stroke, this study proposes a four-stage pipeline— “ADASYN re-sampling → clinical + statistical feature screening → dimensionality reduction → 5-fold cross-validation” —and benchmark composite deep-learning architectures. ADASYN first balances the minority classes in the original feature space. Next, a tri-level filter (clinical domain knowledge, variance threshold, mutual information) removes clinically meaningless or redundant variables, after which PCA compresses the remaining features while preserving critical neurological signatures (e.g., brain-herniation history). Four hybrid CNN–RNN models are trained and compared under strict 5-fold cross-validation; the optimal ensemble yields stable, clinically interpretable probabilities that can support individualized rehabilitation planning.

Evaluation of the Application Effect of Intelligent Empowerment Standardized Airway Management Process in Patients Receiving Mechanical Ventilation

Duo Yu — 2026-02-11

Objective: To investigate the application effect of intelligent empowerment standardized airway management process in patients receiving mechanical ventilation. Methods: A retrospective analysis was conducted on the clinical data of 79 EICU inpatients who underwent tracheal intubation and mechanical ventilation treatment at our hospital from January 2023 to May 2025. The patients were divided into a control group (conventional airway management process, n = 40) and a study group (intelligent empowerment standardized airway management process, n = 39) based on the intervention protocols they received. Oral health scores, dental plaque index, oral odor, serum inflammatory markers [C-reactive protein (CRP), procalcitonin (PCT)], clinical pulmonary infection score (CPIS), as well as the incidence of ventilator-associated pneumonia (VAP), duration of mechanical ventilation, and length of stay in the EICU were assessed before and after treatment. Results: The baseline values of all indicators were consistent between the two groups before intervention (p > 0.05). After corresponding interventions, both groups showed significant improvements in Beck oral health scores, dental plaque index, and oral odor, with more pronounced improvements observed in the study group (p < 0.05). After the intervention, the research group showed a significant decrease in serum CRP and PCT levels, as well as CPIS scores (p < 0.05). In contrast, the control group experienced an increase in these three indicators to a certain extent (p < 0.05). Moreover, the incidence of ventilator-associated pneumonia (VAP), duration of mechanical ventilation, and length of stay in the EICU were all lower in the research group compared to the control group, while the nurse’s compliance rate with the protocol was higher in the research group (p < 0.05). Conclusion: The standardized airway management protocol empowered by intelligent technology can significantly improve nursing compliance, benefit oral health status, reduce the risk of pulmonary infection and systemic inflammation levels, and promote rapid patient recovery, demonstrating considerable potential for widespread adoption.

Examining the Impact of Heparin-Free Dialysis Supplemented with Infrared Lamp Irradiation on Coagulation in Dialyzers

Qin Chen — 2026-02-11

Objective: To investigate the effects of infrared lamp irradiation therapy on the risk of arteriovenous fistula thrombosis in patients undergoing heparin-free dialysis and those receiving appropriate reductions in heparin anticoagulation dosage during dialysis. Methods: This study was conducted from January 1, 2021, to December 31, 2021, involving 19 patients who regularly underwent heparin-free dialysis for more than three months at our hospital, totaling 70 patient encounters. Each patient underwent heparin-free dialysis for more than two cycles during the experimental period. The study employed a self-control design. Prior to the experiment, an experienced medical team established an emergency management group and formulated relevant emergency measures, ensuring the long-term stability of patients’ vital signs before enrollment. Patients requiring heparin-free dialysis as per medical advice underwent the procedure according to the treatment manual without additional interventions. During the second heparin-free dialysis session within the experimental period, patients received 40 minutes of infrared lamp irradiation as an adjunctive therapy during the dialysis process. The study observed coagulation in the dialyzer, blood biochemical indicators, the occurrence of adverse reactions, and patient satisfaction during treatment. Results: The use of heparin-free dialysis combined with infrared irradiation therapy resulted in better coagulation outcomes compared to heparin-free dialysis alone (p < 0.05). There was no statistically significant difference in blood biochemical indicators between patients receiving heparin-free dialysis combined with infrared irradiation therapy and those receiving heparin-free dialysis alone (p > 0.05). There was no statistically significant difference in the number of patients experiencing adverse clinical symptoms such as angina, dizziness, and lower limb cramps, leading to treatment interruption, between those receiving heparin-free dialysis combined with infrared therapy and those receiving heparin-free dialysis alone (p > 0.05). Patient satisfaction was higher among those receiving heparin-free dialysis combined with infrared therapy compared to those receiving heparin-free dialysis alone (p < 0.05). Conclusion: The use of infrared lamp irradiation therapy as an adjunct to heparin-free dialysis can reduce the risk of coagulation to a certain extent without affecting the stability of core blood biochemical indicators in patients. It also reduces the incidence of clinical adverse reactions caused by coagulation, demonstrating good safety and improving patient satisfaction.

Research on the Efficacy of Autologous Periosteum Graft Combined with PRP in the Treatment of Long Bone Fractures in the Extremities

Xiang Chen — 2026-02-11

Objective: To analyze the clinical application value of autologous periosteum graft combined with platelet-rich plasma (PRP) in the treatment of long bone fractures in the extremities. Methods: A total of 40 patients with long bone fractures in the extremities admitted to Santai Hospital Affiliated to North Sichuan Medical College from January 2023 to January 2025 were included, including cases of upper extremity forearm fractures and lower extremity femoral and tibial fractures. The patients were evenly divided using a random number table, with the control group undergoing open reduction and internal fixation (ORIF) combined with autologous periosteum graft, and the observation group undergoing ORIF, autologous periosteum graft, and PRP injection. Surgical indicators, complication rates, excellent fracture healing rates, functional satisfaction, and joint range of motion were compared between the two groups. Results: The surgical indicators in the observation group were similar to those in the control group (p > 0.05). The complication rate in the observation group was lower than that in the control group, while the excellent fracture healing rate and functional satisfaction were higher in the observation group (p < 0.05). Conclusion: Autologous periosteum graft combined with PRP technology is safe and reliable for the treatment of long bone fractures in the extremities, with satisfactory clinical outcomes.

Qualitative Research on the Current Implementation Status and Barriers of Nurses’ Non-Pharmacological Prescription Authority

Ying Li — 2026-02-12

Objective: To systematically review the current implementation status of nurses’ non-pharmacological prescription authority and analyze the barriers encountered during its implementation in China, providing countermeasures and references for promoting the standardized implementation of nurses’ non-pharmacological prescription authority. Methods: A secondary analysis of literature was conducted to systematically search for domestic and international literature related to nurses’ non-pharmacological prescription authority. Meta-analysis was performed on eligible literature to evaluate the implementation effects. Simultaneously, semi-structured in-depth interviews were conducted with healthcare workers, patients, and policymakers. Content analysis was used to organize the interview data and extract core issues and barriers. Results: A total of 46 international articles were included in the Meta-analysis, which revealed that the implementation of nurses’ non-pharmacological prescription authority significantly improved patients’ health management outcomes, enhanced healthcare service efficiency, and increased patient satisfaction. Conclusion: The implementation of nurses’ non-pharmacological prescription authority has demonstrated significant positive effects. However, China faces multiple barriers in its advancement, necessitating efforts in optimizing policy systems, constructing collaborative models, strengthening professional skills training, and improving social awareness to guide the scientific and rational implementation of nurses’ non-pharmacological prescription authority.

Research Advances in Modern Analytical Techniques for Quality Control and Clinical Application of Ganmai Dazao Decoction

Zihan Zhu — 2026-02-12

Ganmai Dazao Decoction, originating from “Jin Gui Yao Lue” (Synopsis of the Golden Chamber), is a classical prescription for treating visceral agitation. Composed of three medicinal and edible substances—licorice (Gancao), wheat (Xiaomai), and jujube (Dazao), it functions to nourish the heart and calm the mind, harmonize the middle burner and regulate Qi, and alleviate urgency and restlessness. As its clinical application has expanded from traditional emotional disorders to neurological, endocrine, and various psychosomatic diseases, establishing a scientifically precise quality control system and deeply elucidating its pharmacodynamic material basis and mechanism of action have become critical tasks. Modern analytical methods, typified by chromatography, spectroscopy, and their hyphenated techniques, with their high sensitivity, high resolution, and powerful substance characterization capabilities, have become the core driving force for standardizing the quality control and modernizing the clinical application research of this formula. This paper systematically reviews the progress of the aforementioned analytical techniques and chemometrics in interpreting the chemical composition, establishing fingerprint profiles, controlling process quality, and researching the pharmacodynamic material basis of Ganmai Dazao Decoction. Furthermore, it discusses integrated approaches combining analytical techniques with pharmacology and clinical medicine to reveal mechanisms of action and explore therapeutic biomarkers. Finally, it provides an outlook on future directions and challenges, including technological integration and innovation, standardization of whole-process quality control systems, and evidence-based research aimed at internationalization.

Curvilinear Supine Position for Pressure Injury Prevention in Pediatric Cardiac Surgery Patients: A Randomized Controlled Trial

Qianxue Yang — 2026-02-09

Background: Pressure injury (PI) is a prevalent complication in pediatric cardiac surgery, with higher incidence than in general pediatric populations due to children’s thin skin, underdeveloped subcutaneous tissue, and prolonged intraoperative pressure. Objective: To evaluate the effectiveness of the curvilinear supine position (CSP) in preventing PI among children undergoing congenital heart disease (CHD) surgery. Methods: Between October 2024 and February 2025, a single-center randomized controlled trial was conducted. Of the 80 children initially enrolled for congenital heart disease (CHD) surgery, 77 (aged 1 month to 14 years) completed the study and were included in the final analysis after 3 were excluded due to protocol violations. Participants were randomly assigned to the CSP group (n = 38) or the conventional supine position group (n = 39). Results: The incidence of PI was significantly lower in the CSP group (2.6%) compared to the control group (20.5%) (p = 0.029). Postoperative LDH levels were also significantly reduced in the CSP group (422.67 ± 86.52 U/L vs. 592.92 ± 215.71 U/L; p = 0.031), while preoperative LDH and surgical variables (e.g., cardiopulmonary bypass time) were comparable between groups. Although the CSP group had a shorter hospital stay (17.24 vs. 22.51 days), the difference was not statistically significant (p = 0.085). Caregiver satisfaction was significantly higher in the CSP group (100.0% vs. 84.6%; p = 0.025). Conclusion: CSP effectively reduces PI incidence, mitigates tissue injury, and enhances caregiver satisfaction in pediatric cardiac surgery, offering a safe and feasible strategy for perioperative PI prevention.

The Application Value of Chest CT Combined with Serum Vanin-1 and SPP1 in Diagnosing the Severity of Chronic Obstructive Pulmonary Disease

Yufei Wei — 2026-02-12

Objective: To investigate the quantitative assessment efficacy of chest CT combined with serum Vanin-1 and SPP1 in determining the progression stage of chronic obstructive pulmonary disease (COPD). Methods: A total of 100 COPD subjects from our hospital from January 2020 to December 2023 were included and randomly divided into a healthy control group and an experimental group (50 cases each). The healthy control group underwent slow vital capacity measurement using a spirometer, while the experimental group underwent high-resolution thin-slice CT scans and serum Vanin-1 and SPP1 concentration measurements. Pulmonary function parameters, symptom burden, biomarker concentrations, and imaging characteristics were compared between the two groups. Results: The FEV1/FVC ratio in the experimental group (58.3 ± 7.2) was lower than that in the healthy control group (92.1 ± 4.8); the total CAT score (22.4 ± 3.5) was higher than that in the healthy control group (3.1 ± 1.2); both Vanin-1 (18.7 ± 2.3 μg/L) and SPP1 (25.6 ± 4.1 μg/L) levels were higher than those in the healthy control group; LAA%-950 (38.7 ± 6.2%) and WA% (68.5 ± 5.3%) were significantly higher than those in the healthy control group (all p < 0.001). Conclusion: Chest CT combined with serum Vanin-1 and SPP1 can accurately quantify the pathological progression of COPD, providing a dual basis for clinical staging and individualized intervention.

Analysis of the Impact of Sterilization Qualification Rate of Disinfection Supply Center Equipment on Infection Occurrence in Geriatrics Department

Weijie Zhang — 2026-02-12

As a critical department ensuring the sterility of hospital instruments, the Sterile Supply Center (SSC) directly impacts the sterility status of clinical instruments through its sterilization qualification rate. Geriatric patients, due to physiological decline and compromised immune function, constitute a high-risk group for hospital-acquired infections, with more stringent requirements for instrument sterility. This paper analyzes the current status and influencing factors of sterilization qualification rates in SSCs, explores the mechanistic association between sterilization qualification rates and infections in geriatric departments, and proposes targeted strategies to improve sterilization qualification rates. It highlights the pivotal role of SSC instrument sterilization in infection prevention and control for geriatric patients, providing theoretical basis and practical guidance for optimizing SSC management, reducing infection rates in geriatric departments, and ensuring the safety of elderly patients’ medical care. These findings aim to enhance overall infection management standards in hospitals.

Proposal, Promotion, and Practice and Application of Damage Control Surgery Concept in Trauma Treatment at Grassroots Hospitals

Jingcheng Chen — 2026-02-12

The concept of Damage Control Surgery (DCS) emphasizes prioritizing hemorrhage control, preventing hypothermia, correcting coagulopathy, and acidosis in trauma treatment. The application of the DCS concept in trauma treatment at grassroots hospitals faces numerous challenges such as limited resources, high technical difficulty, and insufficient multidisciplinary collaboration. Therefore, DCS strategies need to be adapted to simplified processes to create conditions for subsequent treatment. This paper retrieves relevant literature to discuss the proposal, promotion, and application of the DCS concept, aiming to provide evidence-based basis for optimizing trauma treatment outcomes at grassroots hospitals.

Research on the Clinical Outcomes of Surgical Treatment for Patients with Oral and Maxillofacial Tumors

Ru Xu — 2026-02-12

Due to the special anatomical location, complex functions, and significant impact on patients’ appearance and psychology, the treatment of oral and maxillofacial tumors has always been a key and difficult issue in the field of head and neck surgery. With the rapid development of surgical technology, microsurgical reconstruction technology, perioperative management, and multidisciplinary treatment models, surgical treatment has occupied a core position in the comprehensive treatment system of oral and maxillofacial tumors. Based on this, this paper conducts research on the clinical outcomes of surgical treatment for patients with oral and maxillofacial tumors, expounds the optimization strategies of surgical treatment, and analyzes the clinical effects of the optimized surgical treatment, aiming to provide a reference for the clinical treatment of oral and maxillofacial tumors.

A Case of Severe Trauma with Iliac Vascular Injury was Treated using a Time-Based Chain Approach

Yazheng Shen — 2026-02-12

Severe trauma often involves complex injuries, leading to high disability and fatality rates. Effective treatment requires prompt and coordinated efforts across multiple disciplines to enhance success rates. Time-based chain rescue is crucial in managing severe trauma. A patient with chest and abdominal injuries and hemorrhagic shock was transferred from an ambulance to our hospital. Our trauma team-initiated pre-hospital first aid, utilized an emergency green channel, and conducted rapid ultrasound, collaborating across disciplines. The patient eventually recovered and was discharged.

Comparative Study on the Efficacy and Safety of Faricimab and Conbercept in the Treatment of Diabetic Macular Edema

Xiaoqin Zhao — 2026-02-12

Objective: To compare the clinical efficacy and safety of intravitreal injection of faricimab and conbercept in the treatment of diabetic macular edema (DME). Methods: A total of 50 patients diagnosed with DME in our hospital from January 2023 to May 2025 were selected and randomly divided into an observation group and a control group, with 25 cases in each group, using a random number table method. The observation group received intravitreal injection of faricimab, while the control group received intravitreal injection of conbercept. Both groups adopted a loading phase plus maintenance phase treatment regimen. The best-corrected visual acuity (BCVA, expressed in logMAR) and central subfield thickness (CST) of the two groups were compared before treatment and at 1, 3, and 6 months after treatment, and the incidence of adverse events during treatment was recorded. Results: The logMAR BCVA in the observation group was lower than that in the control group at 3 and 6 months after treatment (both p < 0.05). The CST in the observation group was smaller than that in the control group at 1, 3, and 6 months after treatment (all p < 0.05). There was no statistically significant difference in the overall incidence of adverse events between the two groups (χ² = 0.189, p = 0.663). Conclusion: Both intravitreal injections of faricimab and conbercept are effective in improving visual acuity and reducing macular edema in patients with DME, with good safety profiles. However, faricimab demonstrates superior efficacy in the medium to long term (3 and 6 months) compared to conbercept, making it more suitable for long-term treatment of patients with DME.

The Impact of Early Postoperative Rehabilitation Training on Balance Ability and Quality of Life in Elderly Patients with Hip Fracture

Kaiyu Yang — 2026-02-12

Objective: To analyze the improvement effect of early postoperative rehabilitation training on balance ability and quality of life in elderly patients with hip fracture. Methods: A total of 50 elderly patients with hip fracture admitted to our hospital from January 2023 to January 2024 were selected and divided into the observation group (25 cases) and the control group (25 cases) by random number table method. The control group received routine nursing, while the observation group received early rehabilitation training on the basis of routine nursing. The balance ability (Berg Balance Scale, BBS) and quality of life (SF-36) of the two groups were compared. Results: The BBS scores of the observation group at all postoperative time points were significantly higher than those of the control group (p < 0.05), and the quality-of-life scores of the observation group were also significantly higher than those of the control group (p < 0.05). Conclusion: Early postoperative rehabilitation training for elderly patients with hip fracture can improve their balance ability, enhance their quality of life, and reduce the incidence of postoperative complications, which is worthy of clinical promotion.

Effects of Continuous Care on Children with Enterostomy and Their Families in China

Shanwei Li — 2026-02-09

Background: Continuous care for children with enterostomy and their families has been gaining popularity in China. Objective: To evaluate the feasibility of continuous care for children with enterostomy and their families in China. Methods: The PubMed, Web of Science, Embase, Cochrane Library, EBSCO, CNKI, CBM, VIP, and WanFang were searched for clinical trials until December 30, 2025. Two reviewers independently searched articles, evaluated quality and extracted data. This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Results: 33 studies involving 2774 participants were included. The meta-analysis showed that continuous care strategy can significantly reduce the incidence of complications in children with enterostomy (OR = 0.20, 95% CI = 0.16–0.26, p < 0.001, I²= 0%), effectively improve the family caregiver ability for enterostomy (MD = -10.34, 95% CI= -13.82 to -6.85, p < 0.001, I² = 99%), shorten the time for family members to replace stoma bags (MD= -13.57, 95% CI=-19.66 to -7.49, p < 0.001, I² = 100%), and alleviate negative emotions such as anxiety (SMD= -1.80, 95% CI = -2.36 to -1.23, p < 0.001, I² = 92%) and depression (SMD= -1.54, 95% CI= -2.04 to -1.04, p < 0.001, I² = 89%) in the families of the affected children. Conclusions: Continuous care can reduce complications of enterostomy in children, improve the family caregiver ability for enterostomy and alleviate negative emotions of family members such as anxiety and depression.