Journal of Clinical and Nursing Research

Exploring the Psychological Impact of Narrative Nursing Combined with Positive Reinforcement in Gynecological Chemotherapy Patients

2025-08-02T12:24:29+08:00

Objective: To explore the effect of narrative nursing combined with positive reinforcement nursing intervention on the psychological state of patients with gynecological cancer chemotherapy. Methods: From January 2022 to December 2023, 99 cancer patients with postoperative chemotherapy admitted to the Department of Gynecology in the author’s Class ⅲ Grade A hospital were selected as the research objects, and they were divided into the control group (49 cases) and the observation group (50 cases) by random number method. The control group was intervened by the nursing model based on positive reinforcement theory, while the observation group received narrative nursing intervention measures on this basis. The self-rating Anxiety scale (SAS), self-rating depression scale (SDS), distress thermometer (DT), Pittsburgh sleep quality index (PSQI), and General Self-Efficacy Scale (GSES) were used to evaluate and compare the changes of various indicators between the two groups after intervention. Results: There were no significant differences in the scores of SAS, SDS, DT, PSQI, and GSES between the two groups at the time of intervention (P > 0.05). After chemotherapy, the SAS, SDS, and DT scores of the observation group were significantly lower than those of the control group (P < 0.05), and the PSQI and GSES scores were significantly better than those of the control group (P < 0.01). Conclusion: Compared with the simple positive reinforcement nursing model, narrative nursing combined with positive reinforcement nursing intervention has more advantages in improving the mental health status of patients with gynecological cancer chemotherapy. It can significantly relieve the negative emotions, such as anxiety and depression of patients, effectively improve their self-efficacy level, optimize their sleep quality, and provide more comprehensive support for the physical and mental rehabilitation of patients.

Advancements in the Use of OCTA for Studying Intraocular Pressure and Retinal Perfusion

2025-07-25T12:23:45+08:00

Optical coherence tomography angiography (OCTA) is a non-invasive imaging technique that analyzes the microvascular system of the eye. By capturing high-speed, repeated scans to detect the movement of red blood cells, OCTA visualizes the vascular network, revealing ischemia and reperfusion patterns in retinal vascular diseases. It has become a primary tool for assessing changes in the multilayer microvascular structure of the retina, applicable in conditions such as diabetic retinopathy, age-related macular degeneration, central serous chorioretinopathy, vascular occlusions, and glaucomatous optic neuropathy, among others. Moreover, OCTA is useful in the assessment of central nervous system diseases and is increasingly utilized in routine health examinations and scientific research. Its main advantages include high resolution, rapid, non-invasive scanning, and the ability to analyze microcirculation by observing different vascular layers through tomographic imaging. However, its sensitivity to blood flow velocity and susceptibility to artifacts, such as slow blood flow appearing as non-perfusion, are notable limitations. Overall, OCTA provides a visually intuitive approach for observing retinal blood flow and has significant clinical implications for ocular conditions.

Applied Research on the Impact of SOC Model on Health Literacy and Disease Uncertainty among Young and Middle-aged Patients with Coronary Heart Disease

2025-07-24T12:23:31+08:00

Objective: To analyze the impact and mechanism of the SOC model intervention on improving health literacy and reducing disease uncertainty among young and middle-aged patients with coronary heart disease. Methods: A hundred young and middle-aged patients with coronary heart disease from our hospital between March and October 2024 were randomly divided into an observation group and a control group, with 50 patients in each group. Both groups received routine nursing intervention, while the observation group also received intervention based on the Stages of Change (SOC) model. The intervention period was 30 days. Changes in self-efficacy, health literacy, and disease uncertainty were compared between the two groups before and after the intervention. Results: After the intervention, the self-efficacy scores of both groups increased significantly, and the observation group had higher self-efficacy scores than the control group, with a significant difference (P < 0.05). Additionally, the observation group showed significantly higher levels of health literacy than the control group (P < 0.001). Furthermore, the observation group had significantly lower scores for disease uncertainty compared to the control group (P < 0.001). Conclusion: The SOC model, in addition to routine nursing, significantly affects self-efficacy, disease uncertainty, and health literacy among young and middle-aged patients with coronary heart disease. It helps to enhance patients’ knowledge of coronary heart disease, improve health literacy levels, and reduce disease uncertainty, making it worthy of clinical promotion and application.

The Impact of Psychological Care on Preoperative Anxiety and Postoperative Pain in Patients Undergoing Liver Biopsy

2025-08-08T14:09:52+08:00

Objective: To explore the impact of psychological care on preoperative anxiety and postoperative pain in patients undergoing liver biopsy. Methods: A total of 100 patients undergoing liver biopsy in our hospital from January 2024 to October 2024 were selected as the study subjects. They were divided into a control group and a study group using a random number table method, with 50 patients in each group. The control group received routine care, while the study group received psychological care on the basis of the control group’s treatment. The nursing satisfaction, fear scores, anxiety scores, postoperative pain levels, and incidence of complications (local pain at the puncture site, bleeding at the puncture site, skin irritation, tension blisters, infection, severe abdominal pain, pneumothorax) were compared between the two groups. Results: The nursing satisfaction in the study group was higher than that in the control group (P < 0.05). After nursing, the fear scores and anxiety scores in both groups were lower than before nursing, and the fear scores and anxiety scores in the study group were lower than those in the control group (P < 0.05). The postoperative pain scores in the study group were lower than those in the control group (P < 0.05), and the incidence of complications in the study group was lower than that in the control group (P < 0.05). Conclusion: The application of psychological care in patients undergoing liver biopsy has a definite effect, which can improve patient satisfaction, reduce preoperative anxiety and fear, alleviate postoperative pain, and reduce the incidence of postoperative complications. It is worthy of clinical promotion and application.

Recent Developments in the Study of Moral Injury in Nursing

2025-08-02T12:26:12+08:00

Nurses often face moral dilemmas in their work, and the resulting moral injury has become an important factor affecting the stability of the nursing workforce and nurses' professional health. This article reviews the concept of moral injury, the measurement tools, the influencing factors of moral injury such as demographic factors, psychological factors, and the adverse outcomes, to provide reference for the promotion of nurses' physical and mental health and the enhancement of the quality of nursing services, and the development of effective interventions for nurses’ moral injury, through the systematic summary of the knowledge related to moral injury.

The Associated Stigma of Family Members of Depression Patients: A Qualitative Study

2025-08-04T12:26:00+08:00

Objective: To understand the intertwined stigma experiences of the families of depression patients, providing a basis for implementing targeted interventions for depression patients and their families. To provide a basis for targeted interventions for patients with depression and their families. Methods: Based on the principle of data saturation, the family members of depressed patients in the mental health department and psychological outpatient clinic of a tertiary hospital in Hangzhou from March to May 2025 were selected by the purpose sampling method, and the semi-structured interview method was used to conduct in-depth interviews with the research subjects, and the Colaizzi 7-step analysis method was used for data analysis. Results: A total of 4 themes, and 8 sub-themes were extracted, namely cognitive responses (cognitive biases), emotional responses (internalized stigma and self-blame, feelings of shame, worries and concerns), behavioral responses (concealing the illness, social avoidance), and the potential impact of associated illness stigma (impact on the profession of relatives, emergence of internal family conflicts). Conclusion: Healthcare workers should gain an in-depth understanding of the associated stigma faced by the families of patients with depression and provide targeted psychological support. At the same time, there should be a call for society to pay positive and appropriate attention to patients with depression and their families, improving the families’ understanding of the illness so that they can cope with the associated stigma in a positive manner.

Research Advances in Mitophagy in Hepatic Ischemia-Reperfusion Injury

2025-08-06T12:24:35+08:00

Hepatic ischemia-reperfusion injury (IRI) is a prevalent pathophysiological phenomenon encountered during liver surgeries and transplantation, leading to hepatocyte damage and liver dysfunction, which significantly affects patient prognosis. In recent years, the role of mitophagy in hepatic IRI has garnered considerable attention. Mitochondria, known as the "powerhouses" of the cell, are crucial for maintaining normal cellular physiological functions. During the ischemia-reperfusion process, mitochondria are susceptible to damage, generating excessive harmful substances, such as reactive oxygen species (ROS), which further exacerbate cellular injury. Mitophagy is a selective cellular self-protection mechanism that maintains the quality and quantity balance of mitochondria within cells by clearing damaged or dysfunctional mitochondria. In the context of liver IRI, the activation of mitophagy is of significant importance. On one hand, mitophagy can rapidly remove damaged mitochondria, thereby reducing the release of harmful products and alleviating oxidative stress and cellular damage. Research has indicated that under ischemia-reperfusion conditions, mitophagy-related pathways are activated, promoting the clearance of damaged mitochondria. On the other hand, mitophagy also regulates cellular energy metabolism, providing essential energy support for cells under stress. With the continuous advancement of research, the understanding of the role of mitophagy in hepatic IRI has become increasingly clear. Numerous studies are dedicated to exploring the specific molecular mechanisms of mitophagy and its regulation, aiming to develop new therapeutic strategies to alleviate hepatic IRI. Although studies have demonstrated that mitophagy has a protective effect in hepatic ischemia-reperfusion injury, many issues still require further investigation. First, it is essential to further elucidate the mechanisms underlying the role of mitophagy in ischemia-reperfusion. Additionally, understanding how to mitigate liver ischemia-reperfusion injury through the modulation of mitophagy represents a key focus for future research. Future studies may encompass drug development, gene therapy, and cell therapy approaches aimed at improving the prognosis of patients affected by liver ischemia-reperfusion.

Research on the Reform of Basic Nursing Experiment and Training Teaching in Higher Vocational Nursing Major

2025-08-02T12:24:00+08:00

With the transformation of medical models and the advancement of medical technology, the new era has put forward higher requirements for nursing talents. Nursing staff should not only master solid professional skills and knowledge, but also possess innovative thinking and interdisciplinary cooperation capabilities. As an important place for cultivating nursing talents, higher vocational colleges should update the teaching content of experiment and training in a timely manner in combination with the needs of social changes. Based on this, this paper studies the experiment and training teaching of basic nursing in higher vocational nursing majors, analyzes the changes in the demand for nursing talents in the new era, expounds the existing problems in the current teaching, and puts forward corresponding implementation countermeasures, to cultivate high-quality nursing talents meeting the needs of the new era and provide reference for the teaching reform of higher vocational nursing majors.

Biomedical Research Based on New Nanomaterials

2025-08-08T12:27:11+08:00

Under the background of the new era, people’s research on nanomaterials continues to deepen, and new nanomaterials continue to develop, which plays an important role and value in many fields. Especially in the field of medicine, nano-new materials have shown great value and potential in the field of biomedicine due to their unique chemical and physical properties, which promote the occurrence of many changes. This article will start with the types of new nano materials, and gradually go into their applications in the field of medical biology. Finally, it will briefly analyze the current problems of new nano materials applied in the field of biomedicine and put forward relevant solutions. It will further show the important scientific significance and wide application prospects of new nano materials, in order to contribute to the development of medicine in the future. This paper will provide a meaningful reference for other researchers.

Visual Analysis of Research Hotspots on Adolescent Obesity in China Based on Citespace

2025-08-06T12:25:18+08:00

Objective: To conduct a visual analysis of the current status and hotspots of adolescent obesity research based on CiteSpace, to provide evidence-based basis for research directions and ideas in this field. Methods: This study used subject words and free words to retrieve literature from China National Knowledge Infrastructure, Wanfang Database, and VIP Core database. The retrieval time was from January 1, 2010 to December 31, 2024. CiteSpace6.3.R2 software was used to perform cluster sub-visualization analysis of the number of articles, authors, and keywords of literature on adolescent obesity. Results: A total of 523 Chinese articles were included. Since 2010, the number of articles on adolescent obesity in China showed an increasing trend, with an average annual growth rate of 12.3%. From the perspective of spatial distribution, more regions, institutions, and researchers have begun to pay attention to the research in this field, exploring the impact of dietary imbalance and insufficient exercise on adolescent obesity in different regions and the management methods. From the perspective of cooperation, the cooperation of various regions and institutions showed the characteristics of regional concentration or professional concentration, mainly distributed in medicine and physical education. High-frequency keywords included “living standard”, “exercise intervention”, “physical activity”, “mental health”, “body fat rate”, and “body fat rate”. After 2020, “intelligent weight management platform” and “remote follow-up” emerged to reflect the deep integration of technology and health management. Keyword cluster analysis showed that research hotspots focused on the etiological mechanism of obesity, intervention models, regional characteristics in different regions, and the risk of obesity-related metabolic diseases. With the launch of the national “Weight Management Year” initiative, research has been tilted to community health promotion and multi-sectoral collaboration, focusing on obesity prevention of preschool children and AI-driven personalized intervention programs ^[1]. However, there is a bottleneck of lack of tracking mechanisms for long-term effects such as adolescent development and metabolic adaptability. Conclusions: The research status and hotspots of adolescent obesity have gradually shifted from early etiological exploration to precise intervention models driven by technology empowerment. In the future, researchers can build an obesity prevention and control network covering the whole life cycle and the whole region through the three-dimensional drive of “technological innovation × policy empowerment × disciplinary integration”, and eventually achieve the goal of reducing the obesity rate in adolescents.

Perioperative Nursing Care for a Case of Replantation of a Hand with Four-Finger Multi-planar 20-segment Amputation

2025-08-06T12:25:04+08:00

Finger reimplantation is a pivotal technique in microsurgery, playing an irreplaceable role in restoring the functional integrity of fingers, maintaining the aesthetic appearance of the hand, ensuring the patient's ability to perform delicate hand operations, and enhancing their social participation and quality of life. This paper reports on the perioperative nursing approach employed in a successful case of replantation involving a single hand with a multi-planar, 20-segment amputation of four fingers. By establishing a specialized nursing team, conducting a comprehensive assessment of the patient's condition, formulating a personalized nursing plan, and implementing precise nursing care, we achieved successful outcomes. After nearly four weeks of meticulous diagnosis, treatment, and nursing, 17 segments of the replanted fingers survived, preserving the functional length of the amputated fingers and maximizing the restoration of hand function. This nursing method provides valuable insights and approaches for effectively managing vascular crises following digital replantation, improving the replantation survival rate, and enhancing patient satisfaction.

Research Progress and Mechanisms of Traditional Chinese Medicine Lotus Leaf in Treating Non-Alcoholic Fatty Liver Disease

2025-08-05T12:26:01+08:00

Non-alcoholic fatty liver disease (NAFLD) is a globally prevalent chronic liver disease with a complex pathogenesis, driven by an intricate interplay of metabolic disorders, oxidative stress, inflammatory, and gut microbiota imbalance. With changes in lifestyle and dietary habits, in recent years, the incidence of NAFLD has significantly risen, becoming an important public health issue. The traditional Chinese medicine (TCM) diagnostic and therapeutic system has shown unique advantages in the prevention and treatment of NAFLD, especially the use of lotus leaf, which has attracted attention due to its multi-target and multi-pathway regulatory effects. This review examines the pathogenesis of NAFLD, explores the application of TCM in NAFLD, and focuses on the pharmacological effects of lotus leaf and its potential therapeutic value, providing a theoretical basis for the comprehensive prevention and treatment of NAFLD.

Application of Body Restraint Reduction Program in Clinical Treatment of Severe Neurological Patients

2025-08-06T12:24:49+08:00

Objective: To analyze the clinical application and effects of the body restraint reduction program for severe neurological patients. Methods: A total of 206 patients admitted to the neurology department of the hospital from January 2022 to May 2025 were selected as the research subjects. Among them, 102 patients from January 2022 to May 2025 were assigned to the observation group, and 104 patients during the same period served as the control group. In practice, the control group received conventional body restraint, while the observation group adopted the reduction program. The incidence of unplanned extubation and restraint-related complications were compared between the two groups. Results: The body restraint rate and complication rate in the observation group were significantly lower (P < 0.05). After nurse training, their knowledge mastery and operational ability were significantly higher than before training (P < 0.01). Conclusion: The body restraint reduction program for severe neurological patients can effectively reduce the restraint rate and complication incidence, while helping improve nurses’ restraint management capabilities, serving as an effective means to enhance overall nursing quality.

A Case Report of MODY 2 with Growth Hormone Deficiency Caused by GCK Mutation

2025-08-08T12:25:15+08:00

Objective: To investigate the clinical and molecular genetic characteristics of Chinese adolescents with maturity-onset diabetes of the young type 2 (MODY 2) and the safety and efficacy of recombinant human growth hormone (r-hGH). Methods: The clinical features and laboratory data of a family with MODY 2 combined with partial growth hormone deficiency (pGHD), diagnosed at the Fourth Clinical Medical College of Xinjiang Medical University, were analyzed. DNA was extracted from peripheral blood using the column method, and Sanger sequencing was conducted to analyze the glucokinase (GCK), hepatocyte nuclear factor 1α (HNF1α), and hepatocyte nuclear factor 4α (HNF4α) in the proband and relevant family members. Results: A heterozygous mutation in GCK (Reference sequence: NM_000162, location: Exon 10) c.1340G > A (p.R447Q)) was detected in three family members (the proband, the proband’s younger brother, and their mother). The proband also had pGHD. Conclusion: GCK mutations causing MODY 2 exist in the Chinese population, and the combined treatment with r-hGH is safe and effective.

Progress in the Application of Mobile Health Technology in the Management of Patients with Comorbid Coronary Heart Disease

2025-08-04T12:27:12+08:00

In recent years, with the rapid development of digital technology, mobile health technology has been widely used in the medical field. This article reviews the application forms, application effects, and existing problems of mobile health technology in patients with comorbid coronary heart disease, aiming to provide a reference for the future development of mobile health technology services for patients with comorbid coronary heart disease in China.

TCT for Atypical Glandular Epithelium in 1 Case and Clinical Analysis

2025-08-05T12:27:28+08:00

Objective: Cervical adenocarcinoma (ECA) screening has low sensitivity and is prone to missed diagnoses. By analyzing a case of atypical glandular epithelium on TCT, this study aims to improve the clinical diagnosis and treatment of such diseases. Methods: The clinical examination findings, laboratory tests, and diagnostic process of a case with atypical glandular epithelium on TCT were analyzed. Results: The patient was diagnosed with cervical adenocarcinoma. Preoperative symptoms and imaging studies suggested the possibility of adenocarcinoma, and postoperative pathology confirmed the diagnosis of cervical adenocarcinoma (ECA). Conclusion: Through the analysis of this case, we aim to improve the clinical diagnosis and treatment of this condition.

Study on the Effect of Improved “Bird’s Nest” Nursing in the Out-of-hospital Transport of Premature Infants

2025-08-04T12:26:14+08:00

Objective: To explore the application effect of improved “Bird’s nest” nursing in the transport of premature infants. Methods: Collecting 100 cases of premature infants, randomly divided into experimental group and control group, two groups of premature 50 cases each. The control group received the traditional “Bird’s nest” nursing. Experimental group in modified the “bird’s nest” nursing intervention, compared two groups of premature monitoring vital signs during the transfer process, transport after the body development indicators, the time and cure warmers intervention. Results: Compared with control group, experimental group premature temperature fluctuation is small, apnea and fewer times of low body temperature and oxygen saturation is higher, the contrast results with statistical significance (P < 0.05). There was no significant difference in physical development, time to get out of the incubator, and cure rate. Conclusion: Modified the “bird’s nest” care in outside the hospital application, help to improve premature transfer process safety, and security for premature success implementation of transshipment is of great significance.

Construction of a Blended Teaching Model for Surgical Nursing Based on OBE Concept

2025-08-04T12:25:45+08:00

Objective: To construct a blended teaching model for surgical nursing based on the OBE (Outcome-Based Education) concept and explore its application effect in nursing education. Methods: A total of 220 undergraduate nursing students in the class of 2023 were selected as the main research subjects. The experimental group (110 students) adopted the OBE-based blended teaching model, while the control group (110 students) used conventional teaching methods. The learning effects, skill mastery, and clinical practice performance of the two groups were compared. Results: The experimental group significantly outperformed the control group in theoretical scores, practical skills, clinical application ability, and learning satisfaction, with statistically significant differences (P < 0.05). Conclusion: The OBE-based blended teaching model has significant teaching advantages, which can effectively improve the comprehensive quality of undergraduate nursing students, enhance their clinical adaptability and innovative thinking, and is worthy of widespread promotion.

A Study on the Application of Compassion Fatigue Resilience Training among Nurses in the Hemato-Oncology Department

2025-08-05T12:27:13+08:00

Objective: To explore the impact of compassion fatigue resilience training on the compassion and psychological resilience of nurses in the hemato-oncology department. Methods: Convenience sampling was used to select 24 nurses from the hemato-oncology department of our hospital as the intervention group and another 24 as the control group. The intervention group received compassion fatigue resilience training, while the control group received routine health education. Results: The compassion fatigue score of the intervention group was lower than that of the control group, and the psychological resilience score was higher, with statistically significant differences (P < 0.05). Conclusion: Compassion fatigue resilience training is beneficial for improving the compassion fatigue and psychological resilience of nurses in the hemato-oncology department.

Exploration and Application of the “Four-Element Linkage” Care Model in the Management of Blood Pressure in Elderly Peritoneal Dialysis Patients

2025-08-02T12:24:14+08:00

Objective: To explore the application of “tertiary hospitals-secondary hospitals and nursing care institutions-community-family” four-dimensional linkage care model in peritoneal dialysis patients. Methods: 99 cases of peritoneal dialysis patients were divided into 47 cases in the control group and 52 cases in the intervention group. In the control group, the routine discharge follow-up model was adopted; in the intervention group, the hospital-led medical unit was adopted as the basis of the “tertiary hospitals-secondary hospitals and nursing care institutions-community-family” quadruple linkage care model, and the patients’ systolic blood pressure was compared with those in the control group before and after discharge. The systolic blood pressure, diastolic blood pressure, N-terminal brain natriuretic peptide, and sodium were compared between the two groups. Results: The systolic blood pressure, diastolic blood pressure, N-terminal brain natriuretic peptide, and blood sodium of patients in the intervention group were significantly better than those of the control group (all P < 0.001). Conclusion: Based on the “tertiary hospital-secondary hospital and nursing home-community-family” quadratic care model, the blood pressure control rate of elderly peritoneal dialysis patients can be increased to meet the standard, reduce the symptoms of the disease, and improve the satisfaction.

The Effect of Interventional Nursing on Treatment Outcome, Negative Emotions and Quality of Life of Patients Undergoing Cardiovascular Interventions

2025-08-04T12:25:16+08:00

Objective: To analyze the effect of interventional nursing on the therapeutic effect, negative emotion and quality of life of patients undergoing cardiovascular and cerebrovascular interventional therapy. Methods: Eighty-four patients who received cardio-cerebral vascular interventional therapy in a hospital during January 2024–December 2024 were selected, and were divided into the control group and the observation group by the mean score method, each with 42 cases. The control group was given standardized perioperative care, and the observation group was given interventional nursing intervention on this basis. The two groups were compared in terms of clinical efficacy, negative emotion score, incidence of related complications, quality of life score and nursing satisfaction. Results: The total effective rate of treatment of patients in the observation group (95.24%) was significantly higher than that of the control group (78.57%), and the difference was statistically significant (P < 0.05); before nursing care, the difference between SDS and SAS scores of patients in the two groups was insignificant (P > 0.05); after nursing care, the scores of various indexes of the two groups were significantly reduced and the observation group was lower than that of the control group, and the difference was statistically significant (P < 0.05); the patients in the observation group had more negative moods than those in the control group; the complication rate of patients in the observation group (2.38%) was significantly lower than that of the control group (19.04%), and the difference was statistically significant (P < 0.05); the quality of life scores of patients in the observation group were higher than that of the control group, and the difference was statistically significant (P < 0.05); the satisfaction rate of patients’ nursing care in the observation group was 97.62%, which was higher than that of the control group (78.57%), and the difference was statistically significant (P < 0.05). The difference is statistically significant (P < 0.05). Conclusion: The implementation of interventional nursing intervention for patients with cardiovascular and cerebrovascular interventional therapy can further enhance the clinical therapeutic effect, improve the negative emotions of patients’ anxiety and depression, reduce the risk of related complications, improve the quality of life of patients, and obtain higher satisfaction.

Research Progress on Suicide Literacy

2025-08-05T12:26:59+08:00

Suicide is a major and urgent issue in the field of mental health, and the United Nations has set “reducing global suicide mortality by one third by 2030” as one of its sustainable development goals. Suicide literacy refers to an individual’s ability to recognize, manage, and prevent suicide-related problems. This article offers a comprehensive review of the concepts, assessment tools, factors, and interventions of suicide literacy, with the goal of helping individuals to better understand suicidal behaviors and providing a scientific basis for developing effective suicide prevention strategies and measures to advance the progress of suicide prevention.

Application of Drug Retention Enema Combined with Deep Hyperthermia in the Rehabilitation of Radiation Proctitis in Patients with Cervical Cancer

2025-08-05T12:26:45+08:00

Objective: To investigate the efficacy of drug retention enema combined with deep hyperthermia in the treatment of radiation proctitis in patients with cervical cancer. Methods: A randomized controlled study was conducted, selecting 60 patients with radiation proctitis after cervical cancer, who were randomly divided into a control group and an experimental group of 30 cases each using the random number table method. Both groups of patients received conventional treatment. On this basis, the control group received drug retention enema. The experimental group was treated with deep hyperthermia in addition to the control group. Both groups were treated continuously for 1 month. Compare the clinical symptoms, quality of life, inflammatory markers, and effective treatment rate of the two groups after treatment. Results: Compared with the control group, the improvement in clinical symptoms after treatment in the experimental group was significantly better than that in the former (P ＜ 0.05); The quality of life score was significantly higher than that of the control group (P < 0.05), and the inflammatory markers were significantly lower than those of the control group (P < 0.05); the effective treatment rate was significantly higher than that of the control group (P < 0.05). Conclusion: Drug retention enema combined with deep hyperthermia has a good therapeutic effect on radiation proctitis in cervical cancer patients undergoing radiotherapy, which can alleviate patient symptoms, improve quality of life, inhibit inflammatory response, and increase the effective treatment rate.

The Emerging Influence of Intestinal Microecological Dynamics on the Pathogenesis and Progression of Hepatic Chronic Pathologies: Current Scientific Perspectives

2025-08-05T12:25:46+08:00

The intestinal microbiome, often characterized as humanity’s “secondary genome,” possesses a genetic repertoire that dwarfs the coding capacity of the human genome by orders of magnitude. The essential architecture of this system is constituted by a vast phylogenetic tapestry of luminal microorganisms, whose dynamic symbiosis serves as a critical determinant of intestinal mucosal homeostasis and functional fidelity. The past decade has witnessed a paradigm shift in biomedical sciences, wherein technological breakthroughs in microbial single-cell genomics and spatial metatranscriptomics have unveiled the gut ecosystem’s pivotal role in host physiology. Emerging evidence from gut-liver interface research demonstrates how microbial-derived signals, facilitated by the portal circulatory nexus, mechanistically contribute to the initiation and perpetuation of chronic hepatopathies. This review elucidates the pathophysiological mechanisms through which intestinal dysbiosis propagates chronic hepatopathies, with the ultimate objective of informing novel diagnostic paradigms and therapeutic interventions.

Clinical Efficacy Study of Transtarsal Approach Combined with Heparin Sodium and Furosemide in Patients with Calcaneal Fracture

2025-08-02T12:25:54+08:00

Objective: To investigate the therapeutic effect of trans-tarsal sinus approach surgery combined with dalteparin sodium and furosemide in the treatment of heel bone fracture. Methods: A hundred patients with heel bone fracture who were hospitalized from August 2023 to January 2025 were selected and randomly divided into two groups of 50 cases each. The control group was operated by purely trans-tarsal sinus approach, and the observation group added dalteparin sodium and furosemide on this basis. Postoperative limb swelling, pain, coagulation and inflammation indexes, fracture healing time, foot function and complications were compared between the two groups. Results: In the observation group, postoperative limb swelling subsided faster, pain score was lower, coagulation and inflammation indexes improved more significantly, fracture healing time was shorter, foot function recovery was better, and complication rate was lower, P < 0.05. Conclusion: The treatment of heel fracture by trans-tarsal sinus approach combined with sodium heparin and furosemide can significantly accelerate the patient’s recovery and reduce the occurrence of complications, which has high clinical application value.

Exploring the Physiological Mechanisms and Clinical Applications of Biofeedback in Emotion Regulation

2025-08-05T12:25:31+08:00

Biofeedback is a behavioral intervention technology based on psychophysiology, which uses various electronic devices to collect the physiological activities of individuals in real time and provides them to themselves through various ways, so that people can actively change their own physiological changes when they perceive the changes in some physiological functions of their own, and consciously control the physiological functions of various aspects of the autonomic nervous system within a fixed range. It can play a role in improving physical health status, preventing and treating some somatic diseases [^1]. Studies have shown that biofeedback relaxation training can make the training subjects learn to regulate their own physiological functions and psychological activities, improve negative emotional states such as depression and anxiety by regulating the body function, and can also be used to assist in the treatment of other clinical diseases. As a new psychological intervention, biofeedback relaxation training has great development potential and can be better applied to the prevention and treatment of physical and mental diseases in the general population in the future.

The Healthcare Efficacy Research Progress on Tea and Herbal Tea

2025-08-02T12:25:40+08:00

Tea and herbal tea, as a combination of traditional medicine and modern health concepts, has been favored by more and more people due to its long-term efficacy and mechanism of action. Based on the introduction of the basic concept and development process of tea and medicinal tea, this article focuses on their health care functions and mechanisms, and analyzes the application effects of tea and medicinal tea in different diseases, to provide scientific basis and useful reference for their application and promotion in practice.

Application Value of Pathological Examination in Gynecological Physical Examination

2025-08-02T12:25:25+08:00

Objective: To study the application value and application path of pathological examination in gynecological physical examination. Methods: A total of 1200 patients undergoing gynecological physical examination in X Hospital from January 2024 to December 2024 were selected. All patients received cervical Pap smear examination, and patients with abnormal examination results underwent colposcopic biopsy and HPV infection test for cervical cancer screening. Results: The results of cervical Pap smear showed that a total of 780 patients among 1200 patients showed cervical abnormalities. The Pap smear combined with colposcopy was used for pathological examination to detect cervical cancer lesions in time, and biopsy and HPV infection examination were arranged for high-risk patients to provide data reference for clinical treatment. Conclusions: Pathological examination has a good screening effect in gynecological physical examination. It can detect lesions early and take timely intervention measures, which is helpful to reduce the incidence and mortality of the disease.

The Application of Case Teaching Combined with PBL and RISE Teaching Method in Medical Immunology Teaching

2025-08-02T12:25:11+08:00

Undergraduate medical immunology education is an important part of the basic course of medical higher education in our country. As an important basic course for medical students, medical immunology teaching has shown all kinds of deficiencies in the teaching effect by using the traditional teaching model of classroom teaching. Combined with the teaching characteristics and teaching difficulties of medical immunology, it is found in the teaching practice that in the key stage of traditional teaching, the combination of PBL and RISE teaching method of case teaching can integrate the previous learning knowledge of medical immunology through students’ independent learning, and stimulate students’ interest in learning. It can improve students’ ability to connect immunology theory with clinical diseases and public health immunological events, and improve students’ comprehensive ability to further learn medical immunology knowledge and other related disciplines in the next stage. A good teaching effect has been achieved.

Effects of Childlike Nursing Combined with Chinese Herbal Patching on Pediatric Bronchopneumonia and Symptom Recovery Time

2025-08-02T12:24:57+08:00

Objective: To evaluate the intervention effect of childlike nursing combined with Chinese herbal patching on pediatric bronchopneumonia. Methods: 1036 children with bronchopneumonia (one family member included for each child) who were admitted to the hospital between January 2024 and June 2024 were selected and randomly divided into two groups using a random number table. The combined group received childlike nursing combined with Chinese herbal patching, while the control group received routine nursing. Symptom recovery time, treatment compliance, inflammatory factor levels, quality of life of the children, and family satisfaction were compared between the two groups. Results: The symptom recovery time in the combined group was shorter than that in the control group, treatment compliance was higher, inflammatory factor levels after intervention were lower, quality of life scores of the children were lower, and family satisfaction was higher (P < 0.05). Conclusion: The implementation of childlike nursing combined with Chinese herbal patching for children with bronchopneumonia can shorten their symptom recovery time, significantly improve treatment compliance and quality of life, reduce inflammatory reactions, and achieve high satisfaction among family members.

Research on the Effect of Shiwei Powder Combined with Stone Composition Analysis on Stone Removal Efficiency and Complication Management after Ureteroscopic Holmium Laser Lithotripsy

2025-08-04T12:25:30+08:00

Objective: To analyze the effect of Shiwei Powder combined with stone composition analysis on stone removal efficiency and complication rates after ureteroscopic holmium laser lithotripsy (FURL). Methods: Ninety six patients with FURL admitted to the hospital from March 2023 to March 2025 were selected and randomly divided into two groups. The observation group was treated with FURL combined with Shiwei Powder, while the control group was treated with FURL monotherapy. Based on the stone composition of the two groups, the stone removal efficiency, complication rates, recurrence rates, TCM syndrome scores, and inflammatory factor levels were compared. Results: The stone removal efficiency of the observation group was higher than that of the control group. The stone composition was mainly calcium oxalate monohydrate and composite stones containing calcium oxalate monohydrate. The incidence of postoperative complications was lower in the observation group than in the control group (P < 0.05). After 3–6 months of follow-up, the recurrence rate in the observation group was lower than that in the control group (P < 0.05). After treatment, the TCM syndrome scores and inflammatory factor levels in the observation group were lower than those in the control group (P < 0.05). Conclusion: Based on the results of urinary stone composition analysis, patients treated with Shiwei Powder after FURL have higher stone removal efficiency. The most significant effect is observed in urinary stones composed of calcium oxalate monohydrate and composite stones containing calcium oxalate monohydrate. This treatment can improve stone removal, prevent complications, reduce recurrences, effectively improve disease symptoms, and reduce inflammation.

Study on the Preventive Effect of Evidence-Based Preventive Nursing on Urinary Tract Infections in Elderly Female Diabetic Patients

2025-08-04T12:25:02+08:00

Objective: To investigate the preventive effect of evidence-based preventive nursing on urinary tract infections (UTIs) in elderly female diabetic patients. Methods: Seventy-nine elderly female diabetic patients admitted to our hospital from March 2023 to March 2025 were selected and randomly divided into observation group (40 cases) and control group (39 cases) using the envelope method. The control group received routine nursing, while the observation group received evidence-based preventive nursing. The outcomes were compared between the two groups. Results: After treatment, blood glucose levels in both groups were significantly reduced, and the improvement in various indicators in the observation group was better than that in the control group (P < 0.05). Additionally, quality of life scores were significantly improved in both groups, with the observation group showing better improvement than the control group (P < 0.05). The duration of catheter indwelling and hospital stay in the observation group were lower than those in the control group (P < 0.05). Conclusion: Evidence-based preventive nursing can systematically reduce the risk of urinary tract infections, improve patient outcomes, and provide effective references for clinical nursing practice.

The Impact of Follow-up Nursing Combined with Collaborative Nursing Model on Patients after Mechanical Thrombectomy for Acute Cerebral Infarction

2025-08-05T12:25:17+08:00

Objective: To explore and analyze the impact of follow-up nursing combined with collaborative nursing model on patients after mechanical thrombectomy for acute cerebral infarction. Methods: A hundred patients with acute cerebral infarction who underwent mechanical thrombectomy in the Department of Neurology, Guangdong Provincial People’s Hospital from January 2023 to January 2025 were randomly divided into control group (routine nursing, n=50) and intervention group (follow-up nursing combined with collaborative nursing, n=50). Differences in neurological function, living ability, complication rate, nursing satisfaction, and medication compliance were observed between the two groups. Results: After nursing, the intervention group had lower NIHSS and mRS scores, and higher Barthel index scores compared to the control group (P < 0.05). Additionally, the intervention group had lower complication and readmission rates, and higher nursing satisfaction and medication compliance scores (P < 0.05). Conclusion: The combination of follow-up nursing and collaborative nursing model has significant value in improving outcomes for patients after mechanical thrombectomy for acute cerebral infarction, and is worthy of promotion and application.

Difficulties and Countermeasures of Monitoring Adverse Drug Reactions in Primary Medical Institutions

2025-08-04T12:24:48+08:00

Monitoring adverse drug reactions (ADRs) in primary medical institutions is crucial to ensuring medication safety. Currently, this work faces difficulties such as insufficient professional ability of staff, imperfect monitoring systems, and low patient awareness. It is necessary to improve the level of ADR monitoring at the grassroots level and ensure the safety and effectiveness of medication through countermeasures such as strengthening personnel training, optimizing monitoring processes, and raising public awareness.

Nursing Care of a Child with Membranous Nephropathy Combined with Cerebral Venous Thrombosis

2025-08-05T12:26:30+08:00

Objective: To explore the key points of holistic nursing for children with membranous nephropathy (MN) combined with cerebral venous thrombosis, providing a reference for similar cases. Methods: The course of illness data of an 8-year-old boy with MN in the recurrent phase complicated with cerebral venous sinus thrombosis (CVST) was retroactively analyzed. Systematic nursing was implemented based on evidence-based practices, including strict neurological monitoring, anticoagulation and thrombolysis medication nursing, fluid and electrolyte management, hypoalbuminemia and edema nursing, complication prevention, and mental health education. Results: After 16 days of continuous infusion of low molecular weight heparin and supportive treatment, the child’s symptoms, such as headache and vomiting, disappeared. The reexamination of MRV showed significant absorption of thrombosis, and there was no residual neurological deficit. During the 3-month follow-up, the anticoagulation compliance was good, and there was no recurrence. Conclusion: Early identification of hypercoagulability risk, strengthening dynamic evaluation of neurological signs and coagulation indicators, standardizing anticoagulation and thrombolysis nursing, and cooperating with continuous health management can significantly improve the prognosis of children with MN combined with CVST.

Research Progress on the Improvement of Clinical Practice Ability of Trainee Nurses Based on Augmented Reality Technology Teaching Mode

2025-08-02T12:24:43+08:00

With the iteration and upgrading of medical technology and the continuous growth of public health demands, the quality of nursing services has become a core indicator for measuring the effectiveness of the medical system. The clinical practice ability of nursing staff is directly related to the safety of patient diagnosis and treatment and the rehabilitation process. However, the current clinical nursing talent training model is facing bottlenecks such as limited practical scenarios and fragmented case cognition. This study focuses on the teaching application of augmented reality (AR) technology in hospital Settings and systematically reviews the research progress on the improvement of clinical practice ability of trainee nurses based on the AR immersive teaching model. By constructing a clinical teaching scenario that integrates virtual and real, AR technology can dynamically simulate complex case handling processes and enhance nursing students’ three-dimensional cognition of condition assessment, operation norms, and emergency plans. Hospitals, as the core base for practical teaching, can effectively shorten the connection cycle between theoretical teaching and clinical practice by integrating AR technology, improve the clinical practice level of trainee nurses, and provide an innovative model for optimizing the path of clinical nursing talent cultivation.

Study on the Content Determination of Shenbei Beigua Ointment

2025-08-04T12:26:58+08:00

Objective: A TLCS method was established for the determination of the content of Shenbei Beigua ointment, and the product quality of six samples from two formulations was evaluated. Methods: The determination method was thin-layer chromatography scanning (TLCS), using a developing solvent composed of ethyl acetate–methanol–strong ammonia water (17: 2: 1). The plates were heated at 105 °C for 5 minutes, then sprayed with a mixture of dilute bismuth potassium iodide and 1% ferric chloride in ethanol (10: 1), and scanned at a wavelength of 500 nm. Results: Peimine showed good linearity in the concentration range of 0.21–2.1 μg with a correlation coefficient of r = 0.9997, and Peiminine also exhibited good linearity in the same range with r = 0.9995. The accuracy was ≥ 95.0%, and the relative standard deviation (RSD) was ≤ 5.0% (n = 6). Conclusion: This method allows for the simultaneous determination of peimine and peiminine, providing a reliable reference for the quality control of the product.

Application of Experience-Based and MRI Radiomics in Differential Diagnosis of Benign and Malignant Pulmonary Nodules and Masses

2025-08-04T12:26:43+08:00

Objective: To investigate the application of experience-based and Magnetic Resonance Imaging (MRI) radiomics in differentiating benign and malignant pulmonary nodules and masses. Methods: Sixty patients with pulmonary nodules or masses admitted from April 2024 to April 2025 were selected as study subjects. Surgical pathology was used as the gold standard to explore the differential diagnostic value of experience-based and MRI radiomics. Results: Twenty one MRI radiomic features were selected for screening, with 14 features removed and 7 remaining for normality testing. Using surgical pathology as the gold standard, among the 60 patients, 36 were benign and 24 were malignant, with detection rates of 60.00% and 40.00%, respectively. The detection rates of lobulation, vascular convergence sign, and GGO components in benign pulmonary nodules/masses were lower than those in malignant ones (P < 0.05). The radiomics formula was Radscore = Intercept + Weight (Feature) × Feature, with the calculated formula being Radscore = 0.16 - 0.32 × Sphericity + 0.11 × Mass. The AUC of the UTE Rad-score model was 0.672, which was lower than the AUC of the UTE nomogram (0.789) and the combined model (0.832) (P < 0.05). Conclusion: Experience-based and MRI radiomics can play a significant role in differentiating benign and malignant pulmonary nodules and masses, with the combined model demonstrating more prominent diagnostic value.

Research Progress and Intervention Strategy Analysis on the Current Status of Drug Literacy in Stroke Patients

2025-08-05T12:26:16+08:00

Stroke, as an acute cerebrovascular disease, is characterized by high incidence, high mortality, and high disability rate, thus attracting great attention from the medical community. Medication literacy, on the other hand, is an active, comprehensive, and sustainable concept of health management, which includes the learning of health knowledge and the guidelines for healthy behaviors, and directly affects the treatment effect and health safety of patients. This paper conducts an in-depth study on the current research status of medication literacy in stroke patients, analyzes its influencing factors, and explores specific intervention strategies from multiple perspectives, aiming to provide a theoretical reference for improving patients’ medication management ability and optimizing clinical prognosis.

Application of the Integrated Medical-Care-Rehabilitation Nursing Model in Elderly Patients with Chronic Diseases

2025-08-04T12:24:34+08:00

Objective: To explore the connotation of the integrated medical-care-rehabilitation nursing model and its application effect in elderly patients with chronic diseases. Methods: A total of 122 elderly patients with chronic diseases admitted to our hospital from January 2023 to June 2023 were selected and randomly divided into an observation group (62 cases) and a control group (60 cases). Both groups received routine nursing during hospitalization. After discharge, the control group received conventional continuous nursing, while the observation group was given the integrated medical-care-rehabilitation nursing model. The psychological status of the elderly patients in the two groups was compared before nursing and 6 months after nursing. Assessments were made on their clinical symptoms of mental health, self-care ability, health behaviors, and mastery of knowledge about elderly chronic diseases. Results: Six months after nursing, the scores of self-rated clinical symptoms of mental health and negative coping in both groups were lower than those before nursing (P < 0.05). Meanwhile, the scores of negative coping, self-care ability, and health behaviors in both groups were higher than those before nursing (P < 0.05). Conclusion: The integrated medical-care-rehabilitation nursing model can not only improve the nursing quality for elderly patients with chronic diseases but also foster their positive mentality, help them understand knowledge about diet and health care related to chronic diseases, enhance their self-care ability and health awareness, and assist them in achieving better recovery ^[1].

The Application Effect of Hysterosalpingography in Infertility

2025-08-05T12:25:02+08:00

Objective: To analyze the application effect of hysterosalpingography in infertility and provide a reference for the clinical diagnosis of infertility. Methods: A total of 80 infertile patients admitted to Guangdong Women and Children’s Hospital from March 2023 to March 2024 were selected as the research objects. They were randomly divided into two groups: the control group and the observation group, with 40 patients in each group, and 80 fallopian tubes were observed in each group. The control group underwent traditional gynecological examinations, while the observation group underwent X-ray hysterosalpingography ^[1]. Four indicators, namely diagnostic accuracy, specificity, sensitivity, and excellent/good rate of image quality, were compared between the two groups to evaluate the diagnostic effect on the fallopian tubes. Results: The values of the above four indicators in the observation group were 95.00%, 93.33%, 95.38%, and 97.50% respectively, while those in the control group were 76.25%, 73.33%, 70.77%, and 80.00% respectively. There were statistically significant differences in the four indicators between the two groups (P < 0.05). The incidence of adverse reactions in the observation group was 5.00%, and that in the control group was 25.00%, showing a significant difference with statistical significance (χ² = 6.275, P < 0.05). Conclusion: Modified hysterosalpingography for infertile patients can significantly improve the diagnostic effect of infertility and reduce the incidence of adverse reactions, which has high clinical promotion value.

Research Advances in the CX3CL1/CX3CR1 Signaling Pathway: Implications for Atherosclerosis

2025-08-08T13:29:27+08:00

The CX3CL1/CX3CR1 signaling axis is established as a pivotal regulator in the pathogenesis of atherosclerosis, with well-documented roles in orchestrating inflammatory responses, mediating immune cell recruitment, and influencing vascular remodeling. This review provides a comprehensive synthesis of current knowledge regarding the structural characteristics and functional properties of the CX3CL1/CX3CR1 pathway. This study delves into its specific mechanistic contributions to atherosclerosis, placing particular emphasis on its regulatory influence across diverse cell types, including arterial endothelial cells, smooth muscle cells, and macrophages. Furthermore, the pathway’s integral involvement in both the initiation and progression of atherosclerotic plaques is dissected, highlighting its critical impact on plaque stability and susceptibility to rupture. The review also extends to the pathogenic significance of CX3CL1/CX3CR1 signaling in atherosclerosis-related comorbidities, incorporating the latest advancements in understanding its roles in coronary heart disease, stroke, and other cardiovascular disorders. By critically integrating findings from the extant literature, this review constructs a foundational framework to guide future investigations and underscores the substantial translational potential of targeting this pathway for therapeutic intervention in clinical settings.

5-HT6 Receptors in the Lateral Habenula: A Potential Regulator of Anxiety in Parkinsonian Rats

2025-08-04T12:24:19+08:00

Objectives: Anxiety represents one of the most frequently observed non-motor manifestations in patients diagnosed with Parkinson’s disease (PD), yet its neurobiological mechanisms remain largely unclear. The lateral habenular nucleus (LHb), an essential part of the limbic-monoaminergic system, plays a vital role in emotional regulation and houses serotonin 5-HT₆ receptors, which are considered promising candidates for anxiolytic therapies. This research aimed to clarify the role of LHb 5-HT6 receptors in modulating anxiety-like behaviors within Parkinsonian contexts. Methods: To model PD, rats underwent unilateral 6-hydroxydopamine (6-OHDA) lesions targeting the medial forebrain bundle (MFB), while control animals received sham operations. Anxiety-related responses were examined utilizing the open field test (OFT) and elevated plus maze (EPM). Pharmacological modulation of LHb 5-HT₆ receptors was achieved via microinjection of either the agonist WAY208466 or the antagonist SB258585. To account for potential locomotor confounds, spontaneous locomotor activity was measured. Results: Animals subjected to MFB lesions exhibited pronounced anxiety-related behaviors. This was evidenced by a reduction in center zone occupancy in the OFT, along with fewer entries into and less time spent within the open arms of the EPM. In the sham-operated rats, administering WAY208466 into the LHb induced anxiety-like behaviors, whereas SB258585 exhibited anxiolytic effects. Interestingly, lesioned rats responded to WAY208466 with anxiolytic effects, while SB258585 elicited anxiety-like behaviors. Notably, both compounds showed efficacy at lower doses among the lesioned rats compared to the sham controls. These behavioral changes occurred without notable alterations in locomotor activity. Conclusion: This study demonstrates that 5-HT₆ receptors in the LHb exert bidirectional modulatory effects on anxiety-like behavior. In the PD model, the pharmacological actions of 5-HT₆ receptor agents diverged from those observed in intact animals, suggesting that PD pathology may alter LHb 5-HT₆ receptor function or sensitivity. These findings indicate that LHb 5-HT₆ receptors may represent a promising therapeutic target for managing anxiety symptoms in PD.

Epidemiological Characteristics of Hepatitis B in Harbin from 2010 to 2023

2025-08-05T12:24:48+08:00

Objective: To analyze the distribution characteristics and trends of hepatitis B in Harbin and provide evidence for the development of hepatitis B prevention and control strategies. Methods: Descriptive epidemiological methods were used to analyze the three-dimensional distribution characteristics and epidemiological trends of hepatitis B data in Harbin from 2010 to 2023. Results: A total of 38,604 cases of hepatitis B were reported in Harbin from 2010 to 2023, with an average annual incidence rate of 26.38 per 100,000. The majority of hepatitis B cases were chronic. There was no obvious seasonal distribution pattern of hepatitis B. The average incidence rate was lowest in the < 10-year-old group (1.72 per 100,000) and highest in the 40-year-old group (34.71 per 100,000). Cases were mainly concentrated in the 30-69-year-old population, accounting for 75.35%. The male-to-female ratio was 1.35:1. The majority of cases were farmers, accounting for 57.31%. Conclusion: Except for a significant decrease from 2020 to 2022, the overall incidence of hepatitis B showed a trend of decreasing first and then increasing from 2010 to 2023. The prevention and control measures for the 0-19-year-old population were effective. It is necessary to strengthen the prevention and control of hepatitis B among adults over 20 years old, especially to develop differentiated hepatitis B prevention and control strategies targeting key areas and high-risk populations.

The Impact of Buzhong Yiqi Decoction Combined with Xuefu Zhuyu Decoction on Cardiac Function and Quality of Life in Patients with Coronary Heart Disease and Heart Failure

2025-08-04T12:26:29+08:00

Objective: To explore the improvement effect of implementing Buzhong Yiqi Decoction combined with Xuefu Zhuyu Decoction on cardiac function and quality of life of patients during the treatment of coronary heart disease complicated with heart failure. Methods: Eighty cases were included in the study, and they were equally divided into a control group (n=40, treated with basic western medicine) and a study group (n=40, treated with Buzhong Yiqi Decoction combined with Xuefu Zhuyu Decoction) according to random sampling grouping method. The intervention index results of the two groups were compared. Results: The improvement of cardiac function index, TCM syndrome score, and quality of life in the study group was more prominent, with a statistical value of P < 0.05. Conclusion: Buzhong Yiqi Decoction combined with Xuefu Zhuyu Decoction and conventional western medicine treatment can effectively improve the cardiac function of patients with coronary heart disease complicated with heart failure and enhance their quality of life. It is worthy of clinical promotion and application.

The Role of Pharmacist-Led Rational Drug Use Management of Antibiotics During the Perioperative Period in Gynecology

2025-08-08T14:09:50+08:00

Objective: To analyze the effect of pharmacist-led rational drug use management of antibiotics during the perioperative period in gynecology. Methods: Two hundred patients who underwent gynecological surgery between March 2023 and December 2023 were selected and randomly divided into two groups. In the experimental group, the pharmacist led the medication management during the perioperative use of antibiotics, while the control group received routine antibiotic management. The management effects were compared between the two groups. Results: The irrational drug use rate, the incidence of adverse drug reactions, the cost of antibiotics, and the incidence of postoperative infection were all lower in the experimental group compared to the control group (P < 0.05). Conclusion: Implementing pharmacist-led medication management during the perioperative period of gynecological surgery can prevent irrational drug use, reduce adverse drug reactions, control drug costs, and lower the risk of postoperative infection.

Analysis of Improved Daily Living Ability after Surgery for Patients with Glioma through the Combination of Enhanced Recovery After Surgery (ERAS) Nursing and Empathy Intervention

2025-08-08T12:26:57+08:00

Objective: To systematically explore the effectiveness of combining Enhanced Recovery After Surgery (ERAS) nursing and empathy intervention for postoperative patients with glioma. Methods: A total of 54 patients with glioma undergoing surgical treatment were selected for the study. The patients were admitted to the hospital between April 2023 and April 2025. The patients were divided into an observation group (n=27) and a control group (n=27) based on a random number table method. Relevant intervention indicators were compared between the two groups. Results: Compared with the control group, the postoperative recovery indicators in the observation group showed significant differences (P < 0.05). After intervention, the scores of stress psychological indicators, FMA, NHISS, and ADL in the observation group were all better than those in the control group (P < 0.05). The incidence of complications in the observation group was significantly lower than that in the control group (P < 0.05). Conclusion: The combined application of empathy intervention and ERAS nursing effectively regulates the postoperative stress psychological state of patients with glioma, significantly improves their limb and neurological functions as well as daily living abilities, accelerates postoperative recovery, and reduces complications. This approach is feasible for wider implementation.

Research Progress on Nursing of Vascular Catheter-Associated Infection (VCAI)

2025-08-08T12:26:42+08:00

The intravascular catheter (IVC) is a commonly used intravenous access for patients with various diseases. It can be used for intravenous infusion, blood transfusion, blood collection, or monitoring of hemodynamic changes in patients, grasp the progress of the patient’s disease, and is an indispensable treatment tool in clinical practice. The intravascular catheter has a longer indwelling time, which can reduce the pain of diagnosis and treatment for patients, and has higher advantages. However, prolonged catheterization can easily lead to vessel catheter-associated infection (VCAI), which can induce serious complications, affect the prognosis of the disease, increase the risk of death for patients, and also bring a great burden to the work of medical staff. There are many prevention and treatment measures for VCAI, such as reasonable selection of catheters, reasonable determination of intubation locations, and standardized nursing catheters. And with the continuous optimization of nursing technology, catheter coating technology or antibacterial solution sealing technology has become a new nursing method for the disease, which can effectively reduce the incidence of VCAI. This study comprehensively expounds on the concept, mechanism, risk factors, and preventive nursing measures of VCAI, in order to explore effective nursing plans for VCAI and improve the quality of nursing for patients with intravascular catheters.

Traditional Chinese Medicine Mechanism and Clinical Research on Brain Health Sleep-Aiding Pillow for Encephalopathy and Cervical Spine Rehabilitation

2025-08-08T12:27:41+08:00

Objective: Based on the theories of “defensive Qi entering Yin” and “Qi and blood in meridians” in traditional Chinese medicine (TCM), this study explores the synergistic intervention effect of the Brain Health Sleep-Aid Pillow on brain diseases (such as insomnia, vertigo) and cervical spondylosis. The pillow achieves “marrow sea replenishment and unobstructed cerebral collaterals” by regulating cerebral blood perfusion and cervical mechanical balance through linear pulsed magnetic guidance of the Du Meridian and Bladder Meridian. Methods: A total of 120 patients with “neck impediment” and “insomnia” who met the Criteria for Diagnosis and Therapeutic Effect of TCM Syndromes were enrolled. They were randomly divided into an experimental group (60 cases, using Yuxuangong magnetic therapy pillow) and a control group (60 cases, using ordinary buckwheat pillow) by block randomization. The intervention lasted for 8 weeks. The efficacy was comprehensively evaluated using indicators including TCM syndrome scores, tongue and pulse analysis, cervical range of motion assessment, sleep quality (PSQI scale), and transcranial Doppler (TCD) ^[1]. Results: The total TCM syndrome score in the experimental group decreased significantly more than that in the control group (-4.5 ± 1.2 vs. -2.3 ± 0.8, P < 0.001); The cervical flexion range of motion increased by 15.3°±3.2° (P < 0.01), and the total PSQI score decreased by 6.5 points (P < 0.001); In the experimental group, the vertebral artery blood flow velocity increased by 12.3% (P < 0.05), and the serum IL-6 level decreased by 0.08 pg/mL (P < 0.05) ^[2]. Conclusion: The Yuxuangong Brain Health Sleep-Aid Pillow provides a modern scientific interpretation of the TCM theory of “defensive Qi entering Yin” through a three-dimensional mechanism of “magnetic field regulating qi and dredging collaterals, and physical mechanical reset”, which has significant clinical transformation value ^[3].

Research Progress on the Application of Human Umbilical Cord Mesenchymal Stem Cells in Acute Liver Failure

2025-08-08T12:25:00+08:00

Acute liver failure (ALF), a severe clinical syndrome marked by high mortality rates and limited conventional treatments, urgently requires innovative therapeutic strategies. In recent years, human umbilical cord mesenchymal stem cells (hUC-MSCs) have emerged as a research hotspot due to their unique differentiation potential, remarkable regenerative capacity, and significant immune regulatory properties. Studies demonstrate that it can improve liver function through multiple mechanisms, promote hepatocyte regeneration, and reduce hepatic injury. Additionally, their role in regulating inflammatory responses provides new therapeutic approaches for ALF. This review systematically examines the latest research progress on hUC-MSCs in ALF treatment, focusing on their mechanisms of action, therapeutic efficacy, and clinical application prospects, aiming to provide valuable references for future research and clinical practice.

Analysis on the Effect of Whole-Course Nutritional Management on Nutritional Intervention in Esophageal Cancer Patients Undergoing Radiotherapy

2025-08-08T12:24:46+08:00

Esophageal cancer is one of the common malignant tumors worldwide, and nutritional support during its treatment is of great significance for improving patients’ quality of life and treatment outcomes. This paper aims to explore the application effect of full-course nutritional management in patients with esophageal cancer undergoing radiotherapy. Using a randomized controlled trial design, patients were randomly divided into an experimental group and a control group in a 1:1 ratio. The experimental group received full-course nutritional management, while the control group received routine care. Statistical analysis showed that the degree of weight loss in the experimental group after radiotherapy was significantly lower than that in the control group (P < 0.05), the improvement in nutritional status was more obvious, and the incidence of radiotherapy-related adverse reactions was also significantly lower than that in the control group (P < 0.05). It can be seen that full-course nutritional management can effectively improve the nutritional status of patients with esophageal cancer undergoing radiotherapy, reduce radiotherapy adverse reactions, and enhance patients’ quality of life and treatment effects^[1]. It has important clinical application value and is worthy of promotion in clinical practice.

Application of Breathing Exercises Based on Self-efficacy Theory in Patients with Chronic Heart Failure

2025-08-08T12:26:28+08:00

Objective: Based on the breathing exercise derived from the self-efficacy theory, this study aims to construct a breathing exercise intervention program according to the conditions of patients with chronic heart failure, to improve their cardiac function, relieve dyspnea, enhance their quality of life, and further enrich the research on the efficacy of respiratory rehabilitation exercises for patients with chronic heart failure. Method: A total of 98 inpatients with chronic heart failure admitted to the hospital from April 2024 to April 2025 were selected and randomly divided into an intervention group and a control group, with 49 patients in each group. The patients in the control group received conventional nursing, while the patients in the intervention group received the breathing exercise intervention program based on the self-efficacy theory in addition to the conventional nursing of the control group, with interventions conducted through guidance, psychological support, health education, and other methods. The conditions of patients in both groups before and after the intervention were observed. Results: After 1 month and 3 months of intervention, in terms of improving the degree of dyspnea in patients of both groups, the main effect of intervention and the time effect on the degree of dyspnea were statistically significant (F = 13.948, P < 0.001; F = 38.423, P < 0.001). Moreover, there was an interaction between the time factor and the intervention factor in both groups (F = 113.763, P < 0.001). In terms of increasing the 6-minute walking distance, the main effect and time effect in both groups were statistically significant (F = 7.371, P = 0.008; F = 459.405, P < 0.001), and there was an interaction effect between the time factor and intervention factor in both groups (F = 177.180, P < 0.001). After 1 month and 3 months of intervention, in terms of improving the level of exercise self-efficacy, the main effect of intervention and the time effect in both groups were statistically significant (F = 6.860, P = 0.01; F = 25.133, P < 0.001), and there was an interaction between the time factor and the intervention factor (F = 159.576, P < 0.05). Conclusion: Breathing exercise based on the self-efficacy theory is helpful to improve the sense of efficacy of patients with chronic heart failure, enable them to persist in breathing exercise for a long time, further alleviate their dyspnea, promote the recovery of cardiopulmonary function, and enhance their quality of life. Breathing exercise based on the self-efficacy theory can be used as a simple, home-based intervention method to provide corresponding help for patients with chronic heart failure during the rehabilitation period.

Research on the Application of Behavior Change Wheel (BCW) Theory in Fall Prevention Management for Elderly Inpatients

2025-08-08T12:27:26+08:00

Objective: To analyze the application effect of the Behavior Change Wheel (BCW) theory in fall prevention management for elderly inpatients. Methods: One hundred elderly inpatients admitted to Kunshan Fourth People’s Hospital from January 2019 to April 2024 were selected and divided into an experimental group (fall prevention management intervention based on BCW theory) and a control group (routine fall prevention management intervention) using random sampling, with 50 patients in each group. The differences in knowledge, attitude, and behavior levels of fall prevention, prevention efficacy, and the incidence of falls and fall-related injuries during hospitalization, 6 months after discharge, and 1 year after discharge were compared between the two groups. Results: Compared with before the intervention, the scores of the fall prevention knowledge, attitude, and behavior scale (knowledge dimension, attitude dimension, behavior dimension, and total score) for elderly inpatients in both groups increased, and the improvement in the experimental group was greater than that in the control group (P < 0.05). After the intervention, the revised fall efficacy scale score was higher in the experimental group compared to the control group (P < 0.05). The incidence of falls during hospitalization, 6 months after discharge, and 1 year after discharge, as well as the rate of fall-related injuries 6 months and 1 year after discharge, were lower in the experimental group than in the control group (P < 0.05). There was no statistically significant difference in the rate of fall-related injuries during hospitalization between the two groups (P > 0.05). Conclusion: The fall prevention management intervention based on BCW theory has good application value in elderly inpatients. It effectively improves patients’ knowledge, attitudes, and behavior levels regarding fall prevention, significantly enhances their self-prevention efficacy, and demonstrates good results in reducing the incidence of falls during hospitalization and after discharge.

Analysis of the Effect of Clinical Nursing Pathway Applied to Patients Receiving Intravenous Therapy via Peripheral Mid-long Catheters

2025-08-08T12:26:13+08:00

Objective: To observe the intervention effect of clinical nursing pathway on patients receiving intravenous therapy via peripheral mid-long catheters. Methods: Ninety patients receiving intravenous therapy via mid-long catheters in the hospital from March 2024 to March 2025 were selected and randomly divided into a control group and an observation group, with 45 patients in each group. The control group received routine nursing intervention, while the observation group received clinical nursing pathway intervention. The nursing risk events, catheter indwelling time, and nursing satisfaction were evaluated in both groups. Results: The observation group had a shorter catheter indwelling time, fewer risk events during intravenous therapy (total incidence rate of 2.22%), and higher nursing satisfaction. Additionally, negative emotional feedback was reduced, and the SAS score (31.02 ± 1.12) was lower in the observation group compared to the control group. There were significant differences between the two groups in all indicators (P < 0.05). Conclusion: Applying the clinical nursing pathway during intravenous therapy via peripheral mid-long catheters can help ensure infusion safety, improve unstable emotional states, and promote high-quality service standards.

Effect of a Nutrition Specialist Nurse-Led Whole-Course Nutrition Management Model in Patients with Distal Cholangiocarcinoma

2025-08-08T14:09:55+08:00

Objective: To study the application effects of the entire-course nutrition management model led by specialized nutrition nurses in patients with distant cholangiocarcinoma. Methods: Using convenience sampling, one hundred and twenty patients with distant cholangiocarcinoma admitted from April 2023 to October 2024 were selected as the experimental subjects of this study. They were grouped using a random number table method. The intervention group consisted of 60 patients with distant cholangiocarcinoma who received the entire-course nutrition management led by specialized nutrition nurses, while the observation group consisted of 60 patients who received conventional management. The intestinal function, nutritional indicators, quality of life, and satisfaction were compared between the intervention and observation groups. Results: After intervention, the intestinal function, nutritional indicators, quality of life, and satisfaction of patients with distant cholangiocarcinoma in the intervention group were significantly better than those in the observation group, with statistically significant differences (P < 0.05). Conclusion: The application of the entire-course nutrition management model led by specialized nutrition nurses in patients with distant cholangiocarcinoma has more prominent effects and can further improve prognosis, making it worthy of widespread clinical application.

Research on the Rehabilitation Effect of Upper Limb Rehabilitation Robot Combined with Isokinetic Muscle Strength Training for Hemiplegic Patients in the Recovery Phase of Stroke

2025-08-08T14:09:54+08:00

Objective: To explore the rehabilitation effect of upper limb rehabilitation robots combined with isokinetic muscle strength training on hemiplegic patients in the recovery phase of stroke, and to provide a more effective intervention plan for clinical rehabilitation treatment. Methods: One hundred and sixty type 2 stroke patients with hemiplegia in recovery phase treated at Jintan First People’s Hospital from May 2024 to May 2025 were selected as the research subjects. They were divided into a control group (n=80) and an observation group (n=80) using a random number table method. The control group received isokinetic muscle strength training, while the observation group received additional upper limb rehabilitation robot-assisted intervention based on the control group’s treatment. The general information (age, gender, course of disease), Brunnstrum staging, Barthel index, FMA score, and facial expression pain score were compared between the two groups. Results: After treatment, the indicators of both groups improved compared to before treatment. The observation group showed significant advantages in improving various indicators. In terms of Brunnstrum staging, the number of patients in stage IV and above was significantly higher than that in the control group; in terms of the Barthel index, the increase was more significant than that of the control group (P = 0.000 < 0.001). In terms of the FMA score, the increase was more pronounced (P = 0.000 < 0.001); and in terms of facial expression pain assessment, the decrease was more evident (P = 0.000 < 0.01). Conclusion: The combination of upper limb rehabilitation robots and isokinetic muscle strength training can significantly improve the recovery of limb function and activities of daily living in hemiplegic patients during the recovery phase of stroke, and reduce pain. Compared with simple isokinetic muscle strength training, the rehabilitation effect is better, and it is worthy of clinical application.

Application Study of OCTA-measured Foveal Avascular Zone in Diabetic Retinopathy

2025-08-08T12:25:58+08:00

Changes in the area, perimeter, and circularity index of the foveal avascular zone (FAZ) can be influenced by the filling or occlusion of tiny capillaries surrounding it. In diabetic retinopathy (DR), FAZ-related indicators can provide a quantitative assessment of early DR, predict early disease changes, and offer a theoretical basis for monitoring disease progression and evaluating patients’ visual outcomes. Therefore, finding a simple and noninvasive method to visualize the FAZ has become a research hotspot in ophthalmology. The emergence of optical coherence tomography angiography (OCTA) has filled the technological gap in FAZ measurement. This article reviews the basic principles of OCTA and the clinical application of OCTA-measured FAZ-related indicators in DR, aiming to improve the diagnosis and treatment of DR.

Research Progress on Exploring Biomarkers for Early Diagnosis of Neonatal Hypoxic-Ischemic Encephalopathy Based on Proteomics Technology

2025-08-08T12:25:44+08:00

Neonatal hypoxic-ischemic encephalopathy (HIE) refers to neonatal brain damage caused by various factors during the perinatal period that lead to hypoxia and reduced cerebral blood flow ^[1]. Globally, 0.2% to 2.26% of newborns develop HIE, with approximately 20% resulting in neonatal death and about 25% of survivors suffering from neurological impairment ^[2]. Currently, there is a lack of highly sensitive and specific diagnostic tools for HIE, posing significant challenges to reducing HIE mortality and neurological abnormalities ^[3]. The development of high-throughput proteomics technology based on mass spectrometry (MS) has significantly enhanced the potential to discover biomarkers in biological fluids such as plasma, cerebrospinal fluid, saliva, and urine ^[4]. Proteomics technology has become an engine for exploring novel markers of HIE ^[5]. This article systematically reviews the progress of proteomics technology in the study of biomarkers for the early diagnosis of HIE, elucidating its potential application value.

Plasma Mycophenolic Acid Determination by Ultra-high Performance Liquid Chromatography-tandem Mass Spectrometry and Its Application in Pediatric Patients with Nephrotic Syndrome

2025-08-08T12:25:30+08:00

Objective: Mycophenolate mofetil (MMF) is frequently prescribed to pediatric patients with nephrotic syndrome (NS); however, information on the active metabolite mycophenolic acid (MPA) in this population is limited. Method: Using ultra-high performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS), we validated a rapid and simple approach to measure MPA in accordance with the Bioanalytical Method Validation Guidance issued by the relevant regulatory authorities. Statistical analyses were performed on 69 pediatric patients with frequently relapsing/steroid-dependent nephrotic syndrome (FRNS/SDNS) who received corticosteroids plus MMF. Results: Forty-two patients achieved the endpoints and reported adverse events (AEs). The area under the concentration–time curve of MPA in the AE group was further distributed. Monitoring blood MPA concentrations is critical to prevent AEs during MMF administration in children with FRNS/SDNS. Conclusion: UHPLC–MS/MS offers a more accurate reference than immunoassays.