Journal of Clinical and Nursing Research

Analysis of the Effects of Combined Spinal-Epidural Anesthesia and Epidural Anesthesia in Appendicitis Surgery at Primary Hospitals

2025-07-03T12:24:38+08:00

Objective: To analyze the effects of combined spinal-epidural anesthesia and epidural anesthesia in patients undergoing appendicitis surgery. Methods: Seventy-eight patients who underwent surgical treatment for appendicitis from February 2022 to February 2025 were selected as samples and randomly divided into two groups. The study group received combined spinal-epidural anesthesia, while the control group received epidural anesthesia. Anesthesia indicators, vital signs, and complication indicators were compared between the two groups. Results: The onset time of anesthesia in the study group was shorter than that in the control group, the visual analog scale (VAS) score was lower than that in the control group, and the highest plane of anesthesia block was lower than that in the control group (P < 0.05). At 15 minutes after anesthesia induction and at the end of surgery, the heart rate (HR), mean arterial pressure (MAP), and blood oxygen saturation (SPO2) in the study group were significantly different from those in the control group (P < 0.05). The complication rate in the study group was lower than that in the control group (P < 0.05). Conclusion: Combined spinal-epidural anesthesia for appendicitis surgery can reduce the impact of anesthesia on vital signs, shorten the onset time of anesthesia, and is highly effective and feasible.

Analysis of the Impact of Predictive Rehabilitation Nursing Model on the Quality of Emergency Transport for Patients with Acute Cerebral Hemorrhage

2025-07-03T12:24:23+08:00

Objective: To analyze the impact of the predictive rehabilitation nursing model on the quality of emergency transport and rehabilitation outcomes for patients with acute cerebral hemorrhage (ICH). Methods: A total of 62 patients with acute cerebral hemorrhage admitted to the hospital from January 2022 to December 2024 were selected as the study subjects. The observation group (n = 31) received conventional nursing combined with the predictive rehabilitation nursing model during the emergency process, while the control group (n = 31) received conventional nursing. The recovery conditions (Fuel-Meyer Assessment (FMA) score, Barthel Index (BI)), incidence of complications, nursing satisfaction, and time to regain consciousness were compared between the two groups. Results: After the intervention, the FMA and BI scores of the observation group were significantly higher than those of the control group, with statistically significant differences. The incidence of complications in the observation group was significantly lower than that in the control group. In terms of nursing satisfaction, the scores of various indicators in the observation group were higher than those in the control group, with statistically significant differences. The time to regain consciousness in the observation group was (48.72 ± 11.76) minutes, compared to (64.29 ± 14.58) minutes in the control group, with the observation group regaining consciousness earlier than the control group. Conclusion: The application of the predictive rehabilitation nursing model in the emergency transport process of patients with acute cerebral hemorrhage can reduce the incidence of complications, shorten the duration of consciousness disorder, improve the quality of transport, and enhance functional rehabilitation levels.

Research on Clinical Nursing Key Points and Complications Prevention Strategies after Coronary Heart Disease Stent Implantation

2025-07-03T12:24:08+08:00

With the development of the social economy and the continuous improvement of people’s living standards, the number of coronary heart disease patients is on the rise, even affecting some younger groups. When a patient’s coronary artery stenosis endangers their life, doctors usually recommend coronary artery stent surgery to effectively improve myocardial ischemia and prevent sudden death. After a successful operation, it is necessary to clarify the key points of clinical nursing and prevent complications. Starting from the situation after coronary heart disease stent implantation, this article analyzes the key points of clinical nursing and proposes specific strategies for preventing complications, aiming to improve the surgical effect and provide a reference for complication prevention activities.

Application and Evaluation of Common Clinical Imaging Techniques in Cancer Diagnosis

2025-07-03T12:23:52+08:00

With the reform and opening up entering a new era, China’s modern civilization and technology are “rolling forward”. In the medical field, innovative changes in radiology imaging technology have presented unprecedented value opportunities in tumor diagnosis. Therefore, this article explores the classification of radiological imaging techniques, specifically including X-ray imaging, Computed Tomography (CT), Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), and ultrasound imaging. Furthermore, it analyzes the practical application of these key technologies in tumor diagnosis and propose new ideas. In the end, the advantages and characteristics of radiology imaging technology are evaluated, and two limitations are also pointed out, which deserves profound reflection.

The Effect of Venetoclax Combined with Azacitidine on the Clinical Efficacy, Immune Function, and Adverse Reactions in Elderly Patients with Acute Myeloid Leukemia

2025-07-03T12:23:37+08:00

Objective: To evaluate the immune function and safety of Venetoclax combined with Azacitidine in the treatment of elderly patients with acute myeloid leukemia (AML). Methods: Sixty-eight elderly AML patients who visited the hospital from January 2021 to December 2024 were selected as samples and randomly divided into two groups. Group A was treated with Venetoclax and Azacitidine, while Group B was treated with Azacitidine alone. Immune indicators, inflammatory factors, tumor markers, and adverse reactions were compared between the two groups. Results: The levels of CD3+, CD4+, and CD8+ in Group A were higher than those in Group B (P < 0.05). The tumor necrosis factor-α (TNF-α) level in Group A was lower than that in Group B, while the interferon-γ (IFN-γ) level was higher (P < 0.05). The levels of cyclooxygenase-2 (COX-2), lactate dehydrogenase (LDH), and vascular endothelial growth factor (VEGF) in Group A were lower than those in Group B (P < 0.05). The adverse reaction rate in Group A was lower than that in Group B (P < 0.05). Conclusion: The combination of Venetoclax and Azacitidine in the treatment of elderly AML patients can improve immune function, inhibit inflammation, delay disease progression, and is safe and efficient.

Oversampling Technology and Its Applications in Biomedical Signal Detection

2025-07-03T12:23:22+08:00

This paper deeply explores oversampling technology and its applications in biomedical signal detection. It first expounds on the significance of oversampling technology in biomedical signal detection, and then analyzes the application strategies of oversampling technology in this field. On this basis, it details the specific applications of oversampling technology in electrophysiological signal detection, biomedical imaging signal processing, and other biomedical signal detections, and verifies its effectiveness through practical case analysis, aiming to provide certain references for relevant researchers.

Effectiveness of Remazolam Combined with Alfentanil for Fiberoptic Bronchoscopy in Elderly Debilitated Patients

2025-07-03T12:23:07+08:00

Objective: To analyze the application value of remazolam compound alfentanil anesthesia regimen in fiberoptic bronchoscopy in elderly debilitated patients. Methods: Seventy-two cases of elderly debilitated patients who underwent fiberoptic bronchoscopy in the Department of Respiratory Medicine of a hospital from August 2023 to July 2024 were selected, and were divided into the control group and the observation group using the mean score method, with 36 cases in each group. In both groups, 7–10 μg/kg alfentanil was injected intravenously after oxygen denitrification, and 1 min later propofol 1.5 mg/kg was given intravenously in the control group and remazolam 0.3 mg/kg was given intravenously in the observation group. Subsequently, mivacurium chloride 0.1mg/kg IV was given to both groups. Propofol 5mg/(kg-h) was given in the control group and remazolam 0.5mg/(kg-h) was given intravenously pumped in the observation group during anesthesia maintenance. Changes in vital signs such as HR, MAP and SpO₂and the occurrence of adverse reactions were recorded in the two groups before anesthesia administration (T₁), at the moment of placing fiberoptic bronchoscope (T₂), at the moment of placing the tracheal tube (T₃), and at 1 min after placing the tracheal tube (T₄). Results: Compared with T₁, patients in the observation group had lower MAP at T₂, T₃, T₄and lower SpO₂at T₃, T₄(P < 0.05); in the control group, HR slowed down at T₂, T₃, T₄and MAP and SpO₂decreased at T₂, T₃, T₄(P < 0.05). SpO₂at T₃ and T₄ was lower in both groups compared with that at T₂(P < 0.05). SpO₂ at T₄was lower in the control group compared with that at T₃(P < 0.05). Compared with the control group, patients in the observation group suffered from increased HR and elevated MAP at T₂, T₃, and T₄, and increased SpO₂at T₃and T₄(P < 0.05). The incidence of intraoperative hypotension and bradycardia in the observation group was lower than that in the control group, and the difference was statistically significant (P < 0.05). The incidence of intraoperative choking and coughing, postoperative hypoxemia, nausea and vomiting, and dizziness were found in the patients of both groups, drowsiness and other adverse reactions incidence rate comparison, the difference are not statistically significant (P > 0.05). Conclusion: Remazolam and alfentanil are used in fiberoptic bronchoscopy for elderly debilitated patients with remarkable effect, which can effectively improve the vital signs of patients, reduce the risk of intraoperative hypotension, bradycardia, and other adverse reactions, and have high anesthetic effectiveness and safety.

Impact of Spiritual Care Nursing Based on the “Four-full Framework” on Liver Cancer Patients

2025-07-03T12:22:51+08:00

Objective: To explore the impact of spiritual care nursing based on the “Four-full Framework” (whole-person, whole-process, whole-department, whole-society) on the spiritual status, psychological distress, and quality of life of liver cancer patients. Methods: A total of 120 terminally ill liver cancer patients admitted to the hospital from January 2022 to December 2023 were divided into a control group (60 cases, receiving routine nursing) and an observation group (60 cases, receiving routine nursing plus spiritual care nursing based on the four-full framework) according to their admission order. Both groups were intervened for 4 consecutive weeks. The two groups were compared in terms of death attitude, spiritual status, psychological distress, and quality of life. Results: After intervention, the observation group had lower scores in death avoidance, death fear, escape acceptance, and psychological distress, while higher scores in natural acceptance, approach acceptance, all dimensions of spiritual status, psychological resilience, and all aspects of quality of life compared with the control group, with statistically significant differences (P ＜ 0.05). Conclusion: Spiritual care nursing based on the four-full framework can effectively help terminally ill liver cancer patients face death positively, improve their spiritual status, reduce psychological distress, and enhance their quality of life.

Reviewing the Role of Oral Microbiota in Cognitive Impairment from Microbiota Homeostasis and Pathogenic Bacteria

2025-07-04T12:23:05+08:00

Cognitive impairment is a common symptom of various neurodegenerative diseases. In recent years, an increasing body of research has focused on the relationship between oral microbiota and cognitive impairment. This review aims to explore the microbial homeostasis of oral microbiota and its interactions and mechanisms with the host, as well as the impact of specific pathogenic bacteria on cognitive function. By summarizing existing studies, this review aims to provide a theoretical basis for the pathogenesis, risk assessment, and early intervention and treatment strategies for cognitive impairment.

A Study of Staged Differences in the Needs of Lymphoma Patients throughout the Service under the Care Perspective

2025-07-04T12:22:50+08:00

Based on the perspective of caring, this study constructs a whole-cycle management programme for lymphoma patients, and systematically explores the pathway of patients’ health management from diagnosis to recovery by integrating literature analysis, clinical practice research, and multidisciplinary experts’ consensus. Focusing on the differentiated needs of patients, the study proposes a dual-track management framework of ‘precise diagnosis and treatment standard’ and ‘humanistic care practice’, and innovatively designs a multidisciplinary collaborative mechanism, an information-based follow-up platform, and a social support network. Through the role of ‘care consultant’, the programme connects the medical team with the individual needs of patients, strengthens treatment compliance and improves the quality of life, and provides a theoretical basis and practical reference for the optimization of the whole management mode of lymphoma patients.

Effects of Healthcare Failure Mode and Effect Analysis on the Prevention of Deep Venous Thrombosis in Elderly Patients Undergoing Femoral Fracture Surgery

2025-07-04T12:22:35+08:00

Purpose: To evaluate the effects of healthcare failure mode and effect analysis (FMEA) on the prevention of deep venous thrombosis (DVT) in elderly patients undergoing femoral fracture surgery. Methods: Eighty elderly patients undergoing femoral fracture surgery who did not apply FMEA in Suzhou BenQ Medical Center from June 1, 2022 to May 31, 2023 were selected as the control group. According to the equal group experiment method, 80 elderly patients who were managed using FMEA from June 1, 2023 to May 31, 2024 were selected as the FMEA group. The control group received traditional nursing management, while the FMEA group applied FMEA to analyze failure causes, calculate Risk Priority Numbers (RPNs), identify failure modes with higher RPNs, analyze the influencing factors, develop improvement measures, and optimize processes. The RPN values and the incidence of DVT, as well as nursing satisfaction scores, were compared in the two groups. Results: Compared with the control group, the total RPN values of the FEMA group decreased significantly, with a reduction rate of 87.0%. Besides, the incidence of DVT was 1.3% in the FMEA group, lower than 10.0% in the control group (8/80). What’s more, the patients in the FMEA group were more satisfied with the nursing service compared with the patients in the control group. Conclusion: The application of the FMEA in elderly patients undergoing femoral fracture surgery has demonstrated its potential to prevent the incidence of DVT, lower RPN values, and improve nursing satisfaction.

Application of 4R Crisis Management Theory in the Management of Incontinence-Associated Dermatitis in ICU Patients with Fecal Incontinence

2025-07-04T12:22:20+08:00

Objective: To analyze the preventive and management effects of the 4R crisis management theory on incontinence-associated dermatitis (IAD) in ICU patients with fecal incontinence. Methods: A hundred patients with fecal incontinence who were admitted to the ICU for treatment between January 2024 and December 2024 were selected and randomly divided into two groups using a random number table. The observation group received 4R crisis management theory, while the control group received routine management. The IAD risk score, incidence of IAD, severity of IAD, and formation and healing time of IAD were compared between the two groups. Results: After management, the IAD risk score of the observation group was lower than that of the control group (P < 0.05). The incidence of IAD in the observation group was lower than that in the control group, the proportion of mild IAD was higher than that in the control group, the formation time of IAD was later than that in the control group, and the healing time was shorter than that in the control group (P < 0.05). Conclusion: Adopting the 4R crisis management theory for ICU patients with fecal incontinence can reduce the risk of IAD occurrence, effectively prevent IAD, reduce its severity, delay its formation time, and promote good healing.

The Significance of the Expression Level of Carbohydrate Antigen 125 (CA125) in Threatened Miscarriage

2025-07-04T12:22:05+08:00

Objective: To investigate the expression level of carbohydrate antigen 125 (CA125) in threatened miscarriage and explore its significance in the auxiliary diagnosis of threatened miscarriage. Method: Pregnant women who underwent prenatal examinations in the hospital from June 2023 to June 2024 were collected. Among them, 66 cases were clinically diagnosed with threatened miscarriage and 74 cases had early normal pregnancies. The expression levels of CA125 in the serum of the above research subjects and the HCG levels of pregnant women with different pregnancy conditions were compared. Result: The expression level of CA125 in the threatened abortion group (119.0 ± 23.37) was significantly higher than that in the normal pregnancy group (57.15 ± 5.554), and the difference was significant (p < 0.05). Clinical data analysis showed that the expression level of human chorionic gonadotropin (HCG) in the threatened abortion group (11690 ± 2337) was significantly lower than that in the normal pregnancy group (36130 ± 6855), and there was a significant difference between the two (p < 0.05); The expression level of progesterone (P) in the threatened abortion group was also significantly lower than that in the normal pregnancy group (P < 0.05). Conclusion: CA125 is abnormally expressed in the serum of pregnant women with threatened miscarriage and can be used as a molecular marker for the auxiliary diagnosis of threatened miscarriage. Regular detection of the concentration of CA125 in the serum of pregnant women can provide a reference for clinical assessment of decidual damage and can be used as an auxiliary basis for predicting the risk of threatened miscarriage.

Analysis of the Clinical Characteristics of Bone Loss in Hospitalized Patients with Graves’ Disease

2025-07-04T12:21:50+08:00

Objective: To analyze the clinical characteristics of bone loss in hospitalized patients with Graves’ disease. Methods: The clinical data of hospitalized patients with Graves’ disease were collected. According to the results of bone density examinations, they were divided into a normal bone density group, a low bone mass group, and an osteoporosis group. The normal bone density group was used as the control group to analyze the clinical characteristics of bone loss. Results: The incidence of bone loss in patients with Graves’ disease was 80.72%, with osteoporosis accounting for 39.16% and low bone mass accounting for 41.57%. The incidences of hyperthyroid heart disease, Graves’ ophthalmopathy, and leukopenia in the osteoporosis group and the low bone mass group were significantly higher than those in the normal bone density group, reaching 84.62%, 60.87%, and 34.38%, respectively (P < 0.05). The age of the osteoporosis group with Graves’ disease was 50.88 ± 12.03 years old, which was higher than that of the normal bone density group (40.03 ± 12.58 years old). The disease course was 55.66 ± 14.21 days, longer than that of the normal bone density group (43.38 ± 8.55 days). FT4 was 61.69 ± 8.42 pmol/L, higher than that of the normal bone density group (51.01 ± 6.77 pmol/L), while TSH was 0.08 ± 0.51 μIU/ml, lower than that of the normal bone density group (0.22 ± 0.55 μIU/ml). The blood phosphorus was 1.25 ± 0.29 mmol/L, lower than that of the normal bone density group (1.34 ± 0.27 mmol/L), with statistical significance (P < 0.05). In the low bone mass group, FT3 (13.08 ± 9.05 pmol/L) and FT4 (46.14 ± 3.46 pmol/L) were lower than those in the normal bone density group, with statistical significance (P < 0.05). Logistic regression analysis revealed that age, disease course, and TSH were contributing factors to bone loss. Conclusion: Patients with Graves’ disease are prone to bone loss, and age, disease course, and TSH are contributing factors to bone loss.

Evidence-Based Strategies for the Prevention and Management of Intradialytic Hypotension in Maintenance Hemodialysis Patients

2025-07-05T12:22:22+08:00

Objective: To summarize evidence on the prevention and management of intradialytic hypotension in maintenance hemodialysis patients, providing reference for clinical practice. Method: Chinese and English databases, guideline websites, and professional society websites were systematically searched for literature on intradialytic hypotension guidance, including clinical decisions, guidelines, evidence summaries, systematic reviews, and expert consensuses, from database inception to October 1, 2024. Evidence was extracted after literature quality evaluation. Results: A total of 11 publications were included: 2 clinical decisions, 7 guidelines, 1 systematic review, and 1 expert consensus. 38 pieces of evidence were summarized across 4 themes: pre-dialysis assessment and prevention, monitoring and management during dialysis, medication use, and patient self-management. Conclusion: The best evidence for prevention and management of intradialytic hypotension in maintenance hemodialysis patients is scientific and comprehensive. Healthcare professionals are advised to apply this evidence judiciously in conjunction with clinical realities to ensure patient safety.

Systematic Evaluation and Meta-analysis of the Effects of Phase I Cardiac Rehabilitation on Heart Function of Patients after Percutaneous Coronary Intervention

2025-07-05T12:22:07+08:00

Objective: To systematically evaluate the impact of phase I cardiac rehabilitation exercise prescriptions on cardiac function levels in patients after coronary intervention. Methods: Seven Chinese and English databases, including Cochrane Library, PubMed, Web of Science, ESC (European Society of Cardiology), and CNKI, as well as professional association websites, were searched using computers, with manual searching as a complement. Relevant literature published from the establishment of the database to February 2025 was retrieved. Two researchers independently screened the literature, extracted data, and evaluated the quality of the literature. Meta-analysis was performed using RevMan 5.3 software. Results: A total of 8 articles were included, involving 843 patients. Meta-analysis results showed that compared with routine nursing, phase I cardiac rehabilitation exercise prescriptions helped increase the 6-minute walking distance in patients after coronary intervention [MD = 0.84, 95% CI (0.57, 1.10), P < 0.001], increase the level of left ventricular ejection fraction in patients after coronary intervention [MD = 0.67, 95% CI (0.33, 1.00), P < 0.001], and cardiac rehabilitation combined with respiratory rehabilitation exercise could improve the level of left ventricular ejection fraction in patients after coronary intervention [MD = 0.58, 95% CI (0.40, 0.76), P < 0.001]. Conclusion: The implementation of phase I cardiac rehabilitation exercise prescriptions can help improve cardiac function levels in patients after coronary intervention. However, the standardization of outcome evaluation indicators needs to be improved, and the long-term effects of rehabilitation still require verification through a large number of high-quality studies.

Emergency Nursing Care for a Pediatric Patient with Severe Scrub Typhus Complicated by Hemophagocytic Syndrome and Septic Shock

2025-07-05T12:21:52+08:00

This article summarizes the nursing management of a pediatric patient with severe scrub typhus complicated by hemophagocytic syndrome (HPS) and septic shock. Key nursing interventions included early recognition and management of septic shock, rational oxygen therapy, fluid resuscitation, administration of vasoactive agents, early and targeted anti-infective therapy, management of hyperpyrexia, care of eschar and edematous skin, strict infection prevention and isolation protocols, and family health education. After 11 days of intensive treatment and nursing care, the patient recovered and was discharged.

Visualization Analysis of Mental Health of Patients with Chronic Kidney Disease at Home and Abroad Based on CiteSpace

2025-07-05T12:23:07+08:00

Objective: To analyze the current status, hotspot and trend of mental health research in patients with chronic kidney disease at home and abroad. Methods: China National Knowledge Infrastructure, WanFang, VIP, China Biology Medicine database, PubMed, and Web of Science core collection database were used as search sources from January 2004 to December 2024, and CiteSpace software was used for visual analysis and knowledge mapping. Results: A total of 2059 Chinese and 1678 foreign literatures were included. The number of publications showed a fluctuating upward trend, but the collaboration among authors was relatively loose. Negative psychology, such as depression and anxiety, as well as the quality of life of chronic kidney disease patients, were the main research hotspots. Conclusion: In the future, it is necessary to enhance cooperation and communication among researchers, continue to explore the mechanism of mental health, optimize research designs, innovate psychological nursing intervention measures, and focus on improving the psychological resilience and social support levels of patients.

A Study of the Correlation between Psychological Status and Disease Perception in Adolescent Inflammatory Bowel Disease Patients

2025-07-05T12:22:52+08:00

Objective: To investigate and explore the current status and correlation between psychological status and disease perception of adolescent patients with inflammatory bowel disease. Methods: Adolescent patients hospitalized in a tertiary hospital in Zhejiang Province and some adolescent patients attending the summer camp of Zhejiang Province Aizaiyanchang Foundation for Inflammatory Bowel Disease were selected as the study subjects, and a questionnaire survey was carried out on 148 adolescent patients with inflammatory bowel disease by using the Generalized Anxiety Disorder Scale (GAD-7), Patient Health Questionnaire (PHQ-9), and the Simplified Version of the Disease Perception Questionnaire (BIPQ). questionnaire survey. Results: The depression score of adolescent inflammatory bowel disease patients was (16.40 ± 8.30), the anxiety score was (12.55 ± 5.34), and the total illness perception score was (43.75 ± 10.41). Disease perception of adolescent inflammatory bowel disease patients was at moderate to high level, in which adolescent inflammatory bowel disease patients had the strongest perception of disease control in cognitive dimension as (7.20 ± 0.98) score, followed by strong perception of treatment effect in cognitive dimension as (6.95 ± 2.23) score. According to Pearson correlation analysis it was concluded that their disease perception was positively correlated with anxiety and depression. Conclusion: The psychological condition of adolescent patients with inflammatory bowel disease is poor, and there are significant individual differences in the level of disease perception. Healthcare professionals should provide appropriate knowledge support and psychological interventions according to the different needs of adolescent patients. In addition, an online and offline communication platform should be established to better help adolescent patients with inflammatory bowel disease.

Current Status and Influencing Factors of Social Alienation Among Young and Middle-Aged Stroke Patients in Dali

2025-07-05T12:22:37+08:00

Objective: To explore the current status of social alienation and its influencing factors among young and middle-aged stroke patients in Dali. Methods: A convenience sampling method was used to survey 385 young and middle-aged stroke patients in a tertiary hospital in Dali from December 2024 to July 2025. Questionnaires including general demographic information, the General Alienation Scale, the Athens insomnia scale, and others were administered. Results: The social alienation score of young and middle-aged stroke patients in Dali was (35.67 ± 3.46). Univariate analysis showed that general demographic factors [education level, monthly household income, whether it was the first onset, presence of sequelae, disease duration, activities of daily living (ADL, Barthel Index)], social support, stigma, self-perceived burden, anxiety and depression, and sleep status were influencing factors of social alienation (P < 0.05). Regression analysis indicated that social support, anxiety and depression, disease duration, stigma, presence of sequelae, and self-care ability were significant influencing factors of social alienation (P < 0.01), explaining 65.3% of the total variance. Conclusion: The level of social alienation among young and middle-aged stroke patients in Dali is relatively low. Special attention should be paid to patients with a disease duration of < 7 days, those with sequelae, moderate-to-severe dependence in self-care, low social support, high stigma, and high levels of anxiety and depression, to effectively reduce their social alienation.

Mechanistic Study of Trimebutine Combined with Berberine Hydrochloride in PI-IBS Rat Intervention via the Brain–Gut–Microbiota Axis

2025-07-07T16:02:16+08:00

This study explored the therapeutic effect of trimebutine maleate dispersible tablets combined with berberine on PI-IBS rats with liver depression and spleen deficiency. Fifty male rats were divided into five groups: normal, model, berberine (XB), trimebutine (QM), and combination (XB+QM). The PI-IBS model was established using maternal separation, TNBS perfusion, and chronic restraint. After 20 days of drug intervention, DAI, CMDI, TDI, AWR scores, histopathology, and expression levels of c-Fos, VIP, NOS, and CHAT in the hippocampus and colon were assessed. The model group showed significant gut and brain changes, while the combination group (XB+QM) improved fecal characteristics, reduced inflammation, regulated brain-gut peptide expression, and alleviated visceral hypersensitivity and colon tissue damage (P < 0.05).

Social Alienation in Adolescents with Depression from an Interaction Perspective: A Qualitative Research

2025-07-07T16:15:54+08:00

Objective: This study aims to explore the experiences of social alienation among adolescents with depression, providing practical This study aims to explore the experiences of social alienation among adolescents with depression, providing practical guidance for improving their interpersonal relationships and facilitating their reintegration into society. Methods: This qualitative research was conducted following the conventional content analysis method. 20 adolescents with depression were employed to select from June to August 2024 for face-to-face semi-structured interviews. The collected data were analyzed using Colaizzi's seven-step method. Results: Three themes and eight sub-themes were analyzed and identified: individual level (feelings of helplessness and powerlessness, cognitive distortion, avoidance and withdrawal), family level (lack of family awareness, family conflict), social level (limitations of academic stress and social circle, lack and degradation of skills, generalization of virtual reality, social “stigma”). Conclusion: Adolescents with depression experience complex social alienation. Healthcare providers should enhance their self-awareness and social adaptation skills, improve family dynamics, and provide a comprehensive range of services and services to help them to cope with the challenges of depression. Healthcare providers should enhance their self-awareness and social adaptation skills, improve family dynamics, strengthen communication, bolster family support systems, and collaborate to develop comprehensive social networks and psychological services. This will create a supportive social atmosphere to help adolescents gradually alleviate their feelings of social alienation.

Study on the Effect of Early Postoperative Enteral Nutrition in the Nursing Care of Elderly Patients with Gastric Cancer

2025-07-07T16:24:01+08:00

Objective: To study the application effect of early postoperative enteral nutrition in the nursing care of elderly patients with gastric cancer. Methods: Sixty elderly patients with gastric cancer admitted to the hospital from January 2022 to January 2024 were selected and divided into groups according to the random number table method. The control group (n = 30) received routine nursing after surgery, while the observation group (n = 30) received early enteral nutrition nursing after surgery. The perioperative indexes, nutritional indexes before and after nursing, humoral and cellular immune indexes before and after nursing, gastrointestinal hormone levels before and after nursing, and the incidence of postoperative complications were compared between the two groups. Results: The perioperative indexes of the observation group were better than those of the control group (P < 0.05). Before nursing, there was no significant difference in the nutritional indexes between the two groups (P > 0.05). After nursing, the nutritional indexes of the observation group were better than those of the control group (P < 0.05). Before nursing, there was no significant difference in the humoral and cellular immune indexes between the two groups (P > 0.05). After nursing, the humoral and cellular immune indexes of the observation group were better than those of the control group (P < 0.05). Before nursing, there was no significant difference in the gastrointestinal hormone levels between the two groups (P > 0.05). After nursing, the gastrointestinal hormone levels of the observation group were better than those of the control group (P < 0.05). The incidence of postoperative complications in the observation group was lower than that in the control group (P < 0.05). Conclusion: For elderly patients with gastric cancer, early enteral nutrition nursing after surgery can improve their nutritional indexes and gastrointestinal hormone levels, enhance their immune ability, and prevent the incidence of postoperative complications, with good effects.

Application and Effects of Lean Management in the Management of Flexible Endoscopes

2025-07-07T16:31:12+08:00

Objective: To evaluate the application value of lean management in the management of flexible endoscopes. Methods: From January to December 2023, routine management was implemented, and 200 flexible endoscopes used for examination and treatment were included in the control group; from January to December 2024, lean management was implemented, and 200 flexible endoscopes used for examination and treatment were included in the observation group. The average daily usage frequency, management effectiveness, and failure rate of flexible endoscopes were compared between the two groups. Results: The average daily usage frequency of flexible endoscopes in the observation group was higher than that in the control group (P < 0.05); the 3S retrieval rate and spot-check qualification rate of endoscopes in the observation group were higher than those in the control group (P < 0.05); the failure rate of flexible endoscopes in the observation group was lower than that in the control group (P < 0.05). Conclusion: Implementing lean management during the management of flexible endoscopes can improve the efficiency of endoscope retrieval, increase the average daily usage frequency of flexible endoscopes, and reduce endoscope failures.

Exploring the Intervention Value of Medical Institution Prescription Review Mechanism on the Rationality of Western Medicine Use

2025-07-07T16:38:06+08:00

Objective: To explore the intervention value of the medical institution prescription review mechanism on the rationality of Western medicine use. Methods: A total of 159 patients (with 159 western medicine prescriptions) admitted to the hospital from January 2023 to December 2024 were selected and divided into an observation group (n=80, adopting the medical institution prescription review mechanism) and a control group (n=79, without prescription review) based on the random number table method. A comparative analysis was conducted on the work quality of medical personnel, irrational prescription drug use, and prescription drug dispensing situations. Results: The work quality of medical personnel in the observation group was significantly better than that in the control group (P < 0.05). The incidence of irrational prescription drug use in the observation group (22.50%) was significantly higher than that in the control group (7.59%) (P < 0.05). The observation group had fewer types of prescribed drugs, lower usage rates of injections and antibiotics, and a significantly higher usage rate of national essential drugs compared to the control group (P < 0.05). Conclusion: The prescription review mechanism can significantly improve the work quality of medical personnel, increase the detection rate of irrational drug use, reduce the types of prescription drugs and the use of injections and antibiotics, and promote the standardized application of national essential drugs, which has important intervention value.

Clinical Efficacy of Modified Shenqi Dihuang Decoction in the Treatment of Early Diabetic Nephropathy and Its Impact on Symptom Scores in Traditional Chinese Medicine

2025-07-07T16:44:43+08:00

Objective: To evaluate the efficacy and symptom scores of early diabetic nephropathy (DKD) treated with modified Shenqi Dihuang Decoction. Methods: 82 patients with early DKD who visited the hospital from February 2023 to February 2025 were randomly divided into two groups by drawing. Group A received modified Shenqi Dihuang Decoction + SGLT2 inhibitor, while Group B received SGLT2 inhibitor only. The efficacy, symptom scores, blood glucose, and renal function were compared between the two groups. Results: The efficacy of Group A was higher than that of Group B in the treatment of early DKD (P < 0.05). The DKD symptom scores of Group A were lower than those of Group B (P < 0.05). The fasting blood glucose (FBG), 2-hour postprandial blood glucose (PBG), and glycated hemoglobin (HbA1c) of Group A were better than those of Group B (P < 0.05). The serum creatinine (SCr), blood urea nitrogen (BUN), and urinary albumin excretion rate (UAER) of Group A were also better than those of Group B. Conclusion: The combination of modified Shenqi Dihuang Decoction and SGLT2 inhibitor dapagliflozin has excellent efficacy in the treatment of early DKD, which can improve renal function, reduce DKD symptoms, and stabilize blood glucose levels.

Evaluation of the Improvement of Blood Pressure Levels in Patients with Hypertensive Disorders of Pregnancy Treated with Labetalol Combined with Aspirin

2025-07-07T16:50:07+08:00

Objective: To evaluate the effect of labetalol combined with aspirin on improving blood pressure in patients with hypertensive disorders of pregnancy (HDP). Methods: Eighty-two patients with HDP who visited the hospital from August 2022 to August 2024 were selected as samples and randomly divided into two groups. Group A was treated with labetalol and aspirin, while Group B was treated with labetalol only. The efficacy, blood pressure, vascular endothelial function, coagulation indexes, and pregnancy outcomes were compared between the two groups. Results: The efficacy of Group A was higher than that of Group B (P < 0.05). The systolic blood pressure (SBP), diastolic blood pressure (DBP), and endothelin-1 (ET-1) in Group A were lower than those in Group B (P < 0.05). The prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (APTT), and fibrinogen (FIB) in Group A were all better than those in Group B (P < 0.05). The rate of adverse pregnancy outcomes in Group A was lower than that in Group B (P < 0.05). Conclusion: The combination of labetalol and aspirin for the treatment of HDP can stabilize blood pressure, optimize vascular endothelial function, improve coagulation indexes and pregnancy outcomes, which is highly effective and feasible.

Multimodal MRI Enhancement Combined with Diffusion-Weighted Imaging for the Differential Diagnosis of Non-Lactating Mastitis and Breast Cancer

2025-07-07T16:56:51+08:00

Objective: To explore the value of multimodal MRI enhancement scanning and diffusion-weighted imaging in differentiating non-puerperal mastitis (NPM) and breast cancer. Methods: From September 2022 to September 2024, 56 patients with breast diseases were selected as samples and grouped according to disease type. Twenty-eight patients with breast cancer were included in Group A, and 28 patients with NPM were included in Group B. All patients underwent multimodal MRI enhancement scanning and diffusion-weighted imaging. The MRI results, time-signal intensity curves, ADC values, lesion intensity, and imaging signs were compared between the two groups. Results: There were no significant differences in enhancement characteristics, lymph node enlargement, and margins between Group A and Group B (P > 0.05). The proportion of outflow curves in Group A was higher than that in Group B (P < 0.05). The ADC value in Group A was lower than that in Group B, and the lesion intensity was higher than that in Group B (P < 0.05). There were significant differences in imaging signs, such as abscess or sinus, ascending time-signal curve, and mammary duct dilation between Group A and Group B (P < 0.05). Conclusion: Multimodal MRI enhancement scanning and diffusion-weighted imaging techniques can be used to diagnose breast diseases. Comprehensive analysis of time-signal intensity curves, lesion intensity, imaging signs, and ADC values can differentiate between NPM and breast cancer.

Clinical Efficacy and Safety Evaluation of Continuous Blood Purification in the Management of Critically Ill Sepsis Patients in the Intensive Care Unit

2025-07-07T17:06:55+08:00

Objective: To observe and explore the effectiveness and safety of continuous blood purification intervention in the clinical treatment of patients with severe sepsis in the Intensive Care Unit (ICU). Methods: Medical records were collected from March 2024 to March 2025, including a total of 54 patients with severe sepsis in the ICU. The patients were divided into two groups using a random number table method: the conventional group (27 patients receiving conventional treatment) and the observation group (27 patients receiving continuous blood purification in addition to conventional treatment). C-reactive protein, arterial lactate, mean arterial pressure, respiration, and heart rate were measured. The Sequential Organ Failure Assessment (SOFA) score was compared, and adverse reactions were observed. Results: The observation group had lower levels of C-reactive protein, arterial lactate, respiration, heart rate, and total SOFA score compared to the conventional group, while the mean arterial pressure was higher (P < 0.05). The incidence of adverse reactions during treatment was lower in the observation group than in the conventional group (P < 0.05). Conclusion: The use of continuous blood purification in the clinical treatment of patients with severe sepsis in the ICU is effective. It can alleviate the disease, improve vital signs, reduce inflammatory damage, and reduce adverse reactions.

Application and Observation of Inulin in the Treatment of Constipation for Critically Ill Patients in the ICU

2025-07-08T12:25:08+08:00

Objective: To explore the application method and clinical effect of inulin in the treatment of constipation for patients in the ICU. Methods: Sixty ICU patients with constipation were randomly divided into an experimental group and a control group, with 30 patients in each group. The control group received nasal feeding with a regular diet. The experimental group received nasal feeding with a regular diet plus inulin. The defecation status of the patients was observed and compared on the 3rd, 5th, and 7th days. Results: Among the 30 patients in the experimental group and 30 patients in the control group, there was a statistically significant difference in treatment effect between the two groups (P < 0.05). The treatment duration was (3.91 ± 1.09) days in the experimental group and (5.78 ± 1.52) days in the control group. Conclusion: Inulin has a significant effect in the treatment of constipation for critically ill patients in the ICU and is worthy of clinical promotion and application.

Clinical Study on the Combination Therapy of Diosmin Tablets and Mayinglong Musk Hemorrhoids Ointment for Patients with Acute Hemorrhoids

2025-07-08T12:24:53+08:00

Objective: To evaluate the clinical effect of combined therapy with Diosmin Tablets and Mayinglong Musk Hemorrhoids Ointment for patients with acute hemorrhoids. Methods: A total of 50 patients with acute hemorrhoids who visited the hospital from January 2023 to January 2025 were selected as samples and randomly divided into two groups. Group A was treated with Diosmin Tablets combined with Mayinglong Musk Hemorrhoids Ointment, while Group B was treated with Mayinglong Musk Hemorrhoids Ointment only. The efficacy, wound recovery time, perianal pain score, hemorrhoid symptom score, and stress indicators were compared between the two groups. Results: The efficacy of Group A was higher than that of Group B (P < 0.05). The postoperative perianal edema time and wound healing time in Group A were shorter than those in Group B, and the Visual Analog Scale (VAS) score was lower than that in Group B (P < 0.05). The hemorrhoid symptom score in Group A was lower than that in Group B (P < 0.05). The stress level in Group A was lower than that in Group B (P < 0.05). Conclusion: The combination therapy of Diosmin Tablets and Mayinglong Musk Hemorrhoids Ointment for postoperative treatment of acute hemorrhoids can effectively relieve perianal pain, shorten the duration of hemorrhoids, and is highly feasible.

Application of CBL Combined with PBL Teaching Model in Teaching Medical Imaging to Undergraduate Students Majoring in Clinical Medicine

2025-07-08T12:24:37+08:00

Objective: To explore the application effect of Case-based Learning (CBL) combined with Problem-Based Learning (PBL) in the teaching of medical imaging to undergraduate students majoring in clinical medicine. Methods: Undergraduates of clinical medicine majoring in the School of Clinical Medicine of Hebei University were selected as the research subjects and divided into the experimental group (CBL combined with PBL teaching mode) and the control group (traditional teaching mode), and the teaching effect was evaluated by the examination results and questionnaires. Results: The test scores of the experimental group were significantly better than those of the control group (P < 0.05), and the satisfaction of the students in the experimental group reached more than 90%. Conclusion: CBL combined with PBL teaching mode can effectively improve the teaching quality of medical imaging in clinical medicine specialty.

Analysis of the Rationality and Management Strategies of Chinese Medicine Formula Granule Prescriptions

2025-07-08T12:24:21+08:00

Objective: To analyze the application value of prescription management of Chinese medicine formula granules in reducing unreasonable prescriptions. Methods: From January to June 2024, before improving prescription management strategies, 118 patients treated with Chinese medicine formula granules were included in the control group. From July to December 2024, after improving prescription management strategies, 118 patients treated with Chinese medicine formula granules were included in the observation group. The unqualified prescription rate, incidence of adverse reactions, complaint rate, and satisfaction were compared. Results: The unqualified prescription rate of Chinese medicine formula granules in the observation group was lower than that in the control group (P < 0.05); the incidence of adverse reactions and patient complaint rate of Chinese medicine formula granules in the observation group were lower than those in the control group (P < 0.05); the satisfaction of Chinese medicine formula granules in the observation group was higher than that in the control group (P < 0.05). Conclusion: Improving the prescription management strategy of Chinese medicine formula granules can reduce the unqualified prescription rate and the incidence of adverse drug reactions, reduce patient complaints, and is conducive to improving patient satisfaction.

Application of Report Analysis in Standardized Training for Resident Physicians in Biochemistry Sub-specialty of Laboratory Medicine

2025-07-08T12:24:06+08:00

In recent years, with the continuous deepening of educational reform in the medical field, standardized training, as an important stage of providing excellent laboratory physicians to the clinic, not only needs to strengthen various professional skills of laboratory physicians, but also needs to integrate medical ethics education into the education. Report analysis uses clinical case test reports as teaching content. Under the guidance of attending physicians, resident physicians are the main body of standardized training. Teaching activities for report analysis are carried out by combining theoretical knowledge and case information. Through detailed planning of report analysis teaching activities and adequate preparation, standardized training activities are smoothly carried out. This targeted and comprehensive teaching model can effectively improve the clinical thinking and clinical laboratory professional ability of resident physicians, strengthen medical ethics, and make biochemistry sub-specialty resident physicians in laboratory medicine more adaptable to clinical work, thus achieving teaching goals.

Clinical Evaluation of the Efficacy of Calcitriol Combined with Low-Calcium Dialysate in the Treatment of Secondary Hyperparathyroidism

2025-07-08T12:23:50+08:00

Objective: To investigate the clinical effect of combined application of calcitriol and low-calcium dialysate in the treatment of secondary hyperparathyroidism (SHPT). Methods: Eighty-nine patients with SHPT who visited the hospital from February 2023 to February 2025 were included in the study. They were divided into an observation group (n=45) and a control group (n=44) using a random number table method. The observation group received calcitriol combined with low-calcium dialysate treatment, while the control group received calcitriol combined with conventional dialysate treatment. The differences in intact parathyroid hormone (iPTH), calcium and phosphorus metabolism indicators, renal function indicators, and adverse reaction rates were compared and evaluated before and after treatment between the two groups. Results: Compared with before treatment, the levels of iPTH, serum phosphorus, and calcium-phosphorus product were significantly reduced in both groups after treatment, and the observation group had lower levels than the control group (P < 0.05). Additionally, the blood calcium levels in both groups increased compared to before treatment, and the observation group had higher levels than the control group (P < 0.05). After intervention, there was no statistically significant difference in renal function indicators between the two groups (P > 0.05). The incidence of adverse reactions in the observation group was lower than that in the control group (P < 0.05). Conclusion: The combination of calcitriol and low-calcium dialysate for the treatment of SHPT can effectively reduce the levels of iPTH, serum phosphorus, and calcium-phosphorus product, increase blood calcium levels, and has a low incidence of adverse reactions. It has no significant effect on renal function and is a safe and effective treatment method.

Application Value Analysis of a New Empowerment Teaching Method Based on Kirkpatrick’s Evaluation Model in Teaching Chinese Medicine Nursing in Otorhinolaryngology

2025-07-08T12:23:34+08:00

Objective: To explore the application value of a new empowerment teaching method based on Kirkpatrick’s evaluation model in teaching Chinese medicine nursing in otorhinolaryngology. Methods: 60 nurses who practiced in the otolaryngology department of our hospital from June 2022 to October 2024 were included in the study and equally divided into two groups using a convenient sampling method. 30 nurses who chose traditional Chinese medicine skill teaching management were included in the control group, and 30 nurses who chose the new empowerment teaching method based on Kirkpatrick’s evaluation model were included in the observation group. Relevant indicators such as clinical teaching environment perception, theoretical knowledge scores of Chinese medicine nursing, and excellent rate of practical operation assessment were compared. Results: The nurses in the observation group had higher scores for clinical teaching environment perception than the control group (P < 0.05). However, the midterm and final exam scores for theoretical knowledge of Chinese medicine nursing were higher in the observation group than in the control group (P < 0.05). Compared with the control group, the observation group had a higher excellent rate of practical operation assessment (93.33% > 73.33%) and a higher Chinese medicine nursing ability score [(215.69 ± 19.73) points > (184.87 ± 15.66) points] (P < 0.05). Conclusion: Applying the new empowerment teaching method based on Kirkpatrick’s evaluation model to Chinese medicine nursing teaching in otolaryngology can help nurses understand the theoretical knowledge of Chinese medicine nursing and optimize the clinical teaching environment, thereby promoting their practical skills and Chinese medicine nursing abilities.

Clinical Effect of Combined Therapy with Triple Nebulization and Montelukast Sodium Orally Dissolving Films in the Treatment of Pediatric Asthmatic Bronchopneumonia

2025-07-08T12:23:18+08:00

Objective: To evaluate the efficacy of montelukast sodium orally dissolving films combined with triple nebulization in the treatment of pediatric asthmatic bronchopneumonia. Methods: A total of 60 pediatric patients with asthmatic bronchopneumonia who visited the hospital from December 2021 to December 2024 were selected as samples and randomly divided into two groups. Group A received combined therapy with montelukast sodium orally dissolving films, while Group B received triple nebulization therapy. The time to symptom relief, serum inflammatory factors, and adverse reactions were compared between the two groups. Results: The duration of asthma, cough, and wheezing, as well as the length of hospital stay, were shorter in Group A than in Group B (P < 0.05). The levels of C-reactive protein (CRP), white blood cell count (WBC), and serum amyloid A (SAA) were lower in Group A than in Group B (P < 0.05). The incidence of adverse reactions was lower in Group A than in Group B (P < 0.05). Conclusion: The combination therapy of montelukast sodium orally dissolving films and triple nebulization for pediatric asthmatic bronchopneumonia can effectively inhibit inflammation, shorten the duration of symptoms, and is safe and efficient.

Impact of Problem-oriented Care on Self-efficacy and Compliance Behavior of Patients Undergoing Coronary Intervention Therapy

2025-07-08T12:23:03+08:00

Objective: To explore the effects of problem-oriented nursing on self-efficacy and compliance behavior of patients undergoing coronary intervention. Methods: Seventy patients who underwent coronary intervention in a hospital from March 2024 to February 2025 were selected and divided into the control group (n=35) and the observation group (n=35) by using the randomized numeric table method. The control group implemented conventional clinical care, and the observation group was given problem-oriented nursing intervention on the basis of conventional care. The self-efficacy, negative psychological state, medical compliance behavior, and quality of life improvement of patients in the two groups were compared. Results: Before nursing intervention, the difference in the scores of patients’ role function, symptom management, emotion management, nurse-patient communication and exchange and other dimensions between the control group and the observation group was not statistically significant (P > 0.05). After nursing intervention, the scores of all indexes of the two groups were significantly higher, and the difference between the two groups was statistically significant (P < 0.05). Before nursing intervention, the difference in the scores of patients’ anxiety and depression status between the control group and the observation group was not statistical significance (P > 0.05). However, after nursing intervention, the negative psychological state of the two groups improved significantly, and the difference between the groups was statistically significant (P < 0.05). The total excellent rate of patients’ compliance behavior in the observation group was 97.14%, which was significantly higher than that of the control group, which was 74.29%, with a statistically significant difference (P < 0.05). The patients of the observation group had a higher psychological state, social function, physical condition, emotional condition and other dimension scores of patients in the observation group were significantly higher than those of the control group, and the difference was statistically significant (P < 0.05). Conclusion: The implementation of problem-oriented nursing care for patients undergoing coronary intervention can not only significantly improve their self-efficacy and enhance their compliance behavior, but also positively improve their negative emotions of anxiety and depression, and improve their quality of life.

Study on the Intervention of Renal Yang Deficiency Hypertension by Combined External Therapies of Traditional Chinese Medicine Through Regulating the RASS System

2025-07-08T10:44:46+08:00

Objective: This study explores the mechanism and clinical efficacy of combined external therapies of traditional Chinese medicine (such as moxibustion, acupoint application, etc.) in intervening renal Yang deficiency hypertension through regulating the renin-angiotensin-aldosterone system (RASS). Methods: Sixty-one patients with renal Yang deficiency hypertension admitted to the hospital were selected as the study subjects. They were divided into a Western medicine combined with external therapies of traditional Chinese medicine group (n=30) and a conventional Western medicine treatment group (n=31) based on a random number table method. The enrollment information, blood pressure changes, and differences in aldosterone, angiotensin II, and renin activity during follow-up were compared between the two groups. Results: There were no statistically significant differences in gender, past history, pre-study medication, hypertension grading, aldosterone, angiotensin II, renin activity levels, and blood pressure between the two groups at baseline (P > 0.05). Aldosterone, angiotensin II, and renin activity levels were significantly reduced in both groups after treatment compared to pre-treatment levels. Moreover, the aldosterone, angiotensin II, and renin activity levels in the Western medicine combined with external therapies of traditional Chinese medicine group were significantly lower than those in the conventional Western medicine treatment group, with statistically significant differences (P < 0.05). Conclusion: Western medicine combined with external therapies of traditional Chinese medicine may regulate the RASS system through multiple targets, restoring renal Yang Qi transformation function and providing a new strategy for the integrated treatment of renal Yang deficiency hypertension with Chinese and Western medicine.

Study on the Construction and Initial Application of Home Skin Care Guidance Program for Neonates

2025-07-08T12:22:47+08:00

Objective: To explore the construction and application value of a home skin care guidance program for neonates. Methods: From February 2024 to February 2025, 60 neonates were selected as samples and randomly grouped by drawing. Group A received the constructed home skin care program for neonates, while Group B received routine care. The mastery of skin care knowledge by parents, emotional scores of mothers, and adverse reaction rates of neonates were compared. Results: The mastery of skin care knowledge by parents in Group A was higher than that in Group B, P < 0.05. The anxiety (SAS) and depression (SDS) scores of mothers in Group A were lower than those in Group B, P < 0.05. The adverse reaction rate of neonates in Group A was lower than that in Group B, P < 0.05. Conclusion: The construction of a home skin care program for neonates can reduce adverse reactions of mothers, improve parents’ mastery of neonatal skin care knowledge, and is beneficial for reducing adverse events such as neonatal eczema, diaper dermatitis, and infection.

Observation on the Intervention Effect of Time-sensitive Incentive Model Combined with Specialized Rehabilitation Nursing in Patients with Severe Pneumonia and Respiratory Failure

2025-07-08T12:22:31+08:00

Objective: To explore the effect of implementing a time-sensitive incentive model combined with specialized rehabilitation nursing in patients with severe pneumonia and respiratory failure. Methods: Seventy-eight patients with severe pneumonia and respiratory failure admitted from January 2024 to February 2025 were selected and randomly divided into two groups using a computer-based random drawing method. The control group (39 patients) received routine nursing, while the observation group (39 patients) received a time-sensitive incentive model combined with specialized rehabilitation nursing. Lung function and adverse emotional states were compared between the two groups. Results: After 2 weeks of nursing, the lung function of the observation group was higher than that of the control group (P < 0.05), and the adverse emotional states of the observation group were lower than those of the control group (P < 0.05). Conclusion: Implementing a time-sensitive incentive model combined with specialized rehabilitation nursing in patients with severe pneumonia and respiratory failure can improve lung function and emotional state.

Evaluation of the Effectiveness and Improvement of Quality of Life of Tianma Gouteng Decoction Combined with Betahistine Mesylate in Treating Posterior Circulation Ischemic Vertigo

2025-07-08T12:22:16+08:00

Objective: To evaluate the therapeutic effect of Tianma Gouteng Decoction combined with Betahistine Mesylate in patients with posterior circulation ischemic vertigo (PCI). Methods: Eighty-two patients with PCI who visited the hospital from February 2024 to February 2025 were selected as samples and randomly divided into two groups. Group A received Tianma Gouteng Decoction combined with Betahistine Mesylate, while Group B received only Betahistine Mesylate. The efficacy, syndrome scores, hemodynamics, and quality of life indicators were compared between the two groups. Results: The efficacy of PCI treatment in Group A was higher than that in Group B (P < 0.05). The syndrome scores in Group A were lower than those in Group B (P < 0.05). The peak systolic velocity (PSV) of the basilar artery and left and right vertebral arteries in Group A were higher than those in Group B (P < 0.05). The quality of life (SF-36) score in Group A was higher than that in Group B (P < 0.05). Conclusion: Tianma Gouteng Decoction combined with Betahistine Mesylate is effective and feasible in the treatment of PCI, with improved hemodynamic indicators and reduced disease scores.

The Impact of Comprehensive Nursing Based on Protection Motivation Theory on Treatment Compliance and Quality of Life in Elderly Patients with Hypertension

2025-07-08T12:22:00+08:00

Objective: To explore the effect of comprehensive nursing based on protection motivation theory in elderly patients with hypertension. Methods: The study period was from August 2023 to May 2025. During this period, 40 elderly patients with hypertension who visited the hospital were selected and divided into an observation group (comprehensive nursing based on protection motivation theory, n=20) and a control group (routine nursing, n=20) based on a random number table method. Nursing indicators were compared between the two groups. Results: After nursing, the diastolic blood pressure (80.12 ± 2.31 mmHg) and systolic blood pressure (136.05 ± 3.47 mmHg) in the observation group were significantly different from those in the control group (P < 0.05). The scores of health behaviors (nutrition, exercise, health responsibility, and psychological comfort) in the observation group were higher than those in the control group (P < 0.05). After nursing, the scores of compliance and negative emotional indicators in the observation group were better than those in the control group (P < 0.05). The scores of psychological function (66.31 ± 5.84), physical function (66.57 ± 6.28), material function (61.85 ± 6.21), and social function (69.51 ± 7.25) in the observation group were higher than those in the control group (P < 0.05). Conclusion: During the treatment of elderly patients with hypertension, the application of a comprehensive nursing program based on protection motivation theory is beneficial for regulating blood pressure levels, significantly improving health behaviors and quality of life, alleviating negative emotions, and improving treatment compliance to some extent. This approach is feasible for promotion.

Clinical Study on the Effect of Elderly Hypertension in Yunnan on Glomerular Filtration Rate

2025-07-08T11:42:40+08:00

Objective: As the prevalence of chronic diseases among the elderly increases year by year, chronic renal insufficiency caused by hypertension has become a hot issue of concern to society and even the world. Methods: This article conducted a retrospective analysis of 1856 elderly people over 65 years old, with a follow-up time of 6 years. The aim is to compare the decline in estimated glomerular filtration rate (EGFR) between hypertensive and non-hypertensive populations under non-intervention conditions, and to explore the impact of blood pressure on EGFR in the elderly. Results: The incidence of hypertension among the elderly in this region is significantly higher than the national level. The EGFR value of hypertensive patients is significantly lower than that of non-hypertensive people. There is a difference in the percentage decline in EGFR between hypertensive and non-hypertensive populations under non-intervention conditions, with hypertensive patients experiencing a higher rate of EGFR decline. When blood pressure is lower than 120/80 mmHg, the EGFR decline ratio is lower compared to when blood pressure is higher than 120/80 mmHg. Conclusion: Lowering blood pressure can effectively slow down the decline of EGFR, and the prevalence of hypertension should be reduced.

Research Progress on Epidemiology and Comprehensive Prevention and Control Strategies of HIV Infection

2025-07-08T13:19:30+08:00

Acquired Immunodeficiency Syndrome (AIDS) caused by Human Immunodeficiency Virus (HIV) infection poses a serious threat to global public health. This article comprehensively reviews the epidemiological characteristics of HIV infection, including the global and domestic epidemic situation, transmission routes, and characteristics of high-risk groups. It also introduces comprehensive prevention and control strategies in detail. Through analysis, it aims to provide a reference for further optimizing HIV prevention and control work.

Analysis of Cognitive Differences and Influencing Factors of Traditional Chinese Medicine Culture in Rural Areas

2025-07-08T13:26:54+08:00

This article compares the cognitive differences and influencing factors of traditional Chinese medicine culture among rural residents in Guigang, Guangxi, and Jinhua, Zhejiang, providing a reference for balanced development. A stratified sampling method was used to conduct a questionnaire survey in three townships in each region, and data were analyzed using SPSS 25.0 and chi-square test. The survey shows that residents in Guigang rely more on personal experience for their understanding, resulting in fragmented cognition, with their needs concentrated on disease treatment. On the other hand, residents in Jinhua rely on rational trust and digital communication, leading to deeper cognition, and their needs tend to focus on preventive health care. Occupational factors significantly affect the cognitive level in Jinhua, while in Guigang, it is closely related to trust and cultural atmosphere. The interaction of regional economy, occupational background, and cultural tradition affects cognitive differences. It is suggested that Guigang should build a community traditional Chinese medicine cultural experience matrix, develop digital content for ethnic medical resources, and strengthen the “experience-identification-dissemination” closed loop. Jinhua should deepen the construction of digital IP and promote the integration of industry and education. The two regions should jointly build a cross-regional cultural corridor, cultivate inheritors, and use new media to expand the coverage of dissemination.

Study on the Correlation between the Expression Level of Interleukin-17D in the Serum of Patients with Severe Pneumonia and Disease Severity

2025-07-08T13:32:42+08:00

Objective: To investigate the expression level of interleukin-17D (IL-17D) in the serum of patients with severe pneumonia and its correlation with disease severity. Methods: This study included 50 patients with severe pneumonia who were diagnosed and treated in the hospital from May 2024 to May 2025. The expression level of IL-17D in the serum of all patients was recorded. Patients were divided into severe and mild groups based on their disease severity. Gender, age, disease duration, presence of fever, atelectasis, pneumothorax, interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-6 (IL-6), and interleukin-17D were selected as independent variables. Statistical software SPSS 22.00 was used for univariate analysis, and variables with statistical significance in the univariate analysis were included in a multivariate logistic regression analysis to determine the correlation between IL-17D and the severity of severe pneumonia. Results: The results of this study showed that the level of IL-17D in patients with severe pneumonia was significantly higher than the normal threshold. Univariate analysis indicated that atelectasis, IL-2, IL-6, and IL-17D were statistically significant (P < 0.05) and could be considered as influencing factors for the severity of severe pneumonia. Multivariate logistic regression analysis revealed that atelectasis (OR=2.141, 95% CI: 1.684–2.391), IL-2 (OR=2.884, 95% CI: 2.240–3.614), IL-6 (OR=2.571, 95% CI: 2.190–2.943), and IL-17D (OR=2.416, 95% CI: 2.093–2.735) were positively correlated with the severity of severe pneumonia. Conclusion: The expression level of IL-17D in the serum of patients with severe pneumonia is higher than the normal threshold and is positively correlated with disease severity.

Analysis of the Clinical Effect of Naomaili Granules in the Treatment of Acute Ischemic Stroke

2025-07-08T13:39:18+08:00

Objective: To explore the clinical efficacy and safety of Naomaili granules in the treatment of acute ischemic stroke. Methods: Eighty-eight patients were randomly divided into a treatment group and a control group, with 44 patients in each group. The control group received conventional Western medicine treatment, while the treatment group was additionally administered Naomaili granules at 10g per time, 3 times per day, for 20 days. Neurological function (NIHSS), activities of daily living (BI), inflammatory factors (hs-CRP, IL-6) levels, and adverse reactions were observed before and after treatment. Results: After 20 days of treatment, the NIHSS score of the treatment group decreased from (9.20 ± 2.10) to (5.12 ± 1.30), the BI index increased from (52.30 ± 8.50) to (78.60 ± 9.20), and hs-CRP and IL-6 decreased to (3.12 ± 1.10) mg/L and (18.20 ± 4.20) pg/mL, respectively, all significantly better than the control group (P < 0.01). The incidence of adverse reactions in the treatment group was 4.55%, lower than the 15.91% in the control group (P < 0.05). Conclusion: Naomaili granules can improve neurological function and living ability, reduce inflammatory response, and have good safety in patients with acute ischemic stroke.

Research Progress on the Feasibility and Effectiveness of Home-Based Exercise Rehabilitation in the Management of Chronic Obstructive Pulmonary Disease (COPD)

2025-07-08T13:47:21+08:00

Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory disease that severely affects patients’ quality of life. Current clinical treatments primarily rely on medication, with limited rehabilitation options and uncertain efficacy. Home-based exercise rehabilitation, as a non-pharmacological therapy, can promote the improvement of respiratory muscle function and cardiopulmonary endurance, exerting a positive preventive effect on COPD. However, due to factors such as the home environment and lack of health knowledge, COPD patients face numerous difficulties in accepting home-based exercise rehabilitation. This article reviews domestic and international research on the feasibility and effectiveness of home-based exercise rehabilitation for COPD, aiming to provide references for medical workers to better implement home-based exercise rehabilitation for COPD, assist patients in performing rehabilitation exercises at home, improve their quality of life, reduce hospitalization rates, and lower medical costs.

The Rehabilitation Effect of Pulmonary Function Rehabilitation Training on Elderly Patients with Chronic Obstructive Pulmonary Disease During Hospitalization

2025-07-08T13:52:38+08:00

Objective: To explore the rehabilitation effect of pulmonary rehabilitation training in elderly patients with chronic obstructive pulmonary disease (COPD). Methods: Elderly COPD patients hospitalized from June 2024 to December 2024 were selected as subjects for a quasi-experimental study. The study randomly assigned patients into two equal groups of 50 each. One group served as the control and received standard treatment and nursing care, while the other group, the intervention group, was given additional pulmonary rehabilitation exercises alongside the conventional care. The lung function indexes [forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), FEV1/FVC], 6-minute walk distance (6MWD), Borg’s Category Scale for perceived exertion (BCSS), COPD Assessment Test (CAT), Barthel Index for activities of daily living, blood oxygen saturation, and Modified Medical Research Council (MMRC) dyspnea scale were compared between the two groups before and after intervention. Results: Following the intervention, the intervention group demonstrated improved lung function compared to the control group (P < 0.05). However, no significant difference was observed in the 6-minute walk distance (6MWD) (P > 0.05). The intervention group had lower Bronchitis Severity Scale (BCSS) scores (P < 0.05) and better quality of life scores (P < 0.05) than the control group. No notable differences were found in activities of daily living scores or blood oxygen saturation (P > 0.05). Additionally, the intervention group exhibited a lower proportion of residual severe dyspnea (P < 0.05). Conclusion: Pulmonary rehabilitation can enhance respiratory function in individuals with COPD, leading to beneficial therapeutic outcomes and ultimately improving their overall quality of life.

The Impact of Quality Nursing on Instrument Quality Management and Department Satisfaction in the Management of Reusable Instruments in the Central Sterile Supply Department

2025-07-08T14:46:25+08:00

Objective: To evaluate the effectiveness of quality nursing in the management of reusable instruments in the Central Sterile Supply Department (CSSD). Methods: Eleven nurses from the CSSD department were selected from January to October 2024, and quality nursing activities were implemented in the management of reusable instruments. The completion of quality indicators was analyzed. The instrument quality management scores, department satisfaction, and nurses’ professional ability scores before and after nursing management were compared. Results: After nursing intervention, the qualified rates of initial cleaning and final cleaning of sterilization instruments were 99.66% and 100%, respectively. The qualified rate of packaging was 99.97%, the wet package rate was 0.1‰, the loading qualified rate was 99.88%, and the qualified rate of distribution was 99.99%. After nursing intervention, the nurses’ instrument quality management scores, department satisfaction, and nurses’ professional ability scores were all higher than those before nursing intervention (P < 0.05). Conclusion: Quality nursing activities can improve the cleaning, packaging, and sterilization qualified rates of reusable instruments in the CSSD, enhance the effect of instrument quality management, obtain higher department satisfaction from nurses, cultivate their professional abilities, and possess significant nursing management advantages.