Dermatological Health

Comparison of Traditional Dressing Change Techniques and Vacuum Sealing Drainage Techniques in the Treatment of Skin and Soft Tissue Injuries

2024-12-09T09:19:54+08:00

Objective: To analyze the therapeutic effects of traditional dressing change techniques and vacuum sealing drainage (VSD) techniques on skin and soft tissue injuries. Methods: 60 patients with skin and soft tissue injuries admitted to the hospital from October 2021 to October 2023 were selected. They were randomly divided into an observation group (30 cases) receiving VSD treatment and a control group (30 cases) receiving the traditional dressing change technique. The total effective rate, treatment indicators, inflammatory factors, and complication rate were compared between the two groups. Results: The total effective rate of the observation group was higher than that of the control group, and the treatment indicators were better than those of the control group (P < 0.05). Before treatment, the levels of inflammatory factors were similar between the two groups (P > 0.05). After four weeks of treatment, the levels of inflammatory factors in the observation group were lower than those in the control group (P < 0.05). The complication rate of the observation group was lower than that of the control group (P < 0.05). Conclusion: In the treatment of skin and soft tissue injuries, VSD can improve the total effective rate, shorten the treatment cycle, alleviate the degree of inflammatory reaction, and reduce the risk of complications.

Evaluation of Antioxidant and Antibacterial Activities in Andaliman Fruit (Zanthoxylum acanthopodium DC.): An Approach to Bioactive Compound Analysis and Use of In Vitro Test Methods

2025-01-08T11:48:21+08:00

Andaliman fruit extract has been shown to exhibit anti-inflammatory activity, immunostimulant effects, and anticancer activity. It contains antioxidant compounds, which can stimulate the immune system. The purpose of the study was to determine the antioxidant activity of andaliman fruit (Zanthoxylum acanthopodium DC.) using the DPPH method (2,2-diphenyl-1-picrylhydrazyl). The experimental research was conducted in January 2024. The sample used in this study was andaliman fruit (Zanthoxylum acanthopodium DC.) purchased from Onan Rungu village, Samosir Regency, North Sumatra Province. Ethanol extract of andaliman fruit showed significant antibacterial activity against Staphylococcus aureus and Staphylococcus epidermidis at various concentrations, with the largest zone of inhibition at a concentration of 300 mg/mL. These results demonstrate the potential of andaliman as a source of natural antibacterial agents that can be used in the development of health products.

Role of MAPK and JNK Signaling Pathways in Skin Cancer Progression and Therapeutic Approach

2025-01-08T11:49:11+08:00

Mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK) pathways exhibit complex signal transduction pathways that modulate multiple processes and the deregulated form of MAPK is involved in many types of cancers including skin cancer. These signaling pathways regulate cellular processes such as differentiation, inflammation, cell proliferation, and survival. Moreover, MAPKs are crucial signaling pathways in regulating various cellular processes, including cell proliferation, differentiation, survival, and apoptosis. Their dysregulation is commonly observed in cancer, making them attractive targets for therapeutic intervention. The critical mechanisms and pathways of MAPKs and JNKs in skin cancer including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma are summarized in this review. In addition to providing new insights into MAPK and JNK pathways in cancer progression and proliferation, we also offered the significance of the mechanism of JNK in drug resistance and the association of KLF4 in influencing JNKs for future endeavors to be targeted as therapeutic approaches as understanding the molecular aspects of these signaling pathways are crucial for novel therapeutic breakthroughs.