Keywords
Lichen planus
Immune regulation
Anti-inflammation
Liver protection
Antioxidation
Submitted : 2024-04-16
Accepted : 2024-05-01
Published : 2024-05-16
Abstract
Lichen planus is a chronic inflammatory skin disease. Due to its unclear etiology, the treatment is slow and complicated. Rubia cordifolia is a drug with a long history, with the effects of cooling blood and removing blood stasis, promoting blood circulation, and dredging meridians. Modern research suggests that the components of Rubia cordifolia have the effects of immune regulation, anti-inflammation, liver protection, and antioxidation. It may be a potential drug for the treatment of lichen planus. However, the specific mechanism of Rubia cordifolia in the treatment of this disease is still under study. This article reviews the mechanism of Rubia cordifolia in the treatment of lichen planus, in order to provide references for the clinical application of the drug.
References
Hua H, Bai L, 2004, Research Progress on the Etiology and Pathogenesis of Lichen Planus. Shanxi Medical Journal, 2004(10): 855–857.
Xia S, Wu J, 2008, Treatment of Oral Lichen Planus from Liver Theory. Shanxi Traditional Chinese Medicine, 2008(11): 14.
Zhu S, Xu M, Guo D, et al., 2021, Preliminary Study of Treating Lichen Planus from ‘the Location of Disease Lies in the Liver, Its Pathogen Lies in Dampness’ Based on Theory of Integrated Chinese and Western Medicine. Chinese Journal of Traditional Chinese Medicine and Pharmacy, 36(03): 1573–1576.
Wei J, Guo X, Mu H, et al., 2018, Study on the Correlation Between Peripheral Blood T-Lymphocyte Subpopulations and Polarization of Helper T-Lymphocyte 1/Helper T-Lymphocyte 2 in Patients with Oral Lichen Planus and Chinese Medicine Evidence. Hebei Traditional Chinese Medicine, 40(08): 1136–1141 + 1155.
Zhao R, 1989, Combination of Chinese and Western Medicine in the Treatment of Oral Mucosal Lichen Planus in 50 Cases. Journal of the Fourth Military Medical University, 1989(03): 207–208.
Yamamoto T, Osaki T, 1994, Cytokine Production by Keratinocytes and Mononuclear Infiltrates in Oral Lichen Planus. J Oral Pathol Med, 23(7): 309–315.
Yang S, Liu F, 1996, Immunosuppressive Effects of Rubia Diester. Chinese Pharmacology Bulletin, 1996(05): 447.
He L, Yang Z, Chen K, et al., 2002, Study on the Proliferative Response of Small Red Ginseng on Normal Human Peripheral Blood T Lymphocytes. Chinese Journal of Dermatology, 2002(02): 67.
Liu X, Li P, Zhao J, et al., 2012, Effects of the Whole Formula and Split Formula of Blood-Cooling and Blood-Activating Capsule on the Proliferation, Activation and Cytokine Release of Jurkat T Lymphocytes. Chinese Journal of Experimental Formulas, 18(22): 198–202.
Ma L, Sun Z, Liu Y, et al., 1979, Isolation and Observation of Properties of Rubiadic Acid Glycoside. Journal of the Academy of Military Medical Sciences of the Chinese People’s Liberation Army, 1979(01): 46–53.
Kang X, Fang Y, 1990, The Effects of Cycloheximide Bilipid and S-2-(3-Aminopropylamino)Ethyl Phosphorothioate on Chemiluminescence and Electron Paramagnetic Resonance in the Phagocytosis of Human Polymorphonuclear Leukocytes. Chinese Journal of Pharmacology and Toxicology, 1990(04): 251–254.
Song S, Ding L, 1985, Studies on Hematopoietic Effect of Rubidate and Its Toxicity. Journal of Chinese and Western Medicine, 1985(10): 625–626 + 581.
Su X, Zhou Y, 1992, Comparative Study on the Pharmacological Effects of Madder and Small Red Ginseng. Chinese Journal of Traditional Chinese Medicine, 1992(06): 377.
Hua H, Bai L, 2004, Progress of Research on the Etiology and Pathogenesis of Lichen Planus. Shanxi Medical Journal, 2004(10): 855–857.
Yao L, Bai L, 2014, Expression and Significance of IL-17, FoxP3 and Caspase-3 in Lichen Planus Lesions. China Contemporary Medicine, 21(05): 25–27.
Xu L, Zhao S, Hu Q, et al., 2002, Effect of Total Anthraquinone of Rubia cordifolia L. on Adjuvant Arthritis of Rat and Its Cytokine. Journal of Weifang Medical College, 2002(01): 11–13.
Zhu ZG, Jin H, 2013, Mollugin Inhibits the Inflammatory Response in Lipopolysaccharide-Stimulated RAW264.7 Macrophages by Blocking the Janus Kinase-Signal Transducers and Activators of Transcription Signaling Pathway. Biol Pharm Bull, 36(3): 399–406.
Monk B, 1985, Lichen Planus and the Liver. J Am Acad Dermatol, 12(1 Pt 1): 122–124.
Mokni M, Rybojad M, 1991, Lichen Planus and Hepatitis C Virus. J Am Acad Dermatol, 24(5 Pt 1): 792.
Scelza G, Amato A, 2022, Effect of Hepatitis C Antiviral Therapy on Oral Lichen Planus and Hyposalivation in Inmates. Ann Gastroenterol, 35(1): 74–79.
Sun B, 1996, Effect of Rubia Extract on Hepatotoxicity Caused by Carbon Tetrachloride and Acetaminophen. Overseas Medicine (Chinese Medicine and Traditional Chinese Medicine), 1996(05): 45.
Quan M, Tian C, 2015, Hepatoprotective Effect of Essential Oil of Rubia cordifolia. Modern Food Science and Technology, 31(05): 12–17.
Rao GMM, Rao CV, Pushpangadan P, et al., 2006, Hepatoprotective Effects of Rubiadin, a Major Constituent of Rubia cordifolia Linn. J Ethnopharmacol, 103(3): 484–490.
Wang H, Wang B, 1998, Isolation, Purification and Structural Analysis of Polysaccharide QA2 from India Madder (Rubia cordifolia). Chinese Herbal Medicine, 1998(04): 219–221.
Wang H, Wang B, Ma B, et al., 1998, Isolation, Purification and Structure Investigation of Glycoprotein QC from Rubia cordifolia L. Journal of the Academy of Military Medical Sciences, 1998(04): 38–41.