Topical Antifungal Therapy Combined with Nail Abrasion for the Treatment of Dermatophytoma: Single-Center Results — A Secondary Publication

Abstract

Objective: Recently, topical antifungal agents have become available for the treatment of dermatophytoma. However, there are few reports of topical onychomycotic agents in combination with debridement of dermatophytoma. Methods: Twelve patients with dermatophytoma diagnosed and treated between April 2017 and March 2020 at the Department of Dermatology, Kansai Rosai Hospital were selected, including two patients with lesions on both toe nails and 14 nails. At the initial visit, the affected nail plate was removed and topical treatment was administered. The observation was terminated when the lesions were completely healed within 1 year. If the patients were not completely healed, the initial efficacy was determined at the date of the first visit closest to 1 year after the start of treatment. The second efficacy evaluation was conducted at the last visit or when the concomitant drug was changed.　Results: Three patients dropped out of the study before the time of the initial efficacy evaluation. In the second efficacy evaluation, eight nails were completely healed, one nail was significantly healed, and one nail was effective. Conclusions: Dermatophytoma can be treated with topical onychomycotic agents in combination with surgical debridement to improve efficacy.