Atypical Lichen Myxedematosus Associated with Multiple Myeloma

Laura Charry Anzola; Isabel Cristina Cuellar; Tatiana Valeria Camayo; Maria Daniela  Polania

doi:10.26689/dh.v1i1.4994

Laura Charry Anzola Pontificia Universidad Javeriana-Hospital Universitario San Ignacio, Bogotá, Colombia
Isabel Cristina Cuellar Pontificia Universidad Javeriana-Hospital Universitario San Ignacio, Bogotá, Colombia
Tatiana Valeria Camayo Pontificia Universidad Javeriana, Bogotá, Colombia
Maria Daniela Polania Pontificia Universidad Javeriana, Bogotá, Colombia

DOI: https://doi.org/10.26689/dh.v1i1.4994

Keywords: Lichen myxedematous, Mucinosis, Scleromyxedema

Abstract

Lichen myxedema (LM) represents a group of rare skin diseases, which falls under chronic mucinoses. LM, previously described as localized scleromyxedema, however, is not associated with systemic involvement. Among the subtypes, atypical LM is rare, with few reported cases associated with multiple myeloma (MM). We present a case of MM, positive for lambda chains, with acute-onset clinical symptoms, and diagnosed with atypical LM. The patient was managed with topical corticosteroid with improvement of lesions after one month of treatment.

References

Geisler A, Hosseinipour M, Vyas NS, et al., 2020, Lichen Myxedematosus: Case Report and Review of Literature. J Drugs Dermatol, 19(3): 320–322. https://doi.org/10.36849/JDD.2020.4864

Cárdenas-Gonzalez RE, Ruelas MEH, Candiani JO, 2019, Lichen Myxedematosus: A Rare Group of Cutaneous Mucinosis. An Bras Dermatol, 94: 462–469. https://doi.org/10.1590/abd1806-4841.20198478

Hermans C, Goldscheider I, Ruzicka T, et al., 2016, Atypical Discrete Papular Lichen Myxedematosus Associated with Monoclonal Gammopathy: Report of Four Cases and Review of the Literature. Journal of the European Academy of Dermatology and Venereology, 30(12): 2048–2051. https://doi.org/10.1111/jdv.13833

Rongioletti F, 2006, Lichen Myxedematosus (Papular Mucinosis): New Concepts and Perspectives for an Old Disease. Semin Cutan MedSurg, 25: 100–104. https://doi.org/10.1016/j.sder.2006.04.001

Nofal A, Amer H, Alakad R, et al., 2017, Lichen Myxedematosus: Diagnostic Criteria, Classification, and Severity Grading. Int J Dermatol, 56(3): 284–290. https://doi.org/10.1111/ijd.13437

Christman MP, Sukhdeo K, Kim RH, et al., 2017, Papular Mucinosis, or Localized Lichen Myxedematosis (LM) (Discrete Papular Type). Dermatol Online J, 23(12): 13030/qt3xp109qd.