Keywords
Psoriasis
Neutrophil-to-lymphocyte ratio
Platelet-to-lymphocyte
Disease assessment
Submitted : 2025-03-03
Accepted : 2025-03-18
Published : 2025-04-02
Abstract
In this study, the changes of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with psoriasis were retrospectively analyzed based on the treatment of apremilast. By screening patients with psoriasis before and after treatment with apremilast, relevant blood routine indicators were collected, and NLR and PLR were calculated. The results showed that both NLR and PLR were significantly reduced after treatment with apremilast. This suggests that the inflammatory response is improved in patients with psoriasis and that apremilast may have an inhibitory effect on white blood cell platelet activation. These results suggest that NLR and PLR may be useful indicators to evaluate the condition of psoriasis and the therapeutic effect of apremilast. This provides a new reference index and treatment strategy for the clinic and has positive practical guiding significance for the prevention and treatment of psoriasis.
References
Wang M, Li J, Fu L, 2022, The Clinical Value of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Mean Platelet Volume in Diagnosis of ACS. Journal of Cardio-Cerebrovascular Diseases of Integrated Chinese and Western Medicine, 20(09): 1660–1666.
Liu X, Yin D, Han X, 2019, Changes of Neutrophil/Lymphocyte Ratio, Platelet/Lymphocyte Ratio, Erythrocyte Distribution Width/Platelet Count Ratio and Their Clinical Significance in Patients with Syphilis. Chinese Journal of Sex Science, 31(06): 145–148.
Zhang X, Liu D, Yan J, et al., 2019, The Value of Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Evaluating the Prognosis of Patients with Sepsis. Journal of Ningxia Medical University, 42(04): 367–371.
Zhang L, Song S, Liu S, et al., 2019, Relationship Between Neutrophil/Lymphocyte Ratio, Platelet/Lymphocyte Ratio and Thyroid-Associated Ocular Diseases. Chinese Journal of Clinical Physicians, 47(10): 1165–1167.
Cao R, Yu J, Zhang J, et al., 2019, Correlation Between Neutrophil/Lymphocyte Ratio, Platelet/Lymphocyte Ratio and Psoriatic Arthritis and Vulgaris. Chinese Journal of Dermatology and Venereology, 34(09): 1000–1004.
Li R, Tian R, Feng F, et al., 2019, Treatment of Severe Plaque Psoriasis Complicated with Silicosis with Apremilast: A Case Report. Chinese Journal of Dermatologic Venereology of Integrated Traditional and Western Medicine, 23(05): 437–439.
Wang H, Tao W, Nie S, et al., 2018, Value of Peripheral Blood Neutrophil Count and Lymphocyte and Platelet Ratio in Predicting 28-Day Death in Elderly Patients with Sepsis. Journal of Clinical Internal Medicine, 41(09): 606–609.
Liao Q, Zheng L, Deng Z, 2024, The Levels of Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, Monocyte to Lymphocyte Ratio in Peripheral Blood of Patients with Advanced Nasopharyngeal Carcinoma and Their Relationship with Prognosis. Big Doctor, 9(17): 9–11.
Wei Y, Zhang P, 2024, Forrest’s Meters in the Progress in the Application of Skin Disease. Chinese Journal of Skin Venereology, 38(11): 1293–1298.
Yang G, Huang F, Hou F, 2024, The Value of the Ratio of Neutrophil Count to Lymphocyte Count and Platelet Count Combined with Blood Lactic Acid in Predicting AKI in Patients with Multiple Injury. Journal of Clinical Emergency Treatment, 25(7): 352–356.
Mao R, 2024, Prognostic Value of the Ratio of Neutrophil to Lymphocyte, Platelet Count, and Red Blood Cell Distribution in Patients with Multiple Myeloma, Anhui Medical University.
Xu Y, Zhan W, Zhao J, 2018, Meta-Analysis of the Efficacy and Safety of Deuterocolexitinib in the Treatment of Moderate and Severe Plaque Psoriasis. Chinese Journal of Leprosy and Dermatology, 40(02): 89–94.
Cao L, Qin P, Wen X, 2019, Clinical Effect of Apremilast Tablets in the Treatment of 40 Cases of Moderate to Severe Plaque Psoriasis. Dermatology and Venereal Diseases, 45(05): 337–340.
Yang WW, 2019, Neutrophil Gelatinase-Related Lipid Carrier Protein, Nuclear Factor-κB, Neutrophil/Lymphocyte Ratio, Neutrophil/Lymphocyte and Platelet Ratio, Cystatin C Level in Predicting Acute Kidney Injury in Patients with Severe Acute Pancreatitis and Its Clinical Significance. Shaanxi Medical Journal, 52(08): 1055–1058 + 1084.
Li J, 2019, To Investigate the Value of Plasma D-Dimer, Neutrophil/Lymphocyte and Platelet/Lymphocyte Ratio in the Evaluation of Severity and Prognosis of Elderly Patients with Acute Ischemic Stroke. Jiangxi Medicine, 58(06): 704–706.