Keywords
Diabetic complications
Adjuvant therapy
Submitted : 2024-12-14
Accepted : 2024-12-29
Published : 2025-01-13
Abstract
Objective: To evaluate the adjuvant therapeutic effect of Epalrestat tablets on diabetic complications. Methods: 96 patients with diabetic complications who were admitted to the hospital from September 2021 to September 2023 were selected and randomly divided into two groups using a random number table. The observation group was treated with Epalrestat tablets combined with Ginkgo Dipyridolum Injection, while the control group was treated with Ginkgo Dipyridolum Injection only. The total effective rate, blood glucose indicators, oxidative stress indicators, and adverse reaction rates were compared between the two groups. Results: The total effective rates of diabetic nephropathy (DN), diabetic foot (DF), and diabetic peripheral neuropathy (DPN) in the observation group were higher than those in the control group (P < 0.05). After 12 weeks of treatment, the blood glucose indicators in the observation group were lower than those in the control group, and the oxidative stress indicators were better than those in the control group (P < 0.05). The adverse reaction rate in the observation group was lower than that in the control group (P < 0.05). Conclusion: Epalrestat tablets can assist in improving the clinical efficacy of patients with diabetic complications, lowering their blood glucose levels, reducing oxidative stress damage, and decreasing adverse reactions after medication.
References
References
Chen L, Lin F, Wei C, 2024, Clinical Effect of Epalrestat Tablets Combined with Thioctic Acid Injection in the Treatment of Diabetic Peripheral Neuropathy. Diabetes New World, 27(7): 183–186.
Lu C, Sun C, Tang B, et al., 2024, Application Effect of Ginkgo Leaf Tablets Combined with Epalrestat Tablets on Diabetic Microvascular Complications. Jilin Medical Journal, 45(5): 1164–1167.
Fan Y, Liang G, Wang C, et al., 2024, Study on the Efficacy and Mechanism of Yuquan Capsule Combined with Epalrestat in the Treatment of Type 2 Diabetic Peripheral Neuropathy. Chinese Journal of Drug Application and Monitoring, 21(1): 1–4.
Chen Y, 2022, Effects of Epalrestat Tablets on Glucose Metabolism, Oxidative Stress, Inflammatory Response, and Renal Function Impairment in Elderly Patients with Diabetic Nephropathy. Jilin Medical Journal, 43(4): 1012–1014.
Liu J, Xu K, He Y, 2022, Efficacy Analysis of Epalrestat Tablets Combined with Metformin in the Treatment of Diabetic Peripheral Neuropathy. Chinese Journal of Prescription Drug, 20(11): 89–91.
Zhou X, Cheng J, 2022, Observation on the Efficacy of Epalrestat Tablets Combined with Alprostadil Injection in the Treatment of Diabetic Retinopathy. Gansu Science and Technology, 38(19): 94–96 + 99.
Li F, Zhang L, Wei A, et al., 2021, Clinical Study on the Treatment of Diabetic Nephropathy with Compound Xueshuantong Capsules Combined with Epalrestat. Drugs & Clinic, 36(6): 1217–1220.
Tao Y, Zhao X, Ren S, et al., 2023, Adjuvant Treatment of Diabetic Enteropathy with Epalrestat and Pinaverium Bromide and Its Effect on Serum GLP-1, MTL, and SP Levels. Hebei Medical Journal, 45(12): 1798–1802.
Wu Y, Zhu X, Qian K, 2024, Efficacy Analysis of Gubu Decoction Combined with Epalrestat Tablets in the Treatment of Diabetic Peripheral Neuropathy. Chinese Journal of Traditional Medical Science and Technology, 31(1): 179–181.
Chen H, Gu Y, Yang J, et al., 2022, Observation on the Efficacy of Bifidobacterium Tetravaccine Tablets Assisted with Mecobalamin and Epalrestat in the Treatment of Diabetic Diarrhea Patients. Journal of Clinical and Experimental Medicine, 21(5): 484–487.
Zhou Y, Yang J, Wang L, et al., 2021, Clinical Effect of Bailing Tablets Combined with Epalrestat in the Treatment of Type 2 Diabetic Peripheral Neuropathy and Its Influence on Oxidative Stress and Inflammatory Response. Clinical Misdiagnosis & Mistherapy, 34(7): 29–33.