Research Progress on Dexmedetomidine Regulating Autophagy in the Treatment of Acute Lung Injury
Download PDF


Acute lung injury



Submitted : 2023-12-11
Accepted : 2023-12-26
Published : 2024-01-10


Dexmedetomidine, extensively utilized as an intravenous anesthetic in anesthesia, intensive care units, and other related medical departments, exhibits significant anti-inflammatory effects while inducing sedation. Numerous studies have demonstrated its capability to regulate autophagy, thereby exerting potent anti-inflammatory effects and offering therapeutic benefits in the treatment of acute lung injury. This article comprehensively reviews the mechanisms underlying autophagy, the role of dexmedetomidine in autophagy regulation, and the protective effects it conders in the context of acute lung injury. By doing so, it contributes positively to the arsenal of strategies aimed at both preventing and treating acute lung injury.


Mokrá D, 2020, Acute Lung Injury – From Pathophysiology to Treatment. Physiol Res, 69(Suppl 3): S353–S366.

Xue L, 2021, Current Status and Future Treatment Strategies for Acute Lung Injury. Shanghai Medical Journal, 44(8): 571–575.

Zhang Z, Chen Z, Liu R, et al., 2020, Bcl-2 Proteins Regulate Mitophagy in Lipopolysaccharide-Induced Acute Lung Injury via PINK1/Parkin Signaling Pathway. Oxid Med Cell Longev, 2020: 6579696.

Glick D, Barth S, Macleod KF, 2010, Autophagy: Cellular and Molecular Mechanisms. J Pathol, 221(1): 3–12.

Parzych KR, Klionsky DJ, 2014, An Overview of Autophagy: Morphology, Mechanism, and Regulation. Antioxid Redox Signal, 20(3): 460–473.

Alers S, Löffler AS, Wesselborg S, et al., 2012, Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks. Mol Cell Biol, 32(1): 2–11.

Hu Y, 2017, Research on the Molecular Regulatory Mechanisms of mTOR and Autophagy in LPS-Induced Acute Lung Injury, thesis, Zhejiang University.

Zhu C-H, Yu J, Wang B-Q, et al., 2020, Dexmedetomidine Reduces Ventilator-Induced Lung Injury via ERK1/2 Pathway Activation. Mol Med Rep, 22(6): 5378–5384.