Study on Left Atrial Function in Patients with Early Left Ventricular Remodeling in Essential Hypertension Based on Two-Dimensional Speckle Tracking Technology
Download PDF


Speckle tracking
Left atrium



Submitted : 2023-08-26
Accepted : 2023-09-10
Published : 2023-09-25


Objective: To use two-dimensional speckle tracking imaging (2D-STI) to analyze the functional changes of the left atrium before hypertrophic changes in the left ventricular configuration in the early stage of hypertension and to explore the clinical value of this technology in evaluating the changes of left atrial characteristics in patients with hypertension. Methods: 70 cases of patients with essential hypertension who met the requirements of this study after clinical diagnosis and routine ultrasound examination were recruited and divided into two groups according to the Ganan method: 38 cases in the left ventricular standard remodeling group, 32 cases in the left ventricular concentric remodeling group, and 40 healthy people with matched age and sex were randomly selected as the control group. The mean peak strains and strain rates of the left atrial systole, early diastole, and late diastole of each group were obtained using 2D-STI. The above parameters and indicators were used for comparative analysis. Results: Compared with the healthy control group, the values of peak strains and strain rates during early diastole were statistically different in both remodeling groups; compared with the standard remodeling group, the values of peak strains and strain rates in all periods were significantly different in the concentric remodeling group (P < 0.05). Conclusion: 2D-STI can be more sensitive and convenient to reflect the characteristic changes of left atrial myocardium in patients with early essential hypertension.


Yildiz M, Oktay AA, Stewart MH, et al., 2020, Left Ventricular Hypertrophy and Hypertension. Progress in Cardiovascular Diseases, 63(1): 10–21.

Li Y, Tian J, Du G, 2022, Research Progress of Two-Dimensional Speckle Tracking Technology Quantifying Left Atrial Function in Cardiovascular Diseases. Advances in Cardiovascular Diseases, 43(5): 435–439.

Karakurt A, Yildiz C, Yildiz A, et al., 2019, Early Detection Strain/Strain Rate and Time to Strain/Strain Rate Abnormalities for Left Atrial Mechanical Function in Hypertensive Patients. Acta Cardiologica, 74(2): 141–151.

Shi F, Feng S, Zhu J, et al., 2018, Left Ventricular Strain and Dyssynchrony in Young and Middle-Aged Peritoneal Dialysis Patients and Healthy Controls: A Case-Matched Study. Cardio Renal Medicine, 8(4): 271–284.

Ganau A, Devereux RB, Roman MJ, et al., 1992, Left Ventricular Hypertrophy and Geometric Remodeling Patterns in Essential Hypertension. Coll Cardiol, 19(7): 1550–1558.

Thomas L, Muraru D, Popescu BA, et al., 2020, Evaluation of Left Atrial Size and Function: Relevance for Clinical Practice. J Am Soc Echocardiogr, 33(8): 934–952.

Modin D, Pedersen S, Fritz-Hansen T, et al., 2020, Left Atrial Function Determined by Echocardiography Predicts Incident Heart Failure in Patients with STEMI treated by Primary Percutaneous Coronary Intervention. J Card Fail, 26(1): 35–42.

Goksuluk H, Habibova U, Ongun A, et al., 2017, Evaluation of the Effect of Dipping Pattern in Hypertensive Patients on the Left Ventricular Systolic Functions by Two-Dimensional Strain Analysis. Echocardiography, 34(5): 668–675.

Qu W, Kang Y, Xu L, et al., 2020, Clinical Study Evaluating Left Atrial Function and Epicardial Fat Thickness in Patients with Hyperuricemia Using Two-Dimensional Speckle Tracking Technology. Shaanxi Medical Journal, 49(4): 474–476 + 505.

Soullier C, Niamkey JT, Ricci JE, et al., 2016, Hypertensive Patients with Left Ventricular Hypertrophy Have Global Left Atrial Dysfunction and Impaired Atrioventricular Coupling. Journal of Hypertension, 34(8): 1615–1620.

Zhang Z, Zheng F, Huang L, et al., 2021, Research on Left Atrial Function of Two-Dimensional Speckle Tracking Technology in Uremic Patients of the Same Age. Geriatric Medicine and Health Care, 27(1): 90–93.

Peng H, Wang C, Wang X, et al., 2019, Clinical Study of 2D-STI Technology to Evaluate Early Left Atrial Function in Patients with Essential Hypertension. Systems Medicine, 4(3): 107–110.

Dai F, Gong Y, Xue Y, 2020, Research on the Application of Two-Dimensional Speckle Tracking and Real-Time Three-Dimensional Ultrasound Imaging in the Early Evaluation of Left Atrial Remodeling in Hypertension. Chinese Medical Equipment, 17(1): 43–47.

Chang Y, Hu G, Zhu X, et al., 2021, Two-Dimensional Speckle Tracking Technology Measures the Thickness of the Interatrial Septum in Patients with Hypertension and Its Relationship with Left Atrial Function. Journal of Clinical Ultrasound in Medicine, 23(4): 251–255.

Chen X, Li L, Song Y, et al., 2020, Quantitative Study of Early Left Atrial Dysfunction in Patients with Hypertension Based on Cardiac Magnetic Resonance Feature Tracking Technology. Magnetic Resonance Imaging, 11(4): 281–285.

Li N, Yang X, Sun P, et al., 2016, The Value of Two-Dimensional Speckle Tracking Technology in Evaluating Left Ventricular Longitudinal Systolic Function in Patients with Essential Hypertension. Chinese Journal of Practical Diagnosis and Treatment, 30(2): 157–159.

Li Z, Yang B, Li Z, et al., 2021, The Application Value of Two-Dimensional Speckle Tracking in the Early Evaluation of Left Atrial Remodeling in Hypertension. Analytical Instruments, 2021(2): 53–58.

You X, Dong Q, Xu J, et al., 2017, Research on Early Evaluation of Left Atrial Function Using Two-Dimensional Speckle Tracking Technology in Patients with Hypertension. Journal of Chongqing Medical University, 42(12): 1676–1680.