Objective: To analyze the therapeutic effect of percutaneous closure of patent foramen ovale (PFO) and migraine. Methods: A total of 150 patients with PFO and migraine who were admitted to the hospital from January 2021 to May 2023 were recruited and divided into groups by random number table, the study group took percutaneous closure and drug treatment, and the control group took conventional drug treatment. The treatment effects between the groups were compared. Results: The total effective rate of the study group was higher than that of the control group (P < 0.05). Before treatment, there was no difference in migraine quantitative evaluation indicators between the groups (P > 0.05). After treatment, the migraine quantitative evaluation indicators in the study group were better than those in the control group (P < 0.05). The complication rate of the study group was lower than that of the control group (P < 0.05). Followed up for 1 to 3 months, the recurrence rate of the study group was lower than that of the control group (P < 0.05). Conclusion: Percutaneous closure for patients with PFO and migraine can improve the symptoms of migraine, enhance the curative effect, and have fewer postoperative complications.
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