Keywords
Enalapril
Elderly hypertension
Treatment
Submitted : 2024-03-17
Accepted : 2024-04-01
Published : 2024-04-16
Abstract
Objective: To explore the application value of amlodipine combined with enalapril in the treatment of elderly hypertension. Methods: A total of 600 hypertensive patients admitted between May 2020–2023 were recruited and divided into the study group and the control group, with 300 cases in each group, using a double-blind mechanism. The study group was treated with enalapril and amlodipine, while the control group was treated with enalapril. The changes in vascular endothelium, blood pressure performance, pulse pressure level, and drug side effects were compared between the groups. Results: Before treatment, the changes in vascular endothelium showed no significant difference between the groups (P > 0.05); after treatment, the changes in the study group were significantly better than the control group (P < 0.05). Before treatment, the performance of systolic and diastolic blood pressures in the two groups showed no significant difference (P > 0.05); after treatment, the performance in the study group was lower than that in the control group (P < 0.05). Before treatment, the pulse pressure levels of the two groups showed no significant difference (P > 0.05); after treatment, the pulse pressure levels of the study group were significantly better than that of the control group (P < 0.05). The side effects of medication in the study group were significantly lower than those in the control group (P < 0.05). Conclusion: Amlodipine combined with enalapril has a higher curative effect in the treatment of elderly hypertension, which is worthy of promotion.
References
Zhang Y, Chen C, 2023, Clinical Efficacy of Amlodipine Besylate Combined with Valsartan in the Treatment of Elderly Hypertension and Evaluation of Its Impact on BUN and SCr Levels. North Pharmacy, 20(04): 137–139.
Chen C, Luo W, 2022, Comparison of Yindan Xinnaotong Soft Capsules and Simvastatin in the Treatment of Elderly Hypertension and Hyperlipidemia and Their Effects on Blood Lipid Metabolism. Journal of Clinical Rational Drug Use, 15(33): 14–17.
Shao Y, Sun Z, Gan X, et al., 2022, Effects of Combined Therapy of Irbesartan, Hydrochlorothiazide and Metoprolol on Blood Pressure Variability and Heart and Kidney Function in Elderly Hypertensive Patients. Chinese Journal of Hospital Pharmacy, 42(24): 2650–2654.
Wu W, 2022, Stigma and Hope Level of Elderly Hypertensive Patients with Pulmonary Tuberculosis. Knowledge of Cardiovascular Disease Prevention, 12(30): 43–45.
Sun Z, Yang Y, Yan Z, 2021, Effects of Amlodipine or Hydrochlorothiazide Combined with Enalapril on the Circadian Rhythm of Blood Pressure in Elderly Hypertensive Patients. Clinical Research, 29(12): 34–37.
Tu J, Wu Y, Nian H, 2021, Effect of Metoprolol Tartrate Tablets Combined with Irbesartan Tablets in the Treatment of Elderly Hypertension and Its Impact on the Quality of Life of Patients. Chinese and Foreign Medical Research, 19(19): 19–21.
Cui J, Feng L, Ma F, 2021, Efficacy of Danshen Ligustrazine Injection in the Treatment of Heart Failure with Normal Ejection Fraction Caused by Hypertension in the Elderly and Its Effect on Serum hs-CRP, IL-6, ET-1. Modern Journal of Integrative Traditional Chinese and Western Medicine, 30(15): 1647–1650.
Xiang H, Fu M, Zhou W, 2021, Analysis of Curative Effect and Serological Changes of Valsartan Amlodipine Tablets Combined with Simvastatin in the Treatment of Elderly Hypertensive Patients with Dyslipidemia. Chinese Modern Doctor, 59(05): 125–128.
Wu K, 2020, The Effect of Benazepril Hydrochloride Combined with Metoprolol Succinate in the Treatment of Elderly Patients with Hypertension Complicated with Chronic Heart Failure. Contemporary Medicine Forum, 18(04): 160–161.
Liu Y, Li P, Zhang S, et al., 2020, Effects of EECP Treatment on NT-ProBNP Levels and Echocardiographic Indicators in Elderly Hypertensive Patients with HFpEF. Contemporary Medicine, 18(01): 14–15.
Li H, 2019, Comparison of Clinical Effects of Single-Tablet Valsartan-Amlodipine Compound Preparation and Free Combination of Amlodipine Sustained-Release Tablets in the Treatment of Elderly Hypertension. Journal of Clinical Rational Drug Use, 12(26): 23–24.
Li C, Yu F, Zhang G, et al., 2019, The Effect of Telemedicine Management Combined with Drugs in the Treatment of Elderly Patients with Hypertension Complicated with Obstructive Sleep Apnea Hypopnea Syndrome. Practical Gerontology, 33(06): 573–576 + 581.
Jiang L, Gu J, 2019, Effects of Dual Combination Therapy of Amlodipine Besylate and Irbesartan on Antihypertensive Effect and Treatment Compliance of Elderly Hypertensive Patients in the Community. Electronic Journal of Cardiovascular Diseases of Integrated Traditional Chinese and Western Medicine, 2019, 7(16): 127–129.
Zhang Y, 2019, Observation on the Effect of Nifedipine Controlled-Release Tablets Combined with Hydrochlorothiazide in the Treatment of Elderly Hypertension and the Incidence of Adverse Reactions. Electronic Journal of Cardiovascular Diseases of Integrated Traditional Chinese and Western Medicine, 7(11): 42.
Shi Y, Zhou Q, Shen N, et al., 2019, The Relationship between Treatment Compliance, Treatment Attitude and Belief, and Medical and Social Support of Elderly Hypertensive Patients in a District of Qiqihar City. Medicine and Society, 32(04): 90–94.