Keywords
Metoprolol
Amlodipine besylate
Submitted : 2026-02-17
Accepted : 2026-03-04
Published : 2026-03-19
Abstract
Objective: To analyze the therapeutic effect of amlodipine besylate combined with metoprolol in elderly patients with essential hypertension. Methods: A total of 600 elderly patients with essential hypertension who were treated from August 2023 to August 2024 were selected as samples and grouped by random number table. Group A was treated with amlodipine besylate combined with metoprolol, while Group B was treated with metoprolol. Cardiovascular function indicators, vascular endothelial indicators, blood viscosity indicators, and adverse reactions were compared. Results: Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and heart rate (HR) in Group A were lower than those in Group B, with P < 0.05; Nitric oxide (NO) in Group A was higher than that in Group B, while endothelin-1 (ET-1) was lower than that in Group B, with P < 0.05; Plasma viscosity (PV), low-shear whole blood viscosity (LBV), and high-shear whole blood viscosity (HBV) in Group A were lower than those in Group B, with P < 0.05; There was no significant difference in adverse drug reactions between Group A and Group B, with P > 0.05. Conclusion: The combination of amlodipine besylate and metoprolol in the treatment of elderly patients with essential hypertension results in stable hemodynamic indicators, improved vascular endothelial function, reduced blood pressure and heart rate, and is highly effective and feasible.
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