Clinical Diagnostic Value of Serum Low-Density Lipoprotein Cholesterol Combined with Carotid Artery Ultrasound Parameters in Patients with Coronary Heart Disease
Download PDF

Keywords

Serum low-density lipoprotein cholesterol
Carotid artery ultrasound parameters
Coronary heart disease
Diagnostic value

DOI

10.26689/cr.v3i4.13499

Submitted : 2025-12-10
Accepted : 2025-12-25
Published : 2026-01-09

Abstract

Objective: To analyze and study the results of carotid artery ultrasound examination and serum low-density lipoprotein cholesterol (LDL-C) detection in patients with coronary heart disease, aiming to explore their application effectiveness and value in the clinical diagnosis of coronary heart disease. Methods: A retrospective analysis was conducted on the diagnostic conditions of suspected coronary heart disease patients who visited our hospital from May 2023 to June 2025. Using coronary angiography results as the gold standard, 60 patients diagnosed with coronary heart disease were selected as the study group, and 60 patients without coronary heart disease were selected as the control group. LDL-C levels and carotid artery ultrasound parameters were compared between the two groups to evaluate their diagnostic value. Results: The IMT and plaque semi-quantitative scores in the study group were higher than those in the control group (P < 0.05); carotid artery plaques were detected in 47 patients in the study group, with a total of 103 plaques. The proportion of patients with ≥ 2 types of plaques was 66.67%, mainly consisting of heterogeneous plaques (34.95%) and soft plaques (56.31%), which were significantly higher than those in the control group (P < 0.05); LDL-C and TC levels in the study group were significantly higher than those in the control group (P < 0.05). Conclusion: The detection of serum LDL-C and carotid artery ultrasound parameters holds significant application value in the diagnosis of coronary heart disease (CHD). A combined detection approach can serve as an important reference for screening coronary artery lesions and provide a reference basis for formulating clinical diagnosis and treatment strategies.

References

Qian C, Wang L, Xiong X, et al., 2025, The Value of Serum Low-Density Lipoprotein Cholesterol and High-Sensitivity C-Reactive Protein Combined with Carotid Artery Ultrasound Parameters in Diagnosing Suspected Coronary Heart Disease Patients. Journal of Practical Medicine, 41(9): 1401–1406.

Fu Y, Zhang Y, Nie Y, et al., 2023, Application Value of Serum hs-CRP, Hcy Combined with Carotid Ultrasound Parameters in Assessing the Severity of Coronary Artery Stenosis in Patients with Coronary Heart Disease. Guangxi Medical Journal, 45(19): 2301–2304.

Wang L, Wang C, Li Y, 2024, The Application Value of Small, Dense Low-Density Lipoprotein Cholesterol in the Diagnosis of Coronary Heart Disease and Stroke. Chinese Community Doctors, 40(32): 107–109.

Liu T, Huang S, 2024, Detection Results of Serum Hcy and Carotid Artery Ultrasound Parameters in Patients with Coronary Heart Disease and their Predictive Value for the Degree of Coronary Artery Stenosis. Knowledge of Prevention and Treatment of Cardiovascular Diseases, 14(21): 26–30.

Interventional Cardiology Group, Cardiovascular Disease Branch of the Chinese Medical Association; Atherosclerosis and Coronary Heart Disease Group, Cardiovascular Disease Branch of the Chinese Medical Association, et al., 2018, Guidelines for the Diagnosis and Treatment of Stable Coronary Heart Disease. Chinese Journal of Cardiology, 46(9): 680–694.

Zhang M, 2024, The Application Value of Combined Detection of Small Dense Low-Density Lipoprotein Cholesterol and High-Sensitivity C-Reactive Protein in the Diagnosis of Coronary Atherosclerotic Heart Disease. Systems Medicine, 9(22): 78–81.

Xie C, Yan L, Xu X, 2023, Research on the Application Value of Combined Detection of Small Dense Low-Density Lipoprotein Cholesterol and Low-Density Lipoprotein Cholesterol in the Diagnosis and Treatment of Cardiovascular Diseases. Medical Information, 36(6): 97–100.

Zhu L, 2023, Research on the Value of Combined Cardiac Color Doppler Ultrasound and Carotid Artery Ultrasound Examination in the Diagnosis of Coronary Heart Disease. Journal of Practical Medical Imaging, 24(6): 466–470.

Liu C, Sun W, Ma D, et al., 2023, Clinical Significance of Combined Carotid Artery and Middle Cerebral Artery Ultrasound Examination in Predicting Coronary Artery Lesions. Journal of Electrocardiology & Circulation, 42(6): 536–540.

Fan P, 2023, Analysis of the Correlation between Serum Small Dense Low-Density Lipoprotein and Coronary Heart Disease. Forum on Primary Medical Care, 27(19): 94–96.

Zhou R, Pang H, Zong L, 2022, Analysis of the Diagnostic Effect of Carotid Artery Ultrasound Examination of Atherosclerotic Plaque Parameters on Coronary Heart Disease in Elderly Hypertensive Patients. Modern Health Preservation, 22(20): 1744–1746.

Huang J, 2021, Diagnostic Value of Carotid Atherosclerotic Plaque Ultrasound in Patients with Coronary Heart Disease. Chinese and Foreign Medical Treatment, 40(17): 1–3.

Ding Y, 2022, Application Effect of Combined Serum Bilirubin and Low-Density Lipoprotein Cholesterol Test in the Early Diagnosis of Coronary Heart Disease. Journal of Clinical Rational Drug Use, 13(27): 19–20.