Objective: To study the efficacy of isosorbide mononitrate combined with nicorandil in the treatment of myocardial ischemia in coronary heart disease. Methods: 100 patients with myocardial ischemia due to coronary heart disease who visited our hospital from January 2022 to January 2025 were selected as samples and randomly divided into two groups. Group A received isosorbide mononitrate combined with nicorandil, while Group B received isosorbide mononitrate only. The efficacy, electrocardiogram, cardiac function, and complications were compared between the two groups. Results: The efficacy of Group A was higher than that of Group B (P < 0.05). The electrocardiogram indicators of Group A were better than those of Group B (P < 0.05). The cardiac function indicators of Group A were better than those of Group B (P < 0.05). The complication rate of Group A was lower than that of Group B (P < 0.05). Conclusion: The combination of isosorbide mononitrate and nicorandil in the treatment of myocardial ischemia in coronary heart disease can improve cardiac function, reduce myocardial ischemia load, and is safe and efficient.
Zhang L, Liu Y, 2024, Analysis of the Effect of Nicorandil Combined with Isosorbide Mononitrate in the Treatment of Coronary Heart Disease and Angina Pectoris. Chinese and Foreign Medical Research, 3(3): 51–53.
Chen X, 2022, Clinical Efficacy of Metoprolol Sustained-Release Tablets Combined with Isosorbide Mononitrate Sustained-Release Tablets in the Treatment of Severe Coronary Heart Disease With Myocardial Ischemia. Systems Medicine, 7(17): 102–105.
Wang C, 2023, Clinical Observation of Nicorandil Combined with Isosorbide Mononitrate in the Treatment of Coronary Heart Disease and Angina Pectoris. Chinese Journal of Modern Drug Application, 17(1): 82–84.
Zhao W, 2023, Analysis of the Effect of Nicorandil Combined with Isosorbide Mononitrate in the Treatment of Coronary Heart Disease and Angina Pectoris. Chinese Community Doctors, 39(30): 65–67.
Shan Y, 2021, Efficacy of Nicorandil Combined with Isosorbide Mononitrate in the Treatment of Chronic Heart Failure Caused by Coronary Heart Disease. Medical Information, 34(21): 153–155.
Guan Y, 2020, Efficacy Analysis of Diltiazem Hydrochloride Tablets Combined with Isosorbide Mononitrate in the Treatment of Patients with Coronary Heart Disease and Angina Pectoris. Huaxia Medical Journal, (2): 58–61.
Gao H, Chen Y, Li P, et al., 2023, Efficacy of Xiangdan Injection Combined with Nicorandil in the Treatment of Stable Exertional Angina Pectoris Caused by Coronary Heart Disease. Journal of Guizhou Medical University, 48(8): 986–992.
Yang X, 2022, Clinical Effect Analysis of Isosorbide Mononitrate in the Treatment of Asymptomatic Myocardial Ischemia Caused by Coronary Heart Disease. Chinese and Foreign Women’s Health Research, (17): 51–52.
Cheng M, Wu W, Wang X, et al., 2022, Clinical Effect of Isosorbide Mononitrate Combined With Nicorandil in the Treatment of Unstable Angina Pectoris with Mild to Moderate Stenosis. Chinese Medical Innovation, 19(2): 1–5.
Jia Q, Qi Q, Liu J, 2022, Efficacy of Isosorbide Mononitrate Combined with Salvianolate in Patients With Coronary Heart Disease and Angina Pectoris. Henan Medical Research, 31(3): 527–530.