Objective: To evaluate the difference in efficacy between single-port and multi-port thoracoscopic techniques for lung cancer surgery. Methods: 82 patients with lung cancer who were admitted to the hospital between February 2023 and February 2025 and underwent lobectomy were selected. They were randomly divided into two groups using a random number table. The experimental group underwent single-port thoracoscopic surgery, while the control group underwent multi-port thoracoscopic surgery. The efficacy and other indicators were compared between the two groups. Results: There was no difference in the total effective rate between the two groups (P > 0.05). The operation time of the experimental group was longer than that of the control group, and the intraoperative blood loss was less than that of the control group. On days 1 and 3 postoperatively, the pain scores of the experimental group were lower than those of the control group. Two months postoperatively, the short-term quality of life score of the experimental group was higher than that of the control group (P < 0.05). Conclusion: Performing single-port thoracoscopic surgery for lung cancer patients can reduce intraoperative blood loss, relieve postoperative pain symptoms, and improve short-term quality of life. However, the operation time is longer, and it requires higher technical requirements for the operator.
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