Keywords
ASI
Sotatercept
WSPH
China
Submitted : 2025-06-11
Accepted : 2025-06-26
Published : 2025-07-11
Abstract
Following the 7th World Symposium on Pulmonary Hypertension in 2024, the European Respiratory Journal published an updated treatment algorithm for pulmonary arterial hypertension (PAH), highlighting the emerging role of the activin signal inhibitor (ASI) sotatercept, as a key therapeutic advancement. The updated plan underscores the importance of indicators such as World Health Organization (WHO) functional class and 6-minute walk distance (6MWD) in risk assessment. It advocates for a personalized treatment approach based on risk stratification, encompassing both initial therapy selection and escalation strategies during follow-up. The anticipated introduction of the novel ASI sotatercept in China is expected to expand the therapeutic landscape for PAH management in the country.
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