Clinical Neuroscience Research

Clinical Effect of Nimodipine Combined with Rosuvastatin Calcium in the Treatment of Hypertensive Intracerebral Hemorrhage

Yanting Wang, Xiaogang Wang — Mon, 07 Apr 2025 08:57:42 +0800

Objective: To explore the clinical effect of nimodipine combined with rosuvastatin calcium in the treatment of hypertensive intracerebral hemorrhage. Methods: Sixty patients with hypertensive intracerebral hemorrhage from January 2023 to December 2023 were randomly divided into a control group (n = 30) and an observation group (n = 30). The control group received conventional treatment, while the observation group was treated with nimodipine + rosuvastatin calcium tablets. The neurological function, edema volume, hematoma volume, adverse reactions, and treatment efficiency were compared between the two groups. Results: After treatment, compared with the control group, the edema volume, hematoma volume index, and NIHSS score in the observation group were all reduced, and the differences were extremely significant (P < 0.001). The clinical efficacy of the observation group was 93.33%, which was much higher than the 66.67% of the control group, and the difference was significant (P < 0.05). The incidence of adverse reactions in the observation group was 3.33%, which was far lower than the 30.00% of the control group, and the difference was significant (P < 0.05). Conclusion: Nimodipine combined with rosuvastatin calcium in the treatment of hypertensive intracerebral hemorrhage shows significant advantages in improving edema volume and hematoma volume, promoting neurological recovery, improving clinical efficacy, and reducing the incidence of adverse reactions, thus having broad clinical application prospects.

To Analyze the Effect of Hemodialysis, Hemoperfusion, and Oral Olanzapine on Uremic Encephalopathy

Yueyue He — Mon, 07 Apr 2025 08:59:47 +0800

Objective: To analyze the effects of hemodialysis, hemoperfusion, and oral olanzapine in patients with uremic encephalopathy. Methods: 70 patients with uremic encephalopathy admitted to the hospital from January 2023 to August 2024 were selected and divided into groups according to a random drawing method, with 35 cases in each group. The control group was treated with hemodialysis and olanzapine orally, and the observation group was treated with hemoperfusion. PANSS scores, biochemical indexes, and inflammatory factors were compared between the two groups. Results: PANSS score, biochemical indexes, and inflammatory factors in the observation group were significantly lower than those in the control group (P < 0.05). Conclusion: The triple therapy of hemodialysis, hemoperfusion, and olanzapine can obviously promote the improvement of the psychological state of the patients. In addition, this treatment can also relieve inflammation in the patients and accelerate the excretion of toxins in the body.

Comprehensive Analysis of Different Laser Devices Treating Lower Extremity Varicose Veins at the Same Power and LEED Value

Zhiqi Song — Mon, 07 Apr 2025 09:02:55 +0800

Objective: To compare the clinical efficacy and complication rate of Biolitec laser and Halo laser for the treatment of lower extremity great saphenous vein (GSV) and small saphenous vein (SSV) under the same LEED value. Methods: A total of 70 cases of GSV and 30 cases of SSV treated with laser in our hospital from May 2022 to May 2023 were selected and treated with Biolitec and Halo laser equipment, respectively. The working mode was continuous mode. The patients were divided into the Biolitec group (35 patients with GSV and 15 patients with SSV) and the Halo group (35 patients with GSV and 15 patients with SSV) according to different laser equipment. The days of returning to normal activity, closure rate, and changes in venous clinical severity score (VCSS) were evaluated. Safety endpoints were deep vein thrombosis (DVT), heat-induced thrombosis (EHIT), surgical site ecchymosis, postoperative paresthesia (numbness), postoperative edema, burns, superficial phlebitis, and other adverse events. Results: There were no significant differences in the days of postoperative recovery, the closure rate of varicose veins, the change of VCSS, and the incidence of postoperative complications between the two groups. Conclusions: The Biolitec and the Halo laser have the same efficacy and safety in treating the GSV and SSV under the same power and LEED.

Experiences in the Application of Acupuncture in Stroke Rehabilitation with Integrated Traditional Chinese and Western Medicine

Qirui Qu — Mon, 07 Apr 2025 09:04:59 +0800

Stroke, characterized by high morbidity, disability, and mortality rates, has become one of the significant diseases seriously threatening human health. Patients often suffer from multiple functional disorders such as hemiplegia, dysphagia, and cognitive dysfunction. Although Western medicine rehabilitation treatment can promote functional recovery to a certain extent, it still has limitations. As an essential part of traditional medicine, acupuncture therapy in traditional Chinese medicine has gradually gained attention in the field of stroke rehabilitation due to its unique theoretical system and treatment methods. This article aims to comprehensively review the application of acupuncture in stroke rehabilitation with integrated traditional Chinese and Western medicine, providing a reference for further optimizing the stroke rehabilitation program that integrates traditional Chinese and Western medicine.

Trend of Global Neck Pain Disease Burden from 1990 to 2021

Weigang Liu, Qian Wu, Heqing Tang — Mon, 07 Apr 2025 09:26:33 +0800

Objective: This study aims to provide an accurate quantitative analysis of the global burden of neck pain, offering a scientific basis for the formulation of effective prevention and control strategies. Methods: Data related to the global burden of neck pain from 1990 to 2021 were collected from the Global Burden of Disease Study (GBD 2021) database. Descriptive analyses were conducted using indicators such as incidence, incidence rate, prevalence, prevalence rate, years lived with disability (YLDs), and YLDs rate. Results: From 1990 to 2021, the total number of cases of neck pain worldwide increased from 24.9 million to 43.26 million, an overall increase of 73.82%; the total number of prevalent cases rose from approximately 114 million to about 206 million, representing an overall increase of 79.78%. However, the age-standardized incidence rate and prevalence rate showed relatively small increases of 1.18% and 0.26%, respectively. The total YLDs increased from about 114 million in 1990 to approximately 204 million in 2021, marking an overall increase of 78.42%. The YLD rate per 100,000 population rose from 214.53 in 1990 to 258.71 in 2021, an increase of about 20.59%. The age-standardized YLD rate only saw a slight increase of 0.14%. The incidence rate, prevalence rate, and YLDs rate of neck pain were all higher in females than in males, with a more significant increase observed in females. In 2021, the incidence rate for females approached 620 per 100,000, the prevalence rate was close to 3,200 per 100,000, and the YLDs rate was nearly 290 per 100,000; whereas for males, the incidence rate was about 480 per 100,000, the prevalence rate was around 2,600 per 100,000, and the YLDs rate was nearly 230 per 100,000. Conclusion: This study reveals a significant increase in the global burden of neck pain from 1990 to 2021, particularly in the total number of cases. Although the age-standardized incidence and prevalence rates increased relatively modestly, the notable rise in total numbers indicates that neck pain continues to have an escalating impact on global health. The higher incidence, prevalence, and YLDs rates in females compared to males suggest a need for more targeted health interventions and management strategies addressing gender differences. Future research should further explore the specific risk factors for neck pain and their relative contributions, providing a scientific basis for developing effective prevention and control strategies.