Keywords
Skeletal muscle stimulation
Myokine
Prevention
Submitted : 2024-02-28
Accepted : 2024-03-14
Published : 2024-03-29
Abstract
The prevalence of chronic diseases, including cardiovascular diseases, type 2 diabetes, and cancer, is escalating at an alarming rate in many countries. These diseases are usually associated with insufficient physical activity since physical activity has beneficial effects on a variety of health outcomes such as decreased mortality and risk of these diseases. Moderate to vigorous physical activity has been recommended to achieve these positive effects. However, many patients cannot perform adequate exercise because of severe diseases, health complications, and/or exercise intolerance. This issue highlights a need for alternative therapies. There is an increasing literature that recognizes the positive effects of neuromuscular electrical stimulation (NMES) on muscle strength, cardiorespiratory fitness, physical performance, and metabolism in healthy adults and clinical settings. The present review introduces the effect of NMES on muscle strength and glucose metabolism as well as NMES-induced physiological responses such as the myokines which are related to preventing dementia and cancer.
References
Manini TM, Pahor M, 2009, Physical Activity and Maintaining Physical Function in Older Adults. British Journal of Sports Medicine, 43(1): 28–31.
Hirvensalo M, Rantanen T, Heikkinen E, 2000, Mobility Difficulties and Physical Activity as Predictors of Mortality and Loss of Independence in the Community-Living Older Population. Journal of the American Geriatrics Society, 48(5): 493–498.
Fleg JL, 2012, Aerobic Exercise in the Elderly: A Key to Successful Aging. Discovery Medicine, 13(70): 223–228.
Nelson ME, Rejeski WJ, Blair SN, et al., 2007, Physical Activity and Public Health in Older Adults: Recommendation from the American College of Sports Medicine and the American Heart Association. Medicine and Science in Sports and Exercise, 39(8): 1435–1445.
Garber CE, Blissmer B, Deschenes MR, et al., 2011, American College of Sports Medicine Position Stand: Quantity and Quality of Exercise for Developing and Maintaining Cardiorespiratory, Musculoskeletal, and Neuromotor Fitness in Apparently Healthy Adults — Guidance for Prescribing Exercise. Medicine and Science in Sports and Exercise, 43(7): 1334–1359.
Chodzko-Zajko WJ, Proctor DN, Fiatarone SMA, 2009, American College of Sports Medicine Position Stand: Exercise and Physical Activity for Older Adults. Medicine and Science in Sports and Exercise, 41(7): 1510–1530.
McPhee JS, French DP, Jackson D, et al., 2016, Physical Activity in Older Age: Perspectives for Healthy Aging and Frailty. Biogerontology, 17(3): 567–580.
Miyamoto T, Kamada H, Tamaki A, et al., 2016, Low-intensity Electrical Muscle Stimulation Induces Significant Increases in Muscle Strength and Cardiorespiratory Fitness. European Journal of Sports Science, 16(8): 1104–1110.
Caulfield B, Prendergast A, Rainsford G, et al., 2013, Self-directed Home-based Electrical Muscle Stimulation Training Improves Exercise Tolerance and Strength in Healthy Elderly. Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2013, 7036–7039.
Banerjee P, 2010, Electrical Muscle Stimulation for Chronic Heart Failure: An Alternative Tool for Exercise Training? Current Heart Failure Reports, 7(2): 52–58.
Henneman E, Somjen G, Carpenter DO, 1965, Functional Significance of Cell Size in Spinal Motorneurons. Journal of Neurophysiology, 1965(28): 560–580.
Henneman E, Somjen G, Carpenter DO, 1965, Excitability and Inhibitability of Motoneurons of Different Sizes. Journal of Neurophysiology, 1965(28): 599–620.
McPhedran AM, Wuerker RB, Henneman E, 1965, Properties of Motor Units in a Heterogeneous Pale Muscle (M. gastrocnemius) of the Cat. Journal of Neurophysiology 1965(28): 85–99.
McPhedran AM, Wuerker RB, Henneman E, 1965, Properties of Motor Units in a Homogeneous Red Muscle (soleus) of the Cat. Journal of Neurophysiology, 1965(28): 71–84.
Jubeau M, Gondin J, Martin A, et al., 2007, Random Motor Unit Activation by Electrostimulation. International Journal of Sports Medicine, 28(11): 901–904.
Maffiuletti NA, Minetto MA, Farina D, et al., 2011, Electrical Stimulation for Neuromuscular Testing and Training: State-of-the Art and Unresolved Issues. European Journal of Applied Physiology, 111(10): 2391–2397.
Sinacore DR, Delitto A, King DS, et al., 1990, Type II Fiber Activation with Electrical Stimulation: A Preliminary Report. Physical Therapy, 70(7): 416–422.
Kimura T, Kameda N, Moritani T, 2010, Impact of Phase Difference between Cardiac Systole and Skeletal Muscle Contraction on Hemodynamic Response during Electrically-Induced Muscle Contractions. Journal of Electromyography and Kinesiology, 20(4): 572–579.
Maffiuletti NA, 2010, Physiological and Methodological Considerations for the Use of Neuromuscular Electrical Stimulation. European Journal of Applied Physiology, 110(2): 223–234.
Crognale D, Vito DG, Grosset JF, et al., 2013, Neuromuscular Electrical Stimulation Can Elicit Aerobic Exercise Response without Undue Discomfort in Healthy Physically Active Adults. Journal of Strength and Conditioning Research, 27(1): 208–215.
Banerjee P, Caulfield B, Crowe L, et al., 2009, Prolonged Electrical Muscle Stimulation Exercise Improves Strength, Peak VO2, and Exercise Capacity in Patients with Stable Chronic Heart Failure. Journal of Cardiac Failure, 15(4): 319–326.
Banerjee P, Clark A, Witte K, et al., 2005, Electrical Stimulation of Unloaded Muscles Causes Cardiovascular Exercise by Increasing Oxygen Demand. European Journal of Cardiovascular Prevention and Rehabilitation, 12(5): 503–508.
Rom O, Kaisari S, Aizenbud D, et al., 2012, Lifestyle and Sarcopenia: Etiology, Prevention, and Treatment. Rambam Maimonides Medical Journal, 3(4): e0024.
Mitchell WK, Williams J, Atherton P, et al., 2012, Sarcopenia, Dynapenia, and the Impact of Advancing Age on Human Skeletal Muscle Size and Strength: A Quantitative Review. Frontiers in Physiology, 2012(3): 260.
Fitzgerald MD, Tanaka H, Tran ZV, et al., 1997, Age-related Declines in Maximal Aerobic Capacity in Regularly Exercising Vs. Sedentary Women: A Meta-Analysis. Journal of Applied Physiology, 83(1): 160–165.
Wei M, Kampert JB, Barlow CE, et al., 1999, Relationship between Low Cardiorespiratory Fitness and Mortality in Normal-Weight, Overweight, and Obese Men. JAMA, 282(16): 1547–1553.
Sun F, Norman IJ, While AE, 2013, Physical Activity in Older People: A Systematic Review. BMC Public Health, 2013(13): 449.
Kern H, Barberi L, Lofler S, et al., 2014, Electrical Stimulation Counteracts Muscle Decline in Seniors. Frontiers in Aging Neuroscience, 2014(6): 189.
Langeard A, Bigot L, Chastan N, et al., 2017, Does Neuromuscular Electrical Stimulation Training of the Lower Limb have Functional Effects on the Elderly?: A Systematic Review. Experimental Gerontology, 2017(91): 88–98.
Hamada T, Sasaki H, Hayashi T, et al., 2003, Enhancement of Whole Body Glucose Uptake during and after Human Skeletal Muscle Low-Frequency Electrical Stimulation. Journal of Applied Physiology, 94(6): 2107–2112.
DeFronzo RA, Jacot E, Jequier E, et al., 1981, The Effect of Insulin on the Disposal of Intravenous Glucose: Results from Indirect Calorimetry and Hepatic and Femoral Venous Catheterization. Diabetes, 30(12): 1000–1007.
Hamada T, Hayashi T, Kimura T, et al., 2004, Electrical Stimulation of Human Lower Extremities Enhances Energy Consumption, Carbohydrate Oxidation, and Whole Body Glucose Uptake. Journal of Applied Physiology, 96(3): 911–916.
Miyamoto T, Fukuda K, Kimura T, et al., 2012, Effect of Percutaneous Electrical Muscle Stimulation on Postprandial Hyperglycemia in Type 2 Diabetes. Diabetes Research and Clinical Practice, 96(3): 306–312.
Diabetes Control and Complications Trial Research Group, 1993, The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus. The New England Journal of Medicine, 329(14): 977–986.
European Diabetes Epidemiology Group, 1999, Glucose Tolerance and Mortality: Comparison of WHO and American Diabetes Association Diagnostic Criteria. Lancet, 354(9179): 617–621.
Miyamoto T, Iwakura T, Matsuoka N, et al., 2018, Impact of Prolonged Neuromuscular Electrical Stimulation on Metabolic Profile and Cognition-related Blood Parameters in Type 2 Diabetes: A Randomized Controlled Cross-Over Trial. Diabetes Research and Clinical Practice, 2018(142): 37–45.
Rohlfing CL, Wiedmeyer HM, Little RR, et al., 2002, Defining the Relationship Between Plasma Glucose and HbA1c: Analysis of Glucose Profiles and HbA1c in the Diabetes Control and Complications Trial. Diabetes Care, 25(2): 275–278.
Pai LW, Li TC, Hwu YJ, et al., 2016, The Effectiveness of Regular Leisure-time Physical Activities on Long-term Glycemic Control in People with Type 2 Diabetes: A Systematic Review and Meta-Analysis. Diabetes Research and Clinical Practice, 2016(113): 77–85.
Prince M, Wimo A, Guerchet MM, et al., 2015, World Alzheimer Report 2015: The Global Impact of Dementia. Alzheimer Disease International, 30–35.
Chang YK, Alderman BL, Chu CH, et al., 2017, Acute Exercise has a General Facilitative Effect on Cognitive Function: A Combined ERP Temporal Dynamics and BDNF Study. Psychophysiology, 54(2): 289–300.
Chang YK, Labban JD, Gapin JI, et al., 2012, The Effects of Acute Exercise on Cognitive Performance: A Meta-Analysis. Brain Research, 2012(1453): 87–101.
Lambourne K, Tomporowski P, 2010, The Effect of Exercise-Induced Arousal on Cognitive Task Performance: A Meta-Regression Analysis. Brain Research, 2010(1341): 12–24.
Erickson KI, Voss MW, Prakash RS, et al., 2011, Exercise Training Increases Size of Hippocampus and Improves Memory. Proceedings of the National Academy of Sciences of the United States of America, 108(7): 3017–3022.
Buchman AS, Yu L, Boyle PA, et al., 2016, Higher Brain BDNF Gene Expression is Associated with Slower Cognitive Decline in Older Adults. Neurology, 86(8): 735–741.
Coelho FG, Gobbi S, Andreatto CA, et al., 2013, Physical Exercise Modulates Peripheral Levels of Brain-Derived Neurotrophic Factor (BDNF): A Systematic Review of Experimental Studies in the Elderly. Archives of Gerontology and Geriatrics, 56(1): 10–15.
Deslandes A, Moraes H, Ferreira C, et al., 2009, Exercise and Mental Health: Many Reasons to Move. Neuropsychobiology, 59(4): 191–198.
Eggermont L, Swaab D, Luiten P, et al., 2006, Exercise, Cognition, and Alzheimer’s Disease: More is Not Necessarily Better. Neuroscience and Biobehavioral Reviews, 30(4): 562–575.
Lista I, Sorrentino G, 2010, Biological Mechanisms of Physical Activity in Preventing Cognitive Decline. Cellular and Molecular Neurobiology, 30(4): 493–503.
Shimada H, Makizako H, Doi T, et al., 2014, A Large, Cross-Sectional Observational Study of Serum BDNF, Cognitive Function, and Mild Cognitive Impairment in the Elderly. Frontiers in Aging Neuroscience, 2014(6): 69.
Ferris LT, Williams JS, Shen CL, 2007, The Effect of Acute Exercise on Serum Brain-Derived Neurotrophic Factor Levels and Cognitive Function. Medicine and Science in Sports and Exercise, 39(4): 728–734.
Schmidt-Kassow M, Schadle S, Otterbein S, et al., 2012, Kinetics of Serum Brain-Derived Neurotrophic Factor Following Low-Intensity Versus High-Intensity Exercise in Men and Women. Neuroreport, 23(15): 889–893.
Miyamoto T, Kou K, Yanamoto H, et al., 2018, Effect of Neuromuscular Electrical Stimulation on Brain-derived Neurotrophic Factor. International Journal of Sports Medicine, 39(1): 5–11.
Schiffer T, Schulte S, Sperlich B, et al., 2011, Lactate Infusion at Rest Increases BDNF Blood Concentration in Humans. Neuroscience Letters, 488(3): 234–237.
Moore SC, Lee IM, Weiderpass E, et al., 2016, Association of Leisure-Time Physical Activity with Risk of 26 Types of Cancer in 1.44 million Adults. JAMA Internal Medicine, 176(6): 816–825.
Delezie J, Handschin C, 2018, Endocrine Crosstalk between Skeletal Muscle and the Brain. Frontiers in Neurology, 2018(9): 698.
Aoi W, Naito Y, Takagi T, et al., 2007, A Novel Myokine, Secreted Protein Acidic and Rich in Cysteine (SPARC), Suppresses Colon Tumorigenesis via Regular Exercise. Gut, 62(6): 882–889.
Yang E, Kang HJ, Koh KH, et al., 2007, Frequent Inactivation of SPARC by Promoter Hypermethylation in Colon Cancers. International Journal of Cancer, 121(3): 567–575.