Keywords
Post-stroke depression
Safety
Effectiveness
Treatment
Submitted : 2024-02-18
Accepted : 2024-03-04
Published : 2024-03-19
Abstract
Objective: To investigate and analyze the safety and effectiveness of accelerated repetitive transcranial magnetic stimulation (arTMS) in the treatment of post-stroke depression. Methods: 70 patients with post-stroke depression from the Department of Psychiatry were selected as research subjects for this study. The study period was from June 2022 to June 2023. The patients were divided into the arTMS group and the general treatment group, with 35 cases in each group. The arTMS group received arTMS and the general treatment group received conventional treatment. The overall efficacy, related scores, sleep level, quality of life, and side effects of treatment were compared between the groups. Results: The overall efficacy of aRTMS was ideal. Besides, there were no significant differences in the scores of relevant scores between the two groups before treatment; after treatment, the arTMS demonstrated a greater decrease in the scores. Besides, the sleep quality of the patients in the arTMS group was better (P < 0.05). Furthermore, the quality of life of the arTMS group was significantly improved (P < 0.05). Lastly, arTMS treatment resulted in fewer adverse reactions, which indicated that it is safer compared to conventional treatment (P < 0.05). Conclusion: arTMS is more effective and secure in the treatment of post-stroke depression.
References
Wang X, Shi F, Lu B, et al., 2022, Effects of Acupuncture and Moxibustion on Neurological Function and Activities of Daily Living in Patients with Post-Stroke Depression. Hebei Medicine, 44(12): 1865–1868.
Xu M, Hao L, Chen G, 2022, Analysis of the Effect and Safety of Bupleurum Plus Longgu Muli Decoction Combined with Transcranial Direct Current Stimulation in the Treatment of Post-Stroke Depression. Chinese Folk Therapy, 30(04): 73–75.
Hu G, Hu X, Xiang M, et al., 2021, Effects of Repetitive Transcranial Magnetic Stimulation Combined with Intensive Cognitive Exercise on the HPA Axis in Patients with Post-Stroke Depression and Cognitive Impairment. Chinese Modern Doctor, 59(14): 99–102.
Wang R, Hu C, Ma Q, et al., 2020, The Curative Effect of Danhong Injection Combined with Sertraline in Treating Post-Stroke Depression and its Impact on Serum Amyloid A and Immune Inflammation Indicators. Clinical Internal Medicine Journal, 37(05): 379–380.
Cheng D, Li P, Ma J, 2019, Discussion on the Curative Effect and Safety Evaluation of Modified Buyang Huanwu Decoction in Treating Post-Ischemic Stroke Depression Based on Fuyang Consolidation. Guizhou Medicine, 43(12): 1934–1936.
Li Z, Chen Y, Zhao Z, et al., 2019, Research on the Regulation Mechanism of Chai Shao Anshen Jieyu Granules on JAK1/STATA3 and cAMP/PKA/CREB Signaling Pathways in Rats with Post-Stroke Depression. Chinese Journal of Traditional Chinese Medicine, 37(12): 3013–3017.
Wang Y, Liu Y, Duan H, et al., 2019, The Effect of Modified Huanglian Wendan Decoction on Post-Stroke Depression and its Impact on the Expression Level of Brain Metabolites. China Medical Herald, 16(32): 75–78 + 94.
Liu Y, Liu L, Yi Y, et al., 2020, Effects of Pepsi Le Modified Prescription on the Inflammatory Balance of the Hippocampus-Prefrontal Cortex Loop in Rats with Post-Stroke Depression. Chinese Journal of Traditional Chinese Medicine, 38(03): 95–99 + 266–269.
Teng X, Gao L, Zhou B, 2019, Effects of Peiyuan Xiaoshuan Jieyu Decoction Combined with Preproprotein Hydrolyzate on the Levels of Cerebrospinal Fluid Monoamine Neurotransmitters, Serum 5-Hydroxytryptamine and Brain-Derived Neurotrophic in Patients with Post-Stroke Depression of Kidney Deficiency and Liver Stagnation Type. The Influence of Factor and Apolipoprotein A1. Hebei Traditional Chinese Medicine, 41(03): 397–401.
Jiang Y, Pan X, Wang H, et al., 2019, Study on the Clinical Efficacy of Chaihu Shugan Pills Combined with Escitalopram in Treating Post-Stroke Depression in Older Women. Practical Drugs and Clinics, 22(03): 299–302.
Zheng L, Zhang L, Zhan J, 2018, Comparison of the Effect of Escitalopram and Venlafaxine in Treating Post-Stroke Depression and the Impact on Patients’ Mental State and Quality of Life. Chinese and Foreign Medical Research, 16(33): 124–126.
Zhang M, Liu Y, Yang Y, et al., 2018, The Effect of Cognitive Behavioral Intervention Based on a Transtheoretical Model on Neurological Function, Negative Emotion, and Quality of Life in Patients with Post-Stroke Depression. International Journal of Psychiatry, 45(05): 934–937.
Ayiguli S, Ayiguli Y, 2018, Observation on the Curative Effect of Hyperbaric Oxygen in Treating Neurological Defects and Depressive Symptoms in Patients with Post-Stroke Depression. World Latest Medical Information Abstracts,18(78):84.
Ye B, Ye D, 2018, The Effect of Sertraline on the Hypothalamus-Pituitary-Adrenaline Axis and Cognitive Function in Patients with Post-Ischemic Stroke Depression. Chinese Modern Doctor, 56(25): 38–41.
Li S, Hu B, Wu Y, et al., 2018, Effect of Xinnao Kaiqiao Acupuncture Combined with Modified Huoxue Jieyu Decoction on HAMD Score and Quality of Life in Patients with Post-Stroke Depression. Chinese Medicine Clinical Journal, 30(03): 491–494.