Clinical Efficacy and Safety Analysis of Amisulpride Combined with Venlafaxine in Treating Geriatric Depression
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Geriatric depression
Clinical efficacy



Submitted : 2023-12-11
Accepted : 2023-12-26
Published : 2024-01-10


Objective: To analyze the therapeutic effect of amisulpride (ASP) combined with venlafaxine (VEN) on depression among the elderly. Methods: 75 elderly patients with depression who were hospitalized between January 2020 and January 2021 were selected and randomly divided into 2 groups: Group A and Group B. The 38 patients in Group A were treated with ASP combined with VEN, and the 37 patients in Group B were treated with VEN. The effects of the two treatments were compared. Results: The treatment in Group A was more effective than Group B (P < 0.05). Before treatment, there was no difference in the depression score and coping mechanisms between the two groups (P > 0.05). After six weeks of treatment, the depression score of Group A was lower than that of Group B, and the coping mechanism score of Group A was higher than that of Group B (P < 0.05). Group A had a lower adverse reaction rate compared to Group B (P < 0.05). Conclusion: ASP combined with VEN therapy is more effective in treating geriatric depression. It improves their symptoms and coping mechanisms, and the drugs used are relatively safe.


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