Keywords
Venlafaxine
Geriatric depression
Clinical efficacy
Safety
Submitted : 2023-12-11
Accepted : 2023-12-26
Published : 2024-01-10
Abstract
Objective: To analyze the therapeutic effect of amisulpride (ASP) combined with venlafaxine (VEN) on depression among the elderly. Methods: 75 elderly patients with depression who were hospitalized between January 2020 and January 2021 were selected and randomly divided into 2 groups: Group A and Group B. The 38 patients in Group A were treated with ASP combined with VEN, and the 37 patients in Group B were treated with VEN. The effects of the two treatments were compared. Results: The treatment in Group A was more effective than Group B (P < 0.05). Before treatment, there was no difference in the depression score and coping mechanisms between the two groups (P > 0.05). After six weeks of treatment, the depression score of Group A was lower than that of Group B, and the coping mechanism score of Group A was higher than that of Group B (P < 0.05). Group A had a lower adverse reaction rate compared to Group B (P < 0.05). Conclusion: ASP combined with VEN therapy is more effective in treating geriatric depression. It improves their symptoms and coping mechanisms, and the drugs used are relatively safe.
References
Xiong J, 2021, Clinical Effect of Escitalopram Combined with Amisulpride in Treating Elderly Patients with Depression. Chinese Modern Drug Application, 15(17): 226–228.
Cai X, 2020, Clinical Study of Escitalopram Combined with Amisulpride or Olanzapine in Treating Senile Depression. Chinese Medicine Guide, 18(18): 174–175.
Huang P, Li Z, 2020, Study on the Efficacy and Safety of Milnacipran Combined with Amisulpride in the Treatment ofSenile Depression. China Practical Medicine, 15(13): 150–151.
Lian Y, Li Y, 2020, The Effect of Escitalopram Combined with Amisulpride in Treating Elderly Patients with Depression. Journal of Practical Clinical Medicine, 24(9): 27–29.
Wang L, Yin Z, Xia B, et al., 2022, Clinical Efficacy and Safety of Venlafaxine Combined with Mirtazapine in Treating Refractory Elderly Depression. Chinese Journal of Gerontology, 42(24): 6011–6013.
Li K, He Y, Wang D, 2022, Efficacy of Venlafaxine Combined with Agomelatine in Treating Elderly Patients with Depression and its Effect on Serum Brain-Derived Neurotrophic Factor. Nervous Diseases and Mental Health, 22(3): 184–188.
Qiao L, 2021, Clinical Effect Analysis of Shugan Jieyu Capsules Combined with Venlafaxine Tablets in Treating Senile Depression. Chinese Modern Medicine Application, 15(1): 208–210.
Liu W, Zou C, Fan M, et al., 2021, The Effect of Repetitive Transcranial Magnetic Stimulation Combined with Venlafaxine on the Curative Effect and Cognitive Function of Elderly Depression. Contemporary Medicine, 27(8): 25–27.