Objective: To explore, evaluate and analyze the effects of surgical treatment on endocrine functional hormone indexes in female patients with endocrine disorders caused by sellar region tumors. Methods: 600 female patients with endocrine disorders caused by sellar region tumors who were admitted to the Department of Neurosurgery of Yunan Shuifu People’s Hosptial and Beijing University of Chinese Medicine Third Affiliated Hospital from March 2018 to March 2023 were selected as the research subjects. The patients were divided into two groups, each consisting of 300 cases: the microscopic group received treatment via the microscopic transsphenoidal approach, while the endoscopic group underwent treatment through the neuroendoscopic transsphenoidal approach. The efficacy of both treatments and surgery-related indicators of the patients of both groups were compared. Besides, the endocrine functional hormone indicators, including estradiol (E2) and follicle-stimulating hormone (FSH) levels, were compared between the two groups before operation and 1 week after operation. Results: The efficacy of the treatment received by the endoscopic group was higher than that of the microscopic group, but the difference was not statistically significant (P > 0.05). The duration of operation and postoperative hospital stay of the endoscopic group were shorter than those of the microscopic group, and the intraoperative blood loss was less than that of the microscopic group, the differences were statistically significant (P < 0.05). The postoperative E2 and FSH levels of the two groups were higher than those before operation, and the E2 and FSH levels of the endoscopic group after treatment were higher than those of the microscopic group, and the difference was statistically significant (P < 0.05). Conclusion: The neuroendoscopic transsphenoidal approach for treating female patients with endocrine disorders caused by sellar region tumors proves to be more effective than the microscopic transsphenoidal approach. It enhances the levels of endocrine functional hormones and alleviates clinical symptoms, making it a promising approach worthy of wider adoption.
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