Keywords
Total knee arthroplasty
Knee osteoarthritis
Submitted : 2023-08-27
Accepted : 2023-09-11
Published : 2023-09-26
Abstract
This paper aims to explore the clinical value of tranexamic acid combined with total knee arthroplasty (TKA) in patients with knee osteoarthritis (KOA). The research period was from March 2020 to December 2022. A total of 50 samples of KOA patients were selected and divided into the study group (n = 25) and the control group (n = 25) by lottery method of medical record envelopes. The patients in the control group were treated with TKA, and the patients in the study group were treated with tranexamic acid combined with TKA. The surgery-related indicators, visual analogue pain score (VAS), inflammatory factor levels, motor function scores, and incidence of complications were compared between the two groups. The intraoperative blood loss in the study group was lower than that in the control group (P < 0.05), and there was no significant difference in postoperative hospital stay between the two groups (P > 0.05). The postoperative VAS scores in the study group were lower than those in the control group (P < 0.05), while the postoperative inflammatory factor levels of the study group were lower than those of the control group (P < 0.05). The postoperative motor function scores of the study group were higher than those of the control group (P < 0.05), and the incidence of complications in the study group was lower than that in the control group (P < 0.05). The treatment of KOA patients with tranexamic acid combined with TKA can reduce intraoperative blood loss, relieve pain, reduce the level of inflammatory factors, improve postoperative motor function, and reduce the incidence of complications, which can be widely applied in clinical practice.
References
Alimujiang Y, Abduupur H, Qin Q, et al., 2023, Efficacy and Safety of Tranexamic Acid and Aminocaproic Acid in the Perioperative Period of Total Knee Arthroplasty. Chinese Tissue Engineering Research, 27(36): 5812–5817.
Wang Y, 2023, Effects of Intravenous Combined Intra-Articular Injection of Tranexamic Acid on Blood Loss and Safety of Total Knee Arthroplasty. Reflexology and Rehabilitation Medicine, 4(5): 148–150,154.
Cheng J, Ding Y, Dong L, et al., 2023, Efficacy and Safety of Total Knee Replacement Combined with Tranexamic Acid. Chinese Tissue Engineering Research, 27(22): 3514–3520.
Wang P, 2023, Research Progress on the Efficacy and Safety of Tranexamic Acid in Total Knee Arthroplasty. Chinese Prescription Drugs, 21(2): 186–189.
Li S, 2023, Effects of Tranexamic Acid Intravenous Infusion and Joint Cavity Perfusion on Blood Loss in Total Knee Replacement. Clinical Medicine, 43(1): 7–10.
Sun B, Sun Y, 2023, Effect Analysis of Periarticular Injection and Infusion of Tranexamic Acid in Total Knee Arthroplasty. Systematic Medicine, 8(8): 115–118, 127.
Liu J, Yin L, Zhang Y, et al., 2022, Effects of Different Volumes and Doses of Intra-Articular Injection of Tranexamic Acid on Blood Loss in Total Knee Replacement. Chinese Tissue Engineering Research, 26(33): 5303–5310.
Zhang J, Yang T, Zhang B, et al., 2023, Effect of Cold Compress Combined with Tranexamic Acid on Early Local Reaction after Total Knee Arthroplasty. Ningxia Medical Journal, 45(5): 397–400.
Zhao H, Zhang J, Zhang B, et al., 2022, Comparison of the Effect of Intravenous Injection of Different Doses of Tranexamic Acid in Elderly Patients with Total Knee Replacement. Chinese Journal of Gerontology, 42(17): 4180–4183.
Zhang J, Man J, Feng S, et al., 2022, Comparison of the Efficacy of Periarticular Injection of Tranexamic Acid and Intra-Articular Infusion in Total Knee Arthroplasty. Journal of Practical Medicine, 38(14): 1788–1792.
Zhang J, Yang Z, 2022, Meta-Analysis of Hemostatic Efficacy of Tranexamic Acid and ?-Aminocaproic Acid in Hip and Knee Arthroplasty. Chinese Orthopedics, 35(5): 484–490.
Wu X, Zhang G, Chen W, et al., 2022, Effect of Cold Compress Combined with Tranexamic Acid on Early Local Reaction After Total Knee Arthroplasty. Journal of Clinical and Experimental Medicine, 21(8): 853–856.
Sun S, Lu W, Shi S, 2022, Effects of Local Application of Bone Wax and Tranexamic Acid on Postoperative Bleeding and Short-Term Knee Joint Function in Unicompartmental Arthroplasty. Hebei Medicine, 28(12): 2017–2022.
Wan X, Xu K, Wang H, et al., 2022, Bibliometric Analysis of Tranexamic Acid in Total Knee Arthroplasty Based on CiteSpace. China Medical Herald, 19(36):11–16.
Wang W, Ping W, Song W, et al., 2022, Effect of Postoperative Intravenous Infusion of Tranexamic Acid on Perioperative Blood Loss in Patients Undergoing Knee Arthroplasty. Chinese Journal of Physician Training, 45(6): 502–505.