Keywords
Collagenase
Clinical observation
Lumbar disc herniation
Submitted : 2026-04-14
Accepted : 2026-04-29
Published : 2026-05-14
Abstract
Objective: To observe and discuss the clinical effect of collagenase lysis in the treatment of lumbar disc herniation through different administration routes. Methods: Sixty patients with lumbar disc herniation admitted to Liuzhou People’s Hospital from February 2023 to February 2024 were selected, including 31 males and 29 females. They were divided into A and B groups according to the random number table method. Group A was injected through sacral hiatus route combined with intervertebral foramen safety triangle route (n = 30), and Group B was injected only through sacral hiatus route (n = 30). The VAS score, ODI index, and the efficacy of Macnab were observed before operation, 3 days, 1 month, and 3 months after operation, and the results were summarized and compared. Results: Compared with Group B (only through the sacral hiatus route), the VAS score, ODI index, and the efficacy evaluation of Macnab in Group A (through the sacral hiatus route combined with the intervertebral foramen safety triangle route) were significantly better, and the differences were statistically significant (P < 0.05). Conclusion: Multi-path collagenase lysis is more effective than single-path collagenase lysis.
References
Wang J, Fu Z, Song W, et al., 2022, Observation on the Efficacy of Percutaneous Discectomy Combined with Collagenase Chemonucleolysis in the Treatment of Giant Cervical Disc Herniation. Chinese Journal of Pain Medicine, 28(4): 314–316.
Li J, Lu P, 2023, Reevaluation and Prognosis Analysis of Radiofrequency Ablation in the Treatment of Lumbar Disc Herniation in Elderly Patients. Science & Technology Review, 41(13): 49–55.
Spinal Source Pain Group, Pain Society, Chinese Medical Association, 2020, Chinese Pain Expert Consensus on the Diagnosis and Treatment of Lumbar Disc Herniation. Chinese Journal of Pain Medicine, 26(1): 2–6.
Lang H, 2024, Analysis of Costs and Influencing Factors in 3520 Hospitalized Patients with Lumbar Disc Herniation. Chinese Medical Record, 25(5): 71–74.
Basic Research and Translation Group, Spinal Cord Professional Committee, Chinese Rehabilitation Medical Association, 2022, Guidelines for the Diagnosis, Treatment, and Rehabilitation Management of Lumbar Disc Herniation. Chinese Journal of Surgery, 60(5): 401–405.
Liu X, Yao B, Zhao S, et al., 2023, Clinical Observation of Radiofrequency Combined with a Small Amount of Collagenase Targeted Injection in the Treatment of Lumbar Disc Herniation. Chinese Journal of Pain Medicine, 29(4): 307–310.
Shi X, Lv Z, Hu L, et al., 2023, Historical Review and Development of Minimally Invasive Interventional Treatment with Collagenase Chemonucleolysis. Journal of Air Force Military Medical University, 44(10): 1006–1010.
Sheng M, Li S, 2020, Application Effect of Predictive Nursing in the Care of Patients After Collagenase Chemonucleolysis for Lumbar Disc Herniation. Chinese Journal of Civil Health, 32(8): 157–158.
Pain Society, Chinese Medical Association, Pain Physician Branch, Chinese Medical Doctor Association, 2023, Chinese Expert Consensus on Perioperative Nursing for Lumbar Disc Collagenase Chemonucleolysis. Chinese Journal of Pain Medicine, 29(11): 801–804.
Zhao J, Zhang R, Zhu B, et al., 2023, Comparison of the Efficacy of Transforaminal Endoscopic Spine System and Collagenase Chemonucleolysis in the Treatment of Extreme Lateral (Type II) Lumbar Disc Herniation. Chinese Journal of Pain Medicine, 29(2): 113–119.
Tang H, Chen S, 2023, Effects of Different Injection Methods of Collagenase on Serum TIMP-2, MMP-9 Expression, and Pain Scores in Patients with Lumbar Disc Herniation. Journal of Neck and Low Back Pain, 44(5): 836.
Song Y, Wang C, Fang B, et al., 2019, Research Progress and Application of Collagenase. CIESC Journal, 70(9): 3213–3227.
Han L, Li T, Chen L, et al., 2023, Effect of Collagenase Chemonucleolysis on Residual Pain After Transforaminal Lumbar Endoscopic Discectomy. Journal of Pain Research, 16(1): 1257–1265.
Ma W, Zhao X, Shi P, et al., 2022, Observation on the Application Effect of CT Manifestations of Lumbar Disc Herniation and Collagenase Chemonucleolysis. Imaging Research and Medical Application, 6(14): 41–43.
Zhang X, 2024, Effects of Radiofrequency Ablation Combined with Collagenase on Serum Pain Mediator Levels and Lumbar Function in Patients with Lumbar Disc Herniation. Practical Journal of Integrated Traditional Chinese and Western Medicine, 24(5): 58–74.
Danazumi MS, 2020, Physiotherapy Management of Lumbar Disc Herniation with Radiculopathy: A Narrative Review. Nigerian Journal of Experimental and Clinical Biosciences, 7(2): 93–100.
Liu C, Chai Y, Ouyang L, 2023, Efficacy and Safety Evaluation of Percutaneous Transforaminal Endoscopic Spine System in the Treatment of Lumbar Disc Herniation with Nerve Root Canal Stenosis. Jiangxi Medical Journal, 58(5): 581–589.