Advances in Obstetrics and Gynecology Research

Observation on the Therapeutic Effect of Lymphocyte Immunotherapy for Repeated Biochemical Pregnancy Loss

Qinyan Xu, Feihu Yu, Zhongying Wan, Qin Han — Fri, 14 Mar 2025 08:42:47 +0800

Objective: To investigate the clinical effect of lymphocyte immunotherapy for women with repeated biochemical pregnancy loss. Methods: A retrospective study was conducted from January 2015 to January 2016, involving 100 patients with repeated biochemical pregnancy loss as observation subjects. After enrollment, patients were divided into two groups (50 patients in each group) according to different treatment regimens. The observation group received conventional tocolysis combined with lymphocyte immunotherapy, while the control group only received conventional tocolysis treatment. The pregnancy outcome, improvement of serum factor levels, and treatment safety were evaluated to compare the clinical effects of different treatment regimens. Results: The pregnancy success rate was 82.00% in the observation group and 48.00% in the control group (χ² = 12.7033, P < 0.05). After treatment, the interferon-y (IFN-y) level in the observation group was higher than that in the control group, while the interleukin-8 (IL-8) and regulated upon activation, normal T-cell expressed and secreted (RANTES) levels were lower than those in the control group (P < 0.05). There was no significant difference in treatment safety between the two groups (P > 0.05). Conclusion: The introduction of lymphocyte immunotherapy in patients with repeated biochemical pregnancy loss can improve the success rate of pregnancy and has a significant therapeutic effect, which is worthy of application.

Research Progress on Blood Pressure Management Strategies for Patients with Hypertensive Disorders in Pregnancy

Yaxin Du — Mon, 28 Apr 2025 15:22:00 +0800

This article summarizes blood pressure management strategies for patients with hypertensive disorders in pregnancy, including establishing a dynamic blood pressure monitoring system from a clinical perspective, strengthening education to improve patients’ self-management abilities, applying portable home instruments to assist in monitoring and guiding medication from a technical perspective, and conducting community screening and graded management of hypertensive disorders in pregnancy from a social perspective. The results indicate that individual differences should be considered in clinical practice, and patient-centered individualized blood pressure management strategies should be established.

An Analysis of the Use of Ultrasonography in the Assessment of the Effects of Rectus Abdominis Muscle Separation and Rehabilitation Therapy in Postpartum Women

Xuan Zhou, Min Kou, Jie Wan — Mon, 28 Apr 2025 15:26:02 +0800

Objective: To explore the effect of ultrasonography in assessing the effect of rectus abdominis muscle separation and rehabilitation in postpartum women. Methods: 254 cases of postpartum women admitted to the hospital from January 2022 to July 2023 were selected as the study group, and 63 cases of women with rectus abdominis muscle not separated during the same period were selected as the control group, and all of them used GEDiscoveryE9 ultrasonic diagnostic instrument to compare the separation distance of rectus abdominis muscle of 3 cm above the umbilicus of the women in the two groups; and to compare the separation distance of rectus abdominis muscle of the women in the study group after treatment. Results: The rectus abdominis muscle separation distance of 3 cm above the umbilicus was (4.36 ± 0.87) cm in the study group and (1.88 ± 0.07) cm in the control group, and the difference between the study group and the control group was significant (P < 0.05); the rectus abdominis muscle separation of the study group was (3.78 ± 0.69) cm, (3.01 ± 0.69) cm and (3.01 ± 0.69) cm respectively in the 1^st, 2^nd, 3^rd, 4^th, 5^th, and 6^th post treatment; and the rectus abdominis muscle separation of the study group was (3.78 ± 0.69) cm, (3.01 ± 0.58) cm, (2.75 ± 0.57) cm, (2.31 ± 0.48) cm, (1.97 ± 0.36) cm, and (1.95 ± 0.44) cm, respectively, with a significant difference compared to the pre-treatment (P < 0.05). Conclusion: The optimal section for ultrasonographic detection of rectus abdominis muscle separation in the postpartum period was 3.5 cm below the umbilicus, and this section was able to effectively assess the degree of rectus abdominis muscle separation in patients.

Exploration of High-Risk HPV Genotyping Test as an Initial Screening Method for Cervical Cancer

Ruihua Li, Qianqian Yang, Yongxia Qian, Juan Xu — Mon, 28 Apr 2025 15:38:20 +0800

Objective: The purpose of this study was to evaluate the clinical value of high-risk HPV typing as a primary screening method for cervical cancer. Methods: From July 2023 to June 2024, 871 women, aged 23 to 77 years old, with an average age of (42.5 ± 3.45) years old, were selected for initial screening of cervical cancer in the health examination center and gynecological clinic of the hospital. All patients underwent HPV-DNA typing and cervical fluid-based thin-layer cytology (TCT). Colposcopic cervical biopsy was performed in women with high-risk HPV single or multiple infection or with TCT ≥ ASC-US. The diagnostic efficacy of HPV-DNA typing, TCT and HPV + TCT combined detection was calculated using the pathological results of biopsy as the gold standard. Results: Compared with TCT alone, HPV-DNA typing was significantly more sensitive in the diagnosis of cervical lesions (P < 0.05), and the rate of missed diagnosis was significantly reduced (P < 0.05). At the same time, the efficacy of the HPV-DNA typing test is similar to that of HPV + TCT combined screening. In terms of misdiagnosis rate and specificity, there was no statistical difference among the three screening strategies (P > 0.05). Conclusion: HPV-DNA typing alone has the same effect as TCT + HPV combined screening for cervical cancer.

Clinical Study on the Treatment of Cold- Dampness Stagnation Type of Dysmenorrhea with Shaofu Zhuyu Decoction Combined with Thunder-Fire Moxibustion

Yamei Wang — Mon, 28 Apr 2025 15:42:22 +0800

Objective: To investigate the therapeutic effect of Shaofu Zhuyu Decoction combined with Thunder-Fire Moxibustion on patients with cold-dampness stagnation type of dysmenorrhea. Methods: A total of 40 patients with cold-dampness stagnation type of dysmenorrhea who visited the hospital from January 2023 to December 2024 were selected as samples and randomly divided into two groups using the lottery method. The observation group received Shaofu Zhuyu Decoction combined with Thunder-Fire Moxibustion, while the control group received Shaofu Zhuyu Decoction only. The efficacy, pain score, menstrual volume, menstrual duration, symptom score, and adverse reactions were compared between the two groups. Results: The efficacy of dysmenorrhea treatment in the observation group was higher than that in the control group (P < 0.05). After treatment, the Visual Analog Scale (VAS) score in the observation group was lower than that in the control group, the menstrual volume was lower, and the menstrual duration was shorter (P < 0.05). The scores for menstrual flow obstruction, menstrual volume reduction, abdominal distension and pain, and menstrual blood clots with purple and dark color were lower in the observation group compared to the control group (P < 0.05). There was no significant difference in the adverse reaction rate between the observation group and the control group (P > 0.05). Conclusion: The combination of Shaofu Zhuyu Decoction and Thunder-Fire Moxibustion is effective in reducing pain and improving related symptoms of cold-dampness stagnation type of dysmenorrhea, and it is safe and efficient.

Study on the Correlation between Pregnancy Anemia and Serum Ferritin Levels in Jinan Area and Prevention of Iron Deficiency

Xiaojuan Wang, Qiuling Zhu — Mon, 28 Apr 2025 15:51:24 +0800

Objective: To analyze the correlation between pregnancy anemia and serum ferritin (SF) levels in Jinan area and explore methods for preventing iron deficiency. Methods: A total of 1000 pregnant women who underwent prenatal check-ups and gave birth in the hospital from January 2020 to July 2022 were selected as samples. Routine blood tests and SF detection were performed, and the number of patients with iron deficiency anemia (IDA) in the second and third trimesters, blood routine data, and SF level data were recorded. Results: There were 160 cases (16.00%) of IDA in the second trimester and 200 cases (20.00%) in the third trimester. The erythrocyte parameters and SF levels of IDA pregnant women in the second trimester were lower than those of healthy pregnant women (P < 0.05). The incidence of IDA was higher in pregnant women with SF < 10 ng/mL than in those with SF 10–19.9 ng/mL, SF 20–29.9 ng/mL, and SF ≥ 30 ng/mL, and the lower the SF level, the higher the incidence of IDA (P < 0.05). There was no statistical difference in adverse pregnancy outcomes between anemic and non-anemic pregnant women among different levels of SF (P > 0.05). Conclusion: Pregnant women with low SF levels in the second and third trimesters are more prone to IDA. Active intervention can reduce adverse pregnancy outcomes and ensure the safety of mothers and babies.

Association between FcγRIIB Gene Polymorphism, Periodontitis and Pregnancy-induced Hypertension in Chinese Pregnancy Women

Thu, 08 May 2025 10:18:33 +0800

Objective: Research suggests a link between maternal periodontitis and pregnancy-induced hypertension (PIH). As an immunoglobulin G (IgG) receptor, FcγRIIB delivers inhibitory signals to B lymphocytes. Previous studies have demonstrated that FcγRIIB-232I/T polymorphism is associated with periodontitis, and the link between 232T allele carriers and periodontitis may stem from their reduced IgG antibody responses to P. gingivalis. The role of FcγRIIB-232I/T polymorphism in predisposing Chinese pregnant women to periodontitis and PIH was explored in this investigation. Methods: Clinical periodontal parameters and obstetric records were retrospectively analyzed in 87 Chinese pregnant women. FcγRIIB-232I/T genotyping was performed using genomic DNA isolated from peripheral blood samples from each participant. The expression levels of FcγRIIb on peripheral B lymphocytes from 10 women were measured by flow cytometry. Results: The FcγRIIB-232T allele was associated with elevated third-trimester blood pressure, with compounded effects observed in carriers concurrently affected by periodontitis. Periodontitis and PIH exhibited a shared genetic predisposition through the FcγRIIB-232I/T polymorphic locus. Among individuals carrying the FcγRIIB-232T allele, periodontitis was significantly associated with PIH. Conclusion: FcγRIIB-232T allele carriers of Chinese pregnancy women are more susceptible to periodontitis and PIH,and those with periodontitis are more susceptible to PIH.

Combination of Misoprostol and Oxytocin for Effective Control of Postpartum Hemorrhage During Cesarean Section

Yuling Guo — Tue, 29 Apr 2025 11:12:19 +0800

Objective: This study is to analyze the value of combining misoprostol and oxytocin in the prevention and control of postpartum hemorrhage during cesarean section. Methods: 82 cesarean section patients from July 2023 to July 2024 were selected as samples and randomly divided into two groups. Group A received misoprostol combined with oxytocin treatment, while Group B received only misoprostol treatment. The amount of postpartum hemorrhage, coagulation indicators, postpartum recovery indicators, and adverse reactions were compared between the two groups. Results: The intraoperative, 2-hour postpartum, 2-24-hour postpartum, and total blood loss in Group A were all lower than those in Group B (P < 0.05). The activated partial thromboplastin time (APTT), plasma prothrombin time (PT), fibrinogen (FIB), and thrombin time (TT) in Group A were all lower than those in Group B (P < 0.05). The first exhaust time, first time out of bed, and hospital stay after cesarean section in Group A were all shorter than those in Group B (P < 0.05). The adverse reaction rate in Group A was lower than that in Group B (P < 0.05). Conclusion: The application of misoprostol combined with oxytocin during cesarean section can optimize coagulation indicators, reduce blood loss, shorten postpartum recovery time, and is highly effective and feasible.