Advances in Obstetrics and Gynecology Research

The Value of 3D-TVS OmniView Imaging Technology Combined with Tomographic Imaging in the Diagnosis of Intrauterine Adhesions

Jun Wang — 2026-03-10

Objective: To investigate the diagnostic efficacy of 3D-TVS OmniView imaging technology combined with tomographic imaging in patients with intrauterine adhesions (IUA). Methods: A total of 150 suspected IUA patients admitted to our hospital and confirmed by hysteroscopy were selected as the study sample from January 2024 to December 2025. All patients underwent preoperative 3D-TVS OmniView imaging scans, and the tomographic imaging mode was employed to observe linear interruptions of the endometrium, alterations in uterine cavity morphology, and adhesion bands. The results of hysteroscopy were used as the “gold standard” for this study, and the diagnostic efficacy of 3D-TVS alone versus 3D-TVS OmniView imaging combined with tomographic imaging in diagnosing IUA was compared. Results: Among the 150 patients, hysteroscopy diagnosed a total of 112 cases (74.7%) of IUA. The sensitivity, specificity, and accuracy of 3D-TVS alone in diagnosing IUA were 82.1%, 78.4%, and 81.0%, respectively; whereas the sensitivity of 3D-TVS OmniView imaging combined with tomographic imaging significantly increased to 93.7%, with a specificity of 89.2% and an accuracy of 92.0%, all of which were significantly higher than those of 3D-TVS alone (P < 0.05). In terms of adhesion degree identification, combined imaging demonstrated higher consistency in judging moderate and severe adhesions (κ = 0.82), particularly in displaying deformations of the uterine cavity contour, adhesion bridges, and focal atresia with greater clarity. Conclusion: The implementation of 3D-TVS OmniView combined with tomographic imaging in patients with intrauterine adhesions yields higher diagnostic accuracy. This non-invasive, intuitive imaging method holds significant clinical value and can serve as an important screening tool prior to hysteroscopy, meriting widespread adoption and application.

Study on the Impact of Early Pregnancy Preeclampsia Screening and Personalized Intervention on Adverse Pregnancy Outcomes in Obese Pregnant Women

Yudi Wang — 2026-03-10

Objective: To investigate the preventive effects of early pregnancy preeclampsia screening combined with personalized intervention on gestational diseases and adverse pregnancy outcomes in obese pregnant women. Methods: A retrospective analysis was conducted on the differences in clinical intervention effects among 67 obese pregnant women in early pregnancy (from June 2023 to February 2025). All subjects underwent early pregnancy preeclampsia screening and were subsequently grouped based on differences in gestational health intervention plans. The clinical effects of conventional intervention (control group, 33 cases) and personalized intervention (study group, 34 cases) were compared. Results: Compared with the control group, the SQHMP score increased in the study group after intervention, and the weight gain at 20 weeks of gestation and before delivery decreased (P < 0.05). Compared with the control group, the study group had a higher rate of normal delivery and lower incidences of gestational diseases and adverse pregnancy outcomes after intervention (P < 0.05). Conclusion: Personalized intervention during pregnancy for obese pregnant women based on the results of early pregnancy preeclampsia screening can maintain healthy weight gain during pregnancy, assist in developing self-management skills during pregnancy, and reduce the risk of gestational diseases and adverse pregnancy outcomes.

The Application of Mindfulness-Based Stress Reduction Therapy in Patients with Postpartum Mood Disorders and Its Impact on Quality of Life

Xuexia Yu — 2026-03-10

Objective: To explore the application of mindfulness-based stress reduction (MBSR) therapy in patients with postpartum mood disorders and its impact on quality of life. Methods: A total of 61 patients with postpartum mood disorders admitted to our hospital from June 2023 to June 2025 were selected and divided into a control group (n = 30, receiving routine intervention) and an observation group (n = 31, receiving additional MBSR therapy) using the red-blue ball method. Changes in mood disorders, serum serotonin, dopamine, norepinephrine, and quality of life were compared between the two groups. Results: After intervention, the anxiety and depression scores in the observation group were significantly lower than those in the control group (all P < 0.05). After intervention, the serum levels of serotonin, dopamine, and norepinephrine in the observation group were significantly higher than those in the control group (all P < 0.05). After intervention, the quality of life score in the observation group was significantly higher than that in the control group (P < 0.05). Conclusion: The application of MBSR therapy in patients with postpartum mood disorders can significantly reduce anxiety and depression, improve serum serotonin, dopamine, and norepinephrine levels, and enhance quality of life, which is worthy of recognition.

Recognition and Management of Adverse Reactions to Immunotherapy in Gynecologic Oncology: A Comprehensive Review

Guangjin Xu — 2026-03-10

Background: Immune checkpoint inhibitors (ICIs) have transformed gynecologic cancer treatment, but their use is complicated by immune-related adverse events (irAEs) that pose significant clinical challenges. Objective: This review systematically summarizes the epidemiology, mechanisms, recognition, and management of irAEs in gynecologic malignancies, highlighting controversies and future directions. Main content: IrAEs occur in a substantial proportion of gynecologic oncology patients, with varying onset and severity profiles by ICI class and cancer type. Pathophysiological mechanisms include off-target T-cell activation and molecular mimicry. Recognition requires vigilance toward multi-organ toxicities. Management follows CTCAE-guided tiered strategies: mild events permit continued immunotherapy with supportive care, while severe toxicities require treatment interruption and corticosteroids, with escalation to second-line agents in refractory cases. Special considerations include combination regimens, elderly patients, and immunotherapy rechallenge decisions. Conclusion: Optimal irAE management requires multidisciplinary collaboration, individualized risk assessment, and standardized protocols. Future research should focus on predictive biomarkers and preventive strategies to maximize efficacy while ensuring safety.

Research on the Role and Mechanism of Vitamins A and D in Pregnant Patients with Hypothyroidism

Jie Fan — 2026-03-10

Objective: To investigate the roles and mechanisms of vitamins A and D in pregnant women with hypothyroidism. Methods: The study sample was collected from January 2024 to December 2025, consisting of 100 pregnant women with hypothyroidism, designated as the hypothyroidism group. Normal pregnant women undergoing prenatal check-ups at our hospital during the same period were selected as the normal group. Serum levels of vitamins A and D were measured in both groups, along with serum thyroid-stimulating hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3) levels. Comparative analysis of relevant indicators between the two groups was conducted, and the correlations between vitamin A and D levels and thyroid function indicators were explored. Results: Compared with the normal group, the hypothyroidism group exhibited significantly lower serum levels of vitamins A and D, with statistically significant differences (P < 0.05). The TSH level in the hypothyroidism group was significantly higher, while FT4 and FT3 levels were significantly lower (P < 0.05). Correlation analysis revealed that serum vitamin A and D levels were significantly negatively correlated with TSH levels and significantly positively correlated with FT4 and FT3 levels (P < 0.05). Questionnaire results indicated that the proportion of inadequate vitamin A and D intake and insufficient sunlight exposure was higher in the hypothyroidism group than in the normal group. Conclusion: Pregnant women with hypothyroidism have reduced levels of vitamins A and D, and their deficiency may contribute to the development of hypothyroidism by affecting thyroid hormone synthesis and secretion as well as immune regulatory mechanisms. Strengthening the assessment and intervention of vitamin A and D nutrition in pregnant women can help improve thyroid function status.